Antibody Drug Conjugates for Cancer Therapy

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Mucin 16 (CA0772) ovarian cancer targetOvCAR-3 (cell line)OVCAR-3Xenograft<strong>Cancer</strong>IHC+Serous24/25Endometrioid16/20Clear cell 5/10Mucinous 0/8IHC Serous3+ 62+ 91+ 90+ 1TumorStroma• Strong membranousstaining in serous OvCa
Page 1 and 2: Antibody Drug Conjugates for Cancer
Page 3: Target Screening- Large scale mRNA-
Page 6 and 7: Naked antibodies are likely to be i
Page 9 and 10: How many xenograft models should we
Page 11 and 12: RelativeTenB2 expression in human p
Page 13 and 14: Antibodies armed with auristatinsAN
Page 15: MRP4 (multi drug resistance protein
Page 19 and 20: OvCAR3-luciferase intraperitoneal o
Page 21 and 22: Targeting broadly expressed antigen
Page 23 and 24: Lots of modelsEndogenous EDNBR expr
Page 25 and 26: Expression levels in tumor models a
Page 27 and 28: Some targets remain effective at ve
Page 29 and 30: Stability impacts SafetyTwo types o
Page 31 and 32: Strategies to Control Stoichiometry
Page 33 and 34: TDC is Better Tolerated than ADC by
Page 35 and 36: In vivo efficacy of an antibody arm

Antibody Drug Conjugates for Cancer Therapy

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