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Current Trends in Biotechnology and PharmacyVol. 5 (2) 1084-1097 April 2011. ISSN 0973-8916 (Print), 2230-7303 (Online)10952508 loaded PLGA nanoparticles. J.Nanoparticle Researc, 10:1045-1052.11. Cegnar, M., Premzl, A., Zavasnik-Bergant,V., Kristl, J. and Kos, J. (2004). Poly(lactideco-glycolide)nanoparticles as a carriersystem for delivering cysteine proteaseinhibitor cystatin into tumor cells.Experimental Cell Research, 301: 223-231.12. Kawashima, Y., Yamamoto, H., Takeuchi,H., Fujioka, S. and Hino T. (1999).Pulmonary delivery of insulin with nebulizedDL- lactide / glycolide copolymer (PLGA)nanosphere to prolong hypoglycemic effect,J. Control. Rel. 62: 279-287.13. Bilati, U., Allemann, E. and Doelker, E.(2005). Strategic approaches forovercoming peptide and protein instabilitywithin biodegradable nano- andmicroparticles. Eur. J. Pharm Biopharm. 59:375-388.14. Bilati, U., Allemann, E. and Doelker, E.(2005). Nanoprecipitation versus emulsionbased techniques for the encapsulation ofprotein into biodegradable nanoparticles andprocess related stability issues. AAPSPharm Sci Tech 6:E594-E604.15. Carino, G.P. and Jacob, J.S. (2000).Mathiowitz E., Nanosphere based oralinsulin delivery, J. Control. Rel. 65: 261–269.16. Emami, J., Hamishehkar, H., Najafabadi, A.R., Gilani, K., Minaiyan, M., Mahdavi, H.and Nokhodochi, A. (2009). A novelapproach to prepare insulin-loaded poly(lactic-co-glycolic acid) microcapsules andthe protein stability study. J. P. S. 98 (5):1712-1731.17. Ibrahim, M. M., Sammour, O. A., Hammad,M., Megrab, N. A., Li, X. and Jasti B.(2008). Novel Aqueous solvent basedmethod for protein based nanoparticles.Current Trends in Biotechnology andPharmacy, 2: (4) 575 -584.18. Rodrigues, J. S., Santos-Magalhães, N. S.,Coelho, L. C. B. B., Couvreur, P., Ponchel,G. and Gref R. (2003). Novel core(polyester)-shell (polysaccharide)nanoparticles: protein loading and surfacemodification with lectins. J. Controll. Rel.,92 (1-2):103-112.19. Sammour, O.A. and Hassan, H.M. (1996).Enhancement of the antibacterial activity ofampicillin by liposome encapsulation. DrugDelivery, 3: 273–278.20. Giuseppe, G., Enrico, R. and Giuseppe, S.(2007). AP/MALDI-MS completecharacterization of the proteolytic fragmentsproduced by the interaction of insulindegrading enzyme with bovine insulin. J.Mass Spectrometry, 42: 1590-1598.21. Sarmento, B., Ribeiro, A., Veiga, F. andFerreira, D. (2006). Development andcharacterization of new insulin containingpolysaccharide nanoparticles. Colloids andSurfaces B: Biointerfaces 53: 193–202.22. Houghton, P., Fang, R., Techatanawat, I.,Steventon, G., Hylands, P. J. and Lee C.C.(2007). The sulphorhodamine (SRB) assayand other approaches to testing plantextracts and derived compounds foractivities related to reputed anticanceractivity. Methods, 42: 377-387.23. Monica, A. V., Napoleon, A., Betts, A. C.,Patrick, I. B. and Kenneth, R. (2006).Streptozotocin (STZ) diabetes enhancesbenzo(á)pyrene induced renal injury inSprague Dawley rats. Toxicology Letters,164 214–220.Mahmoud et al
Current Trends in Biotechnology and PharmacyVol. 5 (2) 1084-1097 April 2011. ISSN 0973-8916 (Print), 2230-7303 (Online)109624. Damge, C., Philipe, M. and Nathalie, U.(2007). Oral delivery of insulin associatedto polymeric nanoparticles in diabetic rats.J. Controll. Rel., 117: 163-170.25. Jiang, G., Qiu, W. and Deluca, P. P. (2003).Preparation and in vitro / in vivo evaluationof insulin loaded poly (Acryloylhydroxyethylstarch) PLGA compositemicrosphere. Pharmaceutical Research,20(3): 452-459.26. Cohen, S., Yoshioka, T., Lucarelli, M.,Hwang, L. H. and Langer R. (1991).Controlled delivery systems for proteinsbased on poly- (lactic/glycolic acid)microspheres. Pharm. Res. 8:713–720.27. Igartua, M., Hernandez, R. M., Esquisabel,A., Gascon, A. R., Calvo, M. B., and PedrazJ. L. (1997). Influence of formulationvariables on the in-vitro release of albuminfrom biodegradable microparticulatesystems. J. Microencapsul. 14:349–356.28. Choi, S.W., Kwon, H.Y., Kim, W.S. andKim, J.H. (2002). Thermdynamicparameters on Poly (D,L-Lactide-Co-Glycolide) Particle size in Emulsification-Diffusion Process. Colloids Surf. A:Physicochem. Eng. Aspects 201: 283–289.29. Song, K. C., Lee, H. S., Choung, I. Y., Cho,K. I., Ahn, Y. and Choi E. J. (2006). Theeffect of type of organic phase solvents onthe particle size of poly(d,l-lactide-coglycolide)nanoparticles. Colloids andSurfaces A: Physicochem. Eng. Aspects276: 162–167.30. Francine, K., Yvonne, H. L. and Damien,W. M. A. (2008). Electrochemical Study ofInsulin at the Polarized Liquid-LiquidInterface. Langmuir, 24:(17), pp 9876–9882.31. Zhao, Z. P., Wang, Z. and Wang, S. C.(2003). Formation, charged characteristicand BSA adsorption behavior ofcarboxymethyl chitosan/PES composite MFmembrane. J. Membrane Sci. 217: 151–158.32. Pillai, R. R., Somayaji, S. N, Rabinovich,M., Hudson, M. C. and Gonsalves, K. E.(2008). Nafcillinloaded PLGA nanoparticlesfor treatment of osteomyelitis. Biomed.Mater. 3:034114.33. Nurhan, E. and Nevin, C. (1996). Factorsinfluencing release of salbutamol sulphatefrom poly(lactide-co-glycolide)microspheres prepared by water-in-oil-inwateremulsion technique. Int. J. Pharm.137: 57-66.34. Brigger, I., Chaminade, P., Marsaud, V.,Appel, M., Besnard, M., Gurny, R. andRenoir, M. (2001). Couvreur P. Tamoxifenencapsulationwithin polyethylene glycolcoatednanospheres. A new antiestrogenformulation, Int. J. Pharm. 214: 37–42.35. Michael, C. , Ilia, F. , Haim, D. D. andGershon, G. (2002). Lipophilic drug loadednanospheres prepared by nanoprecipitation:effect of formulation variables on size, drugrecovery and release kinetics. J. Control.Rel. 83: 389–400.36. Fude, Cui, Kai Shi, Liqiang Zhang, Anjin Taoand Yoshiaki Kawashima. (2006).Biodegradable nanoparticles loaded withinsulin–phospholipid complex for oraldelivery: Preparation, in vitrocharacterization and in vivo evaluation.Journal of Controlled Release 114:242–250.37. Larry, R. B., Elazer, R. E., Fariba, F. G. andRobert L. (1996). Characterization ofGlucose- Mediated Insulin Release fromIntegrity and Bioactivity of Insulin Loaded PLGA
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