Narcotics research, rehabilitation, and treatment. Hearings, Ninety ...

Narcotics research, rehabilitation, and treatment. Hearings, Ninety ... Narcotics research, rehabilitation, and treatment. Hearings, Ninety ...

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308EESULTSStudies concerning tlie pathogenesis of addiction and withdrawal syndromeand of the ditl'erent therapeutic attempts were made in over 1,000 patients. Theywere young and old addicts, ranging from 14 to 48 years of age. Most were addictedto heroin and cocaine, a few to morphine and barbiturates. Some werenewly started on the habit, while others were using the drug for years, someeven for more than 20 years.Almost all patients wlien submitted to adequate treatment responded with thesame promptness. Administration of selenium preparations by injection to anaddict is generally followed within minutes by a favorable subjective change.Most of the subjects use the same terms to describe the sensation they feel. Theysay: "I am normal" to indicate that the effect is fundamentally different fromthat obtained with the addicting drug. And this sensation persists usually from2 to 12 hours. Their manifestation of an immediate loss of the urge, namely theneed for the addicting drug is a very important effect. Concoraitant]y, the patientIs started on the adjuvant acidifying solution, which is repeated as often asany symptom of withdrawal appears. With these medications (the seleniumpreparation and the adjuvant) addiction and withdrawal symptoms are eontrolledwithout being replaced by euplioria. There is no sensation of being ''high"like that induced by the addicting drug, but rather an old sensation of feeling"normal."With the treatment used as indicated above, most of the patients remain freeof symptoms during and after the treatment.Against insomnia we give barbiturates only if the usual doses of chloral hydrateappear insufficient : and this only for the first days of treatment.Although there is no pain or any local or general reaction after the injections,many patients even after first few injections indicate the desire to discontinuethese injections. They say : "I do not need any injections anymore, I have nourge or any trouble, I am normal now." We then continue the treatment with theadjuvant solution orally, recurring to injections only if the withdrawal symptomsare not fully controlled by this oral medication.In a variant of the treatment, the injections of selenium are replaced by theoral administration of the oily concentrated solution of the same px'eparationswith capsules containing up to 3-5 mg. Se. They are administered together withthe adjuvant solution, and in some cases the clinical results are similar to thoseobtained with the injections.In order to evaluate objectively the effects of the different medications uponwithdrawal symptonv'^- we have used a ouantitation of the syndrome accordingto the method of Hi-^'melsliaeh, which we have expanded by adding other symptomsand signs. Each of the withdrawal symptoms or signs such as vomiting,diarrhea, lacrimation etc. are given a numerical value. This eva^i^ation of thecondition is made either once or sevei-al times a day, and at the end of each observationthe points obtained are added up. The curves drawn represent thecour.se of withdrawal. For untreated siibjects the curves have a steep risingabruptly and remaining elevated for a number of days. For patients receiving thetreatment, the curves barely rise and remain very low. for duration of the treatmentand thereafter.CONTROT,RIn order to assess the real effectiveness of this treatment, we have carried outcontrol .studies. Some patients were given only a very small amount of the seleniumpreparation to calm the withdrawal symptoms for a short time. When thepatient felt a return of the symptoms or an urge for the addicting drug, he wasgiven an injection of sterile sesame oil or of a preparation known as being ineffici^'nt.In every instance the incipient withdrawal symi^foms became mngnifiedand the patient often became uncontrollable. A number of these patients becameso agitated that they signed themselves out of the program. An adequate treatmentwith injections of the selenium rtreparation find adjuvant solution cnlmedthe wltlidrn-^'nl pviiiptoms within minntos. Ti.is! pi-T^eduro wns '•r'nen**':! on nnumber of diffei-ent pntients, as v,-ell ns cm the same patient at different times,and was alwavs followed bv the same effect.Double blind studies will have to be carried out next in an institution betterequipped to Implement such an aspect of the program.

309COMPAKISOXThe subjects who had undergone previous detoxification treatments, remarkedon the difference between this and other earlier treatments. They particularlypointedout that with our treatment they no longer felt the need for the addictingdrug. With methadone, for example, they claimed to have remained with painsin the legs and e.specially with the urge for the addicting rlrug during, and evenafter, treatment. In contrast, the urge for the drug disapiieared practically withthe first injection of our treatment, and then did not recur.FOLLOWUPAfter the first injection with the selenium preparation almost no patient hasvoiced the desire the drug. UpoH leaving the hospital after 5 to 8 days, theyall manifest emphatically this lack of need for the drug. On followup visitsmany subjects were seen to have remained free of narcotics weeks and evenmonths after treatment.Others, however, resumed taking drugs. It is nevertheless important to pointout that not a single patient who has resumed taking the drugs and who has comeback for help, has said that he did it because of a return of the "urge." A fewresumed using drugs because of unresolved psychological problems. Many becausethey were "forced" by friends, and have been using addicting drugs withoutany need or desire for the drug. Most of the patients after treatment return totheir old problems and their unchanged environment. They do not receive psychologicalor social help. Yet, inspite of this, of about 1.50 patients referred to usby Rev. Raymond Massey of the Neighborhood Board No. 5, Inc., 22 percenthave returned to steady jobs without additional medication, and without thehelp of psychological or social services. Of those receiving outside help, another17 percent have returned to steady jobs.VArXJE OF THIS APPROACHIn this important problem of addiction, we must evaluate as objectively aspossible the contribution which every new approach may bring to the solution ofthe problem. Based on the the results we obtained, our treatment seems to representa working solution of the medical problem of addiction. In a few days theaddict becomes free from the craving for the drug, without having to undergothe torture of the withdrawal syndrome. This then opens the door for the secondand third approaches, namely the psychological and social ones.Without the physical need for the drug, many of the patients become awareof the important part played by their psychological condition and ask for psychiatricand social help.The efficacy of the treatment gives back to the patient the hope he had lost,namely the possibility of a total recovery. By no longer facing the medical problem,the psychiatrist can treat a subject who is no longer hopeless or even hostile,but one who is looking for help, like a nonaddict in his situation would do. Andthis is the important contribution of our treatment to the psychological problemof addiction. The experience of psychiatrists—in particular that of Dr. D. Casriel,New York City—in the field of addiction has confirmed the importance of therelationship between our medical approach and the indispensable psychologicaltreatment of addiction.While the treatment contributes to the solution of the medical problem ofaddiction, we must emphasize the need to integrate it into the more generalproblem with its psychological and economical aspects. The medical treatmentwill show its full value as part of such a complete program.(Based on a lecture given at the Trafalgar Hospital medical staff meeting.May 23, 1970)Emanuel Revici, M.D., Scientific Director, Institute of Applied Biology, Inc.TREATMENT OF DRUG ADDICTIONIt is unnecessary to emphasize the importance of a simple, safe, efficient, andinexpensive method for the control of the medical a.spect of drug addiction. Thisrepresents the key for the completion of the treatment through an efiicientpsychological approach—and further social adjustments.

309COMPAKISOXThe subjects who had undergone previous detoxification <strong>treatment</strong>s, remarkedon the difference between this <strong>and</strong> other earlier <strong>treatment</strong>s. They particularlypointedout that with our <strong>treatment</strong> they no longer felt the need for the addictingdrug. With methadone, for example, they claimed to have remained with painsin the legs <strong>and</strong> e.specially with the urge for the addicting rlrug during, <strong>and</strong> evenafter, <strong>treatment</strong>. In contrast, the urge for the drug disapiieared practically withthe first injection of our <strong>treatment</strong>, <strong>and</strong> then did not recur.FOLLOWUPAfter the first injection with the selenium preparation almost no patient hasvoiced the desire the drug. UpoH leaving the hospital after 5 to 8 days, theyall manifest emphatically this lack of need for the drug. On followup visitsmany subjects were seen to have remained free of narcotics weeks <strong>and</strong> evenmonths after <strong>treatment</strong>.Others, however, resumed taking drugs. It is nevertheless important to pointout that not a single patient who has resumed taking the drugs <strong>and</strong> who has comeback for help, has said that he did it because of a return of the "urge." A fewresumed using drugs because of unresolved psychological problems. Many becausethey were "forced" by friends, <strong>and</strong> have been using addicting drugs withoutany need or desire for the drug. Most of the patients after <strong>treatment</strong> return totheir old problems <strong>and</strong> their unchanged environment. They do not receive psychologicalor social help. Yet, inspite of this, of about 1.50 patients referred to usby Rev. Raymond Massey of the Neighborhood Board No. 5, Inc., 22 percenthave returned to steady jobs without additional medication, <strong>and</strong> without thehelp of psychological or social services. Of those receiving outside help, another17 percent have returned to steady jobs.VArXJE OF THIS APPROACHIn this important problem of addiction, we must evaluate as objectively aspossible the contribution which every new approach may bring to the solution ofthe problem. Based on the the results we obtained, our <strong>treatment</strong> seems to representa working solution of the medical problem of addiction. In a few days theaddict becomes free from the craving for the drug, without having to undergothe torture of the withdrawal syndrome. This then opens the door for the second<strong>and</strong> third approaches, namely the psychological <strong>and</strong> social ones.Without the physical need for the drug, many of the patients become awareof the important part played by their psychological condition <strong>and</strong> ask for psychiatric<strong>and</strong> social help.The efficacy of the <strong>treatment</strong> gives back to the patient the hope he had lost,namely the possibility of a total recovery. By no longer facing the medical problem,the psychiatrist can treat a subject who is no longer hopeless or even hostile,but one who is looking for help, like a nonaddict in his situation would do. Andthis is the important contribution of our <strong>treatment</strong> to the psychological problemof addiction. The experience of psychiatrists—in particular that of Dr. D. Casriel,New York City—in the field of addiction has confirmed the importance of therelationship between our medical approach <strong>and</strong> the indispensable psychological<strong>treatment</strong> of addiction.While the <strong>treatment</strong> contributes to the solution of the medical problem ofaddiction, we must emphasize the need to integrate it into the more generalproblem with its psychological <strong>and</strong> economical aspects. The medical <strong>treatment</strong>will show its full value as part of such a complete program.(Based on a lecture given at the Trafalgar Hospital medical staff meeting.May 23, 1970)Emanuel Revici, M.D., Scientific Director, Institute of Applied Biology, Inc.TREATMENT OF DRUG ADDICTIONIt is unnecessary to emphasize the importance of a simple, safe, efficient, <strong>and</strong>inexpensive method for the control of the medical a.spect of drug addiction. Thisrepresents the key for the completion of the <strong>treatment</strong> through an efiicientpsychological approach—<strong>and</strong> further social adjustments.

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