Diabetes and Exercise: Why Exercise Works When Insulin Does Not

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ACIAR and Insulin Regulate GlucoseTransport via Distinct Signaling MechanismsGlucoseInsulinReceptorAICARPPPPPExercisePIRS-1Pp85-p110PI 3-KinaseAktGLUT4 TranslocationAMPK
SummarySkeletal Muscle Glucose Transport Exercise and insulin increase glucose transport in skeletal muscle, resulting in glucose clearance from the blood. Exercise and insulin increase glucose transport through the translocation of GLUT4 transporters to the cell surface and transverse tubules in skeletal muscle. There are distinct proximal signaling mechanisms for exercise- and insulin-stimulated GLUT4 translocation. AICAR increases AMPK activity and can increase glucose transport in skeletal muscle.
Page 1 and 2: Diabetes and Exercise:Why Exercise
Page 5 and 6: Type 1 Diabetes(juvenile-onset or i
Page 7 and 8: Diabetes Complications Leading caus
Page 9 and 10: Type 2 Diabetes is Reaching Epidemi
Page 11 and 12: Effect of Exercise on Blood Glucose
Page 13 and 14: Blood VesselGlucoseInsulinMuscle
Page 15 and 16: Skeletal Muscle Glucose UptakeType
Page 17 and 18: Glucose Transport System in Skeleta
Page 19 and 20: Exercise Regulation of Glucose Tran
Page 21 and 22: Insulin Regulation of Glucose Trans
Page 23 and 24: Contraction Stimulates GLUT4 Transl
Page 25 and 26: Contraction + Insulin have Additive
Page 27 and 28: What are the signaling mechanisms t
Page 29 and 30: Exercise and Insulin Regulate Gluco
Page 33 and 34: 5’AMP-Activated Protein Kinase (A
Page 35 and 36: What is the evidence that AMPK medi
Page 37 and 38: NH2COCCH2NNCHNOHOHHOHHHCH2OOOOP--NH
Page 39: AICAR + Contraction do not have Add
Page 43 and 44: What is the physiological relevance
Page 45 and 46: Skeletal Muscle Biopsy from Human S
Page 47 and 48: Insulin-stimulated GLUT4 Translocat
Page 51 and 52: Exercise Increases AMPKα2 Activity
Page 53 and 54: Can we make a drug to activate AMPK
Page 55 and 56: Metformin- Single most prescribed o
Page 57 and 58: Does the mechanism of Metformin act
Page 59 and 60: Effects of 4 and 10 Weeks of Metfor
Page 61 and 62: SummaryStudies in Human Subjects Ex
Page 65 and 66: The Exercise Pill: AICAR
Page 67 and 68: Effects of AICAR Treatment andChron
Page 69 and 70: Benefits of Regular Physical Exerci
Page 71: Ho-Jin KohNobuharu FujiiHans Laurit

Diabetes and Exercise: Why Exercise Works When Insulin Does Not

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