Narcotics research, rehabilitation, and treatment. Hearings, Ninety ...
Narcotics research, rehabilitation, and treatment. Hearings, Ninety ... Narcotics research, rehabilitation, and treatment. Hearings, Ninety ...
Attachment No. 5;r\ N-CH,-CH=CHo , , :i-CH,-CH«CH,3 u/ \ 6/ X, h/N-CHj-CH-CHgC. LEVALLORPHAHFigure 1. The structural formulas of nalorphine (W-allylnor-orpIiine), lavallorphan(li'-allylnorlevorphan) and naloxone (Il-allylnoroxymorphone).Attachment No. 6Naloxone in the Management of the Narcotic Abuser Employing a SystemOP Partial Blockage—A Pilot Study(Albert A. Kurland, M.D., Assistant Commissioner, State Department of MentalHygiene, Superintendent, Maryland Psychiatric Research Center, MedicalDirector, Friends of Ps3^chiatric Research, Inc.)code0= Specimen negative.Blank Space == Authorized absence.X= Unauthorized absence from clinic.N/S=No specimen—could not void.-= Specimen combined with previous day's specimen./= Clinic closed.D = Deceased.H= Hospital.?= Incomplete data from laboratory.F= Absconding,J= Jail.illicit drug usageA= Positive for amphetamines and methamphetamines.B= Positive for barbiturates.C= Positive for codeine.CC= Positive for cocaine.Di= Positive for dilaudid.M= Positive for heroin or morphine.Me= Positive for methadone.Q— Quinine in specimen.1 = 200 Mg.11 = 400 Mg.111 = 000 Mg.1111 = 800 Mg..= Naloxone rejected.:= Naloxone discontinued.t= Placebo.*= OS all medication.naloxone
533TRANSFERS(These were parolees who, on the abstinence program, were beginning to decompensateinto increasing opiate usage and under ordinary circumstanceswould have begun to become considered as possible returnees to the correctionalinstitution for violation of their parole, were transferred to the Naloxoneprogram.)Chart No 11 (case No. 546)Displays the course of a parolee who had two admissions to the abstinenceprogram. On his first admission in May 1969, within a few months he decompensatedinto increasing drug usage of a frequency that led first to his hospitalizationin a desperate effort to interrupt it. Within a few days after he was releasedfrom the hospital, he was once more using drugs and was returned to a correctionalinstitution.On a second admission (case No. 607B) he did quite well for a period of severalmonths and then began to show evidence of drug use, bringing about his transferto the naloxone program. Very promptly he reverted back to his abstinent statusand during this course he was changed from the naloxone medication to a placeboand continued to do well. The placebo medication was discontinued after severalweekrs and he has received no medication at all and has continued to do well.TRANSFER ''00^00 CHART NO. 1 1Name: McC.W. 1st Adm, Case No. 5^ Adtir, 5-6-6a- iis. 9-.3a-;v3'o3 May .I 2 3 4 5 6 7 S 9 10 11 i2 13 I'tlS 16 17 18 19 20 21 22 23 24 2S 26 27 12 29 30 31000000000000000000000Juni 000000000July. Q.-dQM K I". ;vAug. Q-'sXClQHHHH H H H HH H HSept. OOOOCOOXQ Q Q, Cj X Qa X QH a X dM FTQ a M Q a- nQ ^Q 1 0. g'.:'S X J2nd Adn. Case No. 607B Adm. 11-4-69- Naloxor- 5-7-7C'69 Wov..1 2 3 4 5 6 7 3 9 10 11 12 13 14 15 16 17 18 19 20, .21 22 23 24 25 26 27 28 29 3C 31
- Page 501 and 502: NARCOTICS RESEARCH, REHABILITATION,
- Page 503 and 504: 483spending for research through NI
- Page 505 and 506: 485There has been no concerted seri
- Page 507 and 508: 487it is left in one of their veins
- Page 509 and 510: 489I do not think I should explain
- Page 511 and 512: 491Dr. ViLLARREAL. Until the reflex
- Page 513 and 514: 493evidence strongly shows is that
- Page 515 and 516: 495Chairman Pepper. One other quest
- Page 517 and 518: 497Dr. ViLLARREAL. So, it is a biol
- Page 519 and 520: '.499could result in a laboratory s
- Page 521 and 522: 5qifinds it in normal exploration.
- Page 523 and 524: 503synthesized a large number of na
- Page 525 and 526: 505STATEMENT OE DR. ALBERT KURLAND,
- Page 527 and 528: 507discovered if we iiad taken the
- Page 529 and 530: 509Mr. Perito. Dr. Kurland, do you
- Page 531 and 532: 511Chairman Pepper. Has the Food an
- Page 533 and 534: 513]Mr. Steiger. Do you feel from y
- Page 535 and 536: 515In this second study there was a
- Page 537 and 538: 517were any significant differences
- Page 539: 519The Deceptive Communication and
- Page 542 and 543: .522than a State psychiatric hospit
- Page 544 and 545: 524Department of Mental Hygiene), R
- Page 546 and 547: TABLE 3—COMPARISON OF THE 1ST POS
- Page 548 and 549: 528TABLE 10—RELATIONSHIP OF AGE T
- Page 550 and 551: 530tution and his involvement in th
- Page 554 and 555: '-534Chart No. U (case No. 672)Disp
- Page 556 and 557: 536Chart No. 4 (case No. 694)Illust
- Page 558 and 559: 538Chart No. 35 {case No. 697)Excep
- Page 560 and 561: 540This amount of heroin is roughly
- Page 562 and 563: 5msuccessful or not in that short a
- Page 564 and 565: 544Chairman Pepper. Would you repea
- Page 566 and 567: 54^creased amount of licit as well
- Page 568 and 569: —54Sand the bureaucracy and the a
- Page 570 and 571: ,,Mr.550you have used some of the s
- Page 572 and 573: 552so many areas is also a pitiful
- Page 574 and 575: 55,4nitiide of heroin addiction in
- Page 576 and 577: 556reached $976.5 billion, we can w
- Page 578 and 579: 558Mr. Jones was appointed to the c
- Page 580 and 581: 560cant when you consider that Out
- Page 582 and 583: 562criminal act in his lifetime. Ye
- Page 584 and 585: —564Mr. Perito. Would it be fair
- Page 586 and 587: 566Now, Dr. Cliambers, can yon resp
- Page 588 and 589: —568Mr. Raxgel. Our distinguished
- Page 590 and 591: ;-570Mr. Jones. That is correct. Ou
- Page 592 and 593: 572the commissioner, $186 million i
- Page 594 and 595: 574there should be something in the
- Page 596 and 597: 576and the way in which the funds a
- Page 598 and 599: 57SDr. Chambers. I think wliat you
- Page 600 and 601: 580Education is the best way of pre
533TRANSFERS(These were parolees who, on the abstinence program, were beginning to decompensateinto increasing opiate usage <strong>and</strong> under ordinary circumstanceswould have begun to become considered as possible returnees to the correctionalinstitution for violation of their parole, were transferred to the Naloxoneprogram.)Chart No 11 (case No. 546)Displays the course of a parolee who had two admissions to the abstinenceprogram. On his first admission in May 1969, within a few months he decompensatedinto increasing drug usage of a frequency that led first to his hospitalizationin a desperate effort to interrupt it. Within a few days after he was releasedfrom the hospital, he was once more using drugs <strong>and</strong> was returned to a correctionalinstitution.On a second admission (case No. 607B) he did quite well for a period of severalmonths <strong>and</strong> then began to show evidence of drug use, bringing about his transferto the naloxone program. Very promptly he reverted back to his abstinent status<strong>and</strong> during this course he was changed from the naloxone medication to a placebo<strong>and</strong> continued to do well. The placebo medication was discontinued after severalweekrs <strong>and</strong> he has received no medication at all <strong>and</strong> has continued to do well.TRANSFER ''00^00 CHART NO. 1 1Name: McC.W. 1st Adm, Case No. 5^ Adtir, 5-6-6a- iis. 9-.3a-;v3'o3 May .I 2 3 4 5 6 7 S 9 10 11 i2 13 I'tlS 16 17 18 19 20 21 22 23 24 2S 26 27 12 29 30 31000000000000000000000Juni 000000000July. Q.-dQM K I". ;vAug. Q-'sXClQHHHH H H H HH H HSept. OOOOCOOXQ Q Q, Cj X Qa X QH a X dM FTQ a M Q a- nQ ^Q 1 0. g'.:'S X J2nd Adn. Case No. 607B Adm. 11-4-69- Naloxor- 5-7-7C'69 Wov..1 2 3 4 5 6 7 3 9 10 11 12 13 14 15 16 17 18 19 20, .21 22 23 24 25 26 27 28 29 3C 31
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