By: Haydee Cantu and Jennifer Nichols - the UIC Department of ...

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Etiology – Environmental Factors• Best replicated risk factors: paternal age and in uteroexposure to maternal famine• Proposed mechanisms: direct neurological damage,gene-environment interactions, epigenetic effects, denovo mutations
Etiology - Neuroanatomical Abnormalities• Brain volume reductions in multiple regions (trueregardless of age)• Increased lateral ventricle volumes• Reduced hippocampal, thalamic, and frontal lobe volumes• Cortical thickness changes in prefrontal temporal andparietal regions• COS-specific changes: more rapid progressive loss of graymatter in a parietal-to-frontal pattern during adolescence.Plateaus in early adulthood.• Cortical thinning could be a result of increased pruning inadolescence of synaptic projections, affecting thematuration of complex processes. It could also be due todecreased myelination of neurons.• The amount of volume reduction in the brain has nocorrelation with symptom severity
Page 1 and 2: By: Haydee Cantu and Jennifer Nicho
Page 3 and 4: DSM-IV Criteria• Same criteria as
Page 5: Etiology - Genetics• Genetics and
Page 9 and 10: “Cerebellar development in childh
Page 11 and 12: Results• COS diverged from TD in
Page 13 and 14: Clinical Presentation• Negative s
Page 15 and 16: Methods• Subjects: 117 patients w
Page 17 and 18: Psychosocial Factors• Interact wi
Page 19 and 20: Treatment• Combines medication wi

By: Haydee Cantu and Jennifer Nichols - the UIC Department of ...

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