Boston - American Association for Thoracic Surgery

AMERICAN ASSOCIATION FOR THORACIC SURGERYTUESDAY AFTERNOONMAY 12, 20092:00 p.m. SIMULTANEOUS SCIENTIFIC SESSION –CONGENITAL HEART DISEASERoom 312, Hynes Convention Center(8 minutes presentation, 12 minutes discussion)Moderators: J. William GaynorRichard G. Ohye47. Genetic Factors are Important Determinants of Impaired GrowthFollowing Infant Cardiac SurgeryNancy B. Burnham, 1 Richard F. Ittenbach, 2 Virginia A. Stallings, 1 Marsha Gerdes, 1Elaine H. Zackai, 1 Judy Bernbaum, 1 Gil Wernovsky, 1 Robert R. Clancy, 1Jo Ann D’Agostino, 1 Donna McDonald-McGinn, 1 Diane Hartman, 1 Jennifer Raue, 1Jennifer Hufford, 1 Courtney Terrili, 1 Susan C. Nicolson, 1 Thomas L. Spray, 1*J. William Gaynor 1*1. Children’s Hospital of Philadelphia, Philadelphia, PA, USA;2. Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USAInvited Discussant: Thomas J. YehTUESDAYAfternoonOBJECTIVE: To estimate the prevalence and identify predictors of impairedgrowth following infant cardiac surgery.METHODS: Secondary analysis of a prospective study of the role of apolipoprotein E(APOE) gene polymorphisms on neurodevelopment in young children followinginfant cardiac surgery. Prevalence estimates for growth velocity were derived usinganthropometric measures [weight (WT) and head circumference (HC)] obtainedat birth and at 4 years of age. Growth measure z-scores were calculated using theWorld Health Organization Child Growth Standard. Growth velocity was evaluatedusing two different techniques: first by clustering the children into one ofthree growth velocity subgroups based on z-score differences between birth and4 yrs (impaired growth [>0.5σ], stable [–0.5σ to 0.5σ], growth improving [