full issue - Association of Biotechnology and Pharmacy
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full issue - Association of Biotechnology and Pharmacy
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Current Trends in <strong>Biotechnology</strong> <strong>and</strong> <strong>Pharmacy</strong>Vol. 5 (1) 1021-1028 January 2011. ISSN 0973-8916 (Print), 2230-7303 (Online)10241462 (CH=CH), 650 (C-S)1H NMR (CDCl 3, äppm): 7.93(1H,d,J=17Hz,=CH-Ar),7.18 (1H,d,J=17Hz,-CO-CH=),7.88 (1H,s,C-2'-H),2.30 (3H,s,C-3'-CH 3),6.93 (1H,d,J=8.6Hz,C-5'-H)7.78 (1H,d,J=8.6Hz,C-6'-H),7.55(1H,d,J=7.2Hz,C-3'’-H)7.16 (1H,m,J=7.2Hz,C-4'’-H),7.61(1H,d,J=6.8Hz,C-5'’-H)Anal.Calcd. for C 14H 12S0 2: C, 68.334; H, 5.004.Found: C, 68.192; H, 5.041.1-(3'–Methyl -4'-hydroxyphenyl)-3-(2'’-indolyl)-2-propen-1-one (B 7)Yield: 85%; m.p. 195-198 0 CIR (KBr, cm -1 ): 3623 (O-H), 1655 (C=O), 1585(C=N),1506 (C=C Quadrant <strong>of</strong> Ar), 1467 (CH=CH)1H NMR (CDCl 3, äppm): 7.83(1H,d,J=17Hz,=CH-Ar),7.35 (1H,d,J=17Hz,-CO-CH=),7.97 (1H,s,C-2'-H),2.30 (3H,s,C-3'-CH 3),6.93 (1H,d,J=8.6Hz,C-5'-H)7.83 (1H,d,J=8.6Hz,C-6'-H),7.92(1H,d,J=7.2Hz,C-2'’-H),7.93 (1H,d,J=7.8Hz,C-4'’-H),7.19(1H,d,J=7.8Hz,C-5'’-H)7.13 (1H,d,J=7.9Hz,C-6'’-H),7.45 (1H,d,J=7.9Hz,C-7'’-H)Anal.Calcd.forC 18H 15NO 2: C, 77.962; H, 5.453;N, 5.052Found: C, 77.712; H, 5.152; N, 4.983.1-(3'–Methyl -4'-hydroxyphenyl)-3-(2'’-quinolinyl)-2-propen-1-one (B 8)Yield: 84%; m.p. 70-72 0 CIR (KBr, cm -1 ): 3628 (O-H), 1654 (C=O), 1582(C=N),1504 (C=C Quadrant <strong>of</strong> Ar), 1464 (CH=CH)1H NMR (CDCl 3, äppm): 7.82(1H,d,J=17Hz,=CH-Ar),7.75 (1H,d,J=17Hz,-CO-CH=),7.71 (1H,s,C-2'-H),2.30 (3H,s,C-3'-CH 3),6.93 (1H,d,J=8.6Hz,C-5'-H)7.62 (1H,d,J=8.6Hz,C-6'-H),7.64(1H,d,J=8.5Hz,C-3'’-H)’7.86 (1H,d,J=8.5Hz,C-4'’-H),7.78(1H,d,J=7.9Hz,C-5'’-H)7.69 (1H,t,J=7.9Hz,C-6'’-H),7.63 (1H,t,J=7.9Hz,C-7'’-H ),7.68 (1H,d,J=7.9Hz,C-8'’-H)Anal.Calcd.forC 19H 15NO 2: C, 78.803; H, 5.181;N, 4.395.Found: C, 78.772; H, 5.223; N, 4.422.1-(3'–Methyl -4'-hydroxyphenyl)-3-(9'’-anthracenyl)-2-propen-1-one (B 9)Yield: 86%; m.p. 103-105 0 CIR (KBr, cm -1 ): 3627 (O-H), 1655 (C=O),1507 (C=C Quadrant <strong>of</strong> Ar),1463(CH=CH)1H NMR (CDCl 3, äppm): 8.19(1H,d,J=17Hz,=CH-Ar),7.78 (1H,d,J=17Hz,-CO-CH=),7.99 (1H,s,C-2'-H),2.30 (3H,s,C-3'-CH 3),6.93 (1H,d,J=8.6Hz,C-5'-H)7.84 (1H,d,J=8.6Hz,C-6'-H),8.40(1H,d,J=8.2Hz,C-1'’-H),7.02 (1H,m,J=8.2Hz,C-2'’-H),7.30(1H,m,J=8.1Hz,C-3'’-H)7.99 (1H,d,J=8.1Hz,C-4'’-H),7.99(1H,d,J=8.1Hz,C-5'’-H)7.30 (1H,m,J=8.1Hz, C-6'’-H),7.02(1H,m,J=8.2Hz,C-7'’-H)7.82 (1H,d,J=8.2Hz,C-8'’-H),7.80 (1H,s, C-10'’-H)Anal.Calcd. for C 24H 18O 2: C, 85.182; H, 5.362.Found: C, 85.122; H, 5.242.1-(3'–Methyl -4'-hydroxyphenyl)-3-(4'’-fluorophenyl)-2-propen-1-one (B 10)Yield: 78%; m.p. 181-183 0 CIR (KBr, cm -1 ): 3625 (O-H), 1656 (C=O), 1506(C=C Quadrant <strong>of</strong> Ar),1461 (CH=CH), 1120 (C-F)1H-NMR (CDCl 3, äppm): 7.83(1H,d,J=17Hz,=CH-Ar),7.26 (1H,d,J=17Hz,-CO-CH=),7.89 (1H,s,C-2'-H),2.30 (3H,s,C-3'-Srinath et al