Early Development of Poorly Water-Soluble NCEs - American ...

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Preparation <strong>of</strong> Solid Dispersion –Solvent EvaporationTHydrophobic crystalline drugRemove thesolventHydrophilic carrierDissolve inorganic solventSolid dispersion(molecularlydispersed oramorphous drugin hydrophiliccarrier matrix)14
Solid Dispersion by Solvent EvaporationMajor Solvent EvaporationTechnologies– Rotary evaporation– Spray drying– Spray granulation• Bottom spray• Top sprayRef: Timpe et al., A Novel Solvent-Based Fluidized Bed Wet Granulation Process forSolid Dispersions, <strong>American</strong> Pharmaceutical Review, 2008http://www.americanpharmaceuticalreview.com/15
Page 1: Early Development of Poorly Water-S
Page 4 and 5: Development Strategies vsOutsourcin
Page 6 and 7: How Does Salt Formation IncreaseDis
Page 8 and 9: 8Nanotechnology
Page 10 and 11: 10High-energy Solid
Page 12 and 13: Heat content(enthalpy, H)Advantage
Page 16 and 17: Preparation of Solid Dispersion -Me
Page 18 and 19: Solid Dispersion by Melt ExtrusionT
Page 20 and 21: Nanoemulsion/Solid NanoemulsionPrec
Page 22 and 23: Limitation of Lipid-based DrugDeliv
Page 24: Outsourcing of Early Development of

Early Development of Poorly Water-Soluble NCEs - American ...

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