Early Development of Poorly Water-Soluble NCEs - American ...

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How Does Salt Formation IncreaseDissolution Rate?J =dM=dtDAh (C s - C )…. by changingmicroenvironmentalpH and solubility•Saturate•Supersaturate,and/or•Fine precipitateDiffusion Layer ModelSolid(salt)C s, h=0 >>StagnantDiffusionLayerC s, bulk mediumBulk LiquidPhase(Dissolution Medium)C6h
Precipitated Free BaseLimitation <strong>of</strong> Salt FormationDiffusion Layer ModelWhen the intrinsicsolubility is very low, theprecipitated free basecoats the dissolvingsurface, preventingfurther dissolution <strong>of</strong> salt.Please note: Precipitationat the surface, not in thebulk medium. No increasein surface area.Solid(salt)XC s, h=0 >>XStagnantDiffusionLayerC s, bulk mediumBulk LiquidPhase(Dissolution Medium)Ch7
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Page 4 and 5: Development Strategies vsOutsourcin
Page 8 and 9: 8Nanotechnology
Page 10 and 11: 10High-energy Solid
Page 12 and 13: Heat content(enthalpy, H)Advantage
Page 14 and 15: Preparation of Solid Dispersion -So
Page 16 and 17: Preparation of Solid Dispersion -Me
Page 18 and 19: Solid Dispersion by Melt ExtrusionT
Page 20 and 21: Nanoemulsion/Solid NanoemulsionPrec
Page 22 and 23: Limitation of Lipid-based DrugDeliv
Page 24: Outsourcing of Early Development of

Early Development of Poorly Water-Soluble NCEs - American ...

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