Early Development of Poorly Water-Soluble NCEs - American ...

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Early Development of Poorly Water-Soluble NCEs - American ...

Early Development of Poorly Water-Soluble NCEs - American ...

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PercentRecent Trends in NCE Solubility5040Two-thirds (?):Insoluble orPracticallyInsolubleVery slightlysoluble orsoluble3020100100µg/mLSolubilitySolubility < 1 μg/mL (0.001 mg/mL) is common3Source: Personal experience, literature data and anecdotal information

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PercentRecent Trends in NCE Solubility5040Two-thirds (?):Insoluble orPracticallyInsolubleVery slightlysoluble orsoluble3020100100µg/mLSolubilitySolubility < 1 μg/mL (0.001 mg/mL) is common3Source: Personal experience, literature data and anecdotal information

Page 1: Early Development of Poorly Water-S
Page 5 and 6: Salt Formation
Page 7 and 8: Precipitated Free BaseLimitation of
Page 9 and 10: Nanoparticle FormationCommon Techni
Page 11 and 12: Amorphous FormCompound Forms Solubi
Page 13 and 14: What is Solid Dispersion ?“the di
Page 15 and 16: Solid Dispersion by Solvent Evapora
Page 17 and 18: Solid Dispersion byMelt Extrusion17
Page 19 and 20: Challenges with Melt ExtrusionFeed
Page 21 and 22: What is Nanoemulsion? -„Cyclospor
Page 23 and 24: Solid Nanoemulsion PreconcentrateSo