R. Sturza et al./Chem.J.Mold. 2008, 3 (1), 77-84It is necessary to note, that the T 3concentration at the hypothyroid rats (IInd and IIIrd group) did not decreasesignificantly; that can be explained as activation <strong>of</strong> deiodination T 3in T 4processes:The present regularity is observed as the account <strong>of</strong> protective-compensatory animal reaction in the condition <strong>of</strong>iodination blocking <strong>of</strong> remaining tyrosine as a component <strong>of</strong> thyreoglobulin.In the course <strong>of</strong> further research the evaluation <strong>of</strong> efficacy and safety <strong>of</strong> examined iodine complexes wasperformed in the five groups.The analysis <strong>of</strong> the received data confirms that organically connected forms <strong>of</strong> iodine contributed to the increase<strong>of</strong> functional activity <strong>of</strong> thyroid gland. Thus, rats <strong>of</strong> IVth and Vth groups had significantly higher serum T 4level thenanimals <strong>of</strong> IInd and IIIrd group (Figure 2).12010080604020120100806040200II III IVT3 84,65 89,94 90,26T4 93,1 95,81 107,420II III VT3 84,65 89,94 91,15T4 93,1 95,81 119,37Fig. 2. Content <strong>of</strong> thyroid harmonious in the serum <strong>of</strong> rats belonging to II, III, IV V groupsAt the same time T 4concentration in the IVth group made up 107-42±15-02 nmol/l, in the Vth one 119-37±14.43nmol/l against 93.1±14.54 nmol/l in the IInd one and 95.81±19.53 nmol/l in the IIIrd one. Concentration <strong>of</strong> T 3in thecompared groups does not differ in a significant way, remaining in limits <strong>of</strong> 90,26 ±13,39 ng/dl (IVth group) and91,15±16,76 ng/dl (Vth group). The relatively high level <strong>of</strong> T 3<strong>of</strong> the IIIrd group rats (98,94±18,52 ng/dl) is explainedby the activation <strong>of</strong> T 4deiodation processes in the condition <strong>of</strong> iodine deficit.All animals who received additionally daily iodinated sunflower oil and margarine, showed increased level <strong>of</strong> T 4secretion accompanied by rather low TSH level (Figure 3).79
R. Sturza et al./Chem.J.Mold. 2008, 3 (1), 77-841,41,210,80,60,40,20II III IV VTSH 1,272 0,966 0,856 0,814Fig. 3. Influence <strong>of</strong> iodinated food products over the rat thyroid-stimulating hormone synthesisHereby, if animals <strong>of</strong> the IInd and IIIrd group have TSH concentration <strong>of</strong> 1.272±0/037 muI/l and 0/966±0.025muI/l correspondingly, in rats <strong>of</strong> the IVth and Vth groups identical indexes reflected 0/856±0,099 muI/l and 0.814±0/034muI/l. It is the evidence <strong>of</strong> stimulating influence <strong>of</strong> examining iodine products over the functional activity <strong>of</strong> rats’ thyroidglands. Received data match with the research results reported by Kashin, Egorov, Fencenco, Gusakov [14-17].Use <strong>of</strong> iodine sunflower oil and margarine in the rats’ ration contributed to the gradual restoration <strong>of</strong> tyrocytefunctional activity with the formation <strong>of</strong> colloid in follicles. All tested iodinated products have the homogeneous actionsin the view <strong>of</strong> tyrocytes activity restoration.When the main components <strong>of</strong> the tyroglobuline-iodine in the combination with fatty acids enter the organism,the synthesis <strong>of</strong> thyroid hormones in tyrocytes restarts. Consequently, regeneration possibilities and differentiation <strong>of</strong>thyroid glands tyrocytes are high and used substances assist in it. Positive activity <strong>of</strong> iodine products for the animals’organism are marked in the works <strong>of</strong> [14, 18].Besides <strong>of</strong> that we carried out the research in evaluation <strong>of</strong> iodinated sunflower oil safety that included examination<strong>of</strong> chronic toxicity as well. The toxicity was tested on the animals (<strong>of</strong> IVth group) that received daily during the wholeexperiment period 10-fold iodine dose.The value <strong>of</strong> tested iodine dose efficiency and safety over the rat organism held in two compared groups: IV– introduction <strong>of</strong> 1-fold iodine dose in iodine sunflower oil and VI group. The analysed data show that tested organicconnected iodine form is not toxic for the experimental animals. Thus, the rats <strong>of</strong> VI group had the following T 3andT 4concentration level 73,00 ±19.94 ng/dl and 92,83±14.48 nmol/l against 90.26±13.39 ng/dl and 107.42±15.02 nmol/lin the IV group correspondingly. Meantime the TSH level <strong>of</strong> the rats from the VIth group increased and constituted1.257±0.027 muI/l in comparison with TSH concentration <strong>of</strong> rats from IV group – 0.856±0/099 muI/l (Figure 4).120100806040200IVVIT3 90,26 107,42T4 73 92,831,41,210,80,60,40,20IVVITSH 0,856 1,257Fig. 4. Influence <strong>of</strong> 10-fold iodine dose in the structure <strong>of</strong> iodinated food products over the synthesis <strong>of</strong> rat thyroidhormones80
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