Early Development of Poorly Water-Soluble NCEs - American ...

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10High-energy Solid
Amorphous FormCompound Forms Solubility Temp.Ratios (calc)Indomethacin Amorphous/γ-Crystal 25 - 104 25 CGlibenclamide Amorphous/Crystal 112 - 1652 23 CGlucose Amorphous/Crystal 16 - 53 20 CGrise<strong>of</strong>ulvin Amorphous/Crystal 38 - 441 21 CHydrocholoro Amorphous/Crystal 21 – 113 37 C-thiazideIopanoic Acid Amorphous/Crystal 12 – 19 37 CPolythiazide Amorphous/Crystal 48 - 455 37 CRef: Hancock & Parks, Phram. Res, 17, 397 – 404, 200011
Page 1: Early Development of Poorly Water-S
Page 4 and 5: Development Strategies vsOutsourcin
Page 6 and 7: How Does Salt Formation IncreaseDis
Page 8 and 9: 8Nanotechnology
Page 12 and 13: Heat content(enthalpy, H)Advantage
Page 14 and 15: Preparation of Solid Dispersion -So
Page 16 and 17: Preparation of Solid Dispersion -Me
Page 18 and 19: Solid Dispersion by Melt ExtrusionT
Page 20 and 21: Nanoemulsion/Solid NanoemulsionPrec
Page 22 and 23: Limitation of Lipid-based DrugDeliv
Page 24: Outsourcing of Early Development of

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