Early Development of Poorly Water-Soluble NCEs - American ...
Early Development of Poorly Water-Soluble NCEs - American ... Early Development of Poorly Water-Soluble NCEs - American ...
Development Strategies vsOutsourcing OptionsCommon strategies to overcome impacts oflow solubility on product development:– Salt formation– Particle size reduction• Milling• Nanosizing– Conversion to amorphous form/high-energy solid– Solid dispersion– Solubilization– Lipid-based drug delivery4To save time and resources in productdevelopment, relatively simpler approachesshould be tried first.– Which of them should we outsource?
Salt Formation
- Page 1: Early Development of Poorly Water-S
- Page 6 and 7: How Does Salt Formation IncreaseDis
- Page 8 and 9: 8Nanotechnology
- Page 10 and 11: 10High-energy Solid
- Page 12 and 13: Heat content(enthalpy, H)Advantage
- Page 14 and 15: Preparation of Solid Dispersion -So
- Page 16 and 17: Preparation of Solid Dispersion -Me
- Page 18 and 19: Solid Dispersion by Melt ExtrusionT
- Page 20 and 21: Nanoemulsion/Solid NanoemulsionPrec
- Page 22 and 23: Limitation of Lipid-based DrugDeliv
- Page 24: Outsourcing of Early Development of
<strong>Development</strong> Strategies vsOutsourcing OptionsCommon strategies to overcome impacts <strong>of</strong>low solubility on product development:– Salt formation– Particle size reduction• Milling• Nanosizing– Conversion to amorphous form/high-energy solid– Solid dispersion– Solubilization– Lipid-based drug delivery4To save time and resources in productdevelopment, relatively simpler approachesshould be tried first.– Which <strong>of</strong> them should we outsource?