Antibody Drug Conjugates for Cancer Therapy

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Levels of TenB2 mRNA in LuCAP77 > 20/72 Human prostate cancers70000Human prostate cancers60000tenB2 mRNAProstate <strong>Cancer</strong>50000400003000020000100000Adenocarcinoma, Gleason < 7Adenocarcinoma, Gleason < 7Adenocarcinoma, Gleason < 7Adenocarcinoma, Gleason < 7Adenocarcinoma, Gleason < 7Adenocarcinoma, Gleason < 7Adenocarcinoma, Gleason < 7Adenocarcinoma, Gleason < 7Adenocarcinoma, Gleason < 7LuCaP77Adenocarcinoma, Gleason < 7Adenocarcinoma, Gleason = 7Adenocarcinoma, Gleason = 7Adenocarcinoma, Gleason = 7Adenocarcinoma, Gleason = 7Adenocarcinoma, Gleason = 7Adenocarcinoma, Gleason = 7Adenocarcinoma, Gleason = 7Adenocarcinoma, Gleason = 7Adenocarcinoma, Gleason = 7Adenocarcinoma, Gleason = 7Adenocarcinoma, Gleason > 7Adenocarcinoma, Gleason > 7Adenocarcinoma, Gleason > 7Other malignant tumor (rhabdomyosarcoma)Metastatic to elsewhereLuCAP77LuCap 77naExpression ranking77 > 96.1 > 70 > 35v12
Antibodies armed with auristatinsANTIBODYDRUGMaleimidocaproylvalinecitrullinePABA MMAEMAbSONOONHOHNproteolysisONHOONOHNO“Ab-VC-MMAE”NO CH 3ONH ONOC H 3 O HON HN H 2* * **Seattle Genetics***Denotes possible sites of drug conjugation* *
Page 1 and 2: Antibody Drug Conjugates for Cancer
Page 3: Target Screening- Large scale mRNA-
Page 6 and 7: Naked antibodies are likely to be i
Page 9 and 10: How many xenograft models should we
Page 11: RelativeTenB2 expression in human p
Page 15: MRP4 (multi drug resistance protein
Page 18 and 19: Structure of the MUC16 antigen and
Page 20 and 21: Endothelin B receptor: A target for
Page 22 and 23: Melanocytes and EDNBR staining in n
Page 24 and 25: Increased cell killing in vitro wit
Page 26 and 27: ETBR Expression in Cell Lines versu
Page 28 and 29: Efficacy/SafetyFour ways for armed
Page 30 and 31: Antibody doses are normalized to dr
Page 32 and 33: In Vivo Efficacy is Retained With T
Page 34 and 35: Cumulative toxicity from long-lived
Page 36: • GNE ADC Team- Susan Spencer- Ke

Antibody Drug Conjugates for Cancer Therapy

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