full issue - Association of Biotechnology and Pharmacy

Current Trends in Biotechnology and PharmacyVol. 5 (1) 1043-1053 January 2011. ISSN 0973-8916 (Print), 2230-7303 (Online)1051compounds were practically proved as successfullead compounds and are continues to provide newbioactive products that lead to the discovery ofmany novel strains that produce useful secondarymetabolites. There is a broad range ofactinomycetes products such as antibiotics likestreptomycin and novobiocin are firmly cementedthese chemically prolific bacteria in the centrestage of natural products drug discovery research(21). The perspective of rapid emergence of drugresistance among bacterial pathogens shows thatthe potencies of prevalent antibiotics aredecreasing steadily, leading to reduced usefulperiod of drugs. This condition creates a demandfor the investigation of new, safe and effectiveantimicrobial compounds for replacement withexisting antimicrobials or use in antibiotic rotationprograms (22,23,24). In present studyStreptomyces represent a major portion ofactinomycetes in soil of Durg District ofChhattisgarh with significant biological activity.These isolates which show the both antibacterialand antifungal activity, may be produced either abroad spectrum antimicrobial compound or severalcompound with multitude of activity. The presentfinding highlighted the importance of work forfurther investigation towards the goal of obtaininga reliable methodology to isolate rare and unusualactinomycetes, to reduce the re-isolation of strainsproducing known bioactive compounds and toimprove the quality of natural products screenedisolated from Durg District of Chhattisgarh.INDIA.AcknowledgementAuthors are thankful to the School ofStudies in Life Sciences, Pt. Ravishankar ShuklaUniversity, Raipur, for providing lab facilities andfinancial support to carry out this work.References1. Kim, H.J., Lee, S.C. and Hwang, B.K.(2006) Streptomyces cheonanensis sp.nov., a novel Streptomycete with antifungalactivity. International Journal SystemEvolution Microbiology 56: 471-475.2. Watve, M.G., Tickoo, R., Jog, M.M. andBhole, B.D. (2001). How many antibioticsare produced by the genus Streptomyces?Archives Microbiology 176: 386-390.3. Lakshmipathy, D. and Kannabriran, K.(2010) Isolation and characterization ofantagonistic Actinomycetes from marinesoil. Journal of Microbial BiochemicalTechnology 2(1): 1-6.4. Labeda, D.P., Lechevalier, M.P. and Testa,R.T. (1997) Streptomyces stramineus sp.nov., a new species of the verticillateStreptomycetes. Integral Journal SystemBacteriology 47: 747–753.5. Dietera, A., Hamm, A., Fiedler, H.P., Muller,W.E.G., Brun, R., Beil, W., Kim, S.B. andGoodfellow, M. (2002) Streptomycesavermitilis sp. nov., nom. rev., a taxonomichome for the avermectin-producingStreptomycetes. International Journal ofSystem Evolution Microbiology 52: 2011–2014.6. Berdy, J. (2005) Bioactive microbialmetabolites. Journal of Antibiotics (Tokyo)58: 1–26.7. Saintpierre, D., Amir, H., Pineau, R.,Sembiring, L. and Goodfellow, M. (2003)Streptomyces yatensis sp. nov., a novelbioactive streptomycete isolated from aNew-Caledonian ultramafic soil. Antonievan Leeuwenhoek 83: 21–26.8. Huang, Y., Li, W., Wang, L., Lanoot, B.,Vancanneyt, M., Rodriguez, C., Liu, Z.,Swings, J. and Goodfellow, M. (2004)Streptomyces glauciniger sp. nov., a novelmesophilic streptomycete isolated from soilIsolation and Characterization of Streptomyces sp.