Antibody Drug Conjugates for Cancer Therapy

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Antibody doses are normalized to drug equivalenceTumor volume
Strategies to Control Stoichiometry of Cysteine-DirectedAntibody Drug Conjugation* * ** ** ** *Conventional ADCTHioMAb drug conjugate (TDC)Thiol reactive drugsare conjugated toreduced disulfidesEngineeredCysteine Thiol(A118C)2 420681Drugs / antibodyDrugs / antibody31
Page 1 and 2: Antibody Drug Conjugates for Cancer
Page 3: Target Screening- Large scale mRNA-
Page 6 and 7: Naked antibodies are likely to be i
Page 9 and 10: How many xenograft models should we
Page 11 and 12: RelativeTenB2 expression in human p
Page 13 and 14: Antibodies armed with auristatinsAN
Page 15: MRP4 (multi drug resistance protein
Page 18 and 19: Structure of the MUC16 antigen and
Page 20 and 21: Endothelin B receptor: A target for
Page 22 and 23: Melanocytes and EDNBR staining in n
Page 24 and 25: Increased cell killing in vitro wit
Page 26 and 27: ETBR Expression in Cell Lines versu
Page 28 and 29: Efficacy/SafetyFour ways for armed
Page 32 and 33: In Vivo Efficacy is Retained With T
Page 34 and 35: Cumulative toxicity from long-lived
Page 36: • GNE ADC Team- Susan Spencer- Ke

Antibody Drug Conjugates for Cancer Therapy

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