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Current Trends in Biotechnology and PharmacyVol. 5 (2) 1173-1182 April 2011. ISSN 0973-8916 (Print), 2230-7303 (Online)1179shown in Fig 1. Formulations LE4 (6892.1 µg)and LP3 (8014.6 µg) showed maximum amountof release among their series with zero order(r 2 >0.9) release kinetics as it was evidenced fromcorrelation coefficients. It was apparent from therelease profiles of formulations, that the drugrelease was governed by polymer composition.As the concentration of hydrophilic polymer(PVP) increased in the formulations, the drugrelease rate increased substantially. Thereappeared a significant difference (p
Current Trends in Biotechnology and PharmacyVol. 5 (2) 1173-1182 April 2011. ISSN 0973-8916 (Print), 2230-7303 (Online)1180Force (N)Time (m)Fig 3. Tensile strength properties measurement ofLCDP transdermal patchesCumulative amount of LCDP permeated (µg)Time (h)Fig 4. Ex vivo permeation profiles of LCDP transdermalpatchesMechanical properties of films: The tensiletesting gives an indication of the strength andelasticity of the film, reflected by the parameters,TS and E/B. A soft and weak polymer ischaracterized by a low TS and E/B; a hard andbrittle polymer is defined by a moderate TS andlow E/B; a soft and tough polymer is characterizedby a moderate TS and high E/B; where as a hardand tough polymer is characterized by a high TSand E/B (18). Hence, it is suggested that a suitabletransdermal film should have a relatively high TSand E/B.Fig 5. FTIR spectra of LCDP, polymer mixtures andLCDP with polymer mixturesThe results of mechanical properties areshown in Table 2 and Fig 3. Formulation LE1 andLP4 exhibited greater values of TS (2.75 kg mm -2and 1.42 kg mm -2 for LE1 and LP4 respectively).Formulation LE4 (15.4 mm -2 ) and LP4 (95.6 mm-2) showed greater values of elongation at breakin their respective series. The results revealedthat as the concentration of PVP increased in LEseries, the tensile strength was found to decreaseand vice versa seen in elongation at break. BothTS and E/B were found to be increased withincreasing concentration of PVP in LP series.These observations indicate that formulation LE4and LP3 patches were found to be strong, notbrittle and flexible.Ex vivo permeation of LCDP fromtransdermal patches: The results of drugpermeation from transdermal patches of LCDPthrough rat skin are presented in Table 2 andRamesh Gannu et al
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