Antibody Drug Conjugates for Cancer Therapy

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Increased cell killing in vitro with increased EtBR copy numberCopies/cell:1,582 9,410 33,939A2058(low)WM-266-4(med)UACC257(high)180000015000001200000900000600000300000A2058 WM-266-4 UACC257PBScontrol-vc-MMAE5E9-vc-MMAE00.001 0.01 0.1 1 10Ab concentration (ug/ml)100000090000080000070000060000050000040000030000020000010000000.001 0.01 0.1 1 10Ab concentration (ug/ml)PBScontrol-vc-MMAE5E9-vc-MMAE120000011000001000000900000800000700000600000500000400000300000200000100000PBScontrol-vc-MMAE5E9-vc-MMAE00.001 0.01 0.1 1 10Ab concentration (ug/ml)24
Expression levels in tumor models are within the range of human melanomaA2058UACC257melanoma
Page 1 and 2: Antibody Drug Conjugates for Cancer
Page 3: Target Screening- Large scale mRNA-
Page 6 and 7: Naked antibodies are likely to be i
Page 9 and 10: How many xenograft models should we
Page 11 and 12: RelativeTenB2 expression in human p
Page 13 and 14: Antibodies armed with auristatinsAN
Page 15: MRP4 (multi drug resistance protein
Page 18 and 19: Structure of the MUC16 antigen and
Page 20 and 21: Endothelin B receptor: A target for
Page 22 and 23: Melanocytes and EDNBR staining in n
Page 26 and 27: ETBR Expression in Cell Lines versu
Page 28 and 29: Efficacy/SafetyFour ways for armed
Page 30 and 31: Antibody doses are normalized to dr
Page 32 and 33: In Vivo Efficacy is Retained With T
Page 34 and 35: Cumulative toxicity from long-lived
Page 36: • GNE ADC Team- Susan Spencer- Ke

Antibody Drug Conjugates for Cancer Therapy

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