Julie Miller Jones.pdf - jifsan

BPA - Infants 84 to 92% lessthan previously estimated• FDA 2012• 0.2-0.4 μg/kw-bw/day for infants• 0.1-0.2 μg/kg-bw/day for >2 yrs• BPA crossing the placenta too low for detection• Study orally dosed pregnant rodents with 100-1000times more BPA than people are exposed to throughfood, and could not detect the active form of BPA inthe fetus 8 hours after the mother's exposure.• Converted to inactive aglycone form => rapidlyexcreted (rodents have less excretion than primates)FDA’s National Center for Toxicological Research