Names for CROM (ISBT 021) Blood Group Alleles
Names for CROM (ISBT 021) Blood Group Alleles
Names for CROM (ISBT 021) Blood Group Alleles
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<strong>Names</strong> <strong>for</strong> <strong>CROM</strong> blood group alleles v2.0 110914<strong>Names</strong> <strong>for</strong> <strong>CROM</strong> (<strong>ISBT</strong> <strong>021</strong>) <strong>Blood</strong> <strong>Group</strong> <strong>Alleles</strong>General description: The Cromer blood group system consists of 16 antigens carried ona GPI-linked glycoprotein (DAF, CD55) that consists of 481 aminoacids. It has a leader sequence of 34 amino acids and a GPI motifof 28 amino acids, both of which are cleaved from the membranebound protein.Gene name: <strong>CROM</strong>Number of exons: 11Initiation codon: Beginning of exon 2Stop codon: Beginning of exon 11GenBank #: NM_000574Entrez Gene ID: 1604Reference allele (shaded):Accession number: M31516Preferred: <strong>CROM</strong>*01Acceptable: CR*A, or Cr a if inferred by haemagglutinationReference allele <strong>CROM</strong>*01 encodes <strong>CROM</strong>1, <strong>CROM</strong>2, <strong>CROM</strong>5, <strong>CROM</strong>6, <strong>CROM</strong>7 (IFC),<strong>CROM</strong>9, <strong>CROM</strong>10, <strong>CROM</strong>11, <strong>CROM</strong>12, <strong>CROM</strong> 13, <strong>CROM</strong>14, <strong>CROM</strong>15, <strong>CROM</strong>16Phenotype Allele name Nucleotidechange<strong>CROM</strong>:1 or Cra+)<strong>CROM</strong>*01 or CR*AExonAmino acidchange^<strong>CROM</strong>:–1 or Cr(a–) <strong>CROM</strong>*–01 679G>C 6 Ala227Pro<strong>CROM</strong>:3 or Tc(b+) <strong>CROM</strong>*01.03 155G>T 2 52Leu<strong>CROM</strong>:4 or Tc(c+) <strong>CROM</strong>*01.04 155G>C 2 52Pro<strong>CROM</strong>:–5 or Dr(a–) <strong>CROM</strong>*01.–05 596C>T 5 Ser199Leu<strong>CROM</strong>:–6 or Es(a–) <strong>CROM</strong>*01.–06 239T>A 2 Ile80Asn<strong>CROM</strong>:8 orWES(a+)<strong>CROM</strong>:–10 orUMC–<strong>CROM</strong>:–11 orGUTI–<strong>CROM</strong>:–12 orSERF–<strong>CROM</strong>:–13 orZENA–<strong>CROM</strong>:–14 orCROV–<strong>CROM</strong>:–15 orCRAM–<strong>CROM</strong>*01.08 245T>G 2 82Arg<strong>CROM</strong>*01.–10 749C>T 6 Thr250Met<strong>CROM</strong>*01.–11 719G>A 6 Arg240His<strong>CROM</strong>*01.–12 647C>T 5 Pro216Lys<strong>CROM</strong>*01.–13 726T>G 6 His242Gln<strong>CROM</strong>*01.–14 466G>A 3 Glu156Lys<strong>CROM</strong>*01.–15 740A>G 6 Gln247ArgPage 1 of 2
<strong>Names</strong> <strong>for</strong> <strong>CROM</strong> blood group alleles v2.0 110914<strong>CROM</strong>:–16 orCROZ–<strong>CROM</strong>*01.–16 389G>A 3 Arg130His [1]Null phenotypes<strong>CROM</strong>:–7 or Inab <strong>CROM</strong>*01N.01 261G>A 2 Trp87Stop<strong>CROM</strong>:–7 or Inab <strong>CROM</strong>*01N.02 263C>A 2 Ser88Stop<strong>CROM</strong>:–7 or Inab <strong>CROM</strong>*01N.03 508C>T 4 Arg170Stop<strong>CROM</strong>:–7 or Inab <strong>CROM</strong>*01N.04 367insA 3 Thr123fs;Glu128Stop [1]^ change from historical counting of #1 as Asp of the mature (membrane-bound protein);thus, all amino acid numbers have increased by 34.[1] Karamatic Crew V, et al. Two unusual cases within the Cromer blood groupsystem: I)a novel high incidence antigen Croz and II)a novel molecular basis ofInab phenotype. Transfus Med 2010; 20(suppl.1):12.Page 2 of 2