CNS presentation of Lyme disease

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Late neuroborreliosis• <strong>CNS</strong> manifestations.– cerebral vasculitis– chronic progressive <strong>Lyme</strong> encephalitis– encephalomyelitis with tetraspasticsyndrome, spastic– ataxic gait disorder anddisturbed micturition.European national neurological societies guidelines.Mygland et al. Eur J Neurol, 2010 ; 17 : 8-16
Neuroborreliosis an exemple in a recenttherapeutic surveyJ. Oksi, Eur J Clin Microbiol Inf Dis, 2007 ; 26 : 571-581• Inclusion Criteria used :– lymphocytic meningitis,– cranial neuritis,– paresis,– radiculoneuritis,– Encephalomyelitis– Peripheral neuropathy(confirmed by ENMG)– Encephalopathy (confirmed byneuropsychiatric tests)• Observed manifestations (n = 145)– Lymphocytic meningitis without radiculitis :18– Meningoradiculitis : 27– Paresis 5– Encephalomyelitis : 4– Encephalopathy : 6– Facial paresis : 21– Sudden deafness : 6– Tinnitus 8– Other cranial nerve involvement : 13– Peripheral neuritis : 6– Other peripheral nervous systemmanifestations : 24– Headache without meningitis 39– Dizziness or vertigo 29– Transient global amnesia, epileptiformconvulsions 1– Memory impairment 11
Page 5 and 6: The answer• If your referenceis
Page 8 and 9: What do we need to make diagnosis o
Page 10 and 11: Lyme diseasethe three steps of diag
Page 13 and 14: Microbiological Epidemiology- infes
Page 17 and 18: Symptoms of Lyme borreliosiskinetic
Page 19 and 20: Early LNB• PNS manifestations.- m
Page 21: Late neuroborreliosis• PNS manife
Page 27 and 28: Serology two-step approachScreening
Page 29 and 30: Western blot• First antibodies in
Page 31 and 32: Diagnosis criteria
Page 33 and 34: European national neurological soci
Page 35 and 36: Antibiotic choice for neuroborrelio
Page 37 and 38: Doxyxyclin and neuroborreliosis•
Page 39 and 40: Treatment of nervous system Lymedis
Page 42 and 43: Some specific situations
Page 44 and 45: Late stage neuroborreliosis• Ther
Page 46 and 47: Follow up• No correlation between
Page 48 and 49: Koch’s postulate• The microorga
Page 50 and 51: The polemic• Some patients « see
Page 53 and 54: Aim of the study• Evaluate the po
Page 55: Conclusion• Right diagnosis is im

CNS presentation of Lyme disease

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