12.07.2015
•
Views
12a variety of committees of the American Medical Association dealingwith druss for over 20 vears, I am fully aware that physicians areextremely conservative about drug therapy. Codeine, for example,ranks high on the list of "most prescribed" drugs for the relief otcough and minor pains. It is a constituent of many mixtures whichare "prescribed for a varietv of sedative and antispasmodic effects.Whereas we do have effective substitutes for codeine which areknown to be safe, they have made relatively little inroads in the prescribingof codine. Furthermore, they do not substitute for codeine inall respects, particularly since they lack its analgesic and mild sedativeproperties. Relative costs, although not a compelling factor, must beconsidered. Tax-free morphine is now one of the cheapest compoundsavailable to medicine today.The paramount question then which confronts you, in my opinion.is not whether synthetics will substitute for "horticulturally derived"narcotics but rather whether outlawing the latter in favor of syntheticswill accomplish the objectives of significantly diminishing abuse ofall narcotic analgesics or, in fact, of even heroin itself.I say this because of several international situations. I just returnedfrom Japan last week where I consulted with the Minister of Health.They know exactly how most of the heroin and opium arrive in Japan,largely down the Mekong River from the countries which I mentionedearlier, transshipped through Macao in Hong Kong. From there itis smuggled into their many ports, some by air, but mostly by sea toKobe and Yokohama, et cetera.The Japanese have done a good job of heroin control. In 1964, theJapanese had a sharp rise in heroin abuse. They make an all-out effortto control this. They have available to them the facilities which Idoubt are available in the United States. In the first place, when theysay an all-out Government effort they really mean it. This goes fromthe Prime Minister on down. In the last 4 or 5 years they have helclseveral thousand public meetings all over Japan in which governors,states, mayors, even the Prime Minister participate. These are usuallyheld in theaters or a public auditorium and may be attended by asmany as 3,000 or 4,000 people. The hazards of drug addiction aregraphically portrayed.Furthermore, radio, television, newspapers, and other communicationmedia have made an all-out campaign against heroin.One of the things which I believe contributes significantly to theirsuccess is the fact that Japan has attacked one drug at a time ratherthan to try to hit the whole area of drug abuse. This goes back to 1955when they had the world's largest epidemic of stimulant drug abuse.In that year there were 55,000 arrests of methamphetamine abusers.Two years later they had reduced this by strong countermeasures to alevel of about a thousand arrests. This is the only extensive epidemicof drug abuse, with which I am familiar, in the world that has beencontrolled in such a short time. They later did a similar job of controllingheroin.One of the situations involves different attitudes toward authority.In Japan, when an expert goes on television, such as a professor in 'amajor university, people listen to him. I am certain this rarely occurs
13in this country. This raises the question whether we really have thecapabilities of adopting successfully this type of approach.But the Japanese have their problems as well. I bring this in incidentallybecause it doesn't bear on your major thrust but it is a drugabuse problem which must be dealt with.Last year, Japan had 40,000 arrests for glue sniffing, with 200 deaths.That is one kind of substance which is almost impossible to control.To do so, we would have to control all sales from paint stores and purveyorsof more than 50 related solvents. Lacquer thinner is used extensivelyin Japan by teenagers 16, 18 years old. So Japan is not withouther problems, but they have done a remarkably good job in controllingamphetamines and heroin addiction. I was told by the Ministry that itliacl been reduced to a level where they though it was probably impossibleto reduce it further. I think this is important—to recognize thatcontrol will never be absolute.Chairman Pepper. Mr. Perito, any questions ?Mr. Perito, Dr. See vers, I had the opportunity to look at your laborator3^The committee has not had that unique opportunity.I wonder if you could kindly explain to the committee exactly whatis being done in your primate laboratory and how that laboratory isfinanced ?Dr. Seevers. This laboratory has been in operation for 20 years. AsI indicated—we have tested during this time some 800 drugs. This testingprocedure started about 1953. We set it up originally on an entirelyobjective basis and it has always remained so. Dr. Nathan Eddy, whois here in the room, has been a long time collaborator on the project. Hereceived these drugs on a confidential basis from industry. This facilityhas been available to those who wish to submit for testing. Dr. Eddysent them to our laboratory by code number so that we do not knowthe identity of the supplier.Once the tests have been made the information is channeled backto Dr. Eddy and he informs the manufacturer.Until about 5 years ago, our testing procedure involved primarilydrugs which would substitute for morphine or for heroin. In otherwords, we were looking for a drug which was superior to morphinein the sense it reduced respiratory depression, less side effects, less tolerancedevelopment, and less what we call, in general terms, addictionliability, the capacity to produce physical dependence.We tested many compounds for 15 years and didn't find any thatwould fulfill most of these qualifications. Wlien it was discovered thatsome of the antagonists, which I understand you are going to considerlater, also possessed pain-relieving properties, somewhat like morphine,and yet did not produce physical dependence or lead to addiction,then a new concept was born. Since that time we have tested ahundred or more antagonists. We have done this with the objective offinding a substance which would still be useful as a pain reliever butdid not have a capacity to produce physical dependence. I understandthat is a class of drug that you intend to explore.We maintain a colony of around a hundred monkeys. They receivean injection of morphine every 6 hours, day and night, right aroundthe clock, 7 days a week. When we want to test a new drug we simplysubstitute for the morphine which they ordinarily receive. If this drug
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NARCOTICS RESEARCH, REHABILITATION,
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::VEXHIBIT NO. 4 (a) AND (b)Eddy, D
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NARCOTICS RESEARCH, REHABILITATION,
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urden that such addiction imposes u
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1 (lata; (->) the sliariiis" oF iii
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9Chairman Pepper. The committee is
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::11quota production from unrecogni
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15from other clinical projects of w
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:17practice, experience has indicat
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;19.I think a quota would be better
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21When methadone was first introduc
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:::::.—23American Society of Phar
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_'—25.I'BOCUREMENT AND ISSUE DATA
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'.28Fiscal years-1967 1968 1969 197
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30rally in opium. By indirect, the
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32We can, I think, most helpfully g
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34so intense that we haven't done v
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Dr. Eddy. Well, physicians, usually
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38Dr. Eddy. No.Chairman Pepper. Now
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:40get away with it as Dr. Keats su
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:—:42public health hazard was jud
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:44Bibliography(1 Nathan B. Eddy. "
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46(52) Nathan B. Eddy. "Dilaudid."
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48(98) "The New Narcotics, Post-gra
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^.50
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52entails the consideration of addi
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54Chairman Pepper. Have you found t
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56^.I wonder would you care to comm
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58Chairman Pepper. Without objectio
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—1958-681959-«419691962-64196219
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—62abuse and has brought about th
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64bank robbery or an assault. You d
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66Mr. Wiggins. Would the stopping o
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68—Chairman Pepper. Can you give
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:70The problem then would be the wi
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;72taking exceptional measures in t
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)—74pay serious attention to this
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;76From 1958 to 1961, he served as
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78deine in painkilling drugs. So if
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;80ning capabilities, responsibilit
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;:;82terials. If they could introdu
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84Figure 1infrared Ektachrome film
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;86Figure 3.—Tones of wheat (W) a
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88ers at the poppyfields or at any
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:90;:tional situations has handicap
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;;92Locating illicit opium cropsDet
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94Jaffe. Well, there would be some
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96Mr. Jaffe. Primarily on the fact
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98in the same ball park about what
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100Chairman Pepper. Mr, Waldie, do
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::102agencies and input data would
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104most facilities are barely able
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;106We have also studied a ^roup of
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108Dr. Gearing. Yes, sir; I would n
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110somethino: in the nei
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112program is put into the machiner
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I114you have some data there that s
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116Dr. Gearing. It depends on what
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118Chairman Pepper. Would you have
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120it not be so that we could proje
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.122admission rate was approximatel
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124BESULTS(1) Although many of the
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1262. All the members of the methad
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128HETHADOHE MAINTENANCE TREATMENT
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11 1 1 1 1 11130Methadone Halnten?n
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132TABLE 2.-METHAD0NE MAINTENANCE T
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134Figure 9 Methadone tlaintenance
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136Methadone Ka'ntanance Treatmf:nt
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:::.::.138Appendix A^—Methadone M
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140nance treatment patients showing
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142Figure 3 •lethadone Kaintenanc
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144Dr. DuPoNT. 1,760 on methadone m
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:146there are dramatic reductions i
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148Health insurance coverage for me
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150Dr. DtjPont. Well, there are no
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152Mr. Blommer. You would agree the
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154done. Where is the evidence ? No
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156There are several reasons a pers
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158It would seem to me a very busy
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160we had before. I don't think it
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162heroin addiction and support all
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164Dr. DuPoNT. I am reluctant to ge
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166Using this figure as rule of thu
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)168ment facilities for heroin addi
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.170parole departments. None were c
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::172Table 2.— Selected character
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174TABLE 3.—HEROIN ADDICTION RATE
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176W.a^^cc-V.c Cffv..AdF-ro ftcoKjL
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178.^06V f\QrK-'SEt G^ouP/AJ6SIS're
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I180*i coo)u->CM>—'CMUJCOO O COa>
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I(/I182esiMmin0)^> oo.00 =E|c O.2 o
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184encouraged to return to methadon
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186or other side effects. This incr
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:188number as that on the bottle. W
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190Attachment ThreeTo all medical s
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-jI IALLI192ATTACHMENT- FIVE,J: IPA
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194ATTACHMENT NINEGOVERNMENT OF THE
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......—196half of the addicts sta
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198CONCLUSIONSCertain patterns emer
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200TABLE 5.— PROFILE OF BARBITUAR
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202TABLE ll.-SUPPORT OF HEROIN HABI
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204TABLE 17.-AGE OF ADDICTS AND NON
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206TABLE 23.—PRESENT MARITAL STAT
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208TABLE 28.-MILITARY SERVICEAddict
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:210The committee is pleased to cal
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212sists of a network of 21 geograp
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214(6) Basic studies on the nature
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216in fact, constitute autonomous o
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Chairman Pepper. Mr. Perito?218;; M
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^'220is not a very forgiving drug.
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'222Furthermore, in our present con
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—224the Federal Government decide
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-—I have presented one generic ki
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,clinic;?,>•
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230I realize we are running late.Do
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''232'']Vir. Winn. Tiien you mentio
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234So having put it in the area, ha
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,Memberships'—i236privilege of co
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;238A central hypothermic response
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;240South Bronx, Bedford-Stuyvesant
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242€are of patient addicts. We ha
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244hospitals in the city, came into
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246that came into my office, and I
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'Mr.;>•/nmo'.i,,;248deputy commis
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:250two Rockefeller Institute physi
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:252during pliase II that serious e
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254well-structured methadone mainte
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;:256nonsense and serves only to ad
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:258you best complete your statemen
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260Mr. Pertto. Based upon your expe
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262A a'reat case in point was a con
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«264Mr. Steiger. Did you discuss w
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—:266Mr. HoRAN. We don't support
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268Mr. Horan, let's back up a littl
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270It is not up to heroin or morphi
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272nesses yesterday who brought out
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274;Mr. Perito. It is my understand
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276So that at the end of the week t
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278steroid he lias in him we might
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280Mr. Perito. You are referriii"'
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282not drug free. I can say approxi
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28 A$2-a-day habit these individual
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•As286I got to the point once in
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288Mr. Steiger. You mentioned anoxi
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290Mr. Eangel. I could see then tha
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292Dr. Casriel. Mr. Keating, I have
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j294What period of time are ^ve tal
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296was March of 1970—he was admit
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298"The paper by Dole and Nyswander
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:300vent them from coming to New Yo
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302[Exhibit No.14(b)]Casriel Instit
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304to result from the insuflScient
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306It is this role of the intervent
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308EESULTSStudies concerning tlie p
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310The method derives from a specia
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312Why is this happening? What need
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m)effective with uncured alcoholics
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I316Casriel, who is medical-psychia
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318resort to heroin. One must not f
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.320in Permanent Cure of Narcotic A
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322!(4) '-Modification of Adaptatio
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324sections of the country, all sor
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;Mr.Pertto.niuch,I?,Mr. Peritq. Tha
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328Chairman Pepper. Mr. Steiger.Mr.
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, Mr., In''wMr, WiNx.nltiiink tlie
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:332"Stomach cramps" were found to
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'i.We334'""^li'anTOanl^ETPPEiL That
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:))))336would be deprived of any cl
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338less abuse liability than agents
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NARCOTICS RESEARCH, REHABILITATION,
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CONTENTSApril 26 1April 27 77April
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:•vEXHIBIT NO. 4 (a) AND (b)Eddy,
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:lovernor,vnEXHIBIT NO. 21 (a) and
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342have no desire to preempt the au
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344We hope these hearings will prov
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346tons in 1962 and to 155 tons in
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348SOUTHEAST ASIAAs you know also,
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350I would also point out as I did
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352their farmers who have been grow
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354told that much of the insurgency
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356Mr. IxGERSOLL. Well, again, Mr.
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358jority of the heroin problem in
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360years, but I have been frustrate
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362Mr, Steiger. If you were goin^ t
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364report marihuana among junior gr
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366And it seems to me tliat we Avou
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?368effectively, then maybe we will
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370improvement as far as the abilit
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372was there. Your visits probably
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374the purchase of Avitnesses—I s
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:376administrations to publicly say
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378Chairman Pepper. We will take a
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380Mr. Ingersoll. No. I don't recal
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:382can fulfill the vow made by the
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384have to give you the same answer
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386Mr. Brasco. But that is another
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388Mr. Ingeksoll. Well, that is the
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NARCOTICS RESEARCH, REHABILITATION,
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-39,3,Dr. Edwards held a surgical f
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395of Narcotics and Dangerous Drugs
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397Naloxone, recently approved for
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399for example, who might be abusin
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401Now, because of our attention ha
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403and this is only for the investi
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405effects this drug will produce i
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407Now, if it is not used intravene
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409Mr. Wiggins. Dr. Jennings, does
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411Penicillin is good for pneumonia
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413Mr. R ANGEL. But from the studie
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415Dr. Gardner. Again, we don't hav
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417Dr. Edwards. I suspect it at lea
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419On the other hand, if serious si
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421of the best known programs. Alth
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423Medical Association, American Ps
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425of the United States Pharmacopei
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4275. Repeated examinations. Physic
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429agement and rehabilitation of se
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—431As the agenc.v within HEW whi
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433and complex acts such as driving
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435(Inig induces physical and psych
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437Chiiirmtin Pepper. Doctor, I thi
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439A large proportion of youngsters
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441Dr. Brown, what would you say is
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443Chairmiui Pepper. Wliat is tlie
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446The state of the art is promisin
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447Lot nie ask you first, is tlic d
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449Chairman Pepper. Do you happen t
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451want you to take a look at. We w
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453In addition to that, there seems
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455the Mfldict is having a program
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457—on drugs? By that I mean, vei
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459\\ e are basically saying, in or
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—;461that this is the extent to w
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463We could go into the drug area a
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.465program that was i)ut into Jack
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467Mr. Brasco. Possibly. However, w
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469him, arrange to get somebody els
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471ainpheta.mines, or barbiturates.
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473In the meantime, the Institute d
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475treated in the community centers
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477research on narcotics in the sam
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479c 53 03E
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NARCOTICS RESEARCH, REHABILITATION,
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483spending for research through NI
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485There has been no concerted seri
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487it is left in one of their veins
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489I do not think I should explain
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491Dr. ViLLARREAL. Until the reflex
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493evidence strongly shows is that
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495Chairman Pepper. One other quest
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497Dr. ViLLARREAL. So, it is a biol
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'.499could result in a laboratory s
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5qifinds it in normal exploration.
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503synthesized a large number of na
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505STATEMENT OE DR. ALBERT KURLAND,
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507discovered if we iiad taken the
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509Mr. Perito. Dr. Kurland, do you
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511Chairman Pepper. Has the Food an
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513]Mr. Steiger. Do you feel from y
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515In this second study there was a
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517were any significant differences
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519The Deceptive Communication and
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.522than a State psychiatric hospit
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524Department of Mental Hygiene), R
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TABLE 3—COMPARISON OF THE 1ST POS
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528TABLE 10—RELATIONSHIP OF AGE T
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530tution and his involvement in th
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Attachment No. 5;r\ N-CH,-CH=CHo ,
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'-534Chart No. U (case No. 672)Disp
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536Chart No. 4 (case No. 694)Illust
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538Chart No. 35 {case No. 697)Excep
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540This amount of heroin is roughly
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5msuccessful or not in that short a
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544Chairman Pepper. Would you repea
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54^creased amount of licit as well
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—54Sand the bureaucracy and the a
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,,Mr.550you have used some of the s
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552so many areas is also a pitiful
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55,4nitiide of heroin addiction in
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556reached $976.5 billion, we can w
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558Mr. Jones was appointed to the c
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560cant when you consider that Out
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562criminal act in his lifetime. Ye
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—564Mr. Perito. Would it be fair
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566Now, Dr. Cliambers, can yon resp
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—568Mr. Raxgel. Our distinguished
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;-570Mr. Jones. That is correct. Ou
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572the commissioner, $186 million i
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574there should be something in the
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576and the way in which the funds a
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57SDr. Chambers. I think wliat you
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580Education is the best way of pre
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58-2Certain essential facts must re
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584done through determined action,
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586druffs, has the Nation's largest
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:588To repeat, methadone maintenanc
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:590I believe the Federal Governmen
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:take no such satisfaction. We have
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594of value in the testimony you ha
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596gone ahead with several. We have
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598force within our State Police De
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60PRased on the proposed goal of 2.
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602STATEMENT OF HON. MILTON SIIAPP,
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(51)4and apprehend the wholesalers
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J'606[Exhibit No. 23Prepared Statem
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608Under our 1071-72 budget proposa
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GIOcenters for the treatment of her
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. Dr.612Bourne informs me that we h
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614Governors in Atlanta to which re
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616pretty bad news, because it indi
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618Scientific statistical ioformati
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620((')) Finally, I believe that al
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622Governor Carter. I certainly rec
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624programs that are now available,
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626all of the top officials in the
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628perhaps greater than some of the
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)630tion and many others attempting
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632(3) Long term residential self-h
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634for the support of drug service
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:636D. NARCO, Inc.Narcotics Addicti
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638crimes to obtain the necessary m
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640million to $25 milliou per year.
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642Mr. Perito. Thank yoii. Mr. Chai
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644narcotic antagonist, and the oth
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646. Dr. Kramer. From what I have s
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—(348your money on, but methadone
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—650I know of no techinque in pri
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652Dr. Kramer. Yes, sir. As a matte
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:'654prison and who liave no—wlio
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65GDr. KT?A:\rEij. 1 suspect tliat
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658support some of the inethadone p
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'6660Dr. IvKAisrKK. 1 believe that
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662jrest that the Veterans' Adminis
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664opiates may be ingested in sever
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666(5) It suppresses the desire for
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668Many people have benefited from
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—G70Other researches which may di
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672synthetic painkillers, our commi
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074IV. A universal ban on legitimat
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..676iTlius we must look to educati
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678states, from Arnold Becker, publ
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680However, we must look at rehabil
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:682(a) The natural history of narc
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684was a heavy user. The decrease i
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686(13) Wallace. R. K. : Physiologi
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688TABLE 9.-USE OF "HARD LIQUOR" BE
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UFRAL BOOKBINDING CO. Q /-^ /-» .1