Early Development of Poorly Water-Soluble NCEs - American ...
Early Development of Poorly Water-Soluble NCEs - American ... Early Development of Poorly Water-Soluble NCEs - American ...
Limitation of Lipid-based DrugDelivery Systems• Selection of appropriate lipids andsurfactants• Low or limited solubility of drugs inlipids, lipid-like carriers andsurfactants• Need for liquid formulations or softgelatin encapsulation22
Solid Nanoemulsion PreconcentrateSolid dispersion Solid preconcenrate LiquidpreconcentrateOCF 3H 3CNHNHOO CH 3Compound AComponentSolid MicroemulsionPreconcentrateCompound A (%w/w) 4 8Capmul PG8 (%w/w) 28.8 27.6Cremophor EL(%w/w)28.8 27.6PEG 3350 (%) 38.4 36.823Ref: Li et al., J. Pharm. Sci., 98:1750-1763, 2009
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Limitation <strong>of</strong> Lipid-based DrugDelivery Systems• Selection <strong>of</strong> appropriate lipids andsurfactants• Low or limited solubility <strong>of</strong> drugs inlipids, lipid-like carriers andsurfactants• Need for liquid formulations or s<strong>of</strong>tgelatin encapsulation22
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