CNS presentation of Lyme disease

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ELISA• neuroborreliosis– sensitivity 21 à 98 % according to the type of serology– specificity 69 à 99 % according to the type of serology• A positive specific antibody response may persist formonths or even years after successful treatment ofthe infection• No follow-up of antibody titer
Western blot• First antibodies in early borreliosis– IgM p 41– puis IgG p41• American criteria– IgM : at leat 2 among p24, p39, p41– IgG : at least 5 among p19, p21, p28, p30, p39, p41,p45, p58, p66, p93• No european criteria• Lack of reproductibility
Page 5 and 6: The answer• If your referenceis
Page 8 and 9: What do we need to make diagnosis o
Page 10 and 11: Lyme diseasethe three steps of diag
Page 13 and 14: Microbiological Epidemiology- infes
Page 17 and 18: Symptoms of Lyme borreliosiskinetic
Page 19 and 20: Early LNB• PNS manifestations.- m
Page 21 and 22: Late neuroborreliosis• PNS manife
Page 23 and 24: Neuroborreliosis an exemple in a re
Page 27: Serology two-step approachScreening
Page 31 and 32: Diagnosis criteria
Page 33 and 34: European national neurological soci
Page 35 and 36: Antibiotic choice for neuroborrelio
Page 37 and 38: Doxyxyclin and neuroborreliosis•
Page 39 and 40: Treatment of nervous system Lymedis
Page 42 and 43: Some specific situations
Page 44 and 45: Late stage neuroborreliosis• Ther
Page 46 and 47: Follow up• No correlation between
Page 48 and 49: Koch’s postulate• The microorga
Page 50 and 51: The polemic• Some patients « see
Page 53 and 54: Aim of the study• Evaluate the po
Page 55: Conclusion• Right diagnosis is im

CNS presentation of Lyme disease

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