Boston - American Association for Thoracic Surgery

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89 TH ANNUAL MEETING MAY 9–MAY 13, 2009BOSTON, MASSACHUSETTSRESULTS: The intensities of 98 glycans were significantly different among the 3groups; 26 of these correspond to known glycan structures. Pairwise comparisonsshowed that 8 glycans are significantly different in all three pairwise comparisons.Figure 1 shows the mass spectra plots obtained for each category.CONCLUSION: We have demonstrated that comparative glycomic profiling ofEAC reveals a subset of glycans that can be selected as candidate biomarkers.These markers can differentiate normal from HGD, normal from EAC, and HGDfrom EAC. Further validation will be necessary to determine the clinical utility ofthese glycan biomarkers.148
AMERICAN ASSOCIATION FOR THORACIC SURGERYF18. Matrix Metalloproteinase Expression in Adenocarcinoma andSquamous Cell Carcinoma of the LungSonam A. Shah, 1 John S. Ikonomidis, 2* Robert E. Stroud, 2 Eileen I. Chang, 2Francis G. Spinale, 2* Carolyn E. Reed 2*1. Medical University of South Carolina, College of Medicine, Charleston, SC,USA; 2. Medical University of South Carolina, Department of Surgery,Charleston, SC, USAInvited Discussant: David R. JonesOBJECTIVE: Non-small cell lung cancer (NSCLC) is the leading cause of cancerdeaths. Matrix metalloproteinases (MMPs) are an endogenous proteinase systemshown to facilitate cancer invasion and metastasis. The purpose of this study wasto evaluate MMP expression in the two most common histologies of NSCLC,squamous cell (SCC) and adenocarcinoma (AC), relative to normal lung tissue.METHODS: A comprehensive MMP multiplex plate analysis was run on homogenatesof 23 SCC and 22 AC surgically resected tumor specimens and compared(pg of MMP/mg tissue) to MMP concentrations in adjacent normal tissue. A subsetanalysis of patients who recurred versus those who did not was performed.TUESDAYMorningMMP Levels: Squamous Cell Carcinoma vs. Adenocarcinoma.MMP-1: SCC: 30.8* ± 9.3, AC: 6.8 ± 2.1; MMP-2: SCC: 128.2* ± 30.1,AC: 52.1 ± 8.1; MMP-3: SCC: 13.9* ± 4.3, AC: 0.9 ± 0.2; MMP-8:SCC: 396.0* ± 93.5, AC: 31.2 ± 8.6; MMP-9: SCC: 209.9* ± 19.5, AC:65.1 ± 16.2; MMP-12: SCC: 24.7* ± 5.7, AC: 4.9 ± 1.2; MMP-13: SCC:3.4* ± 1.9, AC: 1.4 ± 0.4, *p < 0.05. All values in pg of MMP/mg tissue.* AATS Member149
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AATS FUTURE MEETINGSMay 1-5, 2010Me
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