full issue - Association of Biotechnology and Pharmacy

Current Trends in Biotechnology and PharmacyVol. 5 (1) 1021-1028 January 2011. ISSN 0973-8916 (Print), 2230-7303 (Online)10231504 (C=C Quadrant of Ar), 1464 (CH=CH)1H NMR (CDCl 3, äppm): 7.96 (1H,d,J=17Hz,=CH-Ar), 7.83 (1H,s,J=17Hz, -CO-CH=),7.92(1H,s,C-2'-H),2.30 (3H,s,C-3'-CH 3),6.93(1H,d,J=8.6Hz,C-5'-H)7.80 (1H,d,J=8.6Hz,C-6'-H),8.50 (1H,d,J=7.2Hz,C-3'’-H),7.18 (1H,m,J=7.3Hz,C-4'’-H),7.71 (1H,m ,C-5'’-H),7.78 (1H,d,J=8Hz,C-6'’-H)Anal.Calcd.for C 15H 13N0 2: C, 75.301; H, 5.480;N, 4.852.Found: C, 75.213; H, 5.434; N, 4.827.1-(3'–Methyl -4'-hydroxyphenyl)-3-(3'’-pyridinyl)-2-propen-1-one (B 2)Yield: 82%; m.p. 78-82 0 CIR (KBr, cm -1 ): 3627 (O-H), 1651 (C=O), 1582(C=N),1505 (C=C Quadrant of Ar), 1465 (CH=CH)1H NMR (CDCl 3, äppm): 7.71 (1H,d,J=17Hz,=CH-Ar), 7.32 (1H,d,J=17Hz , -CO-CH=), 7.89(1H,s,C-2'-H),2.30 (3H,s,C-3'-CH 3),6.93(1H,d,J=8.6Hz,C-5'-H),7.80 (1H,d,J=8.6Hz,C-6'-H),8.86 (1H,s,C-2'’-H),8.65 (1H,d,J=7.3Hz,C-4'’-H),7.38 (1H,m,J=8Hz,C-5'’-H),7.96 (1H,d,J=8Hz,C -6'’-H)Anal.Calcd.forC 15H 13N0 2: C, 75.303; H, 5.483;N, 4.852.Found: C, 75.183; H, 5.463; N, 4.802.1-(3'–Methyl -4'-hydroxyphenyl)-3-(4'’-pyridinyl)-2-propen-1-one (B 3)Yield: 75%; m.p. 71-73 0 CIR (KBr, cm -1 ): 3625 (O-H), 1650 (C=O), 1583(C=N),1503 (C=C Quadrant of Ar), 1466 (CH=CH)1H NMR (CDCl 3, äppm): 7.60 (1H,d,J=17Hz,=CH-Ar),7.74 (1H,d,J=17Hz, –CO-CH=),7.89(1H,s,C-2'-H),2.30 (3H,s,C-3'-CH 3),6.93(1H,d,J=8.6Hz,C-5'-H)7.80 (1H,d,J=8.6Hz,C-6'-H),7.32(1H,d,J=7.2Hz,C-2'’-H),8.52 (1H,d,J=7.2Hz,C-3'’-H),8.65(1H,d,J=7.2Hz,C-5'’-H),7.32 (1H,d,J=7.2Hz,c-6'’-H)Anal.Calcd.forC 15H 13N0 2: C, 75.303; H, 5.483;NFound: C, 75.245; H, 5.458; N, 4.833.1-(3'–Methyl -4'-hydroxyphenyl)-3-(2'’-furyl)-2-propen-1-one (B 4)Yield: 63%; m.p. 162-163 0 CIR (KBr, cm -1 ): 3626 (O-H), 1652 (C=O), 1505(C=C Quadrant of Ar),1463 (CH=CH), 1200 (C-O)1H NMR (CDCl 3, äppm): 7.59 (1H,d,J=17Hz,=CH-Ar),7.46 (1H,d,J=17Hz, -CO-CH=),7.85(1H,s,C-2'-H),2.30 (3H,s,C-3'-CH 3),6.93(1H,d,J=8.6Hz,C-5'-H)7.81 (1H,d,J=8.6Hz,C-6'-H),6.66 (1H,d,J=7.2Hz,C-3'’-H),6.43 (1H,d,J=7.2Hz,C-4'’-H),7.45 (1H,s,C-5'’-H)Anal.Calcd. for C 14H 120 3: C, 73.673; H, 5.301.Found: C, 73.583; H, 5.243.1-(3'–Methyl -4'-hydroxyphenyl)-3-(2'’-pyrrolyl)-2-propen-1-one (B 5)Yield: 64%; m.p. 205-207 0 CIR (KBr, cm -1 ): 3624 (O-H), 1653 (C=O), 1580(C=N),1504 (C=C Quadrant of Ar), 1465 (CH=CH)1H-NMR (CDCl 3, äppm): 7.71(1H,d,J=17Hz,=CH-Ar),6.94 (1H,d,J=17Hz,-CO-CH=),7.81 (1H,s,C-2'-H),2.30 (3H,s,C-3'-CH 3),6.93 (1H,d,J=8.6Hz,C-5'-H)7.79 (1H,d,J=8.6Hz,C-6'-H),6.25(1H,d,J=7.2Hz,C-3'’-H)5.98 (1H,m,J=7.2Hz,C-4'’-H),6.99(1H,d,J=6.8Hz,C-5'’-H)Anal.Calcd.forC 14H 13NO 2: C, 73.993; H, 5.772;N, 6.161.Found: C, 74.012; H, 5.742; N, 6.206.1-(3'–Methyl -4'-hydroxyphenyl)-3-(2'’-thienyl)-2-propen-1-one (B 6)Yield: 73%; m.p. 192-196 0 CIR (KBr, cm -1 ): 3625 (O-H), 1650 (C=O), 1505(C=C Quadrant of Ar),Synthesis and Anti-Inflammatory