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--JJHCVJOHN J. HADDADAcademic Professor and Research ScientistBiological, Biomedical and Clinical Laboratory Health Sciences, withSub-Specialties in Cellular/Molecular Physiology and ImmunologyBiomedical and Clinical Laboratory Sciences –http://johnjhaddad.weebly.com/JJH CV

UnabridgedAcademic Curriculum VitaeJOHN J. HADDAD, B.Sc., M.Sc., Ph.D.Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Professor of ScienceThe FBC Bldg., Salim Al-Bustani St., Watwat, El-Zarif, Beirut, LebanonTelephone Contacts: +Email Contacts: john.j.haddad@balamand.edu.lb ; j.haddad@bau.edu.lb ; john.haddad@yahoo.co.ukOBJECTIVES AND AIMSOfficial Website: http://johnjhaddad.weebly.com/BIOMEDICAL RESEARCH AND DEVELOPMENT, LABORATORY MANAGEMENT AND TECHNOLOGY(ACADEMY/INDUSTRY); ADMINISTRATIVE/PROFESSORSHIP IN TEACHING AND LEADERSHIP (ACADEMY).EDUCATION AND TRAININGPostDoc. Postdoctoral Fellow September, 2001 – August, 200 [University of California, San Francisco, CA, USA]Postdoctoral scholar and fellow on a National Institutes of Health (NIH) training fellowship award in Cellular andMolecular Neurophysiology and Biomedicine (Neuroimmunology), Cellular and Molecular Neurophysiology ResearchDivision, Severinghaus-Radiometer Research Laboratories, Department of Anesthesia and Perioperative Care, School ofMedicine, University of California (UCSF), San Francisco, California, USA.Postdoctoral Research Theme“The role of MAPK (mitogen-activated protein kinase) signaling pathways in determining cellular death and survival inhypoxia: Emerging pharmacological targets for therapeutic intervention,” and “The role of intracellular Ca signaling pathwaysin neuroprotection during hypoxia and hypoxia-reoxygenation.”Ph.D. Doctor of Philosophy (Doctor of Science) October, 199 – August, 2001 [University of Dundee, Scotland, UK]Cellular and Molecular Physiology and Immunology (Respiratory Physiology and Medicine), Division of PulmonaryMedicine and Oxygen Sensing, Tayside Institute of Maternal and Child Health, Department of Maternal and Child HealthSciences, Faculty of Medicine, Ninewells Hospital and Medical School, University of Dundee (UoD), Dundee, Scotland,UK.Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Doctorate Research Thesis Title“Oxygen-dependent regulation of redox-sensitive transcription factors HIF- - (hypoxia-inducible factor- ) and NF-B(nuclear factor-B) in the developing perinatal lung: Signaling potential of apoptosis and an association between oxidativestress and pro-inflammatory cytokines.”M.Sc. Master of Science October, 1993 – February, 1996 [American University of Beirut, Lebanon]Biology (Neuroimmunology), American University of Beirut (AUB), Beirut, Lebanon (Chartered, New York, NY, USA).Master of Science Research Thesis Title“Hyperalgesia induced by local endotoxin injections and its modulation by various anti-inflammatory and analgesic drugs.”B.Sc. Bachelor of Science October, 1989 – February, 1992 [American University of Beirut, Lebanon]Pre-medical Biology, American University of Beirut (AUB), Beirut, Lebanon (Chartered, New York, NY, USA).Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

PROFESSIONAL EXPERIENCE – Research, Management and Development Scientist, and Tenure-Track Faculty ProfessorJohn J. HaddadBiomedical, Clinical Laboratory and Health SciencesResearch Scientist and Professor of SciencePROFILERenowned Biomedical and Clinical Laboratory Associate Professorwith ten- years of education and research experience. Adept in performingadministrative responsibilities, educational leadership and researchdevelopment; knowledgeable in areas of Cellular/Molecular Physiology andImmunology with clinical relevance to biomedical laboratory; and excel inanalyzing and solving problems with various biomedical controls andsystems.KEY SKILLS– Member of Professional & AcademicSocieties– Principal Investigator in Project Grants& Extramural Funds– Advisory/Consultant Member– Reviewer for Specialized ScientificJournals– Project Grants & Extramural FundsReviewPROFESSIONAL EXPERIENCE– Editorial Expertise– Editorial Board– Network of HealthcareAdvisors– Science Development Network– Medical Laboratory ConsultantBEIRUT ARAB UNIVERSITY (BAU) — Beirut, LebanonChairman and Associate Professor, 2010 to PresentAdministrative/educational responsibilities affiliated with the Department ofMedical Laboratory Technology (MLT), Faculty of Health Sciences (FHS) forMLT undergraduate/postgraduate programs.Member and General Secretary of the FHS Council, recommended by Deanand appointed by the President of BAU since September, 2010.Member of the FHS Quality Assurance and Accreditation (QAA) committee sinceSeptember, 2010.Chair of the QAA since September, 2011.Key Results:• Supervised and instructed undergraduate students in Principles ofAnatomy and Physiology (HESC 101; 3.0); Specimen Preparation (MLAB201; 2.0); Quality Management for Medical Laboratory (MLAB 206; 2.0);Immunology and Serology (MLAB 301; 2.0); Molecular Genetics (MLAB302; 3.0); Medical Bacteriology (MLAB 306; 3.0); Cancer Biology andBiomedicine (MLAB 412; 2.0); and Biotechnology for MedicalLaboratory (MLAB 413; 2.0).Workplace WisdomLearning about the culture, structure, andmanagement of your company will helpyou perform your job smoother and to thebest of your ability.PROFESSIONAL EXPERIENCE (CONTINUED)LEBANESE INTERNATIONAL UNIVERSITY — Beirut, LebanonProgram Coordinator, Researcher & Assistant/Associate Professor,2003 to 2009Chairman, University Research CouncilKey Results:Advisor and instructor in biological and biomedical sciences, centralized inlecturing on General Biology I (BIOL 200; 4.0); Cell and Molecular Biology(BIOL 275; 4.0); Human Anatomy and Physiology (BIOL 345; 4.0);Genetics (BIOL 365; 3.0); Microbiology (BIOL 385; 4.0); Immunology(BIOL 425; 3.0); Biomedical Science Seminar (BIOL 490; 1.0);Epidemiology and Biostatistics (BMED 255; 3.0); Basic Health Care andMedical Terminology (BMED 310; 3.0); Hematology (BMED 360; 3.0);Medical Microbiology (BMED 430; 4.0); Carcinogenesis and Oncology(BMED 435; 3.0); Pathophysiology (BMED 445; 4.0); Clinical Hematologyand Hemostasis (BMED 475; 3.0); Biotechnology (BIOC 445; 3.0);Molecular Genetics (BIOC 450; 3.0); Immunohematology (MEDL 545;3.0); and Pharmaceutical Biotechnology (PHAR 530; 2.0).UNIVERSITY OF BALAMAND — Beirut/Tripoli, LebanonResearcher & Lecturer, 2005 to 2010Department of Medical Laboratory Sciences, Faculty of Health Sciences(FHS), University of Balamand (UoB), St. George Hospital and MedicalComplex, Aschrafieh, Beirut, Lebanon.Key Results:Supervised and instructed graduate students in Applied Molecular Biology(CLAS 303; 3.0); Cancer Genetics (CLAS 335; 1.0); Genomics (CLAS 336;3.0); and Medical Genetics (CLAS 338; 3.0).Supervised and instructed undergraduate students in General Biology –Genetics (FHSC 200; 4.0); Cell Biology (FHSC 208; 3.0); Basic Immunologyand Hematology (MALB 212; 4.0); Clinical Immunology and Hematology(MLAB 222; 4.0); Molecular Biology (MLAB 230; 3.0); Seminars in MedicalLaboratory Sciences (MLAB 231; 3.0); Applied Clinical Immunology andEndocrinology (MLAB 255; 1.0); and Clinical Pathology – Immunology andSerology (MLAB 260; 4.0).AMERICAN UNIVERSITY OF SCIENCE AND TECHNOLOGY —Beirut, LebanonProgram Coordinator, Researcher & Associate Professor, 2009 to 2010Interdisciplinary Research and Development Fellow, American University ofScience and Technology (AUST), Aschrafieh, Beirut, Lebanon.Coordinator and chair of the Biological (BIO) and Clinical Laboratory Science(CLS) undergraduate programs, Department of Clinical Laboratory Science,Faculty of Health Sciences (FHS), American University of Science andTechnology (AUST), Aschrafieh, Beirut, Lebanon.Key Results:Supervised and instructed undergraduate students in General Biology (BIO102; 3.0); Cells and Molecules (BIO 210; 3.0); Microbiology (BIO 310; 3.0);and Clinical Virology (CLS 452; 3.0).EDUCATION & CREDENTIALSPostdoctoral Fellow, University of California at San Francisco(UCSF)2001 to 2003Doctor of Philosophy (Doctor of Science), Ph.D., University ofDundee, Scotland, UK1998 to 2001Premedical Biology (B.Sc.) & Biology (Neuroimmunology; M.Sc.)American University of Beirut, Beirut, Lebanon1989 to 1996The FBC Building • Beirut, 3269 • (961) 01-37 81 59 / 03-86 33 84 / 71-91 75 91 • john.haddad@yahoo.co.ukDr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Academic Profile at a Glance‣ Chairman Beirut Arab University, Beirut, Lebanon – September, 2010 – Current Status: Chairman‣ Associate Professor Beirut Arab University, Beirut, Lebanon – September, 2010 – Current Status: Associate Professor‣ Associate Professor American University of Science & Technology, Lebanon – February, 2009 – September, 2010 Status: Associate Professor‣ Chairman Lebanese International University, Beirut, Lebanon – January, 2006 – February, 2009 Status: Chairman‣ Associate Professor Lebanese International University, Beirut, Lebanon – October, 2006 – February, 2009 Status: Associate Professor‣ Assistant Professor Lebanese International University, Beirut, Lebanon – October, 2004 – September, 2006 Status: Assistant Professor‣ Lecturer University of Balamand, Beirut/Tripoli, Lebanon – February, 2004 – Current Status: LecturerHaigazian University, Beirut, Lebanon – October, 2003 – February, 2005 Status: LecturerLebanese International University, Beirut, Lebanon – October, 2003 – September Status: Lecturer‣ Post-Doctoral Fellow University of California, San Francisco, CA, USA – September, 2001 – August, 2003 Status: PDRF‣ PhD Candidate University of Dundee, Dundee, Scotland, UK – October 1997 – July, 2001 Status: PhD‣ MSc Candidate American University of Beirut, Beirut, Lebanon – October, 1993 – February, 1996 Status: MSc‣ BSc Candidate American University of Beirut, Beirut, Lebanon – October, 1989 – February, 1992 Status: BScChairman and Associate ProfessorSept. 2010 – CurrentDepartment of Medical Laboratory Technology, Faculty of Health Sciences (FHS), Beirut Arab University (BAU), Beirut,Lebanon.• Member and General Secretary of the FHS Council, recommended by Dean and appointed by the President of BAU sinceSeptember, 2010.• Member of the FHS Quality Assurance and Accreditation (QAA) committee since September, 2010.• Chair of the QAA since September, 2011.• Chairman/coordinator of the Medical Laboratory Technology department for MLT undergraduate/postgraduate programs.‣ Supervised and instructed undergraduate students in Principles of Anatomy and Physiology (HESC 101; 3.0); SpecimenPreparation (MLAB 201; 2.0); Quality Management for Medical Laboratory (MLAB ; ; Immunology and Serology(MLAB ; ; Molecular Genetics (MLAB 302; 3.0); Medical Bacteriology (MLAB Cancer Biology andBiomedicine (MLAB 412; 2.0); and Biotechnology for Medical Laboratory (MLAB 413; 2.0).Program Coordinator and Researcher Feb. 2009 – Sept. 2010Interdisciplinary Research and Development Fellow, American University of Science and Technology (AUST), Aschrafieh,Beirut, Lebanon.Coordinator and chair of the Biological (BIO) and Clinical Laboratory Science (CLS) undergraduate programs, Department ofClinical Laboratory Science, Faculty of Health Sciences (FHS), American University of Science and Technology (AUST), Aschrafieh,Beirut, Lebanon.Associate Professor Feb – Sept. 2010Department of Clinical Laboratory Science, Faculty of Health Sciences (FHS), American University of Science and Technology(AUST), Aschrafieh, Beirut, Lebanon.‣ Supervised and instructed undergraduate students in General Biology (BIO 102; 3.0); Cells and Molecules (BIO ;Microbiology (BIO and Clinical Virology (CLSChairman, University Research Council Jan. 2006 – Feb. 2009The university research council (URC) is an organizing and steering committee at the Lebanese International University (LIU)that oversees promoting research interests, funding high-caliber research applications and accruing extramural grants, domesticallyand internationally. The main objective of the URC is to establish a competitive and highly-credible research center in basic andclinical sciences at the university.Associate Professor Oct. 2006 – Feb. 2009Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Departments of Biology and Biomedical Sciences, Faculty of Arts and Sciences, Lebanese International University (LIU),Mousseitbeh, Al-Mazraa, Beirut, Lebanon. (Courses taught jibes with what is therein stated down below.)Assistant Professor Oct. – Sept. 2006Departments of Biology and Biomedical Sciences, Faculty of Arts and Sciences, Lebanese International University (LIU),Mousseitbeh, Al-Mazraa, Beirut, Lebanon.‣ Advisor and instructor in biological and biomedical sciences, centralized in lecturing on General Biology I (BIOL 200; 4.0);Cell and Molecular Biology (BIOL 275; 4.0); Human Anatomy and Physiology (BIOL 345; 4.0); Genetics (BIOL 365;Microbiology (BIOL 385; 4.0); Immunology (BIOL 425; 3.0); Biomedical Science Seminar (BIOL 490; 1.0);Epidemiology and Biostatistics (BMED 255; 3.0); Basic Health Care and Medical Terminology (BMED 310; 3.0);Hematology (BMED 360; 3.0); Medical Microbiology (BMED 430; Carcinogenesis and Oncology (BMED 435; 3.0);Pathophysiology (BMED 445; 4.0); Clinical Hematology and Hemostasis (BMED 475; 3.0); Biotechnology (BIOC 445;Molecular Genetics (BIOC 450; 3.0); Immunohematology (MEDL 545; 3.0); and Pharmaceutical Biotechnology(PHAR 530; 2.0).Lecturer Oct. 2005 – Sept. 2010Department of Medical Laboratory Sciences, Faculty of Health Sciences (FHS), University of Balamand (UoB), St. GeorgeHospital and Medical Complex, Aschrafieh, Beirut, Lebanon.‣ Supervised and instructed graduate students in Applied Molecular Biology (CLAS 30 ; Cancer Genetics (CLAS 335;Genomics (CLAS 3 ; and Medical Genetics (CLAS 338; 3.0).‣ Supervised and instructed undergraduate students in General Biology – Genetics (FHSC 200; 4.0); Cell Biology (FHSC 208;Basic Immunology and Hematology (MALB 212; 4.0); Clinical Immunology and Hematology (MLAB 222; 4.0);Molecular Biology (MLAB 230; 3.0); Seminars in Medical Laboratory Sciences (MLAB 231; 3.0); Applied ClinicalImmunology and Endocrinology (MLAB 255; 1.0); and Clinical Pathology – Immunology and Serology (MLAB .Lecturer Feb. 200 – Jan. 2006Department of Clinical Laboratory Science, Faculty of Sciences, American University of Science and Technology (AUST),Aschrafieh, Beirut, Lebanon.‣ Supervised and instructed undergraduates and laboratory science students in Biostatistics and Epidemiology (BIOL 320;Lecturer Feb. 2004 – Sept. 2007Department of Biology, Faculty of Sciences (FOS), University of Balamand (UoB), Balamand, Koura, Tripoli, Lebanon.‣ Supervised and instructed undergraduates and premedical students in Immunobiology (BIOL 229; 3.0); Molecular Biology(BIOL 285; 3.0); Molecular Biology Laboratory (BIOL 286; 1.0); and Techniques in Biological Research (BIOL 308; 3.0).Lecturer Oct. 2003 – Feb. 2005Department of Natural Sciences, Faculty of Arts and Sciences, Haigazian University (HU), Rue Mexique, Kantari, Beirut,Lebanon.‣ Supervised and instructed undergraduate and medical laboratory students in Immunology (BIOL /MLS 207 ); PlantPhysiology (BIOL . ); Botany (BIOL ); Cell Biology (BIOL ); and Epidemiology and Biostatistics(MLS 225; 3 ).Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Lecturer Oct. 2003 – Sept. 2004Departments of Biology and Biomedical Sciences, Faculty of Arts and Sciences, Lebanese International University (LIU), Al-Mousseitbeh, Mazraa, Beirut/Saida, Lebanon.‣ Supervised and instructed biology, biochemistry, pharmacy and biomedical sciences students in Introductory Biology I/II(BIOL 100/150; 4.0); General Biology I/II (BIOL 200/250; 4.0); Cell and Molecular Biology (BIOL 275; 4.0); HumanAnatomy and Physiology (BIOL 345; 4.0); Genetics (BIOL 365; ; Microbiology (BIOL 385; 4.0); Immunology (BIOL; Biomedical Science Seminar (BIOL 490; 1.0); Epidemiology and Biostatistics (BMED ; Hematology(BMED 360; 3.0); Pathophysiology (BMED ; Molecular Genetics (BIOC ; Biotechnology (BIOC 445;; and Pharmaceutical Biotechnology (PHAR 530; 2.0).Research Scientist (National Institutes of Health [NIH] Postdoctoral Scholar)Sept. 2001 – AugSeveringhaus-Radiometer Research Laboratories, Cellular and Molecular Neurophysiology Research Division, Department ofAnesthesia and Perioperative Care, School of Medicine, University of California (UCSF), San Francisco, CA, USA.‣ Investigated pharmacological patterns of mitogen-activated protein kinases signaling and their enzymatic role inneuroprotection in anoxia-intolerant species, such as rats and mice, and in anoxia-tolerant species, such as the Westernpaintedturtles.‣ Evaluated subcellular N-methyl- D -aspartate and neurotransmitter receptor regulation, calcium signaling and proteinkinase/transcription in ischemia/reperfusion and hypoxia-induced neurological injury.‣ Developed extensive expertise in diverse techniques and methods of analyses, including, gene micro-array system, ELISA,cell membrane receptor/protein signaling, Western/Northern/Southern analysis, electrophoresis, immunocytochemistry,micro-histology staining, immunohistology, perfusion/embedding/cryosectioning, calcium imaging, HPLC, massspectrophotometry, immunofluorescence and cell plasmid transfection/DNA-RNA analysis assays.Research Associate (Ph.D. Candidate and Postdoctoral Research Fellow) Nov. 1998 – Aug. 2001Division of Molecular Biology, Oxygen Signaling and Pulmonary Physiology Group, Tayside Institute of Maternal and ChildHealth, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK.‣ Provided leadership and biotechnology expertise to research groups focused on the differential regulation of oxygen-sensitivetranscription factors in the lung and alveolar epithelium.‣ Designed experimentations and methodology to study the redox variations and cytokine-dependent pathways associated withrespiratory distress syndrome (RDS) in pre-term infants.‣ Directed molecular physiology and cellular Biology research that utilized diverse techniques and state-of-the-art approaches,including: Enzyme-linked immunosorbent assay (ELISA), electrophoretic mobility shift assay (EMSA), in situ hybridization,histochemistry and immunofluorescence, Western/Northern/Southern blotting, PCR/RT-PCR, RNAase protection assays,transfection/infection and plasmid engineering, DNA laddering, nick-end labeling and terminal transferase immonoreactivity,fluorescent microscopy, cytokine-related immune assays, apoptosis-related techniques, antibody production, vaccine/drugtargeting, metabolism and disposition, and electrophysiology.‣ Undertaken peer-reviewed and published research experimental results in domestically and internationally renownedjournals, including, but not limiting to: Am. J. Physiol.; Am. J. Respir. Cell Mol. Biol.; Biochem. Biophys. Res. Commun.;Biochem. J.; Biochem. Pharmacol.; Brain Res.; Br. J. Pharmacol.; Cell. Immunol.; Cell. Signal.; Crit. Care; Curr. DrugTargets; Curr. Immunol. Rev.; Curr. Opin. Investig. Drugs; Cytokine; Cytokines Cell. Mol. Therap.; Eur. Cytokine Netw.;FEBS Lett.; Free Radic. Biol. Med.; Int. Immunopharmacol.; J. Biol. Chem.; J. Med. Case Reports.; J. Neuroimmunol.; J.Orthop. Surg.; J. Pharmacol. Exp. Therap.; J. Physiol.; Mol. Immunol.; Neuropharmacology; Prog. Neurobiol.; Respir.Res.; amongst others.‣ Presented research findings at several scientific meetings and conferences: American Physiological Society, Federation of theAmerican Societies for Experimental Biology, Society for Neuroscience, and others (see p. 8).Research Assistant Oct. 1995 – Aug. 1998Departments of Biology (Faculty of Arts and Sciences), Internal Medicine, Human Morphology and Physiology (Faculty ofMedicine), American University of Beirut, Beirut, Lebanon (New York, NY).‣ Designed and conducted experiments to study thermal and mechanical hyperalgesia in laboratory animals, using differentprotocols for pain assessment and measurement.Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

‣ Established efficient animal surgical procedures, such as, thymectomy, sympathectomy, cordotomy, vagotomy, and brainelectrolytic lesions.‣ Examined the mechanisms of inflammatory hyperalgesia to understand and enhance alleviation and treatment of pain causedby inflammation (neurogenic inflammation).‣ Performed ELISA and related immunoassays for the measurement of cytokines and growth factors in tissues, sera and wholeblood.Graduate Assistant Oct. 1993 – June 1995Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon (New York, NY, USA).‣ Supervised, instructed and graded General Biology and Physiology courses for undergraduate students.Non-Academic High School and College Teaching Appointments Oct. 1992 – Sept. 1998‣ Associate Teacher for Math and Sciences (Intermediate I IV; Grades VI IX) Near East Evangelical School,Mousseitbeh, Beirut, Lebanon (October 1, 1992 September 30, 1993).‣ Associate Teacher for Sciences (Intermediate IV) and SAT-II (Secondary I, Scientific and Literary) Rawdah High School,Verdun, Beirut, Lebanon (October 1, 1996 September 30, 1997).‣ Associate Teacher for Sciences & Biology (Intermediate III IV); Advisor and Assistant Head of Division Saint Mary’sOrthodox College, Ras-Beirut, Beirut, Lebanon (October 1, 1997 September 30, 1998).ADDITIONAL PROFESSIONAL EXPERTISE- Member of Professional and Academic Societies: American Chemical Society, The Physiological Society (UK), AmericanPhysiological Society, Society for Experimental Biology (UK), National Geographic Society, International Cytokine Society,Neuroscience Society, Federation of the Association of Societies of Experimental Biology (FASEB), and New YorkAcademy of Science.- Principal Investigator in Project Grants and Extramural Funds: The National Institute for Biological Standards andControls (NIBSC), England, UK; Tenovus for Supporting Medical Research, Scotland, UK; National Institutes of Health(NIH), USA.- Advisory/Consultant Member: Consultant for Current Drugs Ltd.: Investigational Drugs Database Company, specialized inpharmaceutical industry, headquartered in London, UK.- Reviewer for Specialized Scientific Journals: Antioxidants & Redox Signaling; BMC Cardiovascular Disorders; CellBiochemistry & Biophysics; Cytokine; Environmental Science & Technology; Free Radical Biology & Medicine; Journal ofNeurochemistry; Journal of Neuroimmunology; Journal of Proteome Research; Proceedings of the National Academy ofSciences, USA; amongst others.- Project Grants and Extramural Funds Review: The American Heart Association (AHA), Dallas, TX, USA; TheWellcome Trust (WT), London, England, UK; The Arthritis Research Campaign (ARC), Chesterfield, Derbyshire, England,UK; Ministry of Education, Youth and Sports of the Czech Republic, Department of Research and Development Support,Karmelitská, Prague, Czech Republic; Sheffield Hospitals Charitable Trust, Sheffield, England, UK; The Medical ResearchCouncil (MRC), London, UK; The Medical Research Scotland (Scottish Hospital Endowments Research Trust; SHERT),Edinburgh, UK. Grants refereed are entitled as follows:‣ April – 2007; The University Research Council – Lebanese International University (Lebanon): Constructing doublystochastic matrices for the inverse spectral problem.‣ March – 2007; The University Research Council – Lebanese International University (Lebanon): Theoreticalelectronic structure investigation of low lying states of diatomic molecules.‣ January – 2007; The Medical Research Scotland – SHERT (UK): Monocyte-fibroblast interactions in pulmonaryfibrosis.‣ March – 2006; The Wellcome Trust (UK): The role of circulating monocytes and HIF-1 in a multi-hit model ofacute lung injury.‣ February – 2006; The Medical Research Council (UK): Non-hypoxic regulation of HIF hydroxylation.‣ November – 2005; Sheffield Hospitals Charitable Trust (UK): Nuclear translocation and processing of pro-IL- .‣ June – The Arthritis Research Campaign (UK): The effects of hypoxia on cell adaptation and function.‣ December – The Wellcome Trust (UK): The IKK-NF-B pathway as a ‘master switch’ in mediating a globalinflammatory response within the airway epithelium.Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

‣ June – 2002; The American Heart Association (USA): The role of MAPK signaling pathways in determining cellulardeath or survival in hypoxia: Emerging pharmacological targets for therapeutic intervention.- Editorial Expertise: Field editor for Springer-Verlag (Heidelberg, Germany; New York, USA) in the creation of the‘Encyclopedic Reference of Neuroscience’ – Neuroimmunology.- Editorial Board: Serving as a member on board of the following journals – NanoScience and NanoTechnology Journal(Trade Science, Inc.).- Network of Healthcare Advisors: A consultant for an exclusive community of academic and industry professionals whoprovide consulting services to the financial industry (http://www.networkofadvisors.com).- Science Development Network: A consultant for the network in sharing science and technology in Middle East-basedinstitutions (http://www.sciencedev.net).- St. Elias Medical Laboratories: Consultant and lecturer for medical laboratory specialists and technologists in norms withISO licensing and accreditation standards (http://www.stelielab.com).OTHER TECHNICAL EXPERTISE‣ Strong background in the characterization, purification and testing of proteins and enzyme-related cofactors(Biomedical/Biochemical Pharmacology).‣ Extensive experience in gel electrophoresis, DNA/RNA assays, microscopy, cell preparation and culturing (Cell Physiology).‣ Extensive experience in immunology techniques, cytokine assessment, inflammation and apoptosis-related assays (CellularImmunology and Hematology).‣ Skilled knowledge in performing plasmid analysis, cell culture and transfection and molecular biology technical assays(Cellular and Molecular Biology).‣ Professional knowledge of electrophysiology, immunofluorescence, immunohistology and related techniques(Neurophysiology and Immunology).OTHER SKILLSComputer and statistical skills:‣ MSWord, Excel, PowerPoint, Publisher, ChemDraw, CorelDraw, SigmaStat, SPSS, Professional PDF and Adobe Photoshop.‣ Conducted administrative work for data assessment, statistical analysis, graphic design, and professional writing.Leadership skills:‣ Supervised and instructed students for university entrance examinations, including FEE, SEE, SQ and SAT-II, at theAmerican University of Beirut and Lebanese American University preparatory centers, Beirut, Lebanon.‣ Supervised and trained medical students in Molecular Biology, at the University of Dundee, Scotland, UK.‣ Mentored and trained high school and college students at University of California, San Francisco, CA, USA, resulting intraining and motivation for the field of Molecular Biology.HONORS, AWARDS AND RECOGNITIONSAmerican University of Beirut awarded studentship for the premedical Biology major.American University of Beirut graduate assistantship award for the degree of Master of Science.American University of Beirut research fellowship at the departments of Biology and Human Morphology.Georges John J. Livanos (London) Ph.D. fellowship at the Tayside Institute of Child Health, Ninewells Hospitaland Medical School, University of Dundee, Dundee, Scotland, UK.NIH Postdoctoral research fellowship at the Severinghaus-Radiometer Research Laboratories, Department ofAnesthesia and Perioperative Care, University of California, San Francisco, CA, USA.2006 – International recognition as an outstanding scientist, documented in the 1 st edition of the major academicreference of ‘Marquis Who’s Who of Emerging Leaders, ’, New Providence, NJ, USA.2009 – Acclaimed field editor of Neuroimmunology in the renowned Encyclopedia of Neuroscience, published withSpringer-Verlag.Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

FELLOWSHIPS AND TRAVEL AWARDSThe University of Dundee, Ninewells Hospital and Medical School, annual travel award to outstanding youngscientists. This fellowship was awarded to attend Experimental Biology-2000 in San Diego, California, USA.Award £500.00 ( $ ).The American Physiological Society, Bethesda, MD (USA), travel award for attending the joint annual meetingwith the Scandinavian Physiological Society in Amsterdam, Sweden. Award £525.00 ( $ ).The Wellcome Trust, London (UK), travel award for attending the joint annual meeting of the FederalAssociation for the Societies of Experimental Biology (FASEB) in Orlando, Florida, USA. Award £800.00 (The Physiological Society, London (UK), travel award, under the Affiliate Travel Grant Scheme, for attendingthe joint annual meeting of the Federal Association for the Societies of Experimental Biology (FASEB) inOrlando, Florida, USA. Award £600.00 ( $ ).PROJECT GRANTS AND EXTRAMURAL FUNDSJan. 20 – Current Supporting Body: Intramural funding at the Faculty of Health Sciences, Beirut Arab University,Beirut, Lebanon. Grant award value: $ ,Project Title: “Hypertension and correlational obesity biomarkers among academic students inLebanon.”Principal Investigators: Prof. Fikrat El-Sahn and Dr. John J. Haddad at the Departments of Nutritionand Dietetics, and Medical Laboratory Technology, Faculty of Health Sciences, Beirut ArabUniversity, Beirut, Lebanon.Oct. 200 – Feb. 2009Supporting Body: The University Research Council (URC) of the Lebanese International University(LIU). Grant award value ,Project Title “The role of MAPK signaling pathways in determining cellular death or survival inhypoxia: Emerging pharmacological targets for therapeutic intervention ”Principal Investigator: Dr. John J. Haddad, Cellular and Molecular Signaling research group,division of Biological sciences, departments of Biology and Biomedical Sciences, Faculty of Arts andSciences, Lebanese International University, Beirut, Lebanon.Oct. 1999 – Jun. 2000Supporting Body: The National Institute for Biological Standards and Controls (NIBSC) (Dr.Stephen Poole, NIBSC, England, UK), in collaboration with the American University of Beirut(Professors Nayef E. Saadé and Bared Safieh-Garabedian, Beirut, Lebanon). Grant award value:£6,000 ( $ ,Projects Titles: “I. Chemioxyexcitation (pO /ROS) dependent release of IL- , IL-6 and TNF-:Evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium ” “II. Thiolregulation of pro-inflammatory cytokines revealed a novel immunopharmacological potential ofglutathione in the alveolar epithelium ”Principal Investigator: Dr. John J. Haddad at the Center for Research into Human Development,Tayside Institute of Maternal and Child Health, Faculty of Medicine, Ninewells Hospital and MedicalSchool, University of Dundee, Dundee, Scotland, UK.Jan. 2000 – Dec. 2000 Supporting Body: Tenovus-Scotland for Supporting Medical Research. Grant award value: £5,000( $ ,Project Title: “Cytokine-mediated activation of HIF- and NF-B in alveolar epithelia: Signalingpathways of apoptosis in oxidative stress ”Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Principal Investigator: Dr. John J. Haddad at the Center of Research for Human Development,Tayside Institute of Maternal and Child Health, Faculty of Medicine, Ninewells Hospital and MedicalSchool, University of Dundee, Dundee, Scotland, UK.SPECIALIZED MEETINGS, WORKSHOPS AND SYMPOSIA ATTENDED, Documented as of 1999The Physiological Society semi-annual meeting in Manchester, England, UK.The 9 th Postgraduate Research Symposium in Dundee, Scotland, UK.The Experimental Biology annual meeting in San Diego, California, USA.The 10 th Postgraduate Research Symposium in Dundee, Scotland, UK.The American Physiological Society and Scandinavian Physiological Society joint annual meeting in Stockholm, Sweden.The Physiological Society annual meeting in London, England, UK.The Experimental Biology annual meeting in Orlando, Florida, USA.The Biochemical Society annual meeting in Bristol, England, UK.The International Society of Neuroimmunology 6 th International Congress in Edinburgh, Scotland, UK.The 17 th Transatlantic Airway Conference in Lucerne, Switzerland.The University of California multi-campus workshop on “Oxygen sensing and adaptation mechanisms” in Riverside,California, USA.The Society for Neuroscience annual meeting in Orlando, Florida, USA.The University of Balamand, Faculty of Health Sciences, Medical Laboratory Sciences graduate program workshop on“First curriculum review” in Beirut, Lebanon.The University of Balamand, Faculty of Health Sciences, Medical Laboratory Sciences graduate program workshop on“Second curriculum review” in Beirut, Lebanon.The 1 st international conference on “Effective teaching and learning in higher education”, American University of Beirut,Beirut, Lebanon.The 1 st international conference on “Towards a comprehensive system for quality assurance of higher education inLebanon”, UNESCO Palace, Beirut, Lebanon.Training workshop on “Communication skills in higher academia”, El-Meouchy Education Consultancy, Beirut ArabUniversity, Beirut, Lebanon.Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

PRESENTATIONS AND PUBLICATIONSInvited Seminars, Symposia and Lectures at Domestic and International Conferences, Workshops and Academic VenueMeetings, Documented as ofDepartments of Human Morphology and Physiology, Faculty of Medicine, and Department of Biology, Faculty of Arts andSciences, American University of Beirut, Beirut, Lebanon “Oxygen-sensing mechanisms in the developing lung:Regulation of gene transcription ”Tayside Institute of Maternal and Child Health, Faculty of Medicine, University of Dundee, Dundee, Scotland, UK “Redoxregulation of HIF- and NF-B in the alveolar epithelium ”Departments of Human Morphology and Physiology, Faculty of Medicine, and Department of Biology, Faculty of Arts andSciences, American University of Beirut, Beirut, Lebanon “Redox regulation of oxygen-sensitive transcription factors ”Department of Medicine, National Jewish Medical and Research Center, global leader in lung, allergic and immunediseases, Denver, Colorado, USA “The role of reactive oxygen species in inducing a pro-inflammatory signal:Therapeutic implications ”Developmental Biology Program, Children’s Hospital Los Angeles Research Institute, Smith Research Tower, Universityof Southern California School of Medicine (UCLA), Los Angeles, California, USA. “Redox regulation of proinflammatorycytokines in the developing lung ”Division of Molecular Cardiovascular Biology, The Children’s Hospital Research Foundation, Children’s Hospital MedicalCenter, Cincinnati, Ohio, USA “Oxygen sensing and redox mechanisms in the perinatal airway epithelium ”Boehringer Ingelheim International GmbH, Transatlantic Airway Conference (17 th TAC annual meeting), Lucerne,Switzerland “Redox and oxidant-mediated regulation of apoptosis signaling pathways ”Division of Pulmonary, Critical Care and Occupational Medicine, Department of Internal Medicine, Health SciencesCenter, School of Medicine, Saint Louis University, Saint Louis, Missouri, USA “Antioxidant/prooxidant mechanisms inthe regulation of redox-sensitive transcription factors, apoptosis signaling cofactors and inflammation ”Programs in Pharmacology and Toxicology, Department of Pharmaceutical Sciences, College of Pharmacy, HealthSciences Center, University of Oklahoma, Oklahoma City, Oklahoma, USA “Immunopharmacologicantioxidant/prooxidant mechanisms in the regulation of redox-sensitive transcription factors, apoptosis signalingcofactors and inflammation ”Center for Environmental Health Sciences, Department of Pharmaceutical Sciences, University of Montana, Missoula,Montana, USA “Antioxidant/prooxidant mechanisms in the regulation of redox-sensitive transcription factors, apoptosissignaling cofactors and inflammation ”Spinal Cord and Brain Injury Research Center, Sanders Brown Center in Aging, University of Kentucky, Lexington,Kentucky, USA “Antioxidant/prooxidant mechanisms in the regulation of redox-sensitive transcription factors,apoptosis signaling cofactors and inflammation ”Departments of Human Morphology and Physiology, Faculty of Medicine, and Department of Biology, Faculty of Arts andSciences, American University of Beirut, Beirut, Lebanon “Antioxidant/pro-oxidant mechanisms in the regulation oftranscription factors, apoptosis and inflammation ”Departments of Biology and Biomedical Sciences, Faculty of Arts and Sciences, and Faculty of Pharmacy, LebaneseInternational University, Beirut, Lebanon “Oxygen, oxygenes and gene regulation: Glutathione antioxidant therapy ”Department of Clinical Laboratory Sciences, American University College of Sciences and Technology, Beirut, Lebanon.“Oxidative stress and the molecular regulation of inflammation ”Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Department of Clinical Laboratory Sciences, Faculty of Health Sciences, St. George Medical Center, University ofBalamand, Aschrafieh, Beirut, Lebanon. “Diagnosis and prevention of viral hepatitis: Cutting edge immunologic andmolecular perspectives.”Department of Biology, Faculty of Sciences, University of Balamand, El-Kurah, Tripoli, Lebanon “Microarray technologyand its molecular and clinical applications ”Department of Clinical Laboratory Sciences, Faculty of Health Sciences, St. George Medical Center, University ofBalamand, Aschrafieh, Beirut, Lebanon. “Apoptosis and gene regulation: A view on embryogenesis signalingtransduction pathways.”Department of Clinical Laboratory Sciences, Faculty of Health Sciences, St. George Medical Center, University ofBalamand, Aschrafieh, Beirut, Lebanon. “Clinical laboratory sciences graduate program: First curriculum review.”Department of Sciences, Faculty of Natural and Applied Sciences, Notre Dame University, Zouk Mosbeh, Louaize,Lebanon “Physiologic oxygen sensing, oxygenes and inflammation ”Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon.“Quality assurance and management in the medical laboratory ”St. Elias Medical Laboratories, Antelias, Lebanon “Diagnostic protein electrophoresis and immunofixation ”Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon.“Diagnosis and prevention of viral hepatitis ”Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Published Abstracts of Domestic and International Conferences and Meetings, Documented as ofSafieh-Garabedian B., Kanaan S.A., Haddad J.J., Malik S., Abdelnoor A., Saadé N.E., and Jabbur S.J.: Hyperalgesia producedby endotoxin (ET) injections: A new model for localized inflammatory pain in rats and mice. Society for Neuroscience Abstracts,21: 643, 1995 (Sacramento, California, USA).Barbour E.K., Hamadeh S.K., Abi Ghanem D., Haddad J.J., and Safieh-Garabedian B.: Immunopotentiation in chicken layers bythymulin, thymopoeitin and zinc. Proceedings of the 46 th Western Poultry Conference, - , Sacramento, California,USA).Haddad J.J., and Land S.C.: Differential activation of oxygen-responsive transcription factors over fetal-to-neonatal alveolaroxygen tensions in rat fetal distal lung epithelial cells. The Journal of Physiology (London), 517P: 91P, 1999 (Manchester,England, UK).Haddad J.J.: Antioxidant and redox regulation of gene transcription in vitro over fetal-to-neonatal oxygen tensions: IntracellularHIF- and NF-B differential activation. The 8 th Postgraduate Research Symposium, 8: 12P-13P, 1999 (Dundee, Scotland,UK).Haddad J.J., Safieh-Garabedian B.H., Saadé N.E., and Land S.C.: Reactive oxygen species-dependent induction of IL- , IL-6and TNF- in the alveolar epithelium. The FASEB Journal, 14: A358, 2000 (San Diego, California, USA).Haddad J.J., Olver R.E., Murphie H.M., and Land S.C.: Redox-mediated differential expression of signaling factors involved inapoptosis in the perinatal lung. The FASEB Journal, 14: A582, 2000 (San Diego, California, USA).Haddad J.J., Olver R.E., and Land S.C.: Antioxidant/pro-oxidant equilibrium modulates the redox sensitivity of the alveolarepithelium: Kinematics of glutathione oxidation-mediated inhibition of HIF- and NF-B. The FASEB Journal, 14: A585,2000 (San Diego, California, USA).Haddad J.J.: Immunopharmacological properties of glutathione revealed: Redox disequilibrium and chemioxyexcitation(pO /ROS) regulation of cytokines in the alveolar epithelium. The 9 th Postgraduate Research Symposium, 9: 43P, 2000(Dundee, Scotland, UK).Haddad J.J., Land S.C., Olver R.E., Safieh-Garabedian B., and Saadé N.E.: Redox disequilibrium and chemioxyexcitation(pO /ROS) mediated regulation of the cytokine network in the alveolar epithelium. Acta Physiologica Scandinavica, 170:A105-106, 2001 (Stockholm, Sweden).Haddad J.J., Saadé N.E., Safieh-Garabedian B., and Land S.C.: The immunoregulatory potential of thymulin-Zn is cAMPsensitiveand mediated by selective targeting of the redox-sensitive transcription factor NF-B in the alveolar epithelium. TheJournal of Physiology (London), 531P: 177P, 2001 (London, England, UK).Haddad J.J., Olver R.E., and Land S.C.: The ex vivo differential expression of apoptosis signaling co-factors in the developingperinatal lung. The FASEB Journal, 15: A82, 2001 (Orlando, Florida, USA).Haddad J.J., Saadé N.E., Safieh-Garabedian B., and Land S.C.: Thiol regulation of pro-inflammatory cytokines inlipopolysaccharide-induced alveolar epithelial cells. The FASEB Journal, 15: A162, 2001 (Orlando, Florida, USA).Haddad J.J., Safieh-Garabedian B., Saadé N.E., and Land S.C.: The involvement of a NF-B-dependent pathway in regulatingpro-inflammatory cytokine biosynthesis in the alveolar epithelium. The FASEB Journal, 15: A162, 2001 (Orlando, Florida,USA).Haddad J.J., Safieh-Garabedian B., Saadé N.E., and Land S.C.: Exogenous rmTNF- and redox-sensitive transcription factorsHIF- and NF-B: Up-regulation of endogenous pro- and anti-inflammatory cytokine biosynthesis and involvement of an IB- dependent pathway. The FASEB Journal, 15: A162, 2001 (Orlando, Florida, USA).Haddad J.J.: O -dependent regulation of redox-sensitive transcription factors HIF- and NF-B: Signaling potential ofapoptosis and an association between oxidative stress and pro-inflammatory cytokines. The 10 th Postgraduate ResearchSymposium, 10: 31P-32P, 2001 (Dundee, Scotland, UK).Haddad J.J., and Land S.C.: N-[1-(4-{[4-(pyrimidin-2-yl)piperazin-1-yl]methyl}phenyl)cyclopropyl] acetamide, (Y-40138), is anovel dual regulator of pro- and anti-inflammatory cytokines. 1, Involvement of an interleukin (IL)-10 sensitive pathway. Genesand Immunity, 2: A175, 2001 (Berlin, Germany).Haddad J.J., and Land S.C.: Y-40138 is a novel dual regulator of pro- and anti-inflammatory cytokines. 2, Requirement for anIB-/NF-B signal transduction sensitive pathway. Genes and Immunity, 2: A17 , 2001 (Berlin, Germany).Haddad J.J., and Land S.C.: Mitogen-activated protein kinase selective regulation of pro-inflammatory cytokines in the alveolarepithelium. The Biochemical Society Transactions, A55, 2001 (Bristol, England, UK).Safieh-Garabedian B., Haddad J.J., Jabbur S.J., and Saadé N.E.: Regulation of the nuclear factor B (NF-B) translocation byintracerebroventricular (ICV) endotoxin and its modulation by thymulin. The Journal of Neuroimmunology, 118 (1): 30, 2001(Edinburgh, Scotland, UK).Fahlman C.S., Haddad J.J., Schuyler J.A., and Bickler P.E.: Differential induction by hypoxia of MAPK p38 and MAPK ERKsignaling. Society for Neuroscience Abstracts, , (Orlando, Florida, USA).Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Haddad J.J., Schuyler J.A., Fahlman C.S., and Bickler P.E.: Hypoxia induces up-regulation of the JNK and ERK but not p38MAPK pathways in anoxia-tolerant turtle cortex. Society for Neuroscience Abstracts, , (Orlando, Florida, USA).Peer-Reviewed Publications in Specialized Journals, Documented as of the Academic Year of– Periodically UpdatedAll citations if and where applicable are technically based on the acclaimed Thomson reference for journal citations – Institute forScientific Information; ISI – The official websites are: http://www.isiwebofknowledge.com/; http://highwire.stanford.edu/; andhttp://www.scopus.com/.Manuscripts Published in 1996Kanaan S., Saadé N.E., Haddad J.J., Abdelnoor A.M., Atweh S.F., Jabbur S.J., and Safieh-Garabedian B.: Endotoxin-inducedlocal inflammation and hyperalgesia in rats and mice: A new model for inflammatory pain. Pain, (2-3): 373 – ,(Cited in papers) – MedLine (PubMed) Cross-reference PMID: 8880861 (Publisher: Elsevierhttp://www.sciencedirect.com/).Safieh-Garabedian B., Jalakhian R.H., Saadé N.E., Haddad J.J., Jabbur S.J., and Kanaan S.A.: Thymulin reduces hyperalgesiainduced by peripheral endotoxin injection in rats and mice. Brain Research, (1-2): 179 – , . (Cited in papers) –MedLine (PubMed) Cross-reference PMID: 8738269 (Publisher: Elsevier http://www.sciencedirect.com/).Manuscripts Published in 1997Kanaan S.A., Safieh-Garabedian B., Haddad J.J., Atweh S.F., Abdelnoor A.M., Jabbur S.J., and Saadé N.E.: Effects of variousanalgesic and anti-inflammatory drugs on endotoxin-induced hyperalgesia in rats and mice. Pharmacology, (6): 285 – ,(Cited in papers) – MedLine (PubMed) Cross-reference PMID: 9286812 (Publisher: http://www.karger.com/).Safieh-Garabedian B., Kanaan S.A., Haddad J.J., Abou Jaoude P., Jabbur S.J., and Saadé N.E.: Involvement of interleukin- ,nerve growth factor and prostaglandin-E in endotoxin-induced localized inflammatory hyperalgesia. The British Journal ofPharmacology, (8): 1619 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 9283695(Publisher: http://www3.interscience.wiley.com/).Manuscripts Published in 1998Barbour E.K., Hamadeh S.K., Abi Ghanem D., Haddad J.J., and Safieh-Garabedian B.: Humoral and cell-mediatedimmunopotentiation in vaccinated chicken layers by thymic hormones and zinc. Vaccine, (17): 1650 – , MedLine(PubMed) Cross-reference PMID: 9713942 (Publisher: Elsevier http://www.sciencedirect.com/).Kreydiyyeh S., Haddad J.J., and Safieh-Garabedian B.: Interleukin- inhibits the intestinal transport of [ C]3-Omethylglucosein the rat. Life Sciences, (21): 1913 – , (Cited in papers). MedLine (PubMed) Cross-referencePMID: 9825769 (Publisher: Elsevier http://www.sciencedirect.com/).Manuscripts Published in 2000Haddad J.J., and Land S.C.: O -evoked regulation of HIF- and NF-B in perinatal lung epithelium requires glutathionebiosynthesis. The American Journal of Physiology – Lung Cellular and Molecular Physiology, (3): L492 – L503, 2000. Thisarticle is recognized with high access and input on the journal’s website. (Cited in 12 papers) – MedLine(PubMed) Cross-reference PMID: 10710521 (Publisher: http://ajplung.physiology.org/).Haddad J.J., and Land S.C.: The differential expression of apoptosis factors in the alveolar epithelium is redox sensitive andrequires NF-B (RelA)-selective targeting. Biochemical and Biophysical Research Communications, (1): 257 – ,(Cited in papers) – MedLine (PubMed) Cross-reference PMID: 10777712 (Publisher: Elsevierhttp://www.sciencedirect.com/).Haddad J.J., Olver R.E., and Land S.C.: Antioxidant/pro-oxidant equilibrium regulates HIF- and NF-B redox sensitivity:Evidence for inhibition by glutathione oxidation in alveolar epithelial cells. The Journal of Biological Chemistry, (28):21130 – , This article is recognized with high access and input on the journal’s website. (Cited inpapers) – MedLine (PubMed) Cross-reference PMID: 10801793 (Publisher: http://www.jbc.org/).Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Haddad J.J., Land S.C., Saadé N.E., and Safieh-Garabedian B.: Immunomodulatory potential of thymulin-Zn in the alveolarepithelium: Amelioration of endotoxin-induced cytokine release and partial amplification of a cytoprotective IL-10-sensitivepathway. Biochemical and Biophysical Research Communications, (2): 500 – , (Cited in papers) – MedLine(PubMed) Cross-reference PMID: 10913367 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: Glutathione depletion is associated with augmenting a pro-inflammatory signal: Evidence for an antioxidant/prooxidantmechanism regulating cytokines in the alveolar epithelium. Cytokines, Cellular and Molecular Therapy, (4); 177 –, . – MedLine (PubMed) Cross-reference PMID: 11565956 (Publisher: http://www.tandf.co.uk/).Land S.C., Haddad J.J., and Darakhshan F.: Oxygen signaling in perinatal lung development. Comparative Biochemistry andPhysiology Part B: Biochemistry and Molecular Biology, (1); S58, 2000. – MedLine (PubMed) Cross-reference PMID:(Publisher: Elsevier http://www.sciencedirect.com/).Manuscripts Published inHaddad J.J., Safieh-Garabedian B., Saadé N.E., Kanaan S.A., and Land S.C.: Chemioxyexcitation (pO /ROS)-dependentrelease of IL- , IL-6 and TNF-: Evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium. Cytokine,(3): 138 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11161456 (Publisher:Elsevier http://www.sciencedirect.com/).Haddad J.J., Choudhary K.K., and Land S.C.: The ex vivo differential expression of apoptosis signaling cofactors in thedeveloping lung: Essential role of oxygenation during the transition from placental to pulmonary-based respiration. Biochemicaland Biophysical Research Communications, (2): 311 – , . (Cited in papers) – MedLine (PubMed) CrossreferencePMID: 11181047 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J., Safieh-Garabedian B., Saadé N.E., and Land S.C.: Thiol regulation of pro-inflammatory cytokines reveals a novelimmunopharmacological potential of glutathione in the alveolar epithelium. The Journal of Pharmacology and ExperimentalTherapeutics, (3): 996 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11181934 (Publisher:http://jpet.aspetjournals.org/).Haddad J.J., Lauterbach R., Saadé N.E., Safieh-Garabedian B., and Land S.C.: -Melanocyte-related tripeptide, lys- D -pro-val,ameliorates endotoxin-induced nuclear factor-B translocation and activation: Evidence for involvement of an interleukin- -receptor antagonism in the alveolar epithelium. The Biochemical Journal, 355 (1): 29 – , – MedLine (PubMed) CrossreferencePMID: 11256945 (Publisher: http://www.biochemj.org/).Haddad J.J., Collett A., Land S.C., Olver R.E., and Wilson S.C.: NF-B blockade reduces the O -evoked rise in Na +conductance in fetal alveolar cells. Biochemical and Biophysical Research Communications, (4): 987 – , . (Cited inpapers) – MedLine (PubMed) Cross-reference PMID: 11237760 (Publisher: Elsevier http://www.sciencedirect.com/).Baines D.L., Ramminger S.J., Collet A., Haddad J.J., Best O.G., Olver R.E., Land S.C., and Wilson S.M.: Oxygen-evoked Na +transport in rat fetal distal lung epithelial cells. The Journal of Physiology (London), (1): 105 – , (Cited inpapers) – MedLine (PubMed) Cross-reference PMID: 11283228 (Publisher: http://jp.physoc.org/).Haddad J.J., Safieh-Garabedian B., Saadé N.E., and Land S.C.: The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-B targeting in the alveolar epithelium. The British Journal of Pharmacology,(1): 49 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11325794 (Publisher:http://www3.interscience.wiley.com/).Haddad J.J., and Land S.C.: Nuclear factor (NF)-B blockade attenuates but does not abrogate lipopolysaccharide-dependenttumor necrosis factor (TNF)- biosynthesis in alveolar epithelial cells. Biochemical and Biophysical ResearchCommunications, (2): 267 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11444836(Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: Reduction-oxidation mediated regulation of MAPK p38 -dependent pro-inflammatory cytokine biosynthesis: On themechanism of glutathione as a novel immunoregulatory antioxidant thiol. International Archives of Bioscience, (1): 1001 – ,– (Publisher: http://www.iabs.us/).Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Haddad J.J.: VX-745, a novel MAPK p38 inhibitor with anti-inflammatory actions (Vertex Pharmaceuticals). Current Opinion inInvestigational Drugs, (8): 1070 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11892915(Publisher: http://www.biomedcentral.com/).Haddad J.J., and Land S.C.: A non-hypoxic, ROS-sensitive pathway mediates TNF--dependent regulation of HIF- .Federation of European Biochemical Societies (FEBS) Letters, (2): 269 – , This article is recognized with highaccess and input on the journal’s website. (Cited in papers) – MedLine (PubMed) Cross-reference PMID:(Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: L -Buthionine-(S,R)-sulfoximine, an irreversible inhibitor of -glutamylcysteine synthetase, augments proinflammatorycytokine biosynthesis: Evidence for the implication of an IB-/NF-B insensitive pathway. European CytokineNetwork, (4): 614 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11781188 (Publisher:http://www.john-libbey-eurotext.fr/).Haddad J.J.: Oxygen-sensitive pro-inflammatory cytokines, apoptosis signaling and redox-responsive transcription factors indevelopment and pathophysiology. Cytokines, Cellular and Molecular Therapy, (1): 1 – , (Cited in papers) –MedLine (PubMed) Cross-reference PMID: 12171246 (Publisher: http://www.tandf.co.uk/).Manuscripts Published in 2002Haddad J.J., and Land S.C.: Amiloride blockades lipopolysaccharide-induced cytokine biosynthesis in an IB-/NF-Bdependentmechanism: Evidence for the amplification of an anti-inflammatory pathway in the alveolar epithelium. The AmericanJournal of Respiratory Cell and Molecular Biology, (1): 114 – , (Cited in papers) – MedLine (PubMed) CrossreferencePMID: 11751211 (Publisher: http://ajrcmb.atsjournals.org/).Haddad J.J., Saadé N.E., and Safieh-Garabedian B.: Redox regulation of TNF- biosynthesis: Augmentation by irreversibleinhibition of -glutamylcysteine synthetase and the involvement of an IB-/NF-B-independent pathway in alveolar epithelialcells. Cellular Signalling, (3): 211 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11812649(Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J., Land S.C., Tarnow-Mordi W.O., Zembala M., KowaLczyk D., and Lauterbach R.: Immunopharmacologicalpotential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated pro-inflammatorycytokine (interleukin-6 and tumor necrosis factor-) biosynthesis in alveolar epithelial cells. The Journal of Pharmacology andExperimental Therapeutics, (2): 559 – , . This article is recognized with high access and input on the journal’swebsite. (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 11805217 (Publisher: http://jpet.aspetjournals.org/).Haddad J.J., Land S.C., Tarnow-Mordi W.O., Zembala M., KowaLczyk D., and Lauterbach R.: Immunopharmacologicalpotential of selective phosphodiesterase inhibition. II. Evidence for the involvement of an inhibitory-B/nuclear factor-Bsensitivepathway in alveolar epithelial cells. The Journal of Pharmacology and Experimental Therapeutics, (2): 567 –, . (Cited in papers) – MedLine (PubMed) Cross-reference PMID: (Publisher: http://jpet.aspetjournals.org/).Haddad J.J., and Land S.C.: Redox/ROS regulation of lipopolysaccharide-induced mitogen-activated protein kinase (MAPK)activation and MAPK-mediated TNF- biosynthesis. The British Journal of Pharmacology, (2): 520 – , Thisarticle is recognized with high access and input on the journal’s website. (Cited in papers) – MedLine (PubMed) CrossreferencePMID: 11815388 (Publisher: http://www3.interscience.wiley.com/).Haddad J.J.: The involvement of L --glutamyl- L -cysteinyl-glycine (glutathione/GSH) in the mechanism of redox signallingmediating MAPK p38 -dependent regulation of pro-inflammatory cytokine production. Biochemical Pharmacology, (2): 305 –, This article is recognized with high access and input on the journal’s website. (Cited in papers) –MedLine (PubMed) Cross-reference PMID: 11841806 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J., and Fahlman C.S.: Nuclear factor-B-independent regulation of lipopolysaccharide-mediated interleukin-6biosynthesis. Biochemical and Biophysical Research Communications, (4): 1045 – , . (Cited in papers) –MedLine (PubMed) Cross-reference PMID: 11866471 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J., and Land S.C.: Redox signaling-mediated regulation of lipopolysaccharide-induced pro-inflammatory cytokinebiosynthesis in alveolar epithelial cells. Antioxidants and Redox Signaling, (1): 179 – , (Cited in papers) –MedLine (PubMed) Cross-reference PMID: 11970852 (Publisher: http://www.liebertonline.com/).Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Safieh-Garabedian B., Poole S., Haddad J.J., Massaad C.A., Jabbur S.J., and Saadé N.E.: The role of the sympathetic efferents inendotoxin-induced localized inflammatory hyperalgesia and cytokine up-regulation. Neuropharmacology, (6): 864 – ,– MedLine (PubMed) Cross-reference PMID: 12015213 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: Recombinant TNF- mediated regulation of the IB-/NF-B signaling pathway: Evidence for the enhancement ofpro- and anti-inflammatory cytokines in alveolar epithelial cells. Cytokine, (6): 301 – , (Cited in papers) –MedLine (PubMed) Cross-reference PMID: 12061837 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: Nuclear factor (NF)-B blockade attenuates but does not abrogate LPS-mediated interleukin (IL)- biosynthesisin alveolar epithelial cells. Biochemical and Biophysical Research Communications, (1): 252 – , . (Cited inpapers) – MedLine (PubMed) Cross-reference PMID: 12054592 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: Oxygen homeostasis, thiol equilibrium and redox regulation of signaling transcription factors in the alveolarepithelium. Cellular Signalling, (10): 799 – , . (Cited in papers) – MedLine (PubMed) Cross-reference PMID:(Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: Recombinant human interleukin (IL)- -mediated regulation of hypoxia-inducible factor- (HIF- )stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism.European Cytokine Network, (2): 250 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID:(Publisher: http://www.john-libbey-eurotext.fr/).Haddad J.J.: Redox regulation of pro-inflammatory cytokines and IB-/NF-B nuclear translocation and activation.Biochemical and Biophysical Research Communications, (4): 847 – , (Cited in papers) – MedLine (PubMed)Cross-reference PMID: 12200125 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors. CellularSignalling, (11): 879 – , This article is recognized with high access and input on the journal’s website.(Cited in papers) – MedLine (PubMed) Cross-reference PMID: 12220615 (Publisher: Elsevierhttp://www.sciencedirect.com/).Haddad J.J.: Pharmaco-redox regulation of cytokine-related pathways: From receptor signaling to pharmacogenomics. FreeRadical Biology and Medicine, (7): 907 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID:(Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J., and Fahlman C.S.: Redox and oxidant-mediated regulation of interleukin-10: An anti-inflammatory, antioxidantcytokine? Biochemical and Biophysical Research Communications, (2): 163 – , . (Cited in papers) – MedLine(PubMed) Cross-reference PMID: 12237098 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: Cytokines and related receptor-mediated signaling pathways. Biochemical and Biophysical ResearchCommunications, (4): 700 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 12359210(Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J., Safieh-Garabedian B., Saadé N.E., and Lauterbach R.: Inhibition of glutathione-related enzymes augments LPSmediatedcytokine biosynthesis: Involvement of an IB/NF-B-sensitive pathway in the alveolar epithelium. InternationalImmunopharmacology, (11): 1567 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 12433058(Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J., Saadé N.E., and Safieh-Garabedian B.: Cytokines and neuro-immune-endocrine interactions: A role for thehypothalamic-pituitary-adrenal revolving axis. The Journal of Neuroimmunology, (1-2): 1 – ,(Cited in papers) – MedLine (PubMed) Cross-reference PMID: 12446003 (Publisher: Elsevierhttp://www.sciencedirect.com/).Haddad J.J.: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury. I. Role fornuclear factor-B. Critical Care, (5): 481 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID:(Publisher: http://www.biomedcentral.com/).Commentary: Craig K., and Dorscheid D.: Understanding the roles of the transcription factors nuclear factor-κB and hypoxiainduciblefactor- α in lung injury. Critical Care, : 471 –Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Citation: Recognized by the World Intellectual Property Organization (http://www.wipo.int/) in the patent (WO/2007/002895)entitled “Integrative framework for three stage integrative pathway search,” submitted by the board of trustees of Michigan StateUniversity, Michigan, USA (www.msu.edu).Haddad J.J.: Oxygen sensing mechanisms and the regulation of redox-responsive transcription factors in development andpathophysiology. Respiratory Research, (1): 26 – , . This article is recognized with high access and input on thejournal’s website. (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 12537605 (Publisher:http://www.biomedcentral.com/).Manuscripts Published in 2003Haddad J.J.: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury. II. Role forhypoxia-inducible factor- . Critical Care, (1): 47 – , (Cited in papers) – MedLine (PubMed) Cross-referencePMID: 12617740 (Publisher: http://www.biomedcentral.com/).Citation: Recognized by the World Intellectual Property Organization (http://www.wipo.int/) in the patent (WO/2007/002895)entitled “Integrative framework for three stage integrative pathway search,” submitted by the board of trustees of Michigan StateUniversity, Michigan, USA (www.msu.edu).Haddad J.J., Saadé N.E., and Safieh-Garabedian B.: Interleukin-10 and the regulation of mitogen-activated protein kinases: Arethese signaling modules targets for the anti-inflammatory action of this cytokine? Cellular Signalling, (3): 255 – ,(Cited in 2 papers) – MedLine (PubMed) Cross-reference PMID: 12531424 (Publisher: Elsevierhttp://www.sciencedirect.com/).Manuscripts Published in 2004Haddad J.J.: Oxygen sensing and oxidant/redox-related pathways. Biochemical and Biophysical Research Communications,(4): 969 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 15044079(Publisher: http://www.sciencedirect.com/).Haddad J.J.: Redox and oxidant-mediated regulation of apoptosis signaling pathways: Immuno-pharmaco-redox conception ofoxidative siege versus cell deal commitment. International Immunopharmacology, (4): 475 – , . (Cited in papers) –MedLine (PubMed) Cross-reference PMID: 15099526 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: Mitogen-activated protein kinases and the evolution of Alzheimer’s: A revolutionary neurogenetic axis fortherapeutic intervention? Progress in Neurobiology, (5): 359 – , (Cited in papers) – MedLine (PubMed) CrossreferencePMID: 15312913 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: Hypoxia and the regulation of mitogen-activated protein kinases: Gene transcription and the assessment ofpotential pharmacologic therapeutic interventions. International Immunopharmacology, (10-11), 1249 – , (Cited inpapers) – MedLine (PubMed) Cross-reference PMID: (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: On the antioxidant mechanisms of Bcl-2: A retrospective of NF-B signaling and oxidative stress. Biochemical andBiophysical Research Communications, (2): 355 – , (Cited in papers) – MedLine (PubMed) Cross-referencePMID: 15325238 (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: Alcoholism and neuro-immune-endocrine interactions: Physiochemical aspects. Biochemical and BiophysicalResearch Communications, (2): 361 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID:(Publisher: Elsevier http://www.sciencedirect.com/).Safieh-Garabedian B., Haddad J.J., and Saadé N.E.: Cytokines in the central nervous system: Targets for therapeuticintervention. Current Drug Targets – CNS & Neurological Disorders, (4): 271 – , – MedLine (PubMed) CrossreferencePMID: 15379603 (Publisher: http://www.bentham.org/).Manuscripts Published in 2005Haddad J.J.: Amiloride and the regulation of NF-B: An unsung crosstalk and missing link between fluid dynamics andoxidative stress-related inflammation – controversy or pseudo-controversy? Biochemical and Biophysical ResearchCommunications, (2): 373 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 15629126(Publisher: Elsevier http://www.sciencedirect.com/).Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Haddad J.J., and Harb H.L.: Cytokines and the regulation of hypoxia-inducible factor- . International Immunopharmacology,(3): 461 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 15683844 (Publisher: Elsevierhttp://www.sciencedirect.com/).Haddad J.J., and Harb H.L.: L --Glutamyl- L -cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation ofpro- and anti-inflammatory cytokines: A signaling transcriptional scenario for redox(y) immunologic sensor(s)? MolecularImmunology, (9): 987 – , (Cited in papers) – MedLine (PubMed) Cross-reference PMID: 15829290 (Publisher:Elsevier http://www.sciencedirect.com/).Haddad J.J., Saadé N.E., and Safieh-Garabedian B.: Thymulin: An emerging anti-inflammatory molecule. Current MedicinalChemistry – Anti-inflammatory and Anti-allergy Agents, (3): 333 – , (Publisher: http://www.bentham.org/).Haddad J.J.: N-Methyl- D -aspartate and the regulation of MAPK signaling pathways: A revolving neurochemical axis fortherapeutic intervention? Progress in Neurobiology, (4): 252 – , (Cited in papers) – MedLine (PubMed) CrossreferencePMID: 16343729 (Publisher: Elsevier http://www.sciencedirect.com/).Manuscripts Published in 2007Haddad J.J.: On the enigma of pain and hyperalgesia: A molecular perspective. Biochemical and Biophysical ResearchCommunications, (2): 217 – , (Cited in 2 papers) – MedLine (PubMed) Cross-reference PMID: 17184730(Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: The role of Bax/Bcl-2 and pro-caspase peptides in hypoxia/reperfusion-dependent regulation of MAPK ERK :Discordant proteomic effect of MAPK p38 . Protein and Peptide Letters, (4): 361 – , – MedLine (PubMed) CrossreferencePMID: 17504094 (Publisher: http://www.bentham.org/).Haddad J.J.: Discordant tissue-specific expression of SAPK/MAPK JNK -related cofactors in hypoxia and hypoxia/reoxygenationin a model of anoxia-tolerance. Protein and Peptide Letters, (4): 373 – , . – MedLine (PubMed) Cross-referencePMID: 17504095 (Publisher: http://www.bentham.org/).Haddad J.J.: Cellular and molecular regulation of inflammatory pain, nociception and hyperalgesia – The role of thetranscription factor NF-B as the lynchpin nocisensor: Hyperalgesic or analgesic effect? Current Immunology Reviews, (2):117 – , . (Publisher: http://www.bentham.org/).Samaha A.A., Ivanov A.V., Haddad J.J., Kolesnik A.I., Baydoun S., Yashina I.N., Samaha R.A., and Ivanov D.A.:Biomechanical and system analysis of the human femoral bone: Correlation and anatomical approach. Journal of OrthopedicSurgery and Research, (5): 8 – , . – MedLine (PubMed) Cross-reference PMID: (Publisher:http://www.biomedcentral.com/).Manuscripts Published in 2008Samaha A.A., Hatoum H., Abou Ghazal F., Mattar H., Itany O.S., and Haddad J.J.: A case study with breast cancer and brainmetastasis encompassing acute onset of amnesia and altered mental status due to limbic encephalitis – Biochemical andproteomic aspects. Experimental and Clinical Sciences Journal, : 132 – 138, 2008. (Publisher: http://www.excli.de/).Samaha A.A., Ivanov A.V., Haddad J.J., Baydoun S., Arabi M.R., Yashina I.N., Kolesnik A.I., Samaha R.A., and Ivanov D.A.:Asymmetry and structural system analysis of the proximal femur meta-epiphysis: Osteoarticular anatomical pathology. Journalof Orthopedic Surgery and Research, (2): 11 – , . – MedLine (PubMed) Cross-reference PMID:(Publisher: http://www.biomedcentral.com/).Haddad J.J.: On the mechanisms and putative pathways involving neuroimmune interactions. Biochemical and BiophysicalResearch Communications, (4): 531 – , – MedLine (PubMed) Cross-reference PMID: 18413144 (Publisher:Elsevier http://www.sciencedirect.com/).Haddad J.J.: The regulation of neuroimmune-endocrine interactions: Mechanisms, molecular pathways unraveled and thepivotal role of cytokines – A unsung putative bidirectional interdependence between the immune and neuroendocrine interfaces.Current Immunology Reviews, (3): 134 – , . (Publisher: http://www.bentham.org/).Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Manuscripts Published in 2009Samaha A.A., Nasser-Eddine W., Shatila E., Haddad J.J., Wazne J., and Eid A.H.: Multi-organ damage induced by anabolicsteroid supplements: Case report and literature review. Journal of Medical Case Reports, : 340 – , –MedLine (PubMed) Cross-reference PMID: 18976461 (Publisher: http://www.biomedcentral.com/).Haddad J.J.: The role of inflammatory cytokines and NF-B/MAPK signaling pathways in the evolution of familialMediterranean fever: Current clinical perspectives and potential therapeutic approaches. Cellular Immunology, (1): 6 – ,. – MedLine (PubMed) Cross-reference PMID: (Publisher: Elsevier http://www.sciencedirect.com/).Haddad JJ.: Endotoxin-mediated regulation of nuclear factor-B nuclear translocation and activation in the hippocampus of thecentral nervous system: modulation by intracerebroventricular treatment with thymulin and the immunomodulatory role of theIB-/pIB- pathway. Neuroscience, ( ): – , . – MedLine (PubMed) Cross-reference PMID: TBA(Publisher: Elsevier http://www.sciencedirect.com/).Manuscripts Published in 2010Haddad J.J.: Thymulin and zinc (Zn )-mediated inhibition of endotoxin-induced production of proinflammatory cytokines andNF-B nuclear translocation and activation in the alveolar epithelium: Unraveling the molecular immunomodulatory, antiinflammatoryeffect of thymulin/Zn in vitro. Molecular Immunology, (1): 205 – , . – MedLine (PubMed) CrossreferencePMID: (Publisher: Elsevier http://www.sciencedirect.com/).Manuscripts Published in 2011Haddad J.J.: A redox microenvironment is essential for MAPK-dependent secretion of pro-inflammatory cytokines: Modulationby glutathione (GSH/GSSG) biosynthesis and equilibrium in the alveolar epithelium. Cellular Immunology, (1): 53 – ,– MedLine (PubMed) Cross-reference PMID: TBA (Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J., and Abdel-Karim N.E.: NF-B cellular and molecular regulatory mechanisms and pathways: Therapeutic patternor pseudoregulation? Cellular Immunology, (1): 5 – , – MedLine (PubMed) Cross-reference PMID: TBA(Publisher: Elsevier http://www.sciencedirect.com/).Haddad J.J.: The immunopharmacologic potential of semaxanib and new generation directed therapeutic drugs: Receptortyrosine kinase regulation with anti-tumorigenesis/angiogenesis properties. Saudi Pharmaceutical Journal, In press, –MedLine (PubMed) Cross-reference PMID: TBA (Publisher: Elsevier http://www.sciencedirect.com/).Manuscripts Submitted for Publication in Specialized Journals, Documented as ofHaddad J.J.: Regulatory neuroimmune mechanisms and putative pathways. Progress in Neurobiology, .Samaha A.A., Ivanov A.V., Arabi M.R., Yashina I.N., Samaha R.A., Termos S.H., Ivanov D.A., and Haddad J.J.: Structuralpeculiarities of the proximal femur meta-epiphysis in the idiopathic coxarthrosis according to localization. Journal ofOrthopedic Surgery and Research, .Haddad J.J.: Glutathione and cancer: A glimpse of the immunotherapeutic efficacy of an antioxidant. Biochemical andBiophysical Research Communications, .Haddad J.J.: Amalgamation of glutathione and MAPK p38 pathways in the oxidant regulation of TNF-α secretion n alveolarepithelial cells. European Cytokine Network, .Haddad J.J.: Interactive NMDA signaling modules: Are MAPKs lynchpins? Current Medicinal Chemistry, .Manuscripts in Preparation for Consideration for Publication in Specialized Journals, Documented as ofHaddad J.J.: Glutathione and cancer: A glimpse of the immunotherapeutic efficacy of an antioxidant. Biochemical andBiophysical Research Communications, .Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Haddad J.J.: Redox and oxidant-dependent regulatory mechanisms in apoptosis revisited. Biochemical andBiophysical Research Communications,Samaha A.A., and Haddad J.J.: Case report: A 51 year old lady under warfarin complicated by gastric ulcer and jejunalhematoma. Journal of Medical Case Reports, .Haddad J.J.: On the molecular mechanisms of deciphering the anthrax code. International Immunopharmacology, .Saadé N.E., Haddad J.J., and Safieh-Garabedian B.: NF-B-mediated regulation of nociception in a model of inflammatoryhyperalgesia and neuropathic pain in the rat. Proceedings of the National Academy of Sciences USA, .Haddad J.J.: An interactive mitogen-activated protein kinase and nitric oxide crosstalk in neurodegeneration: A neurochemicalaxis for therapeutic intervention? Experimental Neurology, .Haddad J.J.: Glutathione oxidation and GSSG-mediated regulation of transcription factors. The International Journal ofBiochemistry and Cell Biology, .CURRENT AND ONGOING RESEARCHThe immunomodulatory potential of thymulin-Zn (Collaboration with the American University of Beirut, Beirut, Lebanon).The role of mitogen-activated protein kinase in LPS-induced pro-inflammatory cytokines and NF-B signaling(Collaboration with the University of California, San Francisco, USA).Regulation of redox-sensitive transcription factors by pro-inflammatory cytokines (Collaboration with the University ofCalifornia, San Francisco, USA).Purinergic regulation of pro-inflammatory cytokines (Collaboration with the University of California, San Francisco, USA).Adrenoreceptor regulation of pro-inflammatory cytokines (Collaboration with the University of California, San Francisco,USA).Immunomodulatory potential of histamine and the cytokine network (Collaboration with the University of California, SanFrancisco, USA and the American University of Beirut, Beirut, Lebanon).Thiol regulation of pro-inflammatory cytokines and redox-sensitive transcription factors (Collaboration with the Universityof California, San Francisco, USA and the American University of Beirut, Beirut, Lebanon).Phosphodiesterases and pro-inflammatory cytokines (Collaboration with the American University of Beirut, Beirut, Lebanon,the University of Sydney, Sydney, Australia and the Jagiellonian University Medical College, Cracow, Poland).Hypoxia-mediated regulation of MAPK and apoptosis signaling (Collaboration with the University of California, SanFrancisco, USA).The involvement of neuroprotection mechanisms in NMDA and Ca -mediated regulation of MAPK signaling pathways(Collaboration with the University of California, San Francisco, USA).The regulation of MAPK signaling in anoxia-tolerant turtles (Collaboration with the University of California, San Francisco,USA).The regulation of MAPK signaling under the influence of anesthetics (Collaboration with the University of California, SanFrancisco, USA).Domestic and International CollaborationsAmerican University of Beirut (AUB) – AUB is one of the most prestigious academic institution in the Middle Eastand operates directly under charter from New York State – (Professor Nayef E. Saadé (Ph.D.; D.Sc.), chairman of thedepartment of Human Morphology at the School of Medicine).American University of Beirut (AUB) – (Professor Bared Safieh-Garabedian (Ph.D.), faculty member of the department ofBiology and an honorary professor at the Institute of Cellular and Molecular Sciences, Queen Mary University of London,UK).University of Dundee (UoD) – UoD is an accredited academic institution in Scotland, affiliated with Saint AndrewsUniversity, founded in the 14 th century A.D. – (Professor John D. Hayes (Ph.D.), chairman of the Higher DegreesCommittee and faculty at the Biomedical Research Center BRC at Ninewells Hospital and Medical School It’s noteworthyto mention that Professor John Hayes is a collaborator of Sir Professor David Lane (Ph.D.), who discovered the mutated gene,p53, the prevalence of which causes pervasive cancer.Jagiellonian University Medical College, Cracow, Poland – (Professor Ryszard Lauterbach (M.D., Ph.D.), faculty memberof the department of Neonatology).University of California, San Francisco (UCSF) – UCSF is rated amongst the top 10 university hospitals and medicalschools in the United States – (Professor Teiji Sawa (M.D., Ph.D.), faculty member of the department of Microbiology atUCSF School of Medicine).University of California, San Francisco (UCSF) – (Professor Donald M. Taylor (M.D., Ph.D.), faculty member of thedepartment of Anesthesia and Perioperative Care at UCSF School of Medicine).Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Journal Citations Impact Factors, According to ISI, Alphabetically Arranged as of 200 (Periodically Updated)The American Journal of Physiology – Lung Cellular and Molecular Physiology ISI .The American Journal of Respiratory Cell and Molecular Biology ISI 4.Antioxidant and Redox Signaling ISI 3.763Biochemical and Biophysical Research Communications ISI .Biochemical Journal ISI 4.Biochemical Pharmacology ISI 3.617Brain Research ISI .The British Journal of Pharmacology ISI 3.410Cellular ImmunologyISICellular SignallingISIComparative Biochemistry and Physiology Part B – Cellular and Molecular Biology ISI 1.4Critical Care ISI 2.93Current Drug Targets – CNS and Neurological Disorders ISI 4.900Current Medicinal Chemistry – Antiinflammatory and Anti-allergy Agents ISI 4.900CytokineISIEuropean Cytokine Network ISI 1.073FEBS LettersISIFree Radical Biology and Medicine ISI .International ImmunopharmacologyISIThe Journal of Biological Chemistry ISI 7.385Journal of Medical Case Reports ISI 1.416Journal of Neuroimmunology ISI .The Journal of Pharmacology and Experimental Therapeutics ISI 7.064The Journal of Physiology (London)ISILife SciencesISIMolecular ImmunologyISINeuroscience ISI 3.358PainISIPharmacology ISI 2.961Progress in NeurobiologyISIProtein and Peptide Letters ISI 1.840Respiratory Research ISI 2.68VaccineISIChapters, Textbooks, Dissertations and Encyclopedias, Documented as ofHaddad J.J.: Hyperalgesia induced by local endotoxin injections and its modulation by various anti-inflammatory andanalgesic drugs. Master of Science (M.Sc.) Thesis, pp. 1-67, 1996 (American University of Beirut, Beirut, Lebanon and NewYork City, New York, USA).Saadé N.E., Kanaan S.A., Haddad J.J., Atweh S.F., Jabbur S.J., and Safieh-Garabedian B.: Dissociation between peripheraland central components of endotoxin (ET)-induced hyperalgesia. In: Pain Mechanisms and Management (Eds. A.V.Apkarian and S. Ayrapetian). IOS Press, Amsterdam, Ohmsha, pp. 120- ,Haddad J.J.: O -dependent regulation of redox-sensitive transcription factors HIF- and NF-B in the developingperinatal lung: Signaling potential of apoptosis and an association between oxidative stress and pro-inflammatory cytokines.Doctor of Philosophy (Ph.D.) Thesis, pp. 1- , 2001 (University of Dundee [in affiliation with Saint Andrews University,St. Andrews, Scotland], Dundee, Scotland, UK).Haddad J.J.: The role of mitogen-activated protein kinase signaling pathways in determining death and survival in hypoxicneurons. Postdoctoral Research Paper, pp. 1-35, 2003 (University of California, San Francisco, California, USA).Haddad J.J.: The emphatic role of Mitogen-activated protein kinases in Alzheimer’s disease. In: Current Research onAlzheimer’s Disease (Ed. N. Columbus). Nova Science Publishers, Hauppauge, NY, USA, 2007.Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Haddad J.J.: Alcoholism and neuroimmune-endocrine interactions: Physiochemical aspects. In: Research on Neurobiologyof Alcohol Use Disorders (Ed. N. Columbus). Nova Science Publishers, Hauppauge, NY, USA,Haddad J.J.: Transcriptional regulation of inflammatory pain and hyperalgesia. In: Scirus Topic Pages. Elsevier,(http://scitopics.com/Transcriptional_regulation_of_inflammatory_pain_and_hyperalgesia_NF_kB_as_a_lynchpin_and_master_regulator.html).Haddad J.J.: Neuroimmunology. In: Encyclopedia of Neuroscience (Eds.: M.D. Binder, N. Hirokawa, U. Windhorst, andM.C. Hirsch; pp. 1- separate volumes]). Springer-Verlag GmbH Berlin Heidelberg, Heidelberg, pp. 2527- ,(http://refworks.springer.com/neuroscience; ISBN: 978- - - - ).About the Encyclopedia: Unique in its breadth and detail, this encyclopedia offers a comprehensive and highly readableguide to a complex and fast-expanding field. The five-volume reference work gathers more than 10,000 entries, including indepthessays by internationally known experts, and short keynotes explaining essential terms and phrases. In addition, experteditors contribute detailed introductory chapters to each of 43 topic fields ranging from the fundamentals of neuroscience tofascinating developments in the new, inter-disciplinary fields of Computational Neuroscience and Neurophilosophy. Some1,000 multi-color illustrations enhance and expand the writings. This user-friendly reference will be indispensable to basicand clinical scientists and practitioners in academia, hospitals, private practice, and industry, as a source of reliableinformation on the structure and function of the nervous system. The Encyclopedia of Neuroscience opens the topic to healthcare professionals, students, teachers and informed laypersons who require relevant information on this rapidly evolvingfield. (Adapted, courtesy of the publisher’s website: www.springer.com)Haddad J.J., et al.: The Molecular Biology of Pain. (Ed.: J.J. Haddad). Bentham Publishers (www.bentham.org), Inpreparation, .Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

ACADEMIC AND INDUSTRIAL REFERENCESProfessor Nayef E. Saadé, Ph.D., D.Sc.Chairman and Professor of Neurobiology and PhysiologyDepartment of Human MorphologyMedical School, Faculty of MedicineAmerican University of Beirut (AUB), Beirut, LebanonTelephone: ( ) - -ExtensionsFax: -E-mail: nesaade@aub.edu.lbProfessor Bared Safieh-Garabedian, Ph.D.Professor of Neurobiology and BiochemistryInstitute of Cell and Molecular SciencesQueen Mary University of London, London, UKDepartment of BiologyFaculty of Arts and SciencesAmerican University of Beirut (AUB), Beirut, LebanonTelephone: - -( ) -ExtensionsFax: -E-mail: bared@aub.edu.lbProfessor Martin Frank, Ph.D.Executive Director and ProfessorThe American Physiological Society (APS)9650 Rockville Pike, Bethesda, Maryland 20814, USATelephone: -Fax: -E-mail: mfrank@the-aps.orgProfessor Nabil Haidar, Ph.D.Provost and Vice President for International AffairsAmerican University of Science and Technology (AUST),Aschrafieh, Beirut, LebanonTelephone: - /Extensions: /Fax: -E-mail: nhaidar@aust.edu.lbProfessor Nadim Karam, M.D., Ph.D.Dean and Professor of Internal MedicineFaculty of Health SciencesUniversity of Balamand (UoB), Balamand, Beirut, LebanonTelephone: - /Extension:Fax: -E-mail: nadim.karam@balamand.edu.lbDr. Irfan Rahman, Ph.D.Associate Professor of Environmental MedicineDepartment of Environmental MedicineLung Biology and Disease ProgramUniversity of Rochester Medical CenterRochester, NY 14642, USATelephone: + -Fax: + -E-mail: irfan_rahman@urmc.rochester.eduProfessor Jihad Attieh, Ph.D.Dean and ProfessorFaculty of SciencesUniversity of Balamand (UoB), Balamand, El-Koura, Tripoli,LebanonTelephone: -ExtensionFax: ( ) -E-mail:jihad.attieh@balamand.edu.lbfos@balamand.edu.lbProfessor Shihadeh Nayfeh, Ph.D.Provost and Executive Vice President and ProfessorAmerican University of Technology (AUT), Byblos, LebanonTelephone: ) -Extension:Fax: ( ) -E-mail: snn59@hotmail.comDr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

AbridgedAcademic Curriculum Vitae Dr. John J. HaddadO B J E C TI V ER&D Biomedical Research, Laboratory Management and Development(Academy and Industry); Administrative/Professorship Tutoring andTeaching (Academy).E D U C A TI ONPostdoctoral, University of California, San Francisco, CA, USA—2003Ph.D., University of Dundee, Dundee, Scotland, UK—2001M.Sc., American University of Beirut, Beirut, Lebanon—1996B.Sc., American University of Beirut, Beirut, Lebanon—1992A W A R D S, F E L L O W S HI P S , G R A N T SUniversity of California—Postdoctoral (NIH) fellowshipUniversity of Dundee—Ph.D. fellowshipAmerican University of Beirut—M.Sc. & B.Sc. FellowshipsP O SI T IO N S HEL DFebruary, 2009—Current, ProfessorAmerican University of Science and TechnologyJanuary, 2006—February, 2009, Chairman of the UniversityResearch CouncilLebanese International UniversityOctober, 2006—February, 2009, Associate ProfessorLebanese International UniversityOctober, 2004—September, 2006, Associate ProfessorLebanese International UniversityOctober, 2005—Current, LecturerUniversity of BalamandFebruary, 2005—Janaury, 2006, LecturerAmerican University of Science and TechnologySeptember, 2003—February, 2005, LecturerHaigazian UniversityP U B LIC A TI ON SDepartment of Clinical Laboratory SciencesFaculty of Health SciencesUniversity of BalamandAschrafieh, Beirut, LebanonPhone: 961 (1) 562-108/9Fax: 961 (1) 562-110E-mail: john.j.haddad@balamand.edu.lbAs per unabridged academic curriculum vitaeC O N F E R E NC E P R E S E N TA T IO N SAs per unabridged academic curriculum vitaeR E F E R E N C E SMartin Frank, Execuitve Director, American Physiological Society, USAIrfan Rahman, Associate Professor, University of Rochester, USABared Safieh-Garabedian, Professor, Queen Mary University of London, UKJihad Attieh, Dean and Professor, University of Balamand, LebanonDr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

UnabridgedAcademic Curriculum Vitae UnabridgedAcademic Curriculum Vitae Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/

Dr. John J. Haddad – Biomedical, Clinical Laboratory and Health Sciences Research Scientist and Educating Professor ––––––––––––––––––––––––| Biomedical and Clinical Laboratory Sciences – http://johnjhaddad.weebly.com/