2009 Review - the Steele Children's Research Center - University of ...
2009 Review - the Steele Children's Research Center - University of ...
2009 Review - the Steele Children's Research Center - University of ...
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<strong>2009</strong> <strong>Review</strong>
2<br />
“Alone<br />
we can<br />
do so<br />
little;<br />
toge<strong>the</strong>r<br />
we can<br />
do so<br />
much.”<br />
– Helen Keller<br />
Dear Friends,<br />
As I reflect upon <strong>2009</strong>, I am reminded <strong>of</strong> Helen Keller’s simple, yet pr<strong>of</strong>ound<br />
observation: “Alone we can do so little; toge<strong>the</strong>r, we can do so much.” Indeed, everything<br />
we accomplish at <strong>the</strong> <strong>University</strong> <strong>of</strong> Arizona <strong>Steele</strong> Children’s <strong>Research</strong> <strong>Center</strong> is a<br />
result <strong>of</strong> individuals working toge<strong>the</strong>r to make <strong>the</strong> world a better place for children.<br />
You will see this idea woven into <strong>the</strong> articles throughout this annual review.<br />
As UMC and <strong>the</strong> UA <strong>Steele</strong> <strong>Center</strong> work toge<strong>the</strong>r to complete Diamond Children’s<br />
Medical <strong>Center</strong>, I am inspired by what this momentous accomplishment signifies.<br />
Diamond Children’s will provide compassionate, expert and family-centered care by<br />
our world-class physicians, nurses, specialists and residents—in a beautiful, state-<strong>of</strong><strong>the</strong>-art<br />
facility designed for children and <strong>the</strong>ir families. Hope is on <strong>the</strong> horizon!<br />
What’s more, because Diamond Children’s is connected to <strong>the</strong> <strong>Steele</strong> <strong>Center</strong>, our<br />
young patients benefit from being treated by physician-scientists who also are<br />
researching <strong>the</strong> causes <strong>of</strong>, and developing new treatments and cures for, children’s<br />
illnesses. We ardently strive to improve clinical care through translational, or “bench<br />
to bedside” research. This means translating our basic-science research discoveries<br />
(bench) to practical, clinical applications that benefit <strong>the</strong> child (bedside).<br />
For example, our Dorrance Fellow in Pediatric Gastroenterology and Nutrition—<br />
Rajalakshmy Ramalingam—has made a discovery that may bring new understanding<br />
to what causes IBD (inflammatory bowel disease). Collin LaCasse, our Courtney Page<br />
Zillman Fellow, is working with <strong>the</strong> pediatric oncology research team to advance <strong>the</strong><br />
CRCL cancer vaccine developed here and now heading toward clinical trials.<br />
It is no coincidence that <strong>the</strong> most remarkable advances in children’s health over <strong>the</strong><br />
past 10 years were achieved by academically-based children’s medical centers. In fact,<br />
all top-ranked children’s hospitals are connected to academic medical centers, such<br />
as Children’s Hospital Boston (Harvard) and Children’s Hospital <strong>of</strong> Philadelphia<br />
(<strong>University</strong> <strong>of</strong> Pennsylvania). By working toge<strong>the</strong>r, I know Diamond Children’s and<br />
<strong>the</strong> <strong>Steele</strong> <strong>Center</strong> soon will be a top-ranked academic children’s medical center as well.<br />
No child should suffer from cancer, diabetes, gastrointestinal disorders, heart problems<br />
or <strong>the</strong> myriad o<strong>the</strong>r pediatrics illnesses. But, when a child is sick from illness or<br />
injury, we are here to provide exceptional care. Because <strong>of</strong> friends and supporters<br />
like you, <strong>the</strong> <strong>Steele</strong> <strong>Center</strong> continues to improve children’s health through our mission<br />
to teach, to heal and to discover. Toge<strong>the</strong>r, we are making <strong>the</strong> world a healthier place<br />
for children.<br />
With gratitude,<br />
Fayez K. Ghishan, MD<br />
Horace W. <strong>Steele</strong> Endowed Chair in Pediatric <strong>Research</strong><br />
Director, <strong>Steele</strong> Children’s <strong>Research</strong> <strong>Center</strong><br />
Pr<strong>of</strong>essor and Head, Department <strong>of</strong> Pediatrics<br />
The <strong>University</strong> <strong>of</strong> Arizona College <strong>of</strong> Medicine<br />
<strong>Steele</strong> Children’s <strong>Research</strong> <strong>Center</strong> <strong>Review</strong>, February 2010. Issue 16. <strong>Steele</strong> Children’s <strong>Research</strong> <strong>Center</strong> <strong>Review</strong> is published annually<br />
by <strong>the</strong> <strong>University</strong> <strong>of</strong> Arizona, <strong>Steele</strong> Children’s <strong>Research</strong> <strong>Center</strong>, Department <strong>of</strong> Pediatrics, PO Box 245073, Tucson, AZ 85724-5073.<br />
<strong>Steele</strong> <strong>Center</strong> Receives Grant to Study <strong>the</strong> Role <strong>of</strong><br />
Calcium and Klotho Gene in IBD-related Bone Loss<br />
he <strong>Steele</strong> Children’s <strong>Research</strong><br />
T<strong>Center</strong> received an NIH<br />
American Recovery and<br />
Reinvestment Act grant for<br />
$605,250 that expands ongoing<br />
research conducted by Dr. Ghishan<br />
and his research team. The twoyear<br />
grant, titled “Development <strong>of</strong><br />
Intestinal Transport <strong>of</strong> Calcium<br />
and Phosphate,” investigates<br />
ano<strong>the</strong>r key component <strong>of</strong> bone<br />
health—calcium—and how<br />
inflammation affects calcium<br />
absorption by <strong>the</strong> gut and <strong>the</strong><br />
kidneys.<br />
“Our previous research focused<br />
on phosphate balance. This study<br />
will focus on calcium absorption.<br />
It takes both to develop strong<br />
bones,” says Dr. Ghishan, principal<br />
investigator <strong>of</strong> <strong>the</strong> study.<br />
In children and young adults<br />
suffering from inflammatory bowel<br />
diseases (IBD), bone density <strong>of</strong>ten<br />
is affected, resulting in osteopenia<br />
or osteoporosis. This decrease<br />
results in a higher risk <strong>of</strong> bone<br />
fractures later in life.<br />
“Although we have long suspected<br />
that calcium deficiency may be an<br />
underlying factor in IBD-related<br />
bone loss, <strong>the</strong> mechanisms by<br />
which <strong>the</strong> calcium absorptive and<br />
re-absorptive mechanisms are<br />
disrupted by chronic intestinal<br />
inflammation are still unknown,”<br />
says Pawel Kiela, DVM, PhD,<br />
co-investigator <strong>of</strong> <strong>the</strong> study.<br />
“So, it’s vital to understand<br />
how inflammation affects <strong>the</strong><br />
key players involved in <strong>the</strong><br />
maintenance <strong>of</strong> calcium balance.”<br />
One mechanism <strong>the</strong> research<br />
team will explore is <strong>the</strong> role<br />
<strong>the</strong> “Klotho” gene plays in<br />
how calcium is transported and<br />
absorbed by <strong>the</strong> kidneys. Previous<br />
research established that when<br />
Klotho is down-regulated, signs <strong>of</strong><br />
premature aging appear, including<br />
osteoporosis.<br />
Recently, <strong>the</strong> <strong>Steele</strong> <strong>Center</strong> team<br />
discovered that Klotho is downregulated<br />
in acute and chronic<br />
colitis. “This is a fascinating<br />
connection,” Dr. Kiela says. “We’re<br />
now hypo<strong>the</strong>sizing that when Klotho<br />
is down-regulated, it negatively<br />
affects renal calcium reabsorption<br />
which, along with o<strong>the</strong>r metabolic<br />
complications, contributes to colitisassociated<br />
calcium imbalance and <strong>the</strong><br />
resulting bone loss.”<br />
“The more we understand <strong>the</strong><br />
mechanisms involved in calcium<br />
and phosphate absorption, <strong>the</strong> better<br />
chance we’ll have <strong>of</strong> developing new<br />
<strong>the</strong>rapies to help children and adults<br />
suffering from IBD-related bone<br />
loss,” says Dr. Ghishan.<br />
3
4<br />
A Legacy <strong>of</strong> Giving: The Arizona Elks Major Projects<br />
n 1992, <strong>the</strong> Arizona Elks Major Projects began <strong>the</strong>ir incredible commitment to <strong>the</strong> work <strong>of</strong> <strong>the</strong> <strong>Steele</strong> Children’s<br />
I<strong>Research</strong> <strong>Center</strong>. Raising between $200,000 and $300,000 each year, <strong>the</strong> Elks have made a significant difference<br />
in children’s health. Here are highlights <strong>of</strong> Elks-supported projects through <strong>the</strong> years:<br />
Arizona Elks Laboratories for<br />
Transplantation <strong>Research</strong><br />
Amount raised: $275,000<br />
One <strong>of</strong> <strong>the</strong> first projects <strong>the</strong> Elks<br />
undertook was supporting <strong>the</strong><br />
building <strong>of</strong> two research labs<br />
on <strong>the</strong> sixth floor <strong>of</strong> <strong>the</strong> <strong>Steele</strong><br />
<strong>Center</strong>. These labs currently house<br />
researchers who specialize in<br />
gastroenterology and nutrition.<br />
Seed <strong>Research</strong> Awards<br />
Amount raised: $1.2 million<br />
Seed grants allow investigators to<br />
“prime <strong>the</strong> pump” with preliminary<br />
data, which will make <strong>the</strong>ir<br />
research projects more attractive to<br />
state and federal funding agencies.<br />
Education<br />
Amount raised: $50,000<br />
The education funds assisted<br />
with developing <strong>the</strong> first Pediatric<br />
Integrative Medicine Conference,<br />
and supported <strong>the</strong> “Morning for<br />
Children’s Health” workshops for<br />
parents.<br />
Arizona Elks Clinic for<br />
Children and Young Adults<br />
Amount raised: $390,000<br />
In 2001, <strong>the</strong> Arizona Elks<br />
celebrated <strong>the</strong> grand re-opening <strong>of</strong><br />
<strong>the</strong> newly named “Arizona Elks<br />
Clinic for Children and Young<br />
Adults.” The renovated clinic now<br />
includes separate waiting areas for<br />
sick children and well children,<br />
and more efficient space for<br />
doctors, nurses and staff.<br />
Core Support<br />
Amount raised: $255,000<br />
Core support funds are used<br />
to improve facilities and repair<br />
research equipment throughout <strong>the</strong><br />
<strong>Steele</strong> <strong>Center</strong>.<br />
Marvin Lewis Pediatric<br />
Teaching <strong>Center</strong><br />
Amount raised: $130,000<br />
Marvin Lewis, a past Grand<br />
Exalted Ruler, was passionate<br />
about education and helping<br />
children. Funds were used to<br />
renovate <strong>the</strong> pediatric residency<br />
<strong>of</strong>fices and create a conference<br />
room. Upon completion, <strong>the</strong> space<br />
was named <strong>the</strong> “Marvin Lewis<br />
Pediatric Teaching <strong>Center</strong>.”<br />
About this year’s front<br />
cover: Giovanna Manzo, 4,<br />
and her grandfa<strong>the</strong>r, Tom<br />
Welch, member <strong>of</strong> Chandler<br />
Elks Lodge, No. 2429.<br />
Giovanna is currently a<br />
patient <strong>of</strong> <strong>Steele</strong> <strong>Center</strong><br />
pediatric allergist/<br />
immunologist, Michael<br />
Daines, MD, and pediatric<br />
pulmonologist,<br />
Cori Daines, MD.<br />
Amy and John Manzo: Grateful for <strong>the</strong> Arizona Elks<br />
and <strong>Steele</strong> <strong>Center</strong> Physicians<br />
ur second daughter, Giovanna, was born on September 1,<br />
O2005. She seemed to be healthy during her first year <strong>of</strong> life.<br />
After her 1-year-old checkup and vaccinations, we realized<br />
something was seriously wrong. That was <strong>the</strong> beginning <strong>of</strong><br />
Giovanna’s battle with illness after illness, infection after<br />
infection. We were seen by several specialists in <strong>the</strong> Phoenix<br />
area. Over <strong>the</strong> past three years, we’ve traveled to Lucile Packard<br />
Children’s Hospital at Stanford in California, The Mayo Clinic<br />
in Minnesota, and The Children’s Hospital in Colorado. We<br />
watched Giovanna become extremely ill and suffer respiratory<br />
and cardiac arrest. She has been hospitalized eight times.<br />
Most recently, Linda Lewandowski, with <strong>the</strong> Arizona Elks Major Projects, arranged for<br />
Giovanna to be examined by <strong>Steele</strong> <strong>Center</strong> physicians Drs. Michael and Cori Daines.<br />
The “Great Daines,” as we call <strong>the</strong>m, reviewed Giovanna’s medical records and helped us<br />
understand her illness and treatment. Giovanna suffers from an unknown chronic disease that<br />
attacks her sinuses and lungs. Dr. Cori Daines placed Giovanna’s illness in an “unknown<br />
category” with “primary ciliary dyskinesia” and “cystic fibrosis” symptoms.<br />
We are so grateful to <strong>the</strong> Arizona Elks Major Projects and Drs. Michael and Cori Daines for<br />
<strong>the</strong> treatment, support and encouragement <strong>the</strong>y’ve given us in caring for our daughter!<br />
—Amy and John Manzo, members <strong>of</strong> Chandler Elks Lodge, No. 2429<br />
Arizona Elks Endowed Chair<br />
in Neonatology <strong>Research</strong><br />
Amount raised: $1.8 million (Goal: $2.5 million)<br />
In 2003, <strong>the</strong> Arizona Elks committed to creating <strong>the</strong><br />
“Arizona Elks Endowed Chair in Neonatology <strong>Research</strong>.”<br />
An endowed chair generates income that lasts forever.<br />
Every year, a portion <strong>of</strong> <strong>the</strong> interest is available to <strong>the</strong><br />
Chair to support research and provide seed funding to<br />
promising young investigators interested in neonatal<br />
research.<br />
Toys, Blankets, Beanies and Booties<br />
Amount raised: Priceless<br />
There is simply no price that can be assigned to <strong>the</strong><br />
hundreds <strong>of</strong> blankets, beanies and booties that have been<br />
knitted by <strong>the</strong> Elks for <strong>the</strong> premature babies at <strong>University</strong><br />
Medical <strong>Center</strong>. Or <strong>the</strong> thousands <strong>of</strong> donated toys and<br />
blankets that have brought a smile to a sick child’s face.<br />
We are immensely grateful for <strong>the</strong>se priceless gifts from<br />
<strong>the</strong> Arizona Elks lodges throughout Arizona!<br />
5
6<br />
Dorrance Fellow Update:<br />
Rajalakshmy Ramalingam<br />
hanks to <strong>the</strong> Dorrance<br />
TEndowed Fellowship in<br />
Pediatric Gastroenterology and<br />
Nutrition, I’m investigating <strong>the</strong><br />
immunological mechanisms that<br />
may contribute to <strong>the</strong> development<br />
<strong>of</strong> Inflammatory Bowel Disease<br />
(IBD), a painful gastrointestinal<br />
disorder and autoimmune disease<br />
affecting millions <strong>of</strong> Americans,<br />
I<br />
where nearly one in four are<br />
under 20 years old.<br />
Our research team has developed<br />
a mouse model with a specific<br />
gene (tumor growth factor<br />
receptor) deleted from a particular<br />
type <strong>of</strong> immune cell to study its<br />
contribution to <strong>the</strong> cause <strong>of</strong> IBD.<br />
Exceeding our expectations, <strong>the</strong>se<br />
Courtney Page Zillman Fellow<br />
Update: Collin LaCasse<br />
am honored to be <strong>the</strong> sixth<br />
Tee Up For Tots Courtney<br />
Page Zillman Fellow.<br />
A decade ago, Dr. Emmanuel<br />
Katsanis developed a new cancer<br />
vaccine, which takes a patient’s<br />
own tumor and isolates <strong>the</strong><br />
components <strong>of</strong> that tumor that<br />
are most likely to initiate a strong<br />
immune response. It now is<br />
nearing human clinical trials in <strong>the</strong><br />
United States.<br />
Unfortunately, <strong>the</strong>re is an obstacle<br />
that prohibits cancer vaccines<br />
from functioning properly.<br />
This obstacle is cancer-induced<br />
immunosuppression. Many cancer<br />
cells promote <strong>the</strong>ir own survival by<br />
secreting chemicals that virtually<br />
shut down <strong>the</strong> immune response<br />
in and around <strong>the</strong> tumor. They<br />
do this in part by hijacking<br />
immunosuppressive cells whose<br />
purpose in healthy individuals is<br />
to suppress immune cells in order<br />
to prevent over-active immune<br />
responses and autoimmunity.<br />
In cancer patients, <strong>the</strong>se hijacked<br />
immunosuppressive cells, instead <strong>of</strong><br />
protecting against autoimmunity,<br />
surround <strong>the</strong> tumor, preventing <strong>the</strong><br />
immune system from identifying<br />
and destroying <strong>the</strong> cancer. These<br />
genetically modified mice develop<br />
systemic autoimmune disease.<br />
This exciting observation now has<br />
broadened our scope <strong>of</strong> research.<br />
There are approximately 150<br />
different autoimmune diseases,<br />
including IBD. <strong>Research</strong> involved<br />
in understanding <strong>the</strong> mechanisms<br />
<strong>of</strong> <strong>the</strong>se diseases is essential<br />
for developing new methods to<br />
improve diagnosis and treatment.<br />
Because <strong>of</strong> <strong>the</strong> Dorrance Family<br />
Foundation and <strong>the</strong> leadership<br />
<strong>of</strong> Drs. Ghishan and Kiela, our<br />
laboratory not only has survived<br />
during this difficult economic time,<br />
but we have made major scientific<br />
advancements. The Dorrance<br />
Fellowship could not have come at<br />
a better time, with <strong>the</strong> competition<br />
for funding increasing every day.<br />
I am extremely grateful to <strong>the</strong><br />
Dorrance family and Drs. Ghishan<br />
and Kiela for giving me <strong>the</strong><br />
opportunity to pursue my PhD<br />
in immunobiology at <strong>the</strong> <strong>Steele</strong><br />
<strong>Center</strong>. Thank you!<br />
immunosuppressive cells must be<br />
targeted and destroyed. This is my<br />
primary research focus, and we<br />
have made great strides.<br />
I can’t wait for a day when<br />
our discoveries in <strong>the</strong> lab are<br />
implemented in <strong>the</strong> clinic,<br />
contributing to <strong>the</strong> eradication <strong>of</strong><br />
pediatric cancers! I am grateful for<br />
Tee Up For Tots, whose support<br />
makes this research possible.<br />
A Loving Memorial for Beloved Son:<br />
The ‘Kick Cancer for Stephen Foundation’<br />
tephen Placencia was a quiet<br />
S young man with friendly blue<br />
eyes and a warm smile. Humble<br />
in spirit and naturally athletic,<br />
Stephen excelled at soccer. As<br />
a member <strong>of</strong> <strong>the</strong> Cienega High<br />
School varsity soccer team, he<br />
was <strong>the</strong> highest scorer during his<br />
sophomore year. Stephen also<br />
enjoyed riding dirt bikes and<br />
spending time with his friends and<br />
family.<br />
In 2005, when Stephen was 14, he<br />
was diagnosed with a rare form<br />
<strong>of</strong> liver cancer—fibrolamellar<br />
hepatocellular carcinoma. After<br />
many surgeries, radiation and<br />
chemo<strong>the</strong>rapy treatments, Stephen<br />
passed away on January 14, 2008.<br />
He was only 17. “Through it all,”<br />
says Stephen’s mom, Francie,<br />
“he never questioned why he got<br />
cancer. He accepted it with grace<br />
and just went through it. Stephen<br />
had an amazing spirit, and we<br />
loved him beyond words.”<br />
While hospitalized, Stephen<br />
noticed few activities available<br />
for teenagers. “When teens are<br />
hospitalized, <strong>the</strong>ir stay is more<br />
bearable if <strong>the</strong>re are fun things for<br />
<strong>the</strong>m to do, such as playing video<br />
games or <strong>the</strong> Wii, or watching<br />
movies that appeal to <strong>the</strong>m,”<br />
says Francie. “Stephen wanted to<br />
improve <strong>the</strong> experience <strong>of</strong> teens<br />
who were hospitalized.”<br />
About a year after Stephen’s<br />
death, Francie and her husband,<br />
Steve, created <strong>the</strong> Kick Cancer<br />
for Stephen Foundation. The<br />
foundation’s goals are to provide<br />
funding for pediatric cancer<br />
research at <strong>the</strong> <strong>Steele</strong> Children’s<br />
<strong>Research</strong> <strong>Center</strong>, provide activities<br />
for hospitalized teenagers and<br />
provide resources to parents and<br />
family members who have a child<br />
with cancer or have lost a child to<br />
cancer.<br />
So far, <strong>the</strong> foundation has donated<br />
flat-screen TVs, gaming systems,<br />
X-boxes and Playstations, Wii<br />
systems, Guitar Hero, games, movies,<br />
Best Buy gift cards and countless<br />
snacks and drinks to <strong>the</strong> infusion<br />
clinic within <strong>the</strong> Elks Clinic for<br />
Children and Young Adults and to<br />
<strong>the</strong> pediatric wards at <strong>University</strong><br />
Medical <strong>Center</strong>.<br />
“The children get so excited when<br />
<strong>the</strong>y see <strong>the</strong> games <strong>the</strong>y can play<br />
while receiving treatment,” says Laura<br />
DiStefano, one <strong>of</strong> <strong>the</strong> nurses who<br />
treated Stephen at <strong>the</strong> infusion clinic.<br />
“The games help <strong>the</strong>m endure <strong>the</strong>ir<br />
treatments. We are inspired by Steve<br />
and Francie’s commitment to help<br />
<strong>the</strong>se kids and families.”<br />
“This has been a meaningful way for<br />
us to keep Stephen’s memory alive,<br />
and I see something positive coming<br />
out <strong>of</strong> this,” says Francie. “We’re<br />
doing it in Stephen’s honor, because<br />
he touched so many lives and we<br />
want his spirit to be carried on.”<br />
If you would like to contribute to<br />
Kick Cancer for Stephen, please<br />
visit: www.kickcancerforstephen.com.<br />
7
8<br />
Dr. Katsanis Named<br />
Leading Edge<br />
<strong>Research</strong>er at <strong>the</strong><br />
<strong>University</strong> <strong>of</strong> Arizona<br />
teele Children’s <strong>Research</strong> <strong>Center</strong> scientist and<br />
Spediatric oncologist Emmanuel Katsanis, MD,<br />
Pr<strong>of</strong>essor <strong>of</strong> Pediatrics and Chief <strong>of</strong> <strong>the</strong> Section <strong>of</strong><br />
Pediatric Hematology/Oncology was named one <strong>of</strong><br />
only five UA Leading Edge <strong>Research</strong>ers.<br />
Dr. Katsanis, who holds <strong>the</strong> prestigious Louise<br />
Thomas Endowed Chair in Pediatric Cancer<br />
<strong>Research</strong> at <strong>the</strong> <strong>Steele</strong> <strong>Center</strong>, was honored at <strong>the</strong><br />
UA’s sixth annual Innovation Day celebration in<br />
March, which recognized research achievements <strong>of</strong><br />
students, faculty and staff. He was honored for his<br />
ground-breaking research in <strong>the</strong> development <strong>of</strong><br />
<strong>the</strong> novel cancer vaccine, CRCL, which is nearing<br />
human clinical trials.<br />
“We’re very happy for Dr. Katsanis,” said Dr.<br />
Ghishan. “His discovery and development <strong>of</strong> <strong>the</strong><br />
CRCL cancer vaccine will ultimately lead to novel<br />
treatments for patients with leukemia and o<strong>the</strong>r<br />
blood cancers, with <strong>the</strong> ultimate goal <strong>of</strong> saving<br />
lives. We are extremely proud <strong>of</strong> this pioneering<br />
researcher.”<br />
Dr. Ghishan<br />
Receives Prestigious<br />
Distinguished Alumnus<br />
Award for Achievement<br />
ongratulations to Dr. Ghishan, who received a<br />
Cprestigious Distinguished Alumnus Award for<br />
Achievement from <strong>the</strong> <strong>University</strong> <strong>of</strong> Iowa Carver<br />
College <strong>of</strong> Medicine. He was honored during a<br />
special awards luncheon ceremony in June.<br />
The Distinguished Alumni Award is <strong>the</strong> highest<br />
honor <strong>the</strong> college bestows upon its graduates,<br />
recognizing those who have transcended <strong>the</strong>ir<br />
fundamental roles as health-care providers, scientists<br />
and educators to become leaders in <strong>the</strong> advancement<br />
<strong>of</strong> medicine.<br />
Dr. Ghishan was honored with <strong>the</strong> Award for<br />
Achievement for his continued leadership in<br />
pediatric gastroenterology, which has advanced<br />
patient care, research and teaching. Internationally<br />
recognized for his research in pediatric<br />
gastroenterology and nutrition, Dr. Ghishan has<br />
authored more than 400 publications including<br />
original articles, editorials, abstracts, book reviews<br />
and chapters. His groundbreaking research has<br />
continuously been funded by <strong>the</strong> National Institutes<br />
<strong>of</strong> Health for <strong>the</strong> past 30 years.<br />
<strong>Steele</strong> <strong>Center</strong> <strong>Research</strong> Reveals Probiotics a Promising<br />
Treatment for Common Illness among Premature Babies<br />
teele Children’s <strong>Research</strong> <strong>Center</strong><br />
S<strong>Research</strong> Pr<strong>of</strong>essor Bohuslav<br />
Dvorak, PhD, and his research<br />
team have discovered that using<br />
probiotics (healthy live bacteria<br />
found in yogurt) is an effective way<br />
to reduce and prevent a common,<br />
yet devastating, disease that affects<br />
babies born prematurely.<br />
NEC (necrotizing enterocolitis)<br />
is a gastrointestinal disease <strong>of</strong><br />
<strong>the</strong> intestines that afflicts nearly<br />
10,000 premature babies every<br />
year. The exact cause <strong>of</strong> NEC is<br />
unknown, and <strong>the</strong> disease can be<br />
mild to severe. In severe cases, a<br />
child’s inflamed intestines may<br />
tear, causing bacteria to leak into<br />
<strong>the</strong> abdomen—potentially causing<br />
a life-threatening infection. Sadly,<br />
nearly 40 percent <strong>of</strong> babies with<br />
NEC will not survive.<br />
Using an experimental model<br />
<strong>of</strong> NEC, Dr. Dvorak and his<br />
team have shown that oral<br />
administration <strong>of</strong> probiotics is a<br />
promising strategy to prevent and<br />
treat NEC. “We have confirmed<br />
that <strong>the</strong> probiotic Bifidobacterium<br />
bifidum, when added to infant<br />
formula, significantly reduces <strong>the</strong><br />
incidence and severity <strong>of</strong> NEC,”<br />
says Dr. Dvorak. “This particular<br />
strain <strong>of</strong> probiotics reduces<br />
inflammation in <strong>the</strong> intestines and<br />
reinforces <strong>the</strong> intestinal barrier.”<br />
Now that Dr. Dvorak and his<br />
team have established <strong>the</strong> efficacy<br />
<strong>of</strong> Bifidobacterium bifidum, <strong>the</strong>y<br />
are exploring how probiotics<br />
protect against NEC at <strong>the</strong><br />
cellular and molecular levels, and<br />
what long-term consequences—if<br />
any—<strong>the</strong>y have on immune and<br />
gastrointestinal functions.<br />
Their study, “Bifidobacterium<br />
bifidum improves intestinal integrity<br />
in a rat model <strong>of</strong> necrotizing<br />
enterocolitis,” was published in<br />
<strong>the</strong> American Journal <strong>of</strong> Physiology:<br />
Gastrointestinal and Liver<br />
Physiology.<br />
9
10<br />
Grateful for our Volunteer Groups and Events<br />
D<br />
espite many economic challenges this year, <strong>the</strong> <strong>Steele</strong> <strong>Center</strong> continues to receive support from<br />
many volunteer groups and special events. On behalf <strong>of</strong> our doctors, researchers, patients and staff,<br />
thank you to all <strong>of</strong> our volunteers! Your efforts make a difference in <strong>the</strong> lives <strong>of</strong> children.<br />
Arizona Elks Major Projects<br />
(AEMP)<br />
he 49 Elks<br />
lodges<br />
T<br />
across<br />
Arizona<br />
continue<br />
to work<br />
tirelessly to build <strong>the</strong> Arizona Elks<br />
Endowed Chair in Neonatology<br />
<strong>Research</strong>. This year, <strong>the</strong> Elks<br />
gave ano<strong>the</strong>r $250,000, bringing<br />
<strong>the</strong>ir total to more than $4<br />
million. Thanks to <strong>the</strong>ir support,<br />
Alan Bedrick, MD, holder <strong>of</strong> <strong>the</strong><br />
Chair, and his team in <strong>the</strong> NICU<br />
continue to help newborn babies,<br />
while researchers search for better<br />
ways to treat neonatal diseases.<br />
Fa<strong>the</strong>r’s Day Council Tucson<br />
our outstanding fa<strong>the</strong>rs were<br />
honored this year at <strong>the</strong> annual<br />
F<br />
Golf Classic and Fa<strong>the</strong>rs <strong>of</strong> <strong>the</strong><br />
Year Awards Gala. With <strong>the</strong><br />
support and<br />
dedication<br />
<strong>of</strong> Fa<strong>the</strong>r’s<br />
Day Council<br />
behind <strong>the</strong>m,<br />
<strong>the</strong> honorees<br />
raised more<br />
than $200,000 this year. Funds<br />
will support research and clinical<br />
care in type 1 diabetes, and help<br />
build <strong>the</strong> Fa<strong>the</strong>r’s Day Council<br />
Tucson Endowed Chair for Type<br />
1 Diabetes.<br />
Runway for <strong>Research</strong><br />
ore than 50 children–current<br />
cancer patients,<br />
M<br />
survivors and <strong>the</strong>ir<br />
siblings—showed<br />
<strong>of</strong>f <strong>the</strong> latest<br />
designs by<br />
students at The<br />
Art Institute <strong>of</strong><br />
Tucson. The<br />
Runway for <strong>Research</strong> fashion show<br />
drew an impressive crowd, filling<br />
<strong>the</strong> ballroom to capacity. Funds<br />
raised support pediatric cancer<br />
research.<br />
Tee Up For Tots<br />
T<br />
ee Up For<br />
Tots’ brigade<br />
<strong>of</strong> volunteers<br />
worked<br />
relentlessly for this year’s golf<br />
tournament, in memory <strong>of</strong> Courtney<br />
Page Zillman, who passed away<br />
from neuroblastoma when she<br />
was only 4. Proceeds support<br />
graduate student and pediatric<br />
cancer researcher Collin LaCasse,<br />
<strong>the</strong> TUFT Courtney Page Zillman<br />
Fellow.<br />
Women’s Active 20-30 Club <strong>of</strong><br />
Sou<strong>the</strong>rn Arizona<br />
or more than<br />
20 years, <strong>the</strong><br />
F<br />
Women’s Active<br />
20-30 Club<br />
<strong>of</strong> Sou<strong>the</strong>rn<br />
Arizona have provided vital support<br />
to <strong>the</strong> <strong>Steele</strong> <strong>Center</strong> and our efforts<br />
in various research areas. This year’s<br />
Cocktailing for a Cause, with its<br />
poker tournament and gourmet<br />
<strong>of</strong>ferings, enabled <strong>the</strong>m to donate<br />
$5,000 to <strong>the</strong> <strong>Steele</strong> <strong>Center</strong>.<br />
PANDA (People Acting Now<br />
Discover Answers)<br />
his year<br />
marked<br />
T<br />
<strong>the</strong> 10th<br />
anniversary<br />
<strong>of</strong> PANDA,<br />
who celebrated<br />
with <strong>the</strong>ir golf tournament and<br />
signature “Children Helping<br />
Children” Fashion Show. The<br />
PANDAs raised more than<br />
$750,000 toward <strong>the</strong> creation <strong>of</strong> <strong>the</strong><br />
PANDA Children’s Neurological<br />
<strong>Center</strong>. The <strong>Center</strong> will provide<br />
comprehensive care for children<br />
with a variety <strong>of</strong> neurological<br />
conditions.<br />
Raise a Racquet for Kids<br />
ven rain didn’t diminish <strong>the</strong><br />
determination and passion <strong>of</strong><br />
E<br />
<strong>the</strong> Raise<br />
a Racquet<br />
for Kids<br />
volunteers!<br />
This year’s<br />
tennis<br />
tournament<br />
featured a<br />
new kids-only<br />
tournament<br />
and lively<br />
entertainment<br />
from Tucson High School’s steel<br />
drum band. RARK raised nearly<br />
$50,000 to support pediatric cancer<br />
research.<br />
Additional Thanks<br />
and Gratitude!<br />
In <strong>2009</strong>, <strong>the</strong> <strong>Steele</strong> <strong>Center</strong> welcomed<br />
<strong>the</strong> support <strong>of</strong> several new volunteer<br />
groups and events.<br />
• The UA’s Alpha Epsilon Phi sorority<br />
sold beautiful cashmere sweaters to<br />
support <strong>the</strong> <strong>Steele</strong> <strong>Center</strong>.<br />
• The Salpointe Catholic High School<br />
football team raised awareness about<br />
type 1 diabetes through <strong>the</strong>ir Games<br />
for <strong>the</strong> Greater Good. The entire school<br />
got involved, delivering Lancer bags<br />
filled with toys for newly diagnosed<br />
patients, and creating “Denim for<br />
Diabetes” ribbons.<br />
• The Gaslight Theatre actors and staff<br />
donated <strong>the</strong>ir time and talents to put<br />
toge<strong>the</strong>r a live show and auction,<br />
inspired by a loved one who lives with<br />
type 1 diabetes. Proceeds benefitted<br />
type 1 diabetes research and clinical care.<br />
• The sad and untimely loss <strong>of</strong> <strong>the</strong>ir<br />
daughter, Marisa Ann, inspired Laura<br />
and Delbert Gallego to establish <strong>the</strong><br />
Marisa Ann Gallego Foundation.<br />
They hosted <strong>the</strong> first annual iMAGine<br />
A Cure Golf Tournament benefitting<br />
cancer research.<br />
• The Placencia family, who lost <strong>the</strong>ir<br />
beloved son, Stephen, to cancer, used<br />
<strong>the</strong>ir tragedy for good, forming <strong>the</strong><br />
Kick Cancer for Stephen Foundation<br />
and donating several gaming systems<br />
to our hematology/oncology clinic.<br />
• The Tucson Toros named <strong>the</strong> <strong>Steele</strong><br />
<strong>Center</strong> <strong>the</strong>ir charity <strong>of</strong> choice for<br />
<strong>the</strong> annual 4th <strong>of</strong> July Star Spangled<br />
Spectacular and invited one <strong>of</strong> our<br />
diabetes patients to throw out <strong>the</strong><br />
first pitch.<br />
• The Arizona Diamondbacks held a<br />
pediatric cancer awareness night and<br />
invited our cancer patients, survivors,<br />
and <strong>the</strong>ir families to enjoy a carefree<br />
night <strong>of</strong> baseball.<br />
Opening Soon! Diamond<br />
Children’s Medical <strong>Center</strong><br />
T<br />
he excitement is<br />
growing! Construction<br />
is nearing completion<br />
on Diamond Children’s<br />
Medical <strong>Center</strong>. The<br />
facility will open in<br />
phases starting in April<br />
2010. The grand opening<br />
<strong>of</strong> <strong>the</strong> lobby is scheduled for September 2010.<br />
Please visit www.diamondchildrens.org for updates.<br />
Tours:<br />
If you would like a tour <strong>of</strong> <strong>the</strong> <strong>Steele</strong> Children’s<br />
<strong>Research</strong> <strong>Center</strong> and Diamond Children’s, please<br />
contact Mariana Vazquez at (520) 626-9773,<br />
vazquez@peds.arizona.edu.<br />
Donations:<br />
If you are interested in supporting <strong>the</strong> doctors and<br />
programs <strong>of</strong> Diamond Children’s or <strong>the</strong> research<br />
(conducted through <strong>the</strong> <strong>Steele</strong> <strong>Center</strong>), you may<br />
donate online at www.steelecenter.arizona.edu, or<br />
use <strong>the</strong> envelope enclosed with this report. For more<br />
information, please contact Lori Stratton, Director <strong>of</strong><br />
Development for <strong>the</strong> <strong>Steele</strong> <strong>Center</strong>, at (520) 626-7799,<br />
stratton@peds.arizona.edu.<br />
If you are interested in supporting <strong>the</strong> “bricks and<br />
mortar” <strong>of</strong> Diamond Children’s, you may donate<br />
online at www.diamondchildrens.org. For more<br />
information, please contact Tom Sanders, Senior<br />
Development Officer, UMC Foundation, (520) 694-<br />
6599, tsanders@umcaz.org, or Richelle Litteer, Major<br />
Gifts Officer, (520) 694-1324, rlitteer@umcaz.edu.<br />
11
12<br />
Spotlight On Our Patients: <strong>Steele</strong> Story Project<br />
ive <strong>of</strong> our patients participated in <strong>the</strong> <strong>Steele</strong> Story Project to help raise awareness about <strong>the</strong> <strong>Steele</strong> Children’s<br />
F<strong>Research</strong> <strong>Center</strong>. Pr<strong>of</strong>essional photographer Lyra Waggoner photographed each child. We thank our advisory<br />
board members who generously underwrote <strong>the</strong> costs for this project.<br />
Gavin: When born, Gavin couldn’t<br />
eat. He was diagnosed with “EG”<br />
(eosinophilic gastroenteritis), a<br />
painful GI disorder that causes<br />
nausea, vomiting, stomach pain<br />
and choking. Under Dr. Ghishan’s<br />
care, Gavin quickly improved.<br />
After five months on a feeding<br />
tube, his parents were able to<br />
introduce solid foods into Gavin’s<br />
diet. Now 4, “he can eat almost<br />
anything,” says his mom, Erin.<br />
Ian: “When I grow up, I want<br />
to be like Dr. Griffin,” says Ian<br />
about his <strong>Steele</strong> <strong>Center</strong> pediatric<br />
endocrinologist, Kurt Griffin,<br />
PhD, MD. Diagnosed with type 1<br />
diabetes when he was 3, Ian, now<br />
5, uses an insulin pump to manage<br />
his diabetes. “Ian has so much<br />
more freedom with <strong>the</strong> pump,”<br />
says his mom, Lisa.<br />
Ilaria: Three days after she turned<br />
3, Ilaria was diagnosed with yolk<br />
sac germ cell cancer. A tumor <strong>the</strong><br />
size <strong>of</strong> an adult fist was found<br />
in <strong>the</strong> center <strong>of</strong> her chest. “We<br />
were devastated,” says Ilaria’s dad,<br />
Colin. After major surgery to<br />
remove <strong>the</strong> tumor and four rounds<br />
<strong>of</strong> chemo<strong>the</strong>rapy, Ilaria, now 5, is<br />
in remission. “She’s doing great,”<br />
says her pediatric oncologist,<br />
Emmanuel Katsanis, MD.<br />
Jade: Eight-year-old Jade<br />
recently was diagnosed with<br />
supraventricular tachycardia (SVT),<br />
a heart-rhythm disorder that causes<br />
arrhythmia and a rapid heart rate.<br />
Under <strong>the</strong> care <strong>of</strong> her pediatric<br />
cardiologist, Dr. Santiago Valdés,<br />
Jade underwent a successful<br />
cardiac ca<strong>the</strong>terization procedure<br />
that removed <strong>the</strong> extra electrical<br />
connection between <strong>the</strong> top and<br />
bottom chambers <strong>of</strong> her heart.<br />
“She feels wonderful,” says Jade’s<br />
mom, Sherry.<br />
Syd: Five-year-old Syd loves to listen<br />
to classical music and already knows<br />
<strong>the</strong> composers <strong>of</strong> many classical<br />
pieces. Syd receives specialized<br />
care from Sydney Rice, MD, a<br />
developmental pediatrician, to help<br />
with some <strong>of</strong> his neurological and<br />
behavioral challenges. “Syd has<br />
improved tremendously,” says his<br />
dad, Dennis.<br />
Boxed note cards (10 cards per box) are available for a<br />
donation <strong>of</strong> $20 or more. To order, contact Laura Hopkins<br />
at (520) 626-9618 or hopkins@peds.arizona.edu.<br />
Community-based Fundraising:<br />
Canister and Dollar Campaigns<br />
e are grateful for <strong>the</strong> dedicated<br />
Wleadership <strong>of</strong> <strong>Steele</strong> Children’s<br />
<strong>Research</strong> <strong>Center</strong> advisory board<br />
members Bill Cox and<br />
DeeAnne Gibbons.<br />
They created <strong>the</strong><br />
idea for <strong>the</strong> <strong>Steele</strong><br />
<strong>Center</strong> “canister” and<br />
“dollar” campaigns<br />
to raise money for<br />
<strong>the</strong> <strong>Steele</strong> <strong>Center</strong> and<br />
increase pubic awareness.<br />
Funds raised through <strong>the</strong>se<br />
In September, <strong>the</strong> <strong>Steele</strong><br />
<strong>Center</strong> received a Hyundai<br />
Hope on Wheels grant to<br />
benefit pediatric cancer<br />
research. <strong>Steele</strong> <strong>Center</strong><br />
pediatric oncologist Brenda<br />
Wittman, MD, was chosen as<br />
a Hyundai Scholar and<br />
received $20,000 for her research in bacterial<br />
infection and blood clotting related to central<br />
venous ca<strong>the</strong>ters. Dr. Wittman received <strong>the</strong> funding<br />
at a special “Handprint Ceremony,” and our<br />
pediatric cancer patients were invited to participate<br />
in this fun and paint-filled event. Jim Click<br />
Automotive donated an additional $20,000 for a<br />
total <strong>of</strong> $40,000 to support Dr. Wittman’s research!<br />
community-based campaigns will<br />
support <strong>Steele</strong> <strong>Center</strong> programs<br />
with <strong>the</strong> greatest need.<br />
The “canister campaign”<br />
has put change canisters<br />
at many local businesses<br />
throughout Tucson<br />
and Sou<strong>the</strong>rn Arizona.<br />
They feature Faith—a<br />
young cancer survivor<br />
treated by <strong>Steele</strong> <strong>Center</strong> pediatric<br />
oncologists.<br />
The “dollar campaign” lets you<br />
support <strong>the</strong> <strong>Steele</strong> <strong>Center</strong> for as<br />
little as $1! As our dollar campaign<br />
grows, <strong>the</strong> cards will be available<br />
in stores throughout Tucson.<br />
To find locations near you for<br />
both campaigns, or if you would<br />
like to add <strong>the</strong> campaigns to your<br />
business, please contact Laura<br />
Hopkins at (520) 626-9618,<br />
hopkins@peds.arizona.edu, or:<br />
www.steelecenter.arizona.edu/<br />
annualgiving.asp.<br />
<strong>Steele</strong> <strong>Center</strong> Receives Grant from<br />
Hyundai Hope on Wheels<br />
13
14<br />
Facts & Figures<br />
he UA <strong>Steele</strong> Children’s<br />
T<strong>Research</strong> <strong>Center</strong> serves<br />
children throughout<br />
Arizona and neighboring<br />
states, focusing primarily<br />
on difficult-to-treat diseases<br />
like pediatric cancers, type<br />
1 diabetes, autism spectrum<br />
disorders, congenital heart<br />
disease and gastrointestinal<br />
disorders such as Crohn’s<br />
disease and eosinophilic<br />
esophagitis.<br />
<strong>Steele</strong> <strong>Center</strong> pediatricians<br />
and pediatric specialists<br />
care for children and <strong>the</strong>ir<br />
families in approximately<br />
60,000 patient visits a year.<br />
They provide <strong>the</strong> type<br />
<strong>of</strong> support and cuttingedge<br />
care that comes<br />
from being an academic<br />
research institution.<br />
Physician-scientists at <strong>the</strong><br />
<strong>Steele</strong> <strong>Center</strong> focus on<br />
investigating <strong>the</strong> causes <strong>of</strong><br />
pediatric diseases and work<br />
to discover new treatments<br />
and <strong>the</strong>rapies for children<br />
suffering with illness.<br />
Federal and state grants<br />
help fund scientific<br />
investigation, but<br />
philanthropy is an<br />
important catalyst for<br />
nurturing new ideas<br />
because it serves as a<br />
springboard for securing<br />
government aid in <strong>the</strong><br />
future. Only 10% <strong>of</strong><br />
all donations are used<br />
for development and<br />
fundraising efforts.<br />
We thank each <strong>of</strong> our<br />
donors for <strong>the</strong>ir investment<br />
in <strong>the</strong> <strong>Steele</strong> <strong>Center</strong> and<br />
children’s health.<br />
FY 08-09 Where Philanthropy Money Comes From<br />
FY 08-09 Where Philanthropy Funds Were Directed<br />
Faculty Highlights <strong>2009</strong><br />
Brent Barber, MD, promoted to Associate Pr<strong>of</strong>essor, Clinical<br />
Pediatrics, Section <strong>of</strong> Cardiology.<br />
Christopher Cunniff, MD, Pr<strong>of</strong>essor and Chief, Section <strong>of</strong><br />
Genetics; elected President <strong>of</strong> <strong>the</strong> American Board <strong>of</strong> Medical Genetics<br />
(ABMG); received 5-year, $1.25 million grant from <strong>the</strong> <strong>Center</strong>s for<br />
Disease Control and Prevention to study <strong>the</strong> prevalence <strong>of</strong> Fetal<br />
Alcohol Syndrome in children throughout Arizona and Nevada.<br />
Cori Daines, MD, promoted to Associate Pr<strong>of</strong>essor, Clinical<br />
Pediatrics, Section <strong>of</strong> Pulmonary, Allergy and Immunology.<br />
Bohuslav Dvorak, PhD, promoted to <strong>Research</strong> Pr<strong>of</strong>essor, Section<br />
<strong>of</strong> Neonatology; Publication: Bifidobacterium bifidum Improves Intestinal<br />
Integrity in a Rat Model <strong>of</strong> Necrotizing Enterocolitis; American Journal<br />
<strong>of</strong> Physiology: Gastrointestinal and Liver Physiology, <strong>2009</strong>; 297: G1-G10;<br />
received a two-year NIH R21 grant, “Regulation <strong>of</strong> Immune Reactions<br />
by Syn<strong>the</strong>tic Thioglucans,” in collaboration with <strong>the</strong> <strong>University</strong> <strong>of</strong><br />
Louisville.<br />
Sean P. Elliott, MD, Associate Pr<strong>of</strong>essor, Section <strong>of</strong> Infectious<br />
Diseases; inducted into Alpha Omega Alpha at UA College <strong>of</strong><br />
Medicine; received UA College <strong>of</strong> Medicine Faculty Teaching Award,<br />
“Educator <strong>of</strong> <strong>the</strong> Year Lifetime Award—Years III and IV”; Publication:<br />
The Spectrum and Presentation <strong>of</strong> Disseminated Coccidioidomycosis;<br />
American Journal <strong>of</strong> Medicine, <strong>2009</strong>; 122(5): 770-777.<br />
Robert P. Erickson, MD, Pr<strong>of</strong>essor, Section <strong>of</strong> Genetics;<br />
Publication: Autosomal Recessive Disease among <strong>the</strong> Athabaskans<br />
<strong>of</strong> <strong>the</strong> Southwestern United States: Recent Advances and Implications<br />
for <strong>the</strong> Future; American Journal <strong>of</strong> Medical Genetics A, <strong>2009</strong>;<br />
149A:2602-2611.<br />
Fayez K. Ghishan, MD, Pr<strong>of</strong>essor and Department Head, Section<br />
<strong>of</strong> Gastroenterology and Nutrition; received “Distinguished Alumnus<br />
Award for Achievement,” from <strong>the</strong> <strong>University</strong> <strong>of</strong> Iowa Carver<br />
College <strong>of</strong> Medicine; received two-year NIH “American Recovery<br />
and Reinvestment” grant to study <strong>the</strong> role <strong>of</strong> calcium in IBD-related<br />
bone loss. Publication: Tumor Necrosis Factor Alpha Down-Regulates<br />
Intestinal NHE8 Expression by Reducing Basal Promoter Activity;<br />
American Journal <strong>of</strong> Physiology: Cell Physiology, <strong>2009</strong>; 296(3): C489-97.<br />
Melissa Halpern, PhD, promoted to <strong>Research</strong> Associate Pr<strong>of</strong>essor,<br />
Section <strong>of</strong> Neonatology; Publication: Bifidobacterium bifidum Improves<br />
Intestinal Integrity in a Rat Model <strong>of</strong> Necrotizing Enterocolitis; American<br />
Journal <strong>of</strong> Physiology: Gastrointestinal and Liver Physiology, <strong>2009</strong>; 297:<br />
G1-G10.<br />
Cleo Hardin, MD, Associate Pr<strong>of</strong>essor and Chief, Section <strong>of</strong><br />
Hospital Medicine & Outreach; earned “Fellow in Hospital Medicine”<br />
(FHM) designation from <strong>the</strong> Society <strong>of</strong> Hospital Medicine.<br />
Emmanuel Katsanis, MD, Pr<strong>of</strong>essor and Chief, Section <strong>of</strong><br />
Hematology/Oncology; named “Leading Edge <strong>Research</strong>er” at <strong>the</strong><br />
<strong>University</strong> <strong>of</strong> Arizona; awarded five-year R01 grant from <strong>the</strong> NIH,<br />
“Immuno<strong>the</strong>rapy for Chronic Myelogenous Leukemia.” Publication:<br />
Signaling Pathways Induced by a Tumor-derived Vaccine in Antigen<br />
Presenting Cells; Immunobiology, <strong>2009</strong>; Oct. 30.<br />
Pawel Kiela, DVM, PhD, <strong>Research</strong> Associate Pr<strong>of</strong>essor, Section<br />
<strong>of</strong> Gastroenterology and Nutrition; received two-year NIH “American<br />
Recovery and Reinvestment” grant to study <strong>the</strong> role <strong>of</strong> calcium in<br />
IBD-related bone loss.<br />
Nicolas Larmonier, PhD, promoted to <strong>Research</strong> Associate<br />
Pr<strong>of</strong>essor, Section <strong>of</strong> Hematology/Oncology; Publication: Imatinib<br />
Mesylate Suppresses CD4+CD25+ Regulatory T Cell Activity and<br />
Enhances Active Immuno<strong>the</strong>rapy Against BCR-ABL Negative Tumors;<br />
Journal <strong>of</strong> Immunology, Nov. 181:6955-63.<br />
William Madden, MD, Pr<strong>of</strong>essor and Chief, Section <strong>of</strong> General<br />
Pediatrics; received UA College <strong>of</strong> Medicine Faculty Teaching Award,<br />
“Dean’s List for Excellence in Teaching Award, Year III.”<br />
Ricardo Samson, MD, Pr<strong>of</strong>essor and Chief, Section <strong>of</strong> Cardiology;<br />
asked to serve as Associate Science Editor for <strong>the</strong> American Heart<br />
Association.<br />
Ziad Shehab, MD, Pr<strong>of</strong>essor, Section <strong>of</strong> Infectious Diseases; UA<br />
College <strong>of</strong> Medicine Faculty Teaching Award, “Outstanding Achievement<br />
in Teaching by a Clerkship or Elective Award for Years III and IV.”<br />
Andreas Theodorou, MD, Pr<strong>of</strong>essor and Chief, Section <strong>of</strong><br />
Critical Care; Publication: Antivenom for Critically Ill Children with<br />
Neurotoxicity from Scorpion Stings; The New England Journal <strong>of</strong> Medicine,<br />
May <strong>2009</strong>, Vol. 360:2090-2098. Named a “Best Doctor,” <strong>2009</strong>.<br />
Richard Wahl, MD, promoted to Pr<strong>of</strong>essor, Clinical Pediatrics,<br />
Section <strong>of</strong> General Pediatrics.<br />
The Department <strong>of</strong> Pediatrics Welcomed New Faculty in <strong>2009</strong><br />
Rachel Cramton, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Clinical Pediatrics<br />
Hospital Medicine/Outreach<br />
Nancy Gruchala, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Clinical Pediatrics<br />
Hospital Medicine/Outreach<br />
Margaret Trouard, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Clinical Pediatrics<br />
Critical Care<br />
Katri Typpo, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Clinical Pediatrics<br />
Critical Care<br />
15
16<br />
Inspired<br />
We are inspired by <strong>the</strong> kindness and generosity <strong>of</strong> our donors and are thankful for every gift made to <strong>the</strong> <strong>Steele</strong> Children’s<br />
<strong>Research</strong> <strong>Center</strong> that allows us to provide today’s care and tomorrow’s cures. We want to give special thanks to <strong>the</strong><br />
following cash and in-kind donors who gave $1,000 or more from January through December <strong>2009</strong>.<br />
$500,000+<br />
PANDA—Phoenix Women’s<br />
Board<br />
$250,000 - $499,999<br />
Arizona Elks Major Projects<br />
$100,000 - $249,999<br />
Fa<strong>the</strong>r’s Day Council Tucson<br />
The <strong>Steele</strong> Foundation, Inc.<br />
$50,000 - $99,999<br />
Jacquelynn and Bennett Dorrance<br />
$25,000 - $49,999<br />
Ashley and Chris Baiker<br />
Dorrance Family Foundation<br />
Gifts in Honor <strong>of</strong> Rick Fink—<br />
Fa<strong>the</strong>r <strong>of</strong> <strong>the</strong> Year <strong>2009</strong><br />
Gifts in Honor <strong>of</strong> Gary Kippur—<br />
Fa<strong>the</strong>r <strong>of</strong> <strong>the</strong> Year <strong>2009</strong><br />
Gifts in Honor <strong>of</strong> Jose Rincon—<br />
Fa<strong>the</strong>r <strong>of</strong> <strong>the</strong> Year <strong>2009</strong><br />
Gifts in Honor <strong>of</strong> Les White—<br />
Fa<strong>the</strong>r <strong>of</strong> <strong>the</strong> Year <strong>2009</strong><br />
J.W. Kieckhefer Foundation<br />
Raise a Racquet for Kids<br />
Tee Up For Tots, Inc.<br />
Tohono O’odham Gaming Enterprise<br />
$15,000 - $24,999<br />
Anonymous<br />
Robyn and Mike DeBell<br />
Maxine and Ralph Henig<br />
Hyundai Hope On Wheels<br />
Jim Click Automotive<br />
Sharon and Donald Ulrich<br />
$10,000 - $14,999<br />
Adelante Foundation<br />
Anonymous<br />
BlueCross BlueShield<br />
Hazel Hare<br />
Karen and Bob Hobbs<br />
Jasam Foundation<br />
Joseph Stanley Leeds Foundation<br />
Carey and John Musil<br />
Ramiro G. Peru<br />
WellPoint Foundation<br />
$5,000 - $9,999<br />
Sydney and Bob Anderson<br />
Bashas’ Charitable Fund<br />
Brenda and George Brimhall<br />
Laurie and Drew Brown<br />
Cardinal Charities, Inc.<br />
Amy and Keith Carney<br />
Missy and Michael Cooley<br />
Cay Cowie<br />
CVS Caremark Corporation<br />
Ardie and Steve Evans<br />
Joan and Fayez Ghishan<br />
DeeAnne and Gregg Gibbons<br />
GoDaddy.com<br />
Shannon and Robert Goldwater<br />
Penny and Larry Gunning<br />
Ruth Ann and Tom Hornaday<br />
Immunovative Therapies, Ltd.<br />
Stephanie and Guy Inzalaco<br />
Steven A. Lightman<br />
Marisa Ann Gallego Foundation<br />
Faye Morse<br />
Melissa and David Mullard<br />
Joellen and Tim Rannow<br />
RBC Dain Rauscher Foundation<br />
Adriana and Jose Rincon<br />
Susan and Larry Ring<br />
Shamrock Foods Company<br />
Linda and William Skov<br />
Nancy and John Teets<br />
The Gaslight Theatre<br />
Benjamin C. Thomas<br />
Tammy and Jon Underwood<br />
Cindy and Les White<br />
Allie and Mike Wilmink<br />
Women <strong>of</strong> <strong>the</strong> Active 20-30 Club<br />
Helen and Chris Yeung<br />
$2,500 - $4,999<br />
Arizona Mail Order, Inc.<br />
Alice and Paul Baker<br />
Laura and Michael Bill<br />
Lee and Frank Bowman<br />
Campbell, Yost, Clare & Norell, P.C.<br />
Caremark Rx, Inc.<br />
Carondelet Health Network<br />
Catalina Mechanical Contracting, Inc.<br />
Kyle and Casey Christensen<br />
Desert Institute for Spine Care, P.C.<br />
DMB Associates<br />
Eli Lilly & Co.<br />
Micheline and Bruce Etkin<br />
Fennemore Craig, P.C.<br />
Stanley D. Friedman<br />
Melinda and John A. Gulick III<br />
Henry Pope Foundation<br />
Sue and Stewart Jean<br />
Jim Boyle Dairy<br />
Linda Kaplan<br />
Lori and James Kelly<br />
Lorna and Mark Kipphut<br />
Jane and Phil Lacovara<br />
Lundy Medical Products, LLC<br />
Magnum Paving, Inc.<br />
Marianne Cracchiolo Mago and<br />
James Mago<br />
Marc Walker Enterprises, Inc.<br />
Judee and David Morrison<br />
Oser Communications Group<br />
PepsiCo Foodservice<br />
Carolyn Ponder<br />
Carol and Jim Schmidt<br />
Sara and Steven Schramm<br />
Susie and Les Small<br />
Maria and Mark Syms<br />
The Hart Family-Orepac Foundation<br />
Art Valles<br />
Kathy and Tom Van Arsdale<br />
Jon C. Walker<br />
Kathy and Craig Walker<br />
Lola and Carl White<br />
$1,000 - $2,499<br />
AAC Structures <strong>of</strong> Arizona, LLC<br />
Anonymous<br />
A.F. Sterling Homes<br />
Alana Studios <strong>of</strong> Design, LLC<br />
Alliance Bank <strong>of</strong> Arizona<br />
Alpha Epsilon Phi Sorority<br />
Amcep Metals, Inc.<br />
American Openings, Inc.<br />
Animas Corporation<br />
Ara Parseghian Medical<br />
<strong>Research</strong> Foundation<br />
Arizona-Sonora Desert Museum<br />
LaDonna and Robin Aron<strong>of</strong>f<br />
Bank <strong>of</strong> Tucson<br />
Carie and Mike Baumann<br />
Beach Fleischman PC<br />
Deanna and Kemp Biddulph<br />
Valerie and Leland Bisbee III<br />
BolchalkFReY Marketing<br />
Louis R. Breton<br />
Broadband Dynamics, LLC<br />
Judy and Darren Burke<br />
Cactus Transport, Inc.<br />
Emily and Daniel Calihan<br />
Norma and Martin Camacho<br />
Joan Kaye Cauthorn and Robert<br />
Cauthorn<br />
Tara and Mark Cavanaugh<br />
Chapman Automotive<br />
Chartwell Group, LLC<br />
John T. Chesley<br />
Ginny Clements<br />
Vicki and Jim Click Jr.<br />
CMS, LLC<br />
Ka<strong>the</strong>rine and Bradley Combs<br />
Marilyn S. Congleton<br />
Donna and Leo Connolly<br />
Lynne K. Cook<br />
Tiffany Crane<br />
Tina and David Curran<br />
David & Sondra Mack Foundation<br />
Carol and Wallace Davis<br />
Kristin and Harrison Dean<br />
Delta Delta Delta Tucson<br />
Alumnae Chapter<br />
Desert Metals Recycling, Inc.<br />
Joan and Don Diamond<br />
Diamond Ventures, Inc.<br />
Marlis and James Dinning<br />
Karen and Mark Doerflein<br />
Dover Associates, LLC<br />
Employer Solutions Group<br />
Enterprise Rent-A-Car Foundation<br />
E<strong>the</strong>l & Jerry Timan Memorial<br />
Family Fund<br />
Meghan and Court Fable<br />
Carmen and Ge<strong>of</strong>frey Ferlan<br />
Susan and Thomas Firth<br />
Pam and Gary Fitzgerald<br />
Susan and David French<br />
Diana and David Freshwater<br />
Anne Fritz<br />
Gary and Teresa Yourtz Foundation<br />
Genentech USA<br />
Alexis and Boz Glascock<br />
Ellen and David Goldstein<br />
Hacienda Del Sol<br />
Megan and Alfred Hackbarth III<br />
Patricia and Howard Harpst<br />
Jamie Cain and Kenneth Head<br />
Stephanie and David Helsten<br />
Becky Hill<br />
Megan and John Hink<br />
Dennis W. Hitzeman<br />
Laura L. Hopkins<br />
Susan and Jim Hunter<br />
Elizabeth and William Imparato<br />
Jewish Federation <strong>of</strong> Sou<strong>the</strong>rn<br />
Arizona<br />
Mark Joseph<br />
J P Industries, Inc.<br />
Tandy and Gary Kippur<br />
Kelly and James Kirke<br />
Kitchell Corporation<br />
Daniel Kivel<br />
Julie and Scott Klewer<br />
Julie and Joe Koeth<br />
Kirsten Korosec<br />
Jill Kusy<br />
Wendy and Sage Lentz<br />
Lewis and Roca LLP<br />
Loews Ventana Canyon<br />
Longbow Golf Club Associates, LLC<br />
Lunda & Associates, P.C.<br />
Macerich Management Company<br />
Jean and Bill Mack<br />
Beth and Bill Madden<br />
Carole and William Mallender<br />
Lisa and Gregory Mallender<br />
Mariana Vazquez and Justin Maloney<br />
Maurice R. & Meta G. Gross<br />
Foundation<br />
John Maus<br />
Amy and Sloane McFarland<br />
McNamara, Goldsmith &<br />
McDonald, P.C.<br />
Clark M. Merkley<br />
Mesch, Clark & Rothschild P.C.<br />
Metal Management Arizona, LLC<br />
Michael P. Bergeron Foundation,<br />
Inc.<br />
Karen and Alexander Mlawsky<br />
Denise A. Monti<br />
Linda and Fred Nachman<br />
Sylvia and Andy Norell<br />
Nova Financial & Investment<br />
Corporation<br />
Novo Nordisk Pharmaceuticals, Inc.<br />
Charles D. Oliver III<br />
Christine and James Orders<br />
Dorothy and Julius Parker<br />
Pfizer, Inc.<br />
Nicole and Larry Pike<br />
Pima County Medical Foundation<br />
Pima County Medical Society<br />
Deborah Oseran and Bobby Present<br />
Monica and David Ramsze<br />
Judy and Bill Ray<br />
Susan B. Rehorn<br />
Gabrielle and Robert Rife<br />
Kathy and Gerald Ritt<br />
Robert J. Kelly DMD, P.C.<br />
Peggy and Jon Rowley<br />
Ryley, Carlock & Applewhite<br />
Sage Tax Group<br />
Sahuaro High School Dance Team<br />
Stephanie and Ricardo Samson<br />
Gretchen and Ryan Schubert<br />
Leila and Ziad Shehab<br />
Casey and James Simmons<br />
Siskiyou Forest Products<br />
Lynne and Volker Sonntag<br />
Lori and Chip Stratton<br />
Cecelia D. Terry<br />
TEVA Pharmaceuticals USA<br />
Sandi and Purdom Thomas<br />
Robyn Kessler and Jeffrey Timan<br />
Kati and Chris Travelle<br />
U.S. Foodservice<br />
Terrye L. Underwood<br />
United Commercial Travelers<br />
<strong>University</strong> Medical <strong>Center</strong><br />
<strong>University</strong> <strong>of</strong> Arizona Foundation<br />
Valley <strong>of</strong> <strong>the</strong> Sun Fine Wines<br />
Blake and Johnjay Van Es<br />
Vantage West Credit Union<br />
Michelle and Marc Walker<br />
Megan and Kris Wall<br />
Donna and T.K. Warfield<br />
Thomas W. Warne<br />
Wells Fargo & Company<br />
Wells Fargo Bank, N.A.<br />
Carol M. Williams<br />
Monica and John Woudenberg<br />
Jaime and Bradley Wright<br />
Victoria and Richard York<br />
In-kind Donors<br />
Abbott Taylor Jewelers<br />
American Openings, Inc.<br />
Christina and K.C. An<br />
Arizona Elks Major Projects<br />
BizTucson<br />
Broadmoor Spa, Golf and Tennis Club<br />
Anita L. Burg<br />
Enchantment Resort<br />
Fairmont Southampton<br />
Jon Wolf Photography, Inc.<br />
Kick Cancer for Stephen Foundation<br />
La Jolla Beach and Tennis Club<br />
Loews Ventana Canyon<br />
St. Regis Resort<br />
Terranea Resort<br />
Tucson Police Foundation<br />
US Airways Group<br />
17
Department <strong>of</strong> Pediatrics Faculty Fayez K. Ghishan, MD, Pr<strong>of</strong>essor and Head<br />
Cardiology<br />
Section Chief: Ricardo Samson, MD<br />
Pr<strong>of</strong>essor<br />
Brent Barber, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Stan Goldberg, MD<br />
Pr<strong>of</strong>essor Emeritus<br />
Scott Klewer, MD<br />
Pr<strong>of</strong>essor<br />
Daniela Lax, MD<br />
Associate Pr<strong>of</strong>essor<br />
Gregory Mike Nichols, MD<br />
Clinical Lecturer<br />
Santiago Valdés, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Critical Care<br />
Section Chief: Andreas Theodorou, MD<br />
Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Marc Berg, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Hillary Franke, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Mary Gaspers, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Michael Karadsheh, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Robyn Meyer, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Katri Typpo, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Mark Witten, PhD<br />
<strong>Research</strong> Pr<strong>of</strong>essor<br />
Simon Wong, MD<br />
<strong>Research</strong> Associate Pr<strong>of</strong>essor<br />
Developmental & Behavioral<br />
Pediatrics<br />
Sydney A. Rice, MD, MS<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Margaret Trouard, MD<br />
Clinical Lecturer<br />
Endocrinology<br />
Section Chief: Mark Wheeler, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Kurt Griffin, PhD, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Chetan Patel, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Gastroenterology<br />
Section Chief: Hassan Hassan, MD<br />
Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Fayez K. Ghishan, MD<br />
Pr<strong>of</strong>essor and Department Head<br />
Pawel Kiela, PhD<br />
<strong>Research</strong> Associate Pr<strong>of</strong>essor<br />
Hua Xu, PhD<br />
<strong>Research</strong> Associate Pr<strong>of</strong>essor<br />
General Pediatrics<br />
Section Chief: Kimberly Gerhart, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Conrad Clemens, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Thomas Ball, MD<br />
Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Kathryn Bowen, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Karen Davenport, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Tracey Kurtzman, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
William Madden, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
William Marshall Jr., MD<br />
Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Richard Wahl, MD<br />
Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Genetics<br />
Section Chief: Christopher Cunniff, MD<br />
Pr<strong>of</strong>essor<br />
Robert Erickson, MD<br />
Pr<strong>of</strong>essor<br />
John Meaney, PhD<br />
<strong>Research</strong> Lecturer<br />
Hematology/Oncology<br />
Section Chief: Emmanuel Katsanis, MD<br />
Pr<strong>of</strong>essor<br />
Michael Graham, MD<br />
Associate Pr<strong>of</strong>essor<br />
Nicolas Larmonier, PhD<br />
<strong>Research</strong> Associate Pr<strong>of</strong>essor<br />
Brenda Wittman, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Hospital Medicine/Outreach<br />
Section Chief: Cleo Hardin, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Rachel Cramton, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Nancy Gruchala, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Eliza Holland, MD<br />
Clinical Lecturer<br />
Zakiya Karim, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Chan Lowe, Jr., MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Hengameh Rastegar-Murphy, MD<br />
Clinical Lecturer<br />
Jasna Seserinac, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Infectious Diseases<br />
Section Chief: Ziad Shehab, MD<br />
Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Sean Elliott, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Neonatology<br />
Section Chief: Alan Bedrick, MD<br />
Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Jasmine Ahmed, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Bohuslav Dvorak, PhD<br />
<strong>Research</strong> Pr<strong>of</strong>essor<br />
Edith Edde, DO<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Melissa Halpern, PhD<br />
<strong>Research</strong> Associate Pr<strong>of</strong>essor<br />
Ca<strong>the</strong>rine Tsai, MD<br />
Assistant Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Nephrology<br />
Section Chief: Emmanuel Apostol, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Pulmonology, Allergy and Immunology<br />
Section Chief: Wayne Morgan, MD<br />
Pr<strong>of</strong>essor<br />
Mark Brown, MD<br />
Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Cori Daines, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Michael Daines, MD<br />
Assistant Pr<strong>of</strong>essor<br />
Roni Grad, MD<br />
Associate Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Fernando Martinez, MD<br />
Pr<strong>of</strong>essor<br />
Anne Wright, PhD<br />
<strong>Research</strong> Pr<strong>of</strong>essor<br />
Phoenix Clerkship Program<br />
Kipp Charlton, MD<br />
Clinical Associate Pr<strong>of</strong>essor<br />
Maricopa Medical <strong>Center</strong><br />
John Muhm Jr., MD<br />
Clinical Assistant Pr<strong>of</strong>essor<br />
Phoenix Children’s Hospital<br />
Kristin Samaddar, MD<br />
Clinical Assistant Pr<strong>of</strong>essor<br />
St. Joseph’s Hospital<br />
Mitchell Shub, MD<br />
Pr<strong>of</strong>essor, Clinical Pediatrics<br />
Phoenix Children’s Hospital<br />
<strong>Steele</strong> <strong>Center</strong> Advisory Boards<br />
Tucson<br />
Advisory Board<br />
Chair: Phil Lacovara, PhD<br />
Active Members<br />
Louis Breton<br />
Ginny Clements<br />
Bill Cox<br />
Bert Dover<br />
Jay Foust<br />
DeeAnne Gibbons<br />
Cynthia Goodman Shaw<br />
Linda Immerman-St<strong>of</strong>fers<br />
Beth Koontz<br />
Bill Krauss<br />
Troy Little<br />
Andrea Malis<br />
Andy Norell<br />
Ray Novak, MD<br />
Kathy Orr<br />
Larry Ring<br />
Steve Rosenberg<br />
Peggy Rowley<br />
Dian Rutin<br />
Judy Smedes<br />
Jeremy Sohn<br />
Tom Strasburg<br />
Louise Thomas<br />
Consulting Members<br />
Judy Abrams<br />
Joan Kaye Cauthorn<br />
Robert Davis<br />
Norma Feldman<br />
Shirley Fulginiti<br />
Mark Kipphut<br />
Ruth Mondschein, PhD<br />
David Sitton<br />
Credits:<br />
Writer/Editor/Art Director/Designer<br />
Darci Slaten, MA<br />
Director <strong>of</strong> Communications and Marketing<br />
Graphic Design<br />
Roma Krebs, AHSC BioCommunications<br />
Editorial Board<br />
George Humphrey, MA<br />
Director, AHSC Office <strong>of</strong> Public Affairs<br />
Honorary Members<br />
Lissa Marinaro<br />
William Foucher<br />
Linda Lewandowski<br />
Life Members<br />
Joan Diamond<br />
Virginia Furrow, MD<br />
Maxine Henig<br />
Cele Peterson<br />
Lynn Taussig, MD<br />
Louise Thomas<br />
Phoenix<br />
Advisory Board<br />
Chair: Kim Sterling-Heflin<br />
Kirk Aleck, MD<br />
John Checkett<br />
Mary Chick<br />
Robyn DeBell<br />
Jodi Freeman<br />
Penny Gunning<br />
Annette Heasman<br />
Patti Lau<br />
Bill Mack<br />
Phillippa Maltese<br />
Karen Meyer<br />
Andy Plattner<br />
Bill Ridenour<br />
Jan Neal Riemar<br />
Joan Rankin Shapiro, PhD<br />
Mitch Shub, MD<br />
Margo Smith<br />
Greg Stanton<br />
Judy Walruff, PhD<br />
Dick Whitney<br />
Phoenix<br />
Women’s<br />
Advisory Board<br />
(PANDA)<br />
President:<br />
Stephanie Helsten<br />
Trisha Anthony<br />
Tifanny Anton<br />
Ashley Baiker<br />
Sara Baldwin<br />
Charlene Berge-Blum<br />
Alexandra Boyle<br />
Judy Burke<br />
Emily Calihan<br />
Sarah Carlenzoli<br />
Kyle Christensen<br />
Heidi Coupland<br />
Lisa Cowan<br />
Tiffany Crane<br />
Tina Curran<br />
Christy Dean<br />
Kristin Dean<br />
Robyn DeBell<br />
Jacquie Dorrance<br />
Jennifer Dougherty<br />
Debbi Douglas<br />
Kay Eskridge<br />
Meghan Fable<br />
Dana Gapusan<br />
Lora Golke<br />
Melinda Gulick<br />
Penny Gunning<br />
Megan Hackbarth<br />
Tori Heintzelman<br />
Nancy Hepburn<br />
Megan Hink<br />
Ca<strong>the</strong>rine Jacobson<br />
Lori Kelly<br />
Melissa Kenly<br />
Kelly Kirke<br />
Julie Koeth<br />
Photography<br />
Martha Lochert Photography (Cover; About Cover)<br />
Margaret Hartshorn<br />
- AHSC BioCommunications (p. 15)<br />
Laura Hopkins (p. 13)<br />
Francie Placencia (p. 7)<br />
Darci Slaten (all o<strong>the</strong>r photos)<br />
Lyra Waggoner (p. 12)<br />
Pam Kolbe<br />
Wendy Lentz<br />
Kari MacDonald<br />
Amy Mahoney<br />
Lisa Mallender<br />
Lizabeth Mat<strong>the</strong>ws<br />
Traci Mead<br />
Ashley Ragan<br />
Julie Rauch<br />
Judy Ray<br />
Kathy Ritt<br />
Laurie Ritt<br />
Erika Sahagun<br />
Gretchen Schubert<br />
Susie Small<br />
Tracy Smith<br />
Kati Travelle<br />
Gerri Tsantilas<br />
Kristin Ulrich<br />
Tammy Underwood<br />
Julie Vogel<br />
Carol Waldrop*<br />
Kathy Walker<br />
Michelle Walker<br />
Megan Wall<br />
Karin Weiler<br />
Nancy White<br />
Linda Whitney<br />
Allie Wilmink<br />
Susan Wissink<br />
Jaime Wright<br />
Helen Yeung<br />
*In memorium<br />
Golden PANDAs<br />
Carolyn Bosworth<br />
Ann Denk<br />
Suellen Edens<br />
Pam Fitzgerald<br />
Carol Schmidt<br />
Mary Lynn Schmidt<br />
Judy Shannon<br />
Sandi Thomas<br />
Associate<br />
Members<br />
Sydney Anderson<br />
Nancy Berge<br />
Muffie Churchill<br />
Joan Colangelo<br />
Kathy DeSanto<br />
Kelly Eaton<br />
Ardie Evans<br />
Diana Finley<br />
Lindsey Gladwin<br />
Ruthann Grace<br />
Carol Hebets<br />
Karen Hobbs<br />
Michelle Hobbs<br />
RuthAnn Hornaday<br />
Mary Hudak<br />
Jennifer Irby<br />
Kerry Jameson<br />
Cathy Kleeman<br />
Kathleen Lang<br />
Beth Mat<strong>the</strong>ws<br />
Carey Musil<br />
Stacie Olson<br />
Pam Overton<br />
Ka<strong>the</strong>y Plenge<br />
Kerrie Schmidt<br />
Judy Schubert<br />
Lynne Sonntag<br />
Anne Spellman<br />
Kim Sterling-Helfin<br />
Sharon Ulrich<br />
Kathy Van Arsdale<br />
Desha Whitney-Wikle<br />
Additional Assistance<br />
Laura Hopkins<br />
Katie Riley<br />
Thomas S. Sanders<br />
Jean Spinelli<br />
Mariana Vazquez, MS<br />
Lori Stratton, MPH<br />
Additional Writing<br />
Laura Hopkins<br />
18<br />
Director <strong>of</strong> Development<br />
Lori Stratton, MPH<br />
Mariana Vazquez, MS<br />
19
2010 Events<br />
April 10<br />
PANDA 11th Annual<br />
“Children Helping Children”<br />
Fashion Show<br />
Arizona Biltmore Resort and Spa, Phoenix<br />
May 7<br />
Fa<strong>the</strong>r’s Day Council Golf Classic<br />
Loews Ventana Canyon<br />
June 19<br />
Fa<strong>the</strong>rs <strong>of</strong> <strong>the</strong> Year Awards Gala<br />
Loews Ventana Canyon<br />
August 27<br />
Tee Up For Tots Golf Tournament<br />
Hilton El Conquistador<br />
Fall 2010<br />
Raise A Racquet for Kids<br />
Tucson Racquet and Fitness Club<br />
Fall 2010<br />
Runway for <strong>Research</strong><br />
Hilton El Conquistador<br />
December 2010<br />
PANDA 3rd Annual<br />
“Playing FORE PANDA”<br />
Golf Tournament<br />
Phoenix, Arizona<br />
The <strong>University</strong> <strong>of</strong> Arizona<br />
<strong>Steele</strong> Children’s <strong>Research</strong> <strong>Center</strong><br />
Department <strong>of</strong> Pediatrics<br />
PO Box 245073<br />
Tucson, AZ 85724-5073<br />
About <strong>the</strong><br />
<strong>Steele</strong> <strong>Center</strong> Logo<br />
O<br />
ur logo is an incomplete puzzle, with a<br />
child in <strong>the</strong> center. The pieces to <strong>the</strong> puzzle<br />
represent everyone who is integral to improving<br />
children’s health…doctors, nurses, medical staff,<br />
researchers, families, volunteer groups, donors<br />
and o<strong>the</strong>rs. We all can be a piece <strong>of</strong> <strong>the</strong> puzzle,<br />
working toge<strong>the</strong>r to improve children’s health.<br />
The puzzle isn’t finished, because we can’t do it without YOU.<br />
Thank you for your support! To learn more about <strong>the</strong> <strong>Steele</strong><br />
<strong>Center</strong>, please visit www.steelecenter.arizona.edu.<br />
Stay connected to <strong>the</strong> <strong>Steele</strong> <strong>Center</strong><br />
Learn more about what’s happening<br />
at <strong>the</strong> <strong>Steele</strong> <strong>Center</strong> through our Web site:<br />
www.steelecenter.arizona.edu<br />
Stay current with our e-newsletter.<br />
Sign up at: www.steelecenter.arizona.edu<br />
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NONPROFIT ORG<br />
US POSTAGE PAID<br />
TUCSON ARIZONA<br />
PERMIT NO. 190