Glucagon-Like Peptide-1 (GLP-1)
Glucagon-Like Peptide-1 (GLP-1)
Glucagon-Like Peptide-1 (GLP-1)
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DPP-IV inhibitors result in lower levels of <strong>GLP</strong>-1 thanexogenous administration of a <strong>GLP</strong>-1 analogueLiraglutide lowers body weight in candy fedobese rats, DPP-IV inhibitors does not<strong>GLP</strong>-1 IR (pmol/L)1209060300Liraglutidedose7 days’ liraglutide6 µg/kg od* (n=13)8 12 16 20 24Time (hours)<strong>GLP</strong>-1 (pmol/L)120906030028 days’ vildagliptin100 mg bid (n=9)VildagliptindoseVildagliptindose8 12 16 20 24Time (hours)Body weight (g)Treatment3753503253002752500 25 50 75 100 125 150 175Time (day)Vehicle,obeseVehicle,leanLiraglutide,obeseVildagliptin,obese*<strong>GLP</strong>-1 levels for liraglutide calculated as 1.5% free liraglutideDegn et al. Diabetes 2004;53:1187–94. Mari et al. J Clin Endocrinol Metab 2005;90:4888–94Raun, Voss, Gotfredsen, Golozoubova, Rolin & Bjerre Kndusen. Diabetes 2007;56:8–15Liraglutide altered food preference: decreasedchocolate but increased chow intakeThe family of incretin-based therapiesAccumulated chocolate(kcal)Accumulated chow(kcal)4000**p=0.001*p
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