12.07.2015 Views

Diabetes and Exercise: Why Exercise Works When Insulin Does Not

Diabetes and Exercise: Why Exercise Works When Insulin Does Not

Diabetes and Exercise: Why Exercise Works When Insulin Does Not

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5’AMP-Activated Protein Kinase (AMPK)βαγα1, α2 (α2 predominant in skeletal muscle)β1, β2γ1, γ2, γ3• A member of metabolite-sensing protein kinase family• Activated under conditions of low energy state, exercise• Proposed to regulate numerous metabolic <strong>and</strong>transcriptional processes in multiple cell types

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