Narcotics research, rehabilitation, and treatment. Hearings, Ninety ...
Narcotics research, rehabilitation, and treatment. Hearings, Ninety ... Narcotics research, rehabilitation, and treatment. Hearings, Ninety ...
—54Sand the bureaucracy and the apparently headless effort that is beingconducted to develop these drugs, do you think there would be anymerit on a very pragmatic basis of a prize established—a bonus orreward of a significant amount of money, a million dollars, perhapsfor the achievement of an antagonist that would last not less than 30days and whatever the other criteria are that logic would dictate? Doyou think that that would produce a response from the researchcommunity?Dr. Resnick. Yes; I think if they were paid for their efforts theywould do the job.Mr. Steiger. Assuming they would only be paid if they weresuccessfid, obviously, and if they were first. I do not mean a contractnow.Dr. Resnick. I would not presume to answer that question.Mr. Steiger. All right. Winthrop is furnishing you with thecyclazocine; right?Dr. Resnick. Yes.Mr. Steiger. Do j^ou know if Winthrop is doing anything to makecyclazocine a longer acting substance?Dr. Resnick. To my knowledge, no.Mr. Steiger. Would it be reasonable to assume that if there weresome commercial incentive for them to do so, that they would do so?Dr. Resnick. It is reasonable.,,f IMr. y-jSteiger. Have they the research capability to do so?Dr. Resnick. I do not know.Mr. Steiger. Do you know of any laboratory that has the experienceor any research organization that has the experience, to make cyclazocinea longer acting substance?Dr. Resnick. Oh, yes. I know, as I stated, that we have arrangeda contract with a particular biochemical laboratory for this purpose.I am sure there are many throughout the country who have thepersonnel and the technical know-how to be able to proceed withsuch studies. I am not a chemist but I do not think the chemicalproblems are that difficult.As I said, I think we have the knowledge. We just need the fundsto pay people to go through the rigor of testing the different vehicles.Mr. Steiger. You apparently have not discussed this possibilitywith Winthrop but you are in a position to, at least speculate. Whyisn't AVinthrop interested in extending the effectiveness of this drug,the effective timespan of cyclazocine? Is it not commercially valuable?Dr. Resnick. I wish you would ask Winthrop. I can only guess.Mr. Steiger. I suspect we might. (See exhibit No. 32.)Dr. Resnick. My guess is that it is economic considerations. It isan expensive thing to have to do and if they want to do it, then theywant to feel that there is some remuneration for it.Mr. Steiger. I have no further questions, Mr. Chairman.Chairman Pepper, ^^r. Murphy.Mr. MuKPHY. Thank you, ^lr. Chairman.I agree with Mr. Steiger's suggestion that we give an inducement tosome chemist or doctor or some laboratory to come up with a cure forthis. I am all for taking the lady down from the Cai)itol and replacingher with whoever comes up with that cure, as it is such an importantproblem. And I cannot understand why none have not pursued this
549with more vigor and funded the program if what you say is true, Doctor.I think a lot of us here in Congress are derelict in our duty andhave been derelict in our duty in the past. I know this may soundself-serving because I am a member of this committee, but I commendthe chairman, Mr. Pepper from Florida, and the members of the committeefor undertaking this study because it is long overdue. I commendyou, Doctor, for your work and I agree with 5*!r. Steiger that itis about time the Federal Government took a lead in this program.We owe a responsibility to a generation of young Americans that weare not only losing in Vietnam but we are losing back here. This soundslike a Fourth of July statement, but I really feel it and I know thatmembers of the committee feel it. Again, I want to congratulate Mr.Pepper for providing the leadership for this study and this testimony.Dr. Resnick. I will second that.Mr. Steiger. I wonder if the gentleman will yield. I thought thegentleman might pursue the military aspect of this.In issuing cyclazocine to the military—much as you made the equationof Atabrine, and, of course, we did it as far as venereal diseases,et cetera; so it is not a unique idea—I wonder what would be thepractical difficulties? Is cyclazocine, for example, readily available asfar as you know? Would it be available in sufficient quantities?Dr. Resnick. To my knowledge cyclazocine is available and couldbe easily made available. We have not had any trouble. I mean,Sterling-Win throp has supplied us with as much cyclazocine and otherindividuals throughout the [country who are fusing fit, with as muchsay we need. There has never been any problem with that.Mr. Steiger. All right.Now, A\dth your clinical knowledge of cyclazocine in its presentstate of the art, and recognizing the side effects as you do probablybetter than anybody in the country, do you anticipate that when givento a great number of people as you are suggesting, it would create anyparticular problems? The side effects, the high, whatever it is?Dr. Resnick. I can only answ^er the question on the basis of myexperience and my experience has been ^^dth all of the individualswhom I have treated, all of whom, of course, are addicts. I do not knowhow a nonaddict is going to react to cyclazocine. These are all addictswho have withdrawn from heroin, who have been drug free for aperiod of time ranging from a week to several weeks and have beenplaced on cyclazocine. If we build them up on the cyclazocine veryslowly they experience minimal or no side effects. If we build thorn upon the cj^clazocine more rapidly they do experience these side effects.But in 100 percent of the cases these side effects diminish, disappear.We have not had a single case of anj^ patient who stopped taking thisdrug, once he has been built-up, because of side effects. What theresults mil be in some other population I do not know.Mr. Steiger. And there have been no deaths ; is that correct?Dr. Resnick. No deaths. No illness. No harmful effect.Mr. Steiger. Thank you.Chairman Pepper. Mr. Winn?Mr. Winn. Thank you, Mr. Chairman.Along that same line, in a paper that I beHeve you and three otherdoctors presented February 16 and 17 of this 3'^ear in Toronto, Canada^
- Page 517 and 518: 497Dr. ViLLARREAL. So, it is a biol
- Page 519 and 520: '.499could result in a laboratory s
- Page 521 and 522: 5qifinds it in normal exploration.
- Page 523 and 524: 503synthesized a large number of na
- Page 525 and 526: 505STATEMENT OE DR. ALBERT KURLAND,
- Page 527 and 528: 507discovered if we iiad taken the
- Page 529 and 530: 509Mr. Perito. Dr. Kurland, do you
- Page 531 and 532: 511Chairman Pepper. Has the Food an
- Page 533 and 534: 513]Mr. Steiger. Do you feel from y
- Page 535 and 536: 515In this second study there was a
- Page 537 and 538: 517were any significant differences
- Page 539: 519The Deceptive Communication and
- Page 542 and 543: .522than a State psychiatric hospit
- Page 544 and 545: 524Department of Mental Hygiene), R
- Page 546 and 547: TABLE 3—COMPARISON OF THE 1ST POS
- Page 548 and 549: 528TABLE 10—RELATIONSHIP OF AGE T
- Page 550 and 551: 530tution and his involvement in th
- Page 552 and 553: Attachment No. 5;r\ N-CH,-CH=CHo ,
- Page 554 and 555: '-534Chart No. U (case No. 672)Disp
- Page 556 and 557: 536Chart No. 4 (case No. 694)Illust
- Page 558 and 559: 538Chart No. 35 {case No. 697)Excep
- Page 560 and 561: 540This amount of heroin is roughly
- Page 562 and 563: 5msuccessful or not in that short a
- Page 564 and 565: 544Chairman Pepper. Would you repea
- Page 566 and 567: 54^creased amount of licit as well
- Page 570 and 571: ,,Mr.550you have used some of the s
- Page 572 and 573: 552so many areas is also a pitiful
- Page 574 and 575: 55,4nitiide of heroin addiction in
- Page 576 and 577: 556reached $976.5 billion, we can w
- Page 578 and 579: 558Mr. Jones was appointed to the c
- Page 580 and 581: 560cant when you consider that Out
- Page 582 and 583: 562criminal act in his lifetime. Ye
- Page 584 and 585: —564Mr. Perito. Would it be fair
- Page 586 and 587: 566Now, Dr. Cliambers, can yon resp
- Page 588 and 589: —568Mr. Raxgel. Our distinguished
- Page 590 and 591: ;-570Mr. Jones. That is correct. Ou
- Page 592 and 593: 572the commissioner, $186 million i
- Page 594 and 595: 574there should be something in the
- Page 596 and 597: 576and the way in which the funds a
- Page 598 and 599: 57SDr. Chambers. I think wliat you
- Page 600 and 601: 580Education is the best way of pre
- Page 602 and 603: 58-2Certain essential facts must re
- Page 604 and 605: 584done through determined action,
- Page 606 and 607: 586druffs, has the Nation's largest
- Page 608 and 609: :588To repeat, methadone maintenanc
- Page 610 and 611: :590I believe the Federal Governmen
- Page 612 and 613: :take no such satisfaction. We have
- Page 614 and 615: 594of value in the testimony you ha
- Page 616 and 617: 596gone ahead with several. We have
549with more vigor <strong>and</strong> funded the program if what you say is true, Doctor.I think a lot of us here in Congress are derelict in our duty <strong>and</strong>have been derelict in our duty in the past. I know this may soundself-serving because I am a member of this committee, but I commendthe chairman, Mr. Pepper from Florida, <strong>and</strong> the members of the committeefor undertaking this study because it is long overdue. I commendyou, Doctor, for your work <strong>and</strong> I agree with 5*!r. Steiger that itis about time the Federal Government took a lead in this program.We owe a responsibility to a generation of young Americans that weare not only losing in Vietnam but we are losing back here. This soundslike a Fourth of July statement, but I really feel it <strong>and</strong> I know thatmembers of the committee feel it. Again, I want to congratulate Mr.Pepper for providing the leadership for this study <strong>and</strong> this testimony.Dr. Resnick. I will second that.Mr. Steiger. I wonder if the gentleman will yield. I thought thegentleman might pursue the military aspect of this.In issuing cyclazocine to the military—much as you made the equationof Atabrine, <strong>and</strong>, of course, we did it as far as venereal diseases,et cetera; so it is not a unique idea—I wonder what would be thepractical difficulties? Is cyclazocine, for example, readily available asfar as you know? Would it be available in sufficient quantities?Dr. Resnick. To my knowledge cyclazocine is available <strong>and</strong> couldbe easily made available. We have not had any trouble. I mean,Sterling-Win throp has supplied us with as much cyclazocine <strong>and</strong> otherindividuals throughout the [country who are fusing fit, with as muchsay we need. There has never been any problem with that.Mr. Steiger. All right.Now, A\dth your clinical knowledge of cyclazocine in its presentstate of the art, <strong>and</strong> recognizing the side effects as you do probablybetter than anybody in the country, do you anticipate that when givento a great number of people as you are suggesting, it would create anyparticular problems? The side effects, the high, whatever it is?Dr. Resnick. I can only answ^er the question on the basis of myexperience <strong>and</strong> my experience has been ^^dth all of the individualswhom I have treated, all of whom, of course, are addicts. I do not knowhow a nonaddict is going to react to cyclazocine. These are all addictswho have withdrawn from heroin, who have been drug free for aperiod of time ranging from a week to several weeks <strong>and</strong> have beenplaced on cyclazocine. If we build them up on the cyclazocine veryslowly they experience minimal or no side effects. If we build thorn upon the cj^clazocine more rapidly they do experience these side effects.But in 100 percent of the cases these side effects diminish, disappear.We have not had a single case of anj^ patient who stopped taking thisdrug, once he has been built-up, because of side effects. What theresults mil be in some other population I do not know.Mr. Steiger. And there have been no deaths ; is that correct?Dr. Resnick. No deaths. No illness. No harmful effect.Mr. Steiger. Thank you.Chairman Pepper. Mr. Winn?Mr. Winn. Thank you, Mr. Chairman.Along that same line, in a paper that I beHeve you <strong>and</strong> three otherdoctors presented February 16 <strong>and</strong> 17 of this 3'^ear in Toronto, Canada^
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