Opadry® amb - Colorcon
Opadry® amb - Colorcon
Opadry® amb - Colorcon
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OPADRY ® <strong>amb</strong>Product InformationAqueous Moisture Barrier Film Coating SystemMoisture Vapor TransmissionUNSURPASSED PROTECTION FROM ENVIRONMENTAL MOISTUREOpadry ® <strong>amb</strong>, aqueous moisture barrier film coating system, is a product specifically designed for the coating oforal solid dosage forms that need to be protected from environmental moisture. Opadry <strong>amb</strong> has shown the lowestmoisture vapor transmission rates of all coatings tested.DISSOLUTION IS NOT COMPROMISEDThe protection of tablet cores against moisture can be achieved with water-insoluble polymers, but the drawbackof such systems is a slower dissolution of the tablet in the stomach or intestine. Since Opadry <strong>amb</strong> is based on awater-soluble polymer, its performance is pH-independent and dissolution is not delayed, even when the tablets are storedin high humidity (Figure 1).Figure 1 – DissolutionDissolution in Water of Coated Aspirin Tablets after Storage inHDPE Bottles at 40°C and 75% Relative Humidity for 6 Months120Time (Minutes)10080604020Opadry® <strong>amb</strong>Methacrylic AcidCopolymer00 5 10 15 20 25 30Percent Drug DissolvedOPADRY ® <strong>amb</strong> - 1 -
For more information, contact your <strong>Colorcon</strong> representative or call:North America Europe/Middle East/Africa Asia Pacific Latin America+1-215-699-7733 +44-(0)-1322-293000 +65-6438-0318 +54-11-4552-1565You can also visit our website at www.colorcon.comInsertProductName - 2 -© <strong>Colorcon</strong>, 2009. The information contained in thisdocument is proprietary to <strong>Colorcon</strong> and may not beused or disseminated inappropriately.All trademarks, except where noted, are propertyof BPSI Holdings, LLC.pi_opadry_<strong>amb</strong>_dissolution_V3_05_2009
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