IMMUNE- MEDIATED INFLAMMATORY DISEASES

5th European Workshop onIMMUNE-MEDIATEDINFLAMMATORYDISEASESSitges-Barcelona, Spain1 – 3 December 2010Preceded by a Masterclass on Psoriasis – 30-11 & 01-12Workshop ChairsJuan D. Cañete, Barcelona, SpainFrancisco Lozano, Barcelona, SpainOrganizing Steering CommitteeDominique Baeten, Amsterdam, The NetherlandsJuan D. Cañete, Barcelona, SpainJoão Eurico Cabral de Fonseca, Lisboa, PortugalFrancisco Lozano, Barcelona, SpainJose Pablos, Madrid, SpainAntonio Puccetti, Genua, ItalyRicardo Pujol, Barcelona, SpainAlberto Sanchez-Fueyo, Barcelona, SpainMartin van Hagen, Rotterdam, The NetherlandsWorkshop SecretariatMedicongressKloosterstraat 5B-9960 Assenede, BelgiumPhone: +32 (0)9 344 39 59Fax: +32 (0)9 344 40 10Email: IMID@medicongress.comPreliminary Program& Call for AbstractsScientific CommitteeFlorence Apparailly, Montpellier, FranceSophie Brouard, Nantes, FranceAndrew Cope, London, UKAndrew Dick, Bristol, UKHerman Eibel, Freiburg, GermanyThomas Giese, Heidelberg, GermanyRegis Josien, Nantes, FranceRik Lories, Leuven, BelgiumFrank Nestle, London, UKFalk Nimmerjahn, Erlangen, GermanyTimothy Radstake, Nijmegen, The NetherlandsLars Rogge, Paris, FranceGeorg Schett, Erlangen, GermanyMiguel Soares, Lisboa, PortugalPeter Taylor, London, UKBing Thio, Rotterdam, The NetherlandsOla Winqvist, Stockholm, SwedenVenueHotel Sol Melia SitgesC/Joan Salvat Papasseit, 3808870 Sitges, BarcelonaT: +34 93 8116709 F: + 34 93 8949097www.melia-sitges.com

Workshop ChairsJuan D. Cañete, Barcelona, SpainFrancisco Lozano, Barcelona, SpainOrganizing Steering CommitteeDominique Baeten, Amsterdam, The NetherlandsJuan D. Cañete, Barcelona, SpainJoão Eurico Cabral de Fonseca, Lisboa, PortugalFrancisco Lozano, Barcelona, SpainJose Pablos, Madrid, SpainAntonio Puccetti, Genua, ItalyRicardo Pujol, Barcelona, SpainAlberto Sanchez-Fueyo, Barcelona, SpainMartin van Hagen, Rotterdam, The NetherlandsScientific CommitteeFlorence Apparailly, Montpellier, FranceSophie Brouard, Nantes, FranceAndrew Cope, London, UKAndrew Dick, Bristol, UKHerman Eibel, Freiburg, GermanyThomas Giese, Heidelberg, GermanyRegis Josien, Nantes, FranceRik Lories, Leuven, BelgiumFrank Nestle, London, UKFalk Nimmerjahn, Erlangen, GermanyTimothy Radstake, Nijmegen, The NetherlandsLars Rogge, Paris, FranceGeorg Schett, Erlangen, GermanyMiguel Soares, Lisboa, PortugalPeter Taylor, London, UKBing Thio, Rotterdam, The NetherlandsOla Winqvist, Stockholm, SwedenWorkshop SecretariatMedicongressKloosterstraat 5B-9960 Assenede, BelgiumPhone: +32 (0)9 344 39 59Fax: +32 (0)9 344 40 10Email: imid@medicongress.com2

Welcome AddressDear Colleagues,As the development and availability of new targeted therapies boosted important evolutions in the fieldof clinical immunology, many of us realized the need for more intensive interaction and collaborationnot only with fundamental immunologists and with industrial partners but also with our academiccolleagues from other organ-specific disciplines than our own. Therefore, we initiated in 2004 anEuropean Working Group of leading academic physician-scientists involved in clinical immunology,rheumatology, dermatology, gastroenterology, transplantation immunology,… Our global aim is to createa forum for informal but intensive interaction and networking between translational immunologistsfrom different organ-specific disciplines.The keys of our organization are:• Focus on translational immunology with direct clinical relevance• Emphasis on cross-disciplinary interactions and projects• Strong interaction between academia and pharmaceutical partners, especially biotechcompanies focusing on immunomodulation and immunomonitoringOur organization is open and democratic. Therefore, all interested partners are welcome to join thisinitiative.Over the last four years, we have made a big step forward to reach this goal through the organization ofthe European Workshop on Immune-Mediated Inflammatory Diseases in Amsterdam in 2006, Nurembergin 2007, London in 2008 and Cascais-Lisbon in 2009.In line with the growing interest for this type of forum for discussion and networking, we are pleased toannounce the Fifth European Workshop on Immune-Mediated Inflammatory Diseases, which willtake place on December 1 – 3, 2010 in Sitges-Barcelona, Spain.The workshop will again be a three-day meeting with thematic cross-disciplinary sessions as well asa lot of time for poster discussions and oral presentation of selected abstracts. We will also include 3satellite symposia which are aimed to focus on immunomodulation and immunomonitoring, in closecollaboration with pharmaceutical and biotech partners.This year the Workshop will be preceded by a Masterclass on Psoriasis and Associated Diseasesorganized by Frank Nestle (London, UK) and Bing Thio (Rotterdam, NL) on November 30 and December1. This masterclass requires a separate registration as it is restricted to a maximum of 40 participants.Indeed, the aim is to have interactive sessions where the experts and the audience define together theactual state of the art in the field as well as the major challenges for the coming years. Accordingly, thismasterclass creates an ideal environment for setting up collaborations and joined research projects.Together with the Organizing Steering Committee and the Scientific Committee, we look forward to youractive participation in the Fifth European Workshop on Immune-Mediated Inflammatory Diseases.Prof. Juan Cañete and Prof. Francisco LozanoWorkshop Chairs3

Masterclass on psoriasis and associated IMIDsOrganized by Frank Nestle (London) and Bing Thio (Rotterdam)Tuesday, November 3013.30 Welcome and registration13.55 IntroductionFrank Nestle and Bing ThioTranslational research insightsChair: Bing Thio (Rotterdam)14.00 GeneticsRichard Trembath, London, UK14.30 Immunology including cytokine networkFrank Nestle, London, UK15.00 Animal modelsErwin Wagner, Madrid, Spain15.30 Coffee BreakClinical state-of-the-artChair: Frank Nestle (London)16.00 Diseases phenotypes and co-morbidities (incl. Psoriatic Arthritis)Mona Ståhle, Stockholm, Sweden16.30 Cardiovascular co-morbidities and metabolic syndromeLluis Puig, Barcelona, Spain17.00 View from rheumatology: Psoriatic arthritisBruce Kirkham, London, UK17.30 Round Table I4

Wednesday, December 108.15 Keynote lecture: View from cardiovascular medicineErik S. Stroes, Amsterdam, The NetherlandsTargeted TherapyChair: Bing Thio (Rotterdam)08.45 Conventional systemic drugsJonathan Barker, London, UK09.15 Anti-TNF therapy and beyondEsteban Dauden, Madrid, Spain09.45 Coffee Break10.15 Anti IL-12/IL-23 therapy and beyondJörg Prinz, München, Germany10.45 Signal transduction and small moleculesLars Iversen, Aarhus, Denmark11.15 Round Table II and Future Outlook12.00 Lunch13.30 Start of the Fifth European Workshop on Immune-Mediated InflammatoryDiseases(separate registration)5

Preliminary ProgramWednesday, December 112.00 RegistrationOpening TalksChairs: Juan Cañete (Barcelona) and Francisco Lozano (Barcelona)13.20 Welcome AddressJuan Cañete and Francisco Lozano13.30 Keynote lecture: Immune tolerance into the clinicsJeffrey A. Bluestone, San Francisco, USA14.15 Keynote lecture: Immunosurveillance by gammadelta T cells - Lessons fromthe cancer fieldAdrian Hayday, London, UK15.00 Coffee Break and Poster ViewingSession 1: Biomarker discovery and immunomonitoringChairs: Alberto Fueyo (Barcelona) and Antonio Pucetti (Genua)15.30 Fundamental lectureVirginia Pascual, Dallas, USA16.00 Fundamental lectureJolanda de Vries, Nijmegen, The Netherlands16.30 Translational lectureMark Peakman, London, UK17.00 Coffee Break and Poster Viewing17.30 Symposium 1 Sponsored by Abbott19.00 Welcome Reception6

Thursday, December 207.30 Meet-the-professor breakfast for fellowsParticipation is free of charge, but as the number of seats are limited, pre-registration isrequired.Session 2: From genes to function in IMIDsChairs: Frank Nestle (London) and Sara Marsal (Barcelona)08.30 Fundamental lectureLars Klareskog, Stockholm, Sweden (to be confirmed)09.00 Translational lectureAnthony Segal, London, UK09.30 Selected oral presentations (2)10.00 Poster Tour 1 and Coffee BreakSession 3: MicroRNAs and IMID (11-12.30 am)Chairs: Florence Apparailly (Montpellier) and Astrid Jüngel (Zürich)11.00 Fundamental lectureMonsef Benkirane, Montpellier, France11.30 Translational lectureEniko Sonkoly, Stockholm, Sweden12.00 Selected oral presentations (2)12.30 LunchWorkshop lunch: The future of translational immunology- Meet the Editor- Meet the Funders- Meet the IndustryParticipation is free of charge, but as the number of seats are limited, pre-registration isrequired.7

Session 4: The expanding Th universeChairs: Lars Rogge (Paris) and Ricardo Pujol (Barcelona)14.00 Fundamental lecture(Speaker to be confirmed)14.30 Translational lectureIain McInnes, Glasgow, Scotland15.00 Selected oral presentations (2)15.30 Coffee BreakSession 5: What have we learned from immunodeficiency?Chairs: Martin van Hagen (Rotterdam) and Hermann Eibel (Freiburg)16.00 Fundamental lectureMirjam van der Burg, Rotterdam, The Netherlands16.30 Translational lectureBodo Grimbacher, London, UK17.00 Symposium 2 Sponsored by Wyeth20.00 Workshop Dinner8

Friday, December 308.30 Symposium 3 Sponsored by UCBThe CD40-CD40L pathway as therapeutic target in IMID10.00 Poster Tour 2 and Coffee BreakSession 6: Inflammation and fibrotic tissue remodellingChairs: Tim Radstake (Nijmegen) and Jose Pablos (Madrid)11.00 Fundamental lectureHermann Wasmuth, Aachen, Germany11.30 Clinical lectureRobert Lafyatis, Boston, USA12.00 Selected oral presentations (2)12.30 LunchWorkshop lunch: 5th ewIMID in clinical perspective- Arthritis- Skin disease- Bowel inflammation- Neuroinflammation- Transplantation- Systemic autoimmune diseases- Remodeling diseases: fibrosis and ankylosisParticipation is free of charge, but as the number of seats are limited, pre-registration isrequired.Session 7: Comorbidities of IMIDsChairs: Thomas Giese (Heidelberg) and Dominique Baeten (Amsterdam)14.00 Fundamental lectureZiad Mallat, Paris, France14.30 Translational lecture - Special lecture sponsored by CentororMiguel Gonzalez-Gay, Santander, SpainClosing Talk15.00 Keynote lecture: Understanding the molecular bases of tissue inflammationRichard Flavell, New Haven, USA9

CALL FOR ABSTRACTSThe Workshop Chairs and the Organizing Steering Committee invite you to participate activelyin the Fifth European Workshop on Immune-Mediated Inflammatory Diseases.We look forward to receiving your scientific contribution on one of the following topics:• Rheumatology• Gastroenterology• Dermatology• Transplantation• Clinical immunology• Basic immunology• Inflammation• Immunodeficiencies• Neuroimmunology• Immunomodulation• ImmunomonitoringTravel grants will be awarded to the best abstract submissions.The call for abstracts will be open from July 1 until September 1.Submit your abstract online at www.ewimid.comSubmission Deadline: September 1, 201010

REGISTRATIONRegistration Fees Until July 15 As of July 16 As of November 1MasterClass on PsoriasisParticipant 150,00 200,00 250,00Trainee or Resident* 100,00 150,00 200,00ewIMID’10Participant 400,00 450,00 500,00Trainee or Resident* 250,00 300,00 350,00*Trainees/Residents must send proof of status to Medicongress (els@medicongress.com or fax: +32 9 344 40 10).Without this proof, the participant fee will be charged.IMPORTANTParticipants or trainees registering for both the Masterclass on Psoriasis and ewIMID’10 willreceive a reduction of 50,00.Masterclass on Psoriasis – The registration fee includesThe registration fee includes access to the scientific sessions on Tuesday afternoon (30November) and Wednesday morning (1 December), two coffee breaks and lunch onWednesday.ewIMID’10 – The registration fee includesThe registration fee includes access to the scientific sessions and the exhibition, the congressbag and badge as well as the Workshop program and abstract book. Coffee breaks and lunchesas indicated in the program are also included. The Welcome Reception on Wednesday andthe Workshop Dinner on Thursday are included in the registration fee, but pre-registration ismandatory.All delegates will receive a certificate of payment and a certificate of attendance at theregistration desk of the Workshop.How to RegisterRegister online at wwww.ewimid.com. The registration and payment form is secured so thatcredit card information can be submitted safely.ConfirmationImmediately after submitting your online registration form, an automatic confirmation is sentby email. If you do not receive this automatic confirmation, your registration has not beenmade successfully.Medicongress will send a formal confirmation by email after receipt of payment.11

PaymentAll payments are to be made in Euro, net of all bank charges and commissions for thereceiver.Payment is to be made by:• Bank transferAccount number: 123-6885217-96Account Name: IMID WorkshopSWIFT: OBKB BE 99 - IBAN BE65123688521796Bank address: BMOV BANK, Graaf Van Vlaanderenplein 19, 9000 Gent, Belgium• Credit Card: All major credit cards are accepted.CancellationCancellations received no later than October 15, 2010, entitle registered persons to a fullrefund less 50,00 administration costs.No refunds can be made for cancellations received after this date.Delegates can be replaced by a colleague at any time.For updates, registration and hotel reservation:www.ewimid.com12

Hotel AccommodationThe organizers have reserved a number of rooms at Meliá Sitges (the workshop venue) atattractive group rates.Single room & Double/Twin room: 90,00 per nightThese rates include continental breakfast, but exclude VAT (8%) and city taxes.Any requests for hotel accommodation must be indicated on the Registration Form, and areto be accompanied by a credit card number, in order to secure the room.This credit card will not be charged by the organizers but only serves as a reservation guarantee.Delegates will have to pay their hotel room and personal expenses at the hotel upon checkout.A confirmation of the hotel booking will be sent by email after receipt of the on-lineregistration form, the housing request and the payment of the registration fee.Participants are requested not to contact the hotel directly in order to avoid double bookings.If changes are to be made to the original hotel reservation, Medicongress is to be contacted.Room availability cannot be guaranteed after September 30, 2010.CancellationsCancellations and modifications must be made in writing through Medicongress.The following cancellation policy applies:• Until 30 September: free of charge• Until 31 October: 1 night will be charged• Until 15 November: 2 nights will be charged• From the 16th November onwards: the full stay will be charged (for cancellations andno-shows).For updates, registration and hotel reservation:www.ewimid.com13

General InformationDatesMasterclass on Psoriasis: 30 November (afternoon) & 1 December (morning) 2010ewIMID’10: 1,2 & 2 December 2010VenueMELIÁ SITGESJoan Salvat Papasseit, 3808870 Sitges – BarcelonaSpainLocated in the heart of the Aiguadolç marina in the northern corner of the charismatic townof Sitges and well communicated with the international airport “El Prat” (Barcelona), thehotel is located right on La Marina and Balmins beaches, only a 10 minute walk from thecentre of Sitges and near the Terramar Golf Club, one of the best golf courses in the region.The hotel provides a total of 307 rooms and has beautiful gardens from which to enjoy theswimming pool and cocktail bar. As an alterative to the leisure options, the hotel also has afitness centre with a heated swimming pool as well as an extensive range of services such asa hairdresser, sauna, fitness classes, massages and beauty treatments.The citySitges is on the Mediterranean coast, some 35 km to the south of Barcelona and only 15minutes from the airport. The coast is famous internationally as a resort destination and isalso a great place for business meetings. This privileged location gives the town a mild andwarm climate.Sitges has preserved many of its important medieval features and of it history as a fishing andpeasant village, and offers visitors a valuable architectural and cultural heritage, also thanksto artists and patrons such as Santiago Rusiñol, Ramón Casas, Miquel Utrillo and CharlesDeering. This creative impulse has led to the creation of new projects over recent years such asthe International Epic Car Rally, the International Film Festival, the International Jazz Festivaland the Concerts in the Summer Cycle.All of this made Sitges an important centre for modernism and for the “Americans”, menwho, on their return from their American adventure, ordered grand mansions to be built bymodernist architects.14

LanguageThe official language of the Masterclass and ewIMID’10 is English. There will be no simultaneoustranslation.AccreditationFor participants from The Netherlands, an application for accreditation units will be submittedfor the following specialties: Rheumatology, MDL, NIV, Allergology, Dermatology andPaediatrics.Scientific ExhibitionAn exhibition of medical and pharmaceutical products will be held during the Workshop.LiabilityNeither the organizers nor Medicongress accept liability for damages and/or losses of any kindwhich may be incurred by Masterclass/ewIMID’10 participants.Participants are advised to take out insurance against loss, accidents or damage which couldbe incurred during the Masterclass/ewIMID’10.15

Platinum SponsorsGold SponsorSilver Sponsor16