Boston - American Association for Thoracic Surgery

89 TH ANNUAL MEETING MAY 9–MAY 13, 2009BOSTON, MASSACHUSETTSRESULTS: Analysis of the combined tumor groups showed increased MMPabundance compared to normal tissue, with the exception of MMP-9 (MMP-1:tumor: 19.4* ± 5.1, normal: 0.4 ± 0.1; MMP-2: tumor: 103.8* ± 18.3, normal: 39.2 ± 5.0;MMP-3: tumor: 7.7* ± 2.4, normal: 0.4 ± 0.1; MMP-8: tumor: 189.5* ± 41.3, normal:61.0 ± 8.9; MMP-9: tumor: 150.2 ± 16.6, normal: 163.7 ± 18.4; MMP-12: tumor: 16.1*± 3.4, normal: 0.2 ± 0.1; MMP-13: tumor: 2.6* ± 1.0, normal: 0.0 ± 0.0; * p < 0.05) ).Analysis of SCC tumor groups versus AC tumor groups revealed a distinct MMPprofile for each histological subtype (data not shown). The profiles of histologicsubtypes were then compared to each other (see figure). The subset analysisshowed that only MMP-9 was significantly elevated in patients whose tumorrecurred (MMP-1: recurred: 14.1 ± 7.5, not: 14.4 ± 3.5; MMP-2: recurred: 86.8 ± 25.7,not: 76.2 ± 11.4; MMP-3: 18.1 ± 13.6, not: 4.4 ± 1.4; MMP-8: recurred: 233.0 ± 78.3,not: 109.3 ± 27.2; MMP-9: recurred: 223.3* ± 31.7, not: 118.9 ± 19.4; MMP-12:recurred: 27.7 ± 11.9, not: 14.7 ± 4.0; MMP-13: recurred: 10.1 ± 7.3, not: 1.0 ± 0.3; *p