ImmunoCAP® X-map - PiRL

ImmunoCAP ® X-mapTec Allergen Component Possible Cross-ReactivityImportantAllergen FamiliesISACImmunoCAPSOURCECOMPONENTPROTEIN FAMILY OR FUNCTIONFruitsVegetablesNuts and seedsLegumesCerealsSpicesGrass pollenWeed pollenTree pollenLatexMoldsAnimalsMeatMilkEggFishSeafoodParasitesMitesInsectsVenomsLTP (non-specific Lipid Transfer Protein, nsLTP)• A protein stable to heat and digestion causing reactions also to cooked foods.• Often associated with systemic and more severe reactions in addition to oral allergy syndrome (OAS).• Often associated with allergic reactions to fruit and vegetables in southern Europe.x xLatex Hev b 1 Rubber elongation factorx x Hev b 3 Small rubber particle proteinx x Hev b 5 Acidic proteinx x Hev b 6 Heveinx x Hev b 8 Profilinx Hev b 9 Glycolytic enzymex Hev b 11 ChitinasesxLATEXxBromelin Ana c 2 CCDx CCDMUXF3 CCD CCDx xMilk Bos d 4 Alpha-lactalbuminx x Bos d 5 Beta-lactoglobulinx x Cow Bos d 6 Serum albuminx x Milk Bos d 8 Caseinsx x Lactoferrin Transferrinx x Egg white Gal d 1 Ovomucoidx x Gal d 2 Ovalbuminx x Gal d 3 Conalbuminx Egg yolk/chicken Gal d 5 Livetin (serum albumin but species specific)x x Carp Cyp c 1 Parvalbuminx x Cod Gad c 1 Parvalbuminx x Shrimp Pen a 1 Tropomyosinx Pen i 1 Tropomyosinx Pen m 1 TropomyosinFOOD OF ANIMAL ORIGINx xMite Der p 1 Cysteine proteasex x Der p 2 NPC2 familyx x Der p 10 Tropomyosinx Der f 1 Cysteine proteasex Der f 2 NPC2 familyx Eur m 2 NPC2 familyMITESx xDog Can f 1 Lipocalinx x Can f 2 Lipocalinx x Can f 3 Serum albuminx x Cat Fel d 1 Uteroglobinx x Fel d 2 Serum albuminx Fel d 4 Lipocalinx Mouse Mus m 1 Lipocalin2010 Horse Equ c 1 Lipocalinx Horse Equ c 3 Serum albuminx Pig Sus s PSA Serum albuminANIMALSx xAlternaria Alt a 1 Acidic glycoproteinx Alt a 6 Enolasex x Aspergillus Asp f 1 Mitogillin familyx x Asp f 2 Fibrinogen binding proteinsx x Asp f 3 Peroxysomal proteinx x Asp f 4 Unknownx x Asp f 6 Mn superoxide dismutasex Cladosporium Cla h 8 Mannitol dehydrogenaseMOLDxCockroach Bla g 1 Cockroach group 1x Bla g 2 Aspartic proteasex Bla g 4 Calycinx Bla g 5 Glutathione S-transferasex Bla g 7 TropomyosinCOCKROACHx xBee Api m 1 Phospholipase A2x Api m 4 Melittin2010 2010 Paper wasp Pol d 5 Ag 5Wasp Ves v 1 Phospholipase A12010 2010 Ves v 5 Ag 5VENOMxAnisakis Ani s 1 Serine protease inhibitorx PARASITE Ani s 3 TropomyosinStorage proteins• Proteins found in seeds serving as source material during the growth of a new plant.• Often stable and heat-resistant proteins causing reactions also to cooked foods.PR-10 protein, Bet v 1 homologue• A heat labile protein, cooked foods are often tolerated.• Often associated with local symptoms such as OAS.• Often associated with allergic reactions to fruit and vegetables in northern Europe.Profilin• An actin-binding protein showing great homology and cross-reactivity even between distant related species.• Recognized as a minor allergen in plants and plant-related foods.• Seldom associated with clinical symptoms but may cause demonstrable or even severe reactions in a small minority of patients.CCD• Cross-reactive carbohydrate determinants are seldom associated with clinical symptoms but may cause demonstrable or even severereactions in a small minority of patients.Lipocalin• Stable proteins and important allergens in animals• Allergen components displaying limited cross-reactivity between species.Parvalbumin• A major allergen in fish.• A marker for cross-reactivity among different species of fish and amphibians.• A protein stable to heat and digestion causing reactions also to cooked foods.Tropomyosin• An actin-binding protein in muscle fibers.• A marker for cross-reactivity between crustaceans, mites and cockroach.Serum albumin• A common protein present in different biological fluids and solids, eg, cow’s milk and beef, eggs and chicken.• Cross-reactions between albumins from different animal species are well known, for example between cat and dogand cat and pig.ImportantAllergensAra h 1, 2, 3, 8 and 9 (peanut)• IgE abs to Ara h 1, 2, 3 and 9 (LTP) are associated with peanut reactions, which in many cases can be severe.• IgE abs to Ara h 8 (PR-10) are usually associated with milder, local symptoms such as OAS, originating from birch sensitization.Ovomucoid (egg white)• IgE abs to ovomucoid are associated with persistent egg allergy and usually neither raw nor cooked is tolerated.Omega-5 gliadin/ Tri a 19 (wheat)• IgE abs to omega-5 gliadin (Tri a 19) in adults are associated with a risk of exercise- or NSAIDs-induced reactions in connection withwheat ingestion.• IgE abs to omega-5 gliadin in children are associated with a risk of immediate reactions to wheat.Alt a 1 (Alternaria)• IgE abs to Alt a 1 are associated with asthma development.Gly m 4, 5 and 6 (soy)• Gly m 5 and 6 are associated with clinical reactions to soy. Gly m 5 - Ara h 1 and Gly m 6 - Ara h 3 share homologous structures.• IgE abs to Gly m 4 (PR-10) are usually associated with milder, local symptoms such as OAS, originating from birch sensitization.Primarily species-specific allergen