Narcotics research, rehabilitation, and treatment. Hearings, Ninety ...

449Chairman Pepper. Do you happen to remember what the overallfigure is?Dr. Brown. We do not have that at hand at the moment.('J'he information requested fon:)ws:)Additional research is sorel.y needed to develop a long-acting narcotic antagonistto be used as a tool in treatment. The National Institute of Mental Healthhad planned to let contracts for this purpose, but was unable to do so becauseof lack of funds. Promising proposals in this area amounted to $360,000 and aredetailed below:Investigator and descriptive title:Alpen— Battelle: Implantable slow release matrix—biodegradable ^styearpolymer $75,000Gray— University of ^"ermont: Preparation of relatively insolublesalts in aqueous or oil suspension 35, 000Meloy Laboratories: Polymer—coupled narcotic antagonists forintramuscular administration 60, 000Willette-— Connecticut, University of: Long acting forms of existingantagonists 40, 000YoUes— Delaware, University of: Sustained release polvmer process1 1 150,000Total 360, 000Note.— Subsequent to thisjjUd passed by both Houses.hearing, a $67,000,000 budget amendment was submitted to the CongressChairman Pepper. Now, you have described those thi'ee sources,])harmaceutical houses, colleges and universities, and the institutions,community and otherwise. Are there others that can be helpful toyou if you could fund them?•'Dr. Brown. Well, the only other category that we are doing somefunding with crosses over the other three and I think it is tremendouslyimportant in the drug area. That is, certain ty])os of research thatcan be best done or better done overseas in the international arena,and I think that is an important facet of our research ])rogram.Chairman Pepper. You are working in collaboration with theUnited Nations or otherwise?Dr. Brown. With the U.N., the World Health Organization, andother bodies, specifically for example, going to places like Indiawhere you have chronic drug usage, working collaboratively evenwith our chapter 480 funding. In the last year I have endeavoredto step up our use of these funds that are already available to increaseour research endeavor at no additional cost to us, so to speak.Chamiian Pepper. That does not come out of your appropriation?That is chapter 480 funds?Dr. Brown. Right; but the other possibilities in overseas research;for example, in identifying chronic use of, say, amphetamines; togo to places where this has perhaps happened more than has happenedhere. This is analogous to what we are trying to do with marihuana.The foreign category of research endeavors is another important lead.There is one other research responsibility that I would like toput on the table, so to speak, which is, that as bad as the problem is,we have to anticipate the problems that are coming on us very rapidly,by which I mean, with the drug industry and science producmg newdrugs, just to stay abreast of screening those drugs with abuse potential,to liave a so-called early warning system to know which drugsare not going to be dangerous so that we can perhaps put them inthe right schedule or alert the medical profession—we need increased