full issue - Association of Biotechnology and Pharmacy

Current Trends in Biotechnology and PharmacyVol. 5 (2) 1104-1109 April 2011. ISSN 0973-8916 (Print), 2230-7303 (Online)1106gramming script. Here, the function ctxt() callsthe starting of program and the function codesfor xslt register all functions.ctxt: the XPath contextApart from that call for getting the element,the input box for the entering the IC 50values,and the document of web pages for gettingthe input element, are as follows.document.getElementById(‘ic’).value = “”;document.getElementById(‘pic’).value = “”;If there is no element with the given id,this function will return null value. Note, that DOMimplementation must have information that saysabout attribute of type ID. Attributes with thename ‘id’ are not type ID, unless defined in thedocument’s DTD. The ‘id’ attribute is defined tobe ID type in the common cases of XHTML,XUL, etc. Implementation do not know whetherattributes are of type ID or not, are expected toreturn as null value. Simply creating an elementand assigning an ID, which will not make the elementaccessible by ‘getElementById’. Oneneeds to insert the element first into the documenttree with insert before or a similar method,probably into a hidden div. Here its getting inputas a IC 50value and finally getting the output valuefrom the programming end, i.e., pIC 50value. Sothe input is given by the user and the output isgetting from the programming index.As input and output environment is setdown, to call for function for output, functionsare first-class objects, that means they can becreated dynamically and stored, passed and returnedjust like any other value, and declaring themathematical function math, which correspondsto a, (i.e., equal to formula calculation.)a = Math.log(a)/Math.log(10);a = 9 - a;It determines the mathematical functionslogarithmic value, which is divided by the base 10for checking the nanomolar value. The result of‘a’ is again equal to 9-a, which explicit the valueof nanomolar and closing the algorithm using thelanguage JavaScript and HTML coding. For detailof algorithm development see Fig.1 whichrepresents the flowchart for conversion of IC 50value to pIC 50value in nanomolar.Fig.1. Representing the flowchart for conversion ofIC 50value to pIC 50value in nanomolar.Getting the value from user, the algorithmconsiders the values as X (unknown values indecimal event), then accessing the value of X=A,here the A is consider the decimal event IC 50.Backend of algorithm accessed with (a=-logA),here the conversion of A value to logarithmic valueof decimal event take place with the base valueof log10. The power of conic set with negativevalue of 9 for nanomolar and negative value of 6for micromolar, so that power of conic, subtractedwith value displayed as value of pIC 50. This algorithmis kept in web based 110mb server inSanjeevslab domain namely and the webpageare constructed with the PHP coding.Results and DiscussionAt some stage in molecular modelingstudies (e.g. ligand based drug design) there areTool development for Prediction of pIC 50values