CNS presentation of Lyme disease

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NeuroborreliosisAt which stage ?• Early manifestations– At the very least 3 weeks after tick bites– Sometimes before seroconversion– Mainly : facial palsy• Secondary manifestations– Mainly radiculitis• Late manifestations– Encephalopathy, myelitis• Post Lyme disease– …
Early LNB• PNS manifestations.– most common manifestation in Europe : meningoradiculitis(Bannwarth’s syndrome)• radicular pain (in 86% of the patients)• paresis (in 61%) especially facial palsy, less often the abducensor the oculomotor nerves, sometimes the abdominal wall or thelimbs• typically exacerbates at night.• Headache (43%)• lymphocytic meningitis• other peripheral neurological manifestations (in 5–10% of thepatients) : plexus neuritis and mononeuritis multiplex.European national neurological societies guidelines.Mygland et al. Eur J Neurol, 2010 ; 17 : 8-16
Page 5 and 6: The answer• If your referenceis
Page 8 and 9: What do we need to make diagnosis o
Page 10 and 11: Lyme diseasethe three steps of diag
Page 13 and 14: Microbiological Epidemiology- infes
Page 17: Symptoms of Lyme borreliosiskinetic
Page 21 and 22: Late neuroborreliosis• PNS manife
Page 23 and 24: Neuroborreliosis an exemple in a re
Page 27 and 28: Serology two-step approachScreening
Page 29 and 30: Western blot• First antibodies in
Page 31 and 32: Diagnosis criteria
Page 33 and 34: European national neurological soci
Page 35 and 36: Antibiotic choice for neuroborrelio
Page 37 and 38: Doxyxyclin and neuroborreliosis•
Page 39 and 40: Treatment of nervous system Lymedis
Page 42 and 43: Some specific situations
Page 44 and 45: Late stage neuroborreliosis• Ther
Page 46 and 47: Follow up• No correlation between
Page 48 and 49: Koch’s postulate• The microorga
Page 50 and 51: The polemic• Some patients « see
Page 53 and 54: Aim of the study• Evaluate the po
Page 55: Conclusion• Right diagnosis is im

CNS presentation of Lyme disease

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