Boston - American Association for Thoracic Surgery

AMERICAN ASSOCIATION FOR THORACIC SURGERYwith male gender (p = 0.013), a history of smoking (p = 0.05), and squamous histology(p < 0.0001). 5-year OS for the entire group was 75.8%. 5-yr OS for MAGE + vsMAGE − patients was 69.1% vs 83.0%, respectively (p = 0.008) (FIGURE). A multivariateCox regression analysis for OS determined male gender (hazard ratio [HR]2.13, p = 0.01) and MAGE expression (HR 2.32, p = 0.01) to be significant negativepredictors of survival.TUESDAYMorningP = 0.0080 by log-rank test.CONCLUSION: This study identified MAGE expression as a significant negativeprognostic factor for survival among stage IA NSCLC patients. In addition thereappears to be a link between MAGE expression and male gender, squamous histology,and a previous history of smoking. These results provide a rationale for immunotherapyin stage IA NSCLC patients where standard cytotoxic therapy is not justified.137