Narcotics research, rehabilitation, and treatment. Hearings, Ninety ...

Narcotics research, rehabilitation, and treatment. Hearings, Ninety ... Narcotics research, rehabilitation, and treatment. Hearings, Ninety ...

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12a variety of committees of the American Medical Association dealingwith druss for over 20 vears, I am fully aware that physicians areextremely conservative about drug therapy. Codeine, for example,ranks high on the list of "most prescribed" drugs for the relief otcough and minor pains. It is a constituent of many mixtures whichare "prescribed for a varietv of sedative and antispasmodic effects.Whereas we do have effective substitutes for codeine which areknown to be safe, they have made relatively little inroads in the prescribingof codine. Furthermore, they do not substitute for codeine inall respects, particularly since they lack its analgesic and mild sedativeproperties. Relative costs, although not a compelling factor, must beconsidered. Tax-free morphine is now one of the cheapest compoundsavailable to medicine today.The paramount question then which confronts you, in my opinion.is not whether synthetics will substitute for "horticulturally derived"narcotics but rather whether outlawing the latter in favor of syntheticswill accomplish the objectives of significantly diminishing abuse ofall narcotic analgesics or, in fact, of even heroin itself.I say this because of several international situations. I just returnedfrom Japan last week where I consulted with the Minister of Health.They know exactly how most of the heroin and opium arrive in Japan,largely down the Mekong River from the countries which I mentionedearlier, transshipped through Macao in Hong Kong. From there itis smuggled into their many ports, some by air, but mostly by sea toKobe and Yokohama, et cetera.The Japanese have done a good job of heroin control. In 1964, theJapanese had a sharp rise in heroin abuse. They make an all-out effortto control this. They have available to them the facilities which Idoubt are available in the United States. In the first place, when theysay an all-out Government effort they really mean it. This goes fromthe Prime Minister on down. In the last 4 or 5 years they have helclseveral thousand public meetings all over Japan in which governors,states, mayors, even the Prime Minister participate. These are usuallyheld in theaters or a public auditorium and may be attended by asmany as 3,000 or 4,000 people. The hazards of drug addiction aregraphically portrayed.Furthermore, radio, television, newspapers, and other communicationmedia have made an all-out campaign against heroin.One of the things which I believe contributes significantly to theirsuccess is the fact that Japan has attacked one drug at a time ratherthan to try to hit the whole area of drug abuse. This goes back to 1955when they had the world's largest epidemic of stimulant drug abuse.In that year there were 55,000 arrests of methamphetamine abusers.Two years later they had reduced this by strong countermeasures to alevel of about a thousand arrests. This is the only extensive epidemicof drug abuse, with which I am familiar, in the world that has beencontrolled in such a short time. They later did a similar job of controllingheroin.One of the situations involves different attitudes toward authority.In Japan, when an expert goes on television, such as a professor in 'amajor university, people listen to him. I am certain this rarely occurs

13in this country. This raises the question whether we really have thecapabilities of adopting successfully this type of approach.But the Japanese have their problems as well. I bring this in incidentallybecause it doesn't bear on your major thrust but it is a drugabuse problem which must be dealt with.Last year, Japan had 40,000 arrests for glue sniffing, with 200 deaths.That is one kind of substance which is almost impossible to control.To do so, we would have to control all sales from paint stores and purveyorsof more than 50 related solvents. Lacquer thinner is used extensivelyin Japan by teenagers 16, 18 years old. So Japan is not withouther problems, but they have done a remarkably good job in controllingamphetamines and heroin addiction. I was told by the Ministry that itliacl been reduced to a level where they though it was probably impossibleto reduce it further. I think this is important—to recognize thatcontrol will never be absolute.Chairman Pepper. Mr. Perito, any questions ?Mr. Perito, Dr. See vers, I had the opportunity to look at your laborator3^The committee has not had that unique opportunity.I wonder if you could kindly explain to the committee exactly whatis being done in your primate laboratory and how that laboratory isfinanced ?Dr. Seevers. This laboratory has been in operation for 20 years. AsI indicated—we have tested during this time some 800 drugs. This testingprocedure started about 1953. We set it up originally on an entirelyobjective basis and it has always remained so. Dr. Nathan Eddy, whois here in the room, has been a long time collaborator on the project. Hereceived these drugs on a confidential basis from industry. This facilityhas been available to those who wish to submit for testing. Dr. Eddysent them to our laboratory by code number so that we do not knowthe identity of the supplier.Once the tests have been made the information is channeled backto Dr. Eddy and he informs the manufacturer.Until about 5 years ago, our testing procedure involved primarilydrugs which would substitute for morphine or for heroin. In otherwords, we were looking for a drug which was superior to morphinein the sense it reduced respiratory depression, less side effects, less tolerancedevelopment, and less what we call, in general terms, addictionliability, the capacity to produce physical dependence.We tested many compounds for 15 years and didn't find any thatwould fulfill most of these qualifications. Wlien it was discovered thatsome of the antagonists, which I understand you are going to considerlater, also possessed pain-relieving properties, somewhat like morphine,and yet did not produce physical dependence or lead to addiction,then a new concept was born. Since that time we have tested ahundred or more antagonists. We have done this with the objective offinding a substance which would still be useful as a pain reliever butdid not have a capacity to produce physical dependence. I understandthat is a class of drug that you intend to explore.We maintain a colony of around a hundred monkeys. They receivean injection of morphine every 6 hours, day and night, right aroundthe clock, 7 days a week. When we want to test a new drug we simplysubstitute for the morphine which they ordinarily receive. If this drug

12a variety of committees of the American Medical Association dealingwith druss for over 20 vears, I am fully aware that physicians areextremely conservative about drug therapy. Codeine, for example,ranks high on the list of "most prescribed" drugs for the relief otcough <strong>and</strong> minor pains. It is a constituent of many mixtures whichare "prescribed for a varietv of sedative <strong>and</strong> antispasmodic effects.Whereas we do have effective substitutes for codeine which areknown to be safe, they have made relatively little inroads in the prescribingof codine. Furthermore, they do not substitute for codeine inall respects, particularly since they lack its analgesic <strong>and</strong> mild sedativeproperties. Relative costs, although not a compelling factor, must beconsidered. Tax-free morphine is now one of the cheapest compoundsavailable to medicine today.The paramount question then which confronts you, in my opinion.is not whether synthetics will substitute for "horticulturally derived"narcotics but rather whether outlawing the latter in favor of syntheticswill accomplish the objectives of significantly diminishing abuse ofall narcotic analgesics or, in fact, of even heroin itself.I say this because of several international situations. I just returnedfrom Japan last week where I consulted with the Minister of Health.They know exactly how most of the heroin <strong>and</strong> opium arrive in Japan,largely down the Mekong River from the countries which I mentionedearlier, transshipped through Macao in Hong Kong. From there itis smuggled into their many ports, some by air, but mostly by sea toKobe <strong>and</strong> Yokohama, et cetera.The Japanese have done a good job of heroin control. In 1964, theJapanese had a sharp rise in heroin abuse. They make an all-out effortto control this. They have available to them the facilities which Idoubt are available in the United States. In the first place, when theysay an all-out Government effort they really mean it. This goes fromthe Prime Minister on down. In the last 4 or 5 years they have helclseveral thous<strong>and</strong> public meetings all over Japan in which governors,states, mayors, even the Prime Minister participate. These are usuallyheld in theaters or a public auditorium <strong>and</strong> may be attended by asmany as 3,000 or 4,000 people. The hazards of drug addiction aregraphically portrayed.Furthermore, radio, television, newspapers, <strong>and</strong> other communicationmedia have made an all-out campaign against heroin.One of the things which I believe contributes significantly to theirsuccess is the fact that Japan has attacked one drug at a time ratherthan to try to hit the whole area of drug abuse. This goes back to 1955when they had the world's largest epidemic of stimulant drug abuse.In that year there were 55,000 arrests of methamphetamine abusers.Two years later they had reduced this by strong countermeasures to alevel of about a thous<strong>and</strong> arrests. This is the only extensive epidemicof drug abuse, with which I am familiar, in the world that has beencontrolled in such a short time. They later did a similar job of controllingheroin.One of the situations involves different attitudes toward authority.In Japan, when an expert goes on television, such as a professor in 'amajor university, people listen to him. I am certain this rarely occurs

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