Antibody Drug Conjugates for Cancer Therapy

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Expression of TENB2/TMEFF1 in prostate cancerPr1N-GlyGAGN-GlySP FS I FS II EGF TM1 40 69 135 162 227 261 301 319 342 374TenB2
RelativeTenB2 expression in human prostate explant cancer modelsIHCLuCaP35vLuCaP70 LuCaP96.1 LuCaP7789Zr-ImmunoPET89Zr-TenB2PET Day 4LuCaP 35V 70 96.1 77PET uptake (%ID/g) 4 6 7 31FACS + ++ ++ +++11
Page 1 and 2: Antibody Drug Conjugates for Cancer
Page 3: Target Screening- Large scale mRNA-
Page 6 and 7: Naked antibodies are likely to be i
Page 9: How many xenograft models should we
Page 13 and 14: Antibodies armed with auristatinsAN
Page 15: MRP4 (multi drug resistance protein
Page 18 and 19: Structure of the MUC16 antigen and
Page 20 and 21: Endothelin B receptor: A target for
Page 22 and 23: Melanocytes and EDNBR staining in n
Page 24 and 25: Increased cell killing in vitro wit
Page 26 and 27: ETBR Expression in Cell Lines versu
Page 28 and 29: Efficacy/SafetyFour ways for armed
Page 30 and 31: Antibody doses are normalized to dr
Page 32 and 33: In Vivo Efficacy is Retained With T
Page 34 and 35: Cumulative toxicity from long-lived
Page 36: • GNE ADC Team- Susan Spencer- Ke

Antibody Drug Conjugates for Cancer Therapy

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