Diabetes and Exercise: Why Exercise Works When Insulin Does Not

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The Exercise Pill — Too Good to Be True? AICAR has a short half-life after intravenous infusionand poor bioavailability after oral ingestion. AICAR treatment causes lactic acidosis in humans. AMPK activation in the hypothalamus can stimulateappetite. Activating mutations of AMPK cause heart conductionabnormalities in humans (WPW syndrome).
Benefits of Regular Physical ExercisePulmonary functionIncrease lung capacityImprove sleepIncrease blood volumeImprove pancreaticfunctionImprove liver functionReduce fat storesPrevention of DiabetesIncrease glucose toleranceIncrease insulin sensitivityIncrease muscle glucose uptakeIncrease mitochondrial functionDecrease depression, anxietyDecrease Alzheimer'sDecrease strokeDecrease appetiteImprove cardiac functionImprove lipid profileLower blood pressureIncrease bone densityIncrease muscle strengthIncrease flexibilityDecrease Rates of CancerColon, breast, endometrial
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Diabetes and Exercise:Why Exercise
Page 3 and 4:
Diabetes and Exercise:Why Exercise
Page 5 and 6:
Type 1 Diabetes(juvenile-onset or i
Page 7 and 8:
Diabetes Complications Leading caus
Page 9 and 10:
Type 2 Diabetes is Reaching Epidemi
Page 11 and 12:
Effect of Exercise on Blood Glucose
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Blood VesselGlucoseInsulinMuscle
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Skeletal Muscle Glucose UptakeType
Page 17 and 18: Glucose Transport System in Skeleta
Page 19 and 20: Exercise Regulation of Glucose Tran
Page 21 and 22: Insulin Regulation of Glucose Trans
Page 23 and 24: Contraction Stimulates GLUT4 Transl
Page 25 and 26: Contraction + Insulin have Additive
Page 27 and 28: What are the signaling mechanisms t
Page 29 and 30: Exercise and Insulin Regulate Gluco
Page 33 and 34: 5’AMP-Activated Protein Kinase (A
Page 35 and 36: What is the evidence that AMPK medi
Page 37 and 38: NH2COCCH2NNCHNOHOHHOHHHCH2OOOOP--NH
Page 39 and 40: AICAR + Contraction do not have Add
Page 41 and 42: SummarySkeletal Muscle Glucose Tran
Page 43 and 44: What is the physiological relevance
Page 45 and 46: Skeletal Muscle Biopsy from Human S
Page 47 and 48: Insulin-stimulated GLUT4 Translocat
Page 51 and 52: Exercise Increases AMPKα2 Activity
Page 53 and 54: Can we make a drug to activate AMPK
Page 55 and 56: Metformin- Single most prescribed o
Page 57 and 58: Does the mechanism of Metformin act
Page 59 and 60: Effects of 4 and 10 Weeks of Metfor
Page 61 and 62: SummaryStudies in Human Subjects Ex
Page 63 and 64: Diabetes and Exercise:Why Exercise
Page 65 and 66: The Exercise Pill: AICAR
Page 67: Effects of AICAR Treatment andChron
Page 71: Ho-Jin KohNobuharu FujiiHans Laurit
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Diabetes and Exercise: Why Exercise Works When Insulin Does Not

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