Reproduktionsmedizin und Endokrinologie - DIR Deutsches IVF ...

Journal für6. Jahrgang 2009 // Nummer 2 // ISSN 1810-2107ReproduktionsmedizinNo.22009und Endokrinologie– Journal of Reproductive Medicine and Endocrinology –Andrologie • Embryologie & Biologie • Endokrinologie • Ethik & Recht • GenetikGynäkologie • Kontrazeption • Psychosomatik • Reproduktionsmedizin • UrologieDIR Annual 2009Bühler K, Bals-Pratsch M, Kupka MSand the Board of TrusteesJ. Reproduktionsmed. Endokrinol 2010; 7 (6), 470-497www.kup.at/repromedizinOnline-Datenbank mit Autoren- und StichwortsucheOffizielles Organ: AGRBM, BRZ, DIR, DVR, DGA, DGGEF, DGRM, EFA, OEGRM, SRBM/DGEIndexed in EMBASE/Excerpta MedicaMember of theKrause & Pachernegg GmbH, Verlag für Medizin und Wirtschaft, A-3003 Gablitz

EditorialD.I.R Annual 2009 – German IVF-Registry e. V.K. Bühler, M. Bals-Pratsch, M. S. Kupka, and the Board of TrusteesChair: Dr. med. K. BühlerPrevious Chairs: Prof. Dr. med. R. Felberbaum (1995–2007), Prof. Dr. med. H.-K. Rjosk (1992–1995), Prof. Dr. med. F. Lehmann (1982–1992)Board of Trustees: Verona Blumenauer, Dr. med. K. Fiedler, PD Dr. med. C. Gnoth, Dr. med. L. Happel, Prof. Dr. med. J. S. Krüssel,coopted member: Prof. Dr. med. R. FelberbaumGerman Society for Gynaecological Endocrinology and Reproductive Medicine e.V.President: Prof. Dr. med. Dr. h. c. mult. T. RabeFederal Association of German Centers for Reproductive Medicine e.V.Chair: Dr. med. U. HillandGerman Society for Reproductive Medicine e. V.Chair: Prof. Dr. med. J.-S. KrüsselJ Reproduktionsmed Endokrinol 2010; 7 (6): 470–97.• PrefacePresenting data of the year 2009, theGerman IVF Registry (Deutsches IVFRegister, D·I·R.) has already started topublish the annual report in this journal.Since 1996 the structure of this reporthas combined standard analysis and specialcharts focusing on new aspects. Thisyear we have included a statistic concerningthe so-called „ideal patient“ andthe pregnancy rates for each center.In Germany advertising is not allowed inthe medical field. Therefore all datamust be published anonymously.In 2009 the number of centers increasedfrom 119 to 121. The amount of socalledfresh IVF and ICSI cycles also increasedby 7% compared to 2008 – includingcycles in which IVF and ICSIwas performed simultaneously.This is a positive development after thetremendous decrease in 2004 caused bya dramatic change in the public healthreimbursement system.In 1997, so-called prospective measureswere introduced to the dataset. Usingone of the three different software toolscurrently available, the treatment cyclemust be recorded within 7 days of controlledovarian stimulation. This featureis intended to prevent cycle selection andis one of the most powerful quality toolsimplemented by the German system. In2009 84.3% of all IVF and ICSI cyclesfit this criterion.A dynamic link library (DLL) maintainedby the registry allows data plausibilityto be monitored either online orshortly after data input. In 2009 97.24%of all cycles fit this criterion.The average pregnancy rate for all11,715 IVF cycles was 29.5%, comparedwith a rate of 28.6% for the 9,830ICSI cycles. A simultaneous treatment ofIVF and ICSI (IVF/ICSI) in one cyclewas performed in 254 cases, while socalledcryopreserved embryo transfer(CPE, embryos derived from cryo-preservedoocytes in the 2-PN-stage) wasperformed in 17,116 cases. Here, thepregnancy rate was recorded as being18.9%.Because of German legal restrictions,oocytes were only allowed to be frozenin the pronuclear stage. No embryo selectionis permitted. The Embryo ProtectionAct, passed in 1991, permits nomore than three embryos to be transferred.A higher rate of multiple births (twins,triplets or more) was documented for amaximum of 7.8% of all pregnancies.The number of lost for follow-up will be40.6% due to the early deadline for dataexport to D·I·R this year. This numberwill be updated and republished as partof the next annual report.Since the registry requests that data forboth the current year as well as for pastyears be sent, this figure generally willdrop to less than 15 % the followingyear.In order to provide additional informationabout pregnancy outcomes, the nationalregistry of assisted reproductivetreatments expends a great deal of effortin following up on induced pregnancies.As in other European nations, numerousforeign couples are also treated in Germany,making it rather difficult to obtaininformation related to the outcome ofthese pregnancies.For the first time, this publication providesan English version of an annual report.In the past, some papers have alreadyprovided details regarding certainspecial aspects. The huge dataset whichis expected to reach one million in 2010also allows us to research specific aspectssuch as lifestyle factors (smoking,weight) or reproductive history (formerpregnancies, miscarriages etc.).From our perspective, the greatest advanceof the German IVF Registry lies inthe decision of nearly every IVF unit tosupport its work through a prospectivedata collection and through paymentsmade to maintain the Registry files.Correspondence: D . I . R committee’s offices, c/o Chamber of Physicians of Schleswig-Holstein, Bismarckallee 8–12, D-23795 Bad Segeberg, Phone 0049 4551/803-147,Fax 0049 4551/803-231, E-Mail: dir@aeksh.orgContact: Mirja Wendelken, Wolfgang Dahncke, Dr. Valentin Babaev, www.deutsches-ivf-register.de470 J Reproduktionsmed Endokrinol 2010; 7 (6)

EditorialPREFACE 470ContentsGENERAL SURVEY OF ART IN GERMANYOutcome of ART 2009 473Number of IVF centres 1982–2009 473Number of treatment cycles 1982–2009 (plausible cycles) 473Number of treatment cycles 2009 (prospective cycles) 474Number of cycles with ovum pick up 2009 474Statistics in short 2009 IVF, ICSI and IVF/ICSI 474D·I·R. statistics in short 2009 475D·I·R. statistics in short 2008 (update to annual 2008) 476Clinical pregnancies, miscarriages, ectopic pregnancies and stillbirths 2008 477Multiple deliveries 2008 477Deliveries as a function of the number of embryos transferred and agegroups (2000–2008) 478Deliveries as a function of the number of embryos transferred –IVF, ICSI, cryo-transfer (2000–2008) 478Fertilisation rate per oocyte IVF, ICSI 2009 479Distribution of indications for IVF and ICSI 2009 479OUTCOME OF IVF, ICSI AND FROZEN-THAWED EMBRYO TRANSFERCYCLE (FET)Outcome of IVF, ICSI and FET 480Outcome as a function of woman’s age – IVF 2009 481Outcome as a function of woman’s age – ICSI 2009 481Clin. Preg. rate as a function of the number of embryos transferredand age groups 2009 482Clin. Preg. rate as a function of the embryo quality IVF, ICSI, IVF/ICSI 2009 482Clin. Preg. rate as a function of the embryo quality, FET 2009 483Miscarriage rates as a function of woman’s age and number of embryostransferred 2009 483Clinical pregnancy-rates as a function of the stimulation protocol –IVF and ICSI 2009 484Preg. rate/ovum pick up (OPU) as a function of the n. OPU and age 485Birth weight of singletons as a function of the kind of treatment (2000–2009) 485Successful fertilisation per treatment cycle as a function of semenanalysis before and after sperm preparation 486Number of initial treatment cycles per year (1997–2009) 487Average age of women and men (1997–2009) 487Triplet births: incidence after two and three embryos transferred (1997–2009) 487J Reproduktionsmed Endokrinol 2010; 7 (6) 471

EditorialContents CHILDREN BORNAll children (1997–2009) 488Childrens birth weight (bw) and week of gestation (wg) 2008 (singleton,twin, triplet) 489OHSS AND COMPLICATIONSComplications as a function of ovum pick up (OPU) 2009 490OHSS as a function of the stimulation protocol – IVF, ICSI, IVF/ICSI 2009 490QUALITY OF THE CENTRES OUTCOMEDistribution of patients with “ideal prognosis” as a function of size ofcentre (2000–2009) 491Pregnancy rate of patients with “ideal prognosis” and of the remainingpatients as a function of size of centre (2000–2009) 492LIST OF CENTRES PARTICIPATING IN D·I·R 493472 J Reproduktionsmed Endokrinol 2010; 7 (6)

Outcome of ART 2009centres for IVF-, ICSI-, GIFT- und cryo-transfer treatmentsParticipating IVF centres n = 121Data received until deadline (19.08.2010) n = 121Documented treatment cycles n = 75,662 (100.00 %)Plausibel n = 73,579 (97.24 %)Prospective (all cycles) n = 61,748 (83.92 %)Prospective (IVF, ICSI, IVF/ICSI) n = 41,924 (84.52 %)Number of treated women* n = 46,281Treatment cycles per women (mean) 1.63*) Base quantity: all women with specified age; implausible treatment cycles are counted also.Number of IVF centres 1982 - 2009for IVF-, ICSI-, GIFT- and cryo-transfer treatments1982 1986 1990 1994 1996 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009IVFICSICryoGIFT5000280014530036663219236659351486856349292758100987771071089551121129761141161018118120112211711710911201201090118118112111712011211191191171Total* 71 86 92 102 108 112 116 120 117 121 118 120 121*) for the years before 1997 (implementation of electronic data processing in D.I.R.) no data is avaiableNumber of treatment cycles 1982 - 2009 (plausible cycles)IVF, ICSI, IVF/ICSI, GIFT, cryo-transfer1982 1986 1990 1994 1996 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009IVF742 3,8067,34316,17514,49416,76321,88028,94528,50623,93628,05811,84811,09811,08211,36211,26411,715ICSI5,85616,23323,57821,24415,75224,89737,69251,38925,33925,53228,01531,45234,33337,006IVF/ICS424962790695678987446590672798834881Cryo4992,6604,6167,6619,45712,19514,92314,26516,88314,47114,92616,56617,64617,912GIFTnone *3809858294201167416,600256,562197,507139,8022211,13344,92824,53904,60015,13705,82526,063Total 742 4,201 8,653 23,684 33,993 45,459 58,388 61,531 73,819 87,044 105,854 59,448 56,232 59,295 65,316 69,902 73,579Since 1999 all started treatment cycles are documented.*) no treatment: aborted treatments before oocyte cultureJ Reproduktionsmed Endokrinol 2010; 7 (6) 473

Number of treatment cycles 2009 (prospective cycles)IVF, ICSI, IVF/ICSI, cryo-transferIVF ICSI IVF/ICSI cryo-transfer no treatment SummeAnzahl 9,882 31,289 753 14,476 5,346 61,748*in % 16.00 50.67 1.22 23.44 8.66 100.00*) two prospective GIFT-treatments are enclosedn 55,000Number of cycles with ovum pick up (OPU) 2009IVF, ICSI50,00045,00040,000IVFICSI35,00030,00025,00020,00015,00010,0005,000019821983198419851986198719881989199019911992199319941995199619971998199920002001200220032004200520062007200820091982 1986 1990 1994 1996 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009IVF742 3,806 7,343 16,17514,34414,02421,88028,94528,50623,93628,05811,84811,41011,08211,36211,04811,715ICSI5,85616,10822,42021,24415,75224,89737,69251,38925,33926,37028,01531,45233,59137,006Total* 742 3,806 7,343 22,031 30,452 37,933 44,086 45,487 54,098 62,306 80,434 37,633 38,382 39,769 43,612 45,461 49,602*) the value for IVF/ICSI is enclosed in “total”, for instance in 2009: 881 OPU.Prospectively and retrospectively collected data were used.Statistics in short 2009 for IVF, ICSI and IVF/ICSIGerman IVF Registry, status: 19.08.2010IVF-, ICSI-,IVF/ICSItreatments49,602100.00 %Fertilisations47,37995.52 %Transfer45,62396.29 %Clin. PR/ET13,17528.88 %Annotation to the loss for follow up-rate (“not yet recorded”):the early deadline for data collection is reflected in here.Prospectively and retrospectively collected data were used.Life-birth5,028 38.16 %Miscarriage2,439 18.51 %Ectopic pregnancy213 1.62 %Not yet recorded5,495 41.71 %Singelton3,938 78.32 %Twin1,047 20.82 %Triplet42 0.84 %Quadruplet1 0.02 %474 J Reproduktionsmed Endokrinol 2010; 7 (6)

D.I.R. statistics in short 2009German IVF Registrystatus: 19.08.2010Recorded cycles 200975,662 100.00 %Plausible cycles 2009 (prospective and not prospective)73,579* 97.24 %Stimulation for ovum pick up54,239 73.71 %Cooperation for cryo-transfer19,340 26.28 %OPU50,993 94.01 %No OPU3,246 5.99 %Oocytes aspirated50,131 98.31 %oocyte culture49,604 98.95 %No oocytes862 1.69 %No oocyte culture527 1.05 %Thawing not performed1,428 7.38 %IVF11,715 23.62 %ICSI37,006 74.60 %IVF/ICSI881 1.78 %Thawings performed17,912 92.62 %FertilisationFertilisationFertilisation10,862 92.72 %35,648 96.33 %869 98.64 %Transfer10,468 96.37 %(per IVF treatment: 89.35 %)Transfer34,334 96.31 %(per ICSI treatment: 92.78 %)Transfer821 94.48 %(per IVF/ICSI treatment: 93,19 %)Cryo-transfer17,116 95.55 %Clin. PR/ETClin. PR/ETClin. PR/ETClin. PR/ET3,091 29.53 %9,830 28.63 %254 30.94 %3,235 18.90 %Delivery Miscarr. Ectopicpregn.1,152 556 6737.27 % 17.99 % 2.17 %Not yet recorded1,316 42.58 %Delivery Miscarr. Ectopicpregn.3,765 1,843 14138.30 % 18.75 % 1.43 %Not yet recorded4,081 41.52 %Delivery Miscarr. Ectopicpregn.111 40 543.70 % 15.75 % 1.97 %Not yet recorded98 38.58 %Delivery Miscarr. Ectopicpregn.1,299 749 5540.15 % 23.15 % 1.70 %Not yet recorded1,132 34.99 %Singleton890 77.26 %Singleton2,960 78.62 %Singleton88 79.28 %Singleton1,104 84.99 %Twin250 21.70 %Twin775 20.58 %Twin22 19.82 %Twin188 14.47 %Triplet12 1.04 %Triplet29 0.77 %Triplet1 0.90 %Triplet7 0.54 %Quadruplet0 0.00 %Quadruplet1 ** 0.03 %Quadruplet0 0.00 %Quadruplet0 0.00 %*) 6,063 cases without continued treatment are enclosed**) Quadruplet: woman 40 years, man 34 years, first treatment cycle, 2 embryos transferredJ Reproduktionsmed Endokrinol 2010; 7 (6) 475

D.I.R. statistics in short 2008 (update to annual 2008)German IVF Registrystatus: 19.08.2010Recorded cycles 200872,053 100.00 %Plausible cycles 2008 (prospective and not prospective)69,902* 97.01 %Stimulation for ovum pick up50,828 72.71 %Cooperation for cryo-transfer19,074 27.29 %OPU47,692 93.83 %No OPU3,136 6.17 %Oocytes aspirated46,875 98.28 %Oocyte culture46,431 99.05 %No oocytes817 1.71 %No oocyte culture444 0.95 %Thawing not performed1,164 6.57 %IVF11,264 24.26 %ICSI34,333 73.94 %IVF/ICSI834 1.80 %Thawings performed17,646 92.51 %FertilisationFertilisationFertilisation10,495 93.17 %33,056 96.28 %831 99.64 %Transfer10,085 96.90 %(per IVF treatment: 89.53 %)Transfer31,888 96.46 %(per ICSI treatment: 92.88 %)Transfer781 93.98 %(per IVF/ICSI treatment: 93.65 %)Cryo-transfer16,823 95.34 %Clin. PR/ETClin. PR/ETClin. PR/ETClin. PR/ET3,033 30.07 %9,161 28.73 %240 30.73 %3,054 18.15 %Delivery Miscarr. Ectopicpregn.1,877 666 7461.89 % 21.96 % 2.44 %Not yet recorded416 13.72 %Delivery Miscarr. Ectopicpregn.5,786 1,814 14663.16 % 19.80 % 1.59 %Not yet recorded1,415 15.45 %Delivery Miscarr. Ectopicpregn.155 41 664.58 % 17.08 % 2.50 %Not yet recorded38 15.83 %Delivery Miscarr. Ectopicpregn.1.890 789 5961.89 % 25.83 % 1.93 %Not yet recorded316 10.35 %Singleton1,434 76.40 %Singleton4,572 79.02 %Singleton118 76.13 %Singleton1,603 84.81 %Twin426 22.70 %Twin1,162 20.08 %Twin35 22.58 %Twin280 14.81 %Triplet17 0.91 %Triplet51 0.88 %Triplet1 0.65 %Triplet7 0.37 %Quadruplet0 0.00 %Quadruplet1** 0.02 %Quadruplet1*** 0.65 %Quadruplet0 0.00 %*) 5,825 cases without continued treatment are enclosed. **) Quadruplet: woman 28 years, man 34 years, first treatment cycle, 2 embryos transferred***) Quadruplet: woman 28 years, man 27 years, first treatment cycle, 2 embryos transferred476 J Reproduktionsmed Endokrinol 2010; 7 (6)

Clinical pregnancies, miscarriages, ectopic pregnancies and still births 20082008IVFn %ICSIn %IVF/ICSIn %cryo-transfern %Treatment cyclesClin. pregnanciesn. a.DeliveriesMiscarriagesInduced abortions and fetalreductions*Ectopic pregnanciesChildrenDead newborns **MalformationsBaby-take-home rate ***11,2643,0334161,87766648 (49)742,3371928Prospectively and retrospectively collected data were used.34,333100.00 9,16113.72 1,41561.89 5,78621.96 1,8141.58 116 (123)2.44 1467,0530.81 411.20 8116.6617.30 118.95 2834100.00 24015.45 3863.16 15519.80 411.27 4 (4)1.59 61950.58 31.15 116.8517.58 119.46 217,646100.00 3,05415.83 31664.58 1,89017.08 7891.67 27 (34)2.50 592,1841.54 170.51 1518.5919.47 121.53 2100.0010.3561.8925.830.88*) Number of cycles, in which an induced abortion/fetal reduction was documented. Detailed data cannot be given. Number of embryos are given in brackets.**) Number of dead newborns corresponding to the number of children***) Number of deliveries in correlation to the number of treated cycles given in percent1 ) Total number of treatment cycles reduced for those cycles with unknown pregnancy outcome2 ) For cycles with unknown pregnancy outcome the probable rate for deliveries was calculated (delivery per pregnancy) and added to the reported numberof deliveries1.930.780.6910.7110.91 111.82 2Delivery rate/transfer for patients with 2 embryos transferred and at least 2 2PN stages in abundance: IVF 24.52 %, ICSI 24.05 %, IVF/ICSI 25.00 %Multiple deliveries 2008%100908070singletontwintripletquadruplet3020Prospectivelyand retrospectivelycollecteddata wereused.100IVF ICSI IVF/ICSIcryo-transferIVF ICSI IVF/ICSI cryo-transferCLin. PR/ETDeliveriesSingletonTwinTripletQuadrupletn. a.MiscarriagesEctopic Pregn.n % % n % % n % % n % %3,0331,8771,43442617041666674100.0061.8944.2814.050.560.0013.7221.962.44100.0076.4022.700.910.009,1615,7864,5721,1625111,4151,814146100,0063,1649,9112,680,560,0115,4519,801,59100.0079.0220.080.880.02240155118351138416100.0064.5849.1714.580.420.4215.8317.082.50100.0076.1322.580.650.653,0541,8901,6032807031678959100.0061.8952.499.170.230.0010.3525.831.93100.0084.8114.810.370.00J Reproduktionsmed Endokrinol 2010; 7 (6) 477

Deliveries as a function of the number of embryos transferredand age groups 2000 - 2008 - IVF, ICSI, IVF/ICSI, cryo-transferage ofwomanup to24years25 - 29years30 - 34years35 - 39years1 embryo2 embryos3 embryos1 embryo2 embryos3 embryos1 embryo2 embryos3 embryos1 embryo2 embryos3 embryosSingleton Twin Triplet Quadruplet Totaln % n % n % n % n1041,376258100.0077.0468.0704031000.0022.5626.3907190.000.395.010020.000.000.531041, 786379Total 1,738 76.60 503 22.17 26 1,15 2 0.09 2,26982611,0822,29398.2275.9768.76153,4468551.7823.6225.640581840.000.405.520230.000.010.0984114,5883,335Total 14,201 75.68 4,316 23.00 242 1,29 5 0.03 18,7641,86821,9786,33998.1678.1270.85356,0492,2431.8421.5025.0701043600.000.374.020150.000.000.061,90328,1328,947Total 30,185 77.43 8,327 21.36 464 1.19 6 0.02 38,9821,92515,0888,10798.1183.6076.65372,9172,2411.8916.1621.190422270.000.232.150120.000.010.021,96218,04810,577Total 25,120 82.13 5,195 16.98 269 0.88 3 0.01 30,58740 andolder1 embryo2 embryos3 embryos2941,4111,64799.6691.9286.9111222390.347.9512.610190.000.070.470100.000.070.002951,5351,895Total 3,352 89.99 362 9.72 10 0.27 1 0.03 3,725Total number of deliveries 2000 - 2008: 94,327Prospectively and retrospectively collected data were used.Deliveries as a function of the number of embryos transferredIVFICSI1 embryo2 embryos3 embryos1 embryo2 embryos3 embryoscryo-transfer1 embryo2 embryos3 embryos2000 - 2008 - IVF, ICSI, cryo-transferSingletonn %1,442 98.3613,861 76.705,189 70.68Twinn %24 1.644,142 22.921,813 24.69Tripletn %0 0.0068 0.38334 4.55Quadrupletn %0 0.001 0.016 0.08Totaln1,46618,0727,342Total 20,492 76.23 5,979 22.24 402 1,50 7 0.03 26,880Singletonn %2,339 98.4828,459 79.199,507 74.22Twinn %36 1.527,359 20.482,914 22.75Tripletn %0 0.00118 0.33383 2.99Quadrupletn %0 0.003 0.015 0.04Totaln2,37535,93912,809Total 40,305 78.84 10,309 20.16 501 0.98 8 0,02 51,123Singletonn %1,190 97.787,844 86.393,735 79.45Twinn %27 2.221,214 13.37890 18.93Tripletn %0 0.0022 0.2475 1.60Quadrupletn %0 0.000 0.001 0.02Totaln1,2179,0804,701Total 12.769 85.14 2,131 14.21 97 0.65 1 0.01 14,998Total number of deliveries 2000 - 2008 IVF, ICSI, cryo-transfer: 93,001Prospectively and retrospectively collected data were used.478 J Reproduktionsmed Endokrinol 2010; 7 (6)

Fertilisation rate per oocyte IVF and ICSI 2009IVF22.53 % 89,312Fertilisation rate52.47 % 46,863Embryos transferred/cycle(mean)2.03Oocytesaspirated396,424ICSI61.92 % 245,454Fertilisation rate64.25 % 157,692Embryos transferred/cycle(mean)2.06Cycles42,479 1Oocytes/cycle9,33Cryopreservation of oocytes0.14 % 553Fertilisation not possible 215.41 % 61,105Only prospectively collected data were used1) In 436 cases no IVF- or ICSI-treatmentIn 117 cases oocytes were aspirated, but then transferof frozen thawed pronuclear stage oocyte was carriedout. 2 GIFT-treatment cycles.2) Reason: e. g. immature oocytes, no spermEmbryos transferred/cycle (mean*) and children IVF, ICSI 1997 - 2009(prospective and non-prospective data)1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009IVFEmbryos transf.Children/transferChildren/delivery2.490.211.312.440.221.302.360.231.302.290.231.282.250.241.272.190.221.262.170.231.262.150.231.252.110.241.232.080.251.232.060.251.242.060.231.242.030.141.24ICSIEmbryos transf.Children/transferChildren/delivery2.560.221.292.490.221.292.440.221.252.390.231.262.300.241.232.210.221.232.170.231.232.150.231.222.110.241.222.090.241.202.080.241.212.080.221.222.060.131.22Embryos transf.cryotransferChildren/transferChildren/delivery2.340.101.142.330.121.182.310.121.172.250.121.162.200.121.162.140.121.162.120.121.162.140.121.172.100.141.162.100.141.162.070.141.162.070.131.162.050.091.16Distribution of indications for IVF and ICSI 2009femalefactormalefactorNormal % Reducedsemen quality% Other** % Total %Normal1,07910.928038.133553.592,23722.64IVFTubal infertilityEndometriosisHyperandrogenismOvulatory dysfunction1,92253222533419.455.382.283.387912891512488.002.921.532.5140812057824.131.210.580.833,12194143366431.589.524.386.72Psychological impact40.0440.0480.08160.16Other*5605.677047.126756.831,93919.62n. a.90,0980.085145.205315.37Total 4,665 47.21 2,998 30.34 2,219 22.45 9,882 100.00femalefactormalefactorNormal % Red. semenquality% Azoospermia% Other** % Total %Normal8432.6910,94634.987022.241,1713.7413,66243.66ICSITubal infertilityEndometriosisHyperandrogenismOvulatory dysfunctionPsychological impact59523712214821.900.760.390.470.012,0321,3551,1591,758206.494.333.705.620.062152488300.070.170.150.270.0027416212616180.880.520.400.510.032,9221,8061,4552,150309.345.774.656.870.10Other*3731.194,98015.921710.551,4984.797,02222.44n. a.140,041120.36100.032,1066.732,2427.17Total 2,334 7.46 22,362 71.47 1,087 3.47 5,506 17.60 31,289 100.00*) Infertility factors “sperm antibodies” and “cervical facotor” are enclosed**) Infertility factor “impaired sperm function” and “impaired sperm-mucus-interaction” are enclosedOnly prospectively collected data were usedJ Reproduktionsmed Endokrinol 2010; 7 (6) 479

Outcome of IVF, ICSI and FET 2009prospective cyclesIVF 2009n % Fertilis. % Embryo present % Transfer % Clin. preg. %IVFSuccessful fertilisation*At least one embryo presentPerformed ETClin. pregnancyDeliveryMiscarriageEctopic pregnancyn. a.9,8829,1548,8268,8232,6551,013480521,110100.0092.6389.3189.2826.87100.0096.4296.3829.00100.0099.9730.08100.0030.09 100.0038.1518.081.9641.81ICSI 2009n % Fertilis. % Embryo present % Transfer % Clin. preg. %ICSISuccessful fertilisation*At least one embryo presentPerformed ETClin. pregnancyDeliveryMiscarriageEctopic pregnancyn. a.31,28930,13829,00228,9978,5623,4311,5931243,414100.0096.3292.6992.6727.36100.096.2396.2128.41100.0099.9829.52100.0029.53 100.0040.0718.611.4539.87ICSI 2009 - sperm retrieval by TESE or cryo-TESEn % Fertilis. % Embryo present % Transfer % Clin. preg. %ICSISuccessful fertilisation*At least one embryo presentPerformed ETClin. pregnancyDeliveryMiscarriageEctopic pregnancyn. a.1,8621,7351,6561,6564401671103160100.0093.1888.9488.9423.63100.0095.4595.4526.35100.00100.0026.57100.0026.57 100,0037.9525.000.6836.36ET from cryo-preserved 2PN 2009n % PN % Transfer % Clin. preg. %Thawing cyclesThawed PN presentPerformed ETClin. pregnancyDeliveryMiscarriageEctopic pregnancyn. a.14,47613,84513,6532,6611,12961948865100.0095.6494.3118.38100.0098.6119.22100.0019.49 100.0042.4323.261.8032.51*) Successful fertilisation of at least one oocyte per cycle480 J Reproduktionsmed Endokrinol 2010; 7 (6)

Outcome as a function of woman’s ageIVF - 2009Clin. PR/ETOnly prospectively collected data were usedMiscarriages/ET% 50100 %459040803570Miscarriages/ET30602550in %2040 Clin. PR/ET1530in %10205100=44 years(51) (107) (148) (209) (255) (367) (421) (467) (513) (583) (623) (645) (654) (700) (717) (1,061) (450) (329) (239) (144) (140) n [ET]45.10 39.25 37.16 36.36 37.25 35.15 38.24 37.90 38.79 35.51 37.56 29.77 30.89 28.43 27.89 23.28 22.89 20.36 11.72 9.72 3.57 Clin. PR/ET [%]Age inyears= 40OPU1,2712,8714,2511,489Oocytes(mean)10.9610.038.096.22Insemin.(mean)10.709.817.916.08ET ET/OPU % Transf. Emb.(mean)1,1372,6073,7771,30289.4690.8088.8587.441.951.992.042.13Clin. preg.4209781,040217Clin. PR/OPU %33.0434.0624.4614.57Clin. PR/ET %36.9437.5127.5416.67Clin. PR/ET %“ideal” *41.7741.7433.2424.53Total 9,882 8.74 8.55 8,823 89.28 2.03 2,655 26.87 30.09 37.46*) “ideal”: 2 embryos were transfered and at least 2 2PN stages in abundanceOutcome as a function of woman’s ageICSI - 2009Clin. PR/ETOnly prospectively collected data were usedMiscarriages/ET% 50100 %459040803570Miscarriages/ET30602550in %2040 Clin. PR/ET1530in %102051000=44 years(260) (496) (608) (809) (1,068) (1,.272) (1,550) (1,784) (1,897) (1,995) (1,998) (2,104) (2,043) (2,167) (2,306) (2,741) (1,415) (971) (682) (392) (439) n [ET]34.23 37.30 38.32 39.31 34.48 39.86 35.48 33.63 35.27 33.93 33.03 32.37 29.07 28.29 25.46 22.33 19.58 16.89 10.85 10.20 4.78 Clin. PR/ET [%]Age inyears= 40OPU4.7969.81212.2654.416Oocytes(mean)11.9310.808.596.41Injection(mean)9.548.726.985.25ET ET/OPU % Transf. Emb.(mean)4.5139.22411.3613.89994.1094.0192.6388.302.012.022.092.12Clin. preg.1.7433.1563.087576Clin. PR/OPU %36.3432.1625.1713.04Clin. PR/ET %38.6234.2227.1714.77Clin. PR/ET %“ideal” *42.1038.5531.8818.78Total 31.289 9.49 7.67 28.997 92.67 2.06 8.562 27.36 29.53 36.16*) “ideal”: 2 embryos were transfered and at least 2 2PN stages in abundanceJ Reproduktionsmed Endokrinol 2010; 7 (6) 481

Clinical pregnancy rate as a function of the number ofembryos transferred and age groups 2009IVF1 EmbryoET Clin. PR/ET %2 EmbryosET Clin. PR/ET %3 EmbryosET Clin. PR/ET %TotalET Clin. PR/ET %up to 24 years25 - 29 years30 - 34 years35 - 39 years40 - 44 years45 years and older41222755652761625.0022.1318.9115.048.330.00478902,0872,4865282046.8138.6539.9629.6919.325.0007424572644418-35.1437.5529.8920.275.56511,0862,6073,7771,2485445.1036.5637.5127.5417.233.70Total 1,258 14.94 6,058 33,69 1,507 28.27 8,823 30.09ICSI1 EmbryoET Clin. PR/ET %2 EmbryosET Clin. PR/ET %3 EmbryosET Clin. PR/ET %TotalET Clin. PR/ET %up to 24 years25 - 29 years30 - 34 years35 - 39 years40 - 44 years45 years and older253348571,5928597112.0021.2619.9513.886.400.002113,5437,3087,1661,5037338.3940.8136.1229.7715.702.74243761,0592,6031,3256820.8336.4432.5828.1621.065.882604,2539,22411,3613,68721234.2338.8934.2227.1715.462.83Total 3,738 13.94 19,804 33.01 5,455 27.55 28,997 29.53Cryo-transfer1 EmbryoET Clin. PR/ET %2 EmbryosET Clin. PR/ET %3 EmbryosET Clin. PR/ET %TotalET Clin. PR/ET %up to 24 years25 - 29 years30 - 34 years35 - 39 years40 - 44 years45 years and older13262698839283523.0811.8311.8910.376.710.00881,2883,0813,2108281318.1822.3621.8420.5613.040.00204249801,1474391730.0023.3524.9023.8015.950.001211,9764,7635,2051,5533520.6621.1521.0019.6212.690.00Total 2,100 10.62 8,508 20.51 3,027 22.86 13,653* 19.49*) Embryos transferred plus 2PN stages; in 18 cases uncalculableOnly prospectively collected data were used.Clinical pregnancy rate as a function of the embryo quality 2009IVF, ICSI, IVF/ICSIQuality = 40 years Totalideal non-ideal ETClin. PR/ET%ETClin. PR/ET%ETClin. PR/ET%ETClin. PR/ET%ETClin. PR/ET%01678.961936.743818.402075.318487.310228722.3065521.8367915.461799.501,80018.28032425.007915.1917713.5610211.7638214.141042522.8296422.411,81315.391,0266.534,22815.591156034.461,14126.561,36921.9136412.643,43424.52123221.889331.1826418.5615012.6753919.29203,91942.647,78939.627,81432.451,62917.6821,15135.84217636.8424030.0059327.1532317.651,23225.813034637.2890436.502,34631.421,31322.544,90930.39Total 5,736 38.37 12,058 34.86 15,436 27.36 5,293 15.36 38,523 29.70Only prospectively collected data were used.482 J Reproduktionsmed Endokrinol 2010; 7 (6)

Clinical pregnancy rate as a function of the embryo quality 2009FETQuality after IVF after ICSIideal non-ideal ET Clin. PR/ET % ET Clin. PR/ET %011051.903397.080226810.8268310.40038012.5020513.661042010.711,15712.531156715.701,22818.081211915.1326221.37201,74523.783,70723.472122725.1138525.193055427.981,06224.01Total* 4,085 20.07 9,028 19.58*) In 10 cases the previous method of treatment was IVF/ICSI; in 530 cases the previous method of treatment was unknown.Only prospectively collected data were used.Miscarriage rates as a function of woman’s age and the numberof embryos transferred 2009IVF, ICSI, IVF/ICSIAge in years1 Embryo2 Embryos3 EmbryosTotalClin. preg. Miscarriage/clin. preg. %Clin. preg. Miscarriage/clin. preg. %Clin. preg. Miscarriage/clin. preg. %Clin. preg. Miscarriage/clin. preg. %0-30.00540.00825.00Total 718 20.47 8,753 17.07 1,970 23.71 11,441 18.42Cryo-transferAge in years1 Embryo2 Embryos3 EmbryosTotalClin. preg. Miscarriage/clin. preg. %Clin. preg. Miscarriage/clin. preg. %Clin. preg. Miscarriage/clin. preg. %Clin. preg. Miscarriage/clin. preg. %0-0-0-0-Total 223 22.42 1,745 22.23 692 26.16 2,661 23.26*) in one case the number of embryos transferred is not knownOnly prospectively collected data were used.J Reproduktionsmed Endokrinol 2010; 7 (6) 483

Clinical pregnancy rates as a function of the stimulation protocolIVF, ICSI 2009- IVF -U-FSH rec-FSH hMG only rec-LH andrec-FSHrec-FSHand hMGOther* n. a. Totalshort GnRH124095392794551,091Transfer rate (%)83.3392.9195.9281.4882.9880.00100.0093.20Clin. PR/ET (%)40.0033.4229.2118.1814.290.000.0029.08long GnRH292,5181,07637375811484,876Transfer rate (%)96.5589.6389.2287.9489.3188.60100.0089.39Clin. PR/ET (%)28.5734.0329.2732.0129.5431.6825.0031.98Without analogues2346193377193106848Transfer rate (%)100.0089.3191.7178.3880.2880.6574.5385.85Clin. PR/ET (%)0.0036.2529.3831.0324.5620.0021.5227.08Antagonists371,69263914421832893,067Transfer rate (%)94.5990.3186.2383.3384.8689.9488.8988.75Clin. PR/ET (%)17.1430.1025.0925.0023.2422.0312.5027.22Total 80 4,965 2,447 581 1,141 540 128 9,882- ICSI -U-FSH rec-FSH hMG only rec-LH andrec-FSHrec-FSHand hMGOther* n. a. Totalshort GnRH641,091867802747912,456Transfer rate (%)92.1994.5993.5487.5091.9791.140.0093.48Clin. PR/ET (%)11.8625.3923.1824.6417.0618.060.0023.06long GnRH1108,5942,7071,3742,7202562015,781Transfer rate (%)93.6493.4794.2491.0594.7194.14100.0093.63Clin. PR/ET (%)28.1633.3029.3333.3331.3428.6325.0032.13Without analogues21,3496851923862274143,255Transfer rate (%)100.0094.5190.8095.8391.9783.7073.9190.14Clin. PR/ET (%)0.0031.3427.3328.2625.6322.6316.0725.02Antagonists595,2671,7806301,174866219,797Transfer rate (%)96.6193.9190.7387.9491.3186.2676.1991.94Clin. PR/ET (%)21.0531.1823.7427.2622.7619.4418.7527.37Total 235 16,301 6,039 2,276 4,554 1,428 456 31,289*) e. g. U-FSH and hMG, Clomifen/rec-FSH, Clomifen/hMG etc.Only prospectively collected data were used.484 J Reproduktionsmed Endokrinol 2010; 7 (6)

Successful fertilisation per treatment cycle as a function of semen analysisbefore and after sperm preparation, 2000 - 2009 1SuccessfulFertilis. 2 %969492908886848280787674727068666462>0=5=10=15=20=25=30-35>=35=40=45=50=55=60=650=5=10=15=20=25=30-35>=35=40=45=50=55=60=650=5=10=15=20=25=30-35>=35=40=450=5=10=15=20=25=30-35>=35=40=45=50=55=60=65

Number of initial treatment cycles per year1997 - 2009 - IVF, ICSI, IVF/ICSI *n 34,00032,00030,00028,00026,00024,00022,00020,00018,00016,0001997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009n = Number of women undergoingtheir treatment cyclein this year*) cancelled cycles are enclosedProspectively and retrospectivelycollected data were used.Average age of women and men1997 - 2009 - IVF, ICSI, IVF/ICSIAge inyears38.238.037.837.637.437.237.036.836.636.436.236.035.835.635.435.235.034.834.634.434.234.033.833.633.433.233.032.832.632.432.232.0Men 2009:37.98 yearsWomen 2009:34.78 years1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009ManWoman: Mean: 95 % confidence interval. (Forinstance: the CI for women during1997 describes a probability of 95 %for the mean age of lying between32.51 and 32.65 years)Prospectively and retrospectivelycollected data were used.Triplet births: incidence after two and three embryos transferred1998 - 2009 IVF, ICSI, IVF/ICSI, cryo-transfer% 0.7Triplet births: incidence after2 embryos transferred% 7Triplet births: incidence after3 embryos transferred0.660.550.440.330.220.1101998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 200901998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009Prospectively and retrospectively collected data were used.J Reproduktionsmed Endokrinol 2010; 7 (6) 487

Singletonn %1997*2,414(2,406)57.50(57,79)1998*4,892(4,867)57.63(57.90)1999*5,472(5,438)59.30(59.55)2000*5,418(5,402)59.01(59.29)2001*6,798(6,774)60.89(61.04)2002*7,746(7,724)62.59(62.78)2003*10,723(10,688)62.13(62.78)2004*5,368(5,352)63.69(62.46)2005*5,527(5,515)63.84(63.90)2006*5,906(5,894)65.50(64.05)2007*6,611(6,578)64.50(64.64)2008*6,359(6,337)63.72(63.93)2009*4,075(4,051)63.94(64.00)1997*2,603(2,593)1998*5,400(5,372)1999*6,175(6,137)2000*6,207(6.189)2001 7,795* (7,764)2002*8,930(8,902)2003*11,922(11,887)2004*6,891(6,869)2005*7,038(7,020)2006*7,419(7,402)2007*8,346(8,305)2008*8,036(8,010)2009*5,205(5,175)Singletonn %58.57(58.84)58.68(58.94)60.55(60.80)60.46(60.72)62.20(62.33)63.84(64.02)63.16(63.48)65.63(65.81)65.76(65.93)66.87(67.14)66.30(66.40)65.47(65.71)65.77(65.81)All children 1997 - 2009prospective und retrospective data1,454(1,436)3,094(3,058)3,408(3,362)3,524(3,479)4,288(4,248)4,662(4,615)6,334(6,237)3,336(3,306)3,440(3,408)3,450(3,417)4,058(4,025)3,994(3.943)2,558(2,538)IVF, ICSI, IVF/ICSITwinn %1,412 33,64(1,394) (33,49)2,916 34.35(2,882) (34.29)3,172 34.38(3,130) (34.28)3,242 35.31(3.200) (35.12)3,956 35.43(3,919) (35.31)4,256 34.39(4,210) (34.22)5,960 34.53(5,866) (34.22)2,826 33.53(2,801) (34.28)2,936 33.91(2,906) (33.44)2,922 32.41(2,890) (33.75)3,488 34.03(3,455) (33.95)3,400 34.07(3,360) (33.89)2,168 34.02(2,150) (33.97)Twinn %32.72(32.58)33.62(33.55)33.42(33.31)34.32(34.13)34.21(34.10)33.33(33.19)33.55(33.31)31.77(31.68)32.14(32.01)31.10(30.99)32.24(32.18)32.54(32.35)32.32(32.28)Tripletn %360 8.58(351) (8.43)681 8.02(657) (7.82)579 6.28(560) (6.13)513 5.59(502) (5.51)411 3.68(405) (3.65)366 2.96(362) (2.94)552 3.20(533) (2.94)234 2.78(223) (3.11)183 2.11(179) (2.66)189 2.10(174) (2.08)147 1.43(140) (1.38)213 2.13(208) (2.10)126 1.98(125) (1.97)375(366)708(684)612(591)528(517)450(444)387(382)597(578)273(262)213(209)222(202)180(173)237(229)147(146)Tripletn %8.44(8.30)7.69(7.50)6.00(5.85)5.14(5.07)3.59(3.56)2.77(2.75)3.16(3.09)2.60(2.51)1.99(1.96)2.00(1.83)1.43(1.38)1.93(1.88)1.86(1.86)Quadrupletn %12 0.29(12) (0.29)0 0.00(0) (0.00)4 0.04(4) (0.04)8 0.09(7) (0.08)0 0.00(0) (0.00)8 0.06(7) (0.06)24 0.14(24) (0.14)0 0.00(0) (0.00)12 0.14(11) (0.13)0 0.00(0) (0.00)4 0.04(4) (0.04)8 0.08(8) (0.08)4 0.06(4) (0.06)Quadrupletn %12(12)0(0)4(4)8(7)0(0)8(7)24(24)0(0)12(11)4(4)4(4)8(8)4(4)0.27(0.27)0.00(0.00)0.04(0.04)0.08(0.07)0.00(0.00)0.06(0.05)0.13(0.13)0.00(0.00)0.11(0.10)0.04(0.04)0.03(0.03)0.07(0.07)0.05(0.05)Totaln4,198(4,163)8,489(8,406)9,227(9,132)9,181(9,111)11,165(11,098)12,376(12,303)17,259(17,111)8,428(8,376)8,658(8,611)9,017(8,958)10,250(10,177)9,980(9,913)6,373(6,330)*) Values in brackets refer to live births. Added values of all years observed revealed the following results: 77,309 singleton (77,026),twin 42,654 (42,163), triplet 4,554 (3,415), quadruplet 84 (81); total: 124,601 (123,689)Total (IVF, ICSI, IVF/ICSI, cryo-transfer)Totaln4,444(4,407)9,202(9,114)10,199(10,094)10,267(10,192)12,533(12,456)13,987(13,906)18,877(18,726)10,500(10,437)10,703(10,648)11,095(11,025)12,588(12,507)12,275(12,190)7,914(7,863)* ) Values in brackets refer to live births. Added values of all years observed revealed the following results: singleton 91,967 (91,625),twin 47,600 (47,072), triplet 4,929 (4,793), quadruplet 88 (85); total: 144,584 (143,565)488 J Reproduktionsmed Endokrinol 2010; 7 (6)

Childrens birth weight (bw) and week of gestation (wg) 2008*Birth weightin grams4,5004,2504,0003,7503,5003,2503,0002,7502,5002,2502,0001,7501,5001,2501,000750500250041 wgSingleton 2008n2,0001,9001,8001,7001,6001,5001,4001,3001,2001,1001,00090080070060050040030020041 wg1000*) data contain 8 cases wg > 40wg < 25 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 > 41 total*n 10 10 8 14 16 19 31 36 35 49 120 154 284 640 1,355 1,744 1,985 946 69 7,525bw Q 25 560 678 825 870 990 1,000 1,230 1,390 1,400 1,710 1,980 2,290 2,475 2,753 2,935 3,100 3,200 3,350 3,320 2,980bw median 610 753 910 990 1,135 1,304 1,420 1,605 1,620 1,900 2,228 2,530 2,750 3,020 3,210 3,360 3,496 3,640 3,575 3,320bw Q 75 670 830 965 1,110 1,245 1,490 1,650 1,800 1,866 2,150 2,493 2,840 3,000 3,315 3,500 3,650 3,800 3,920 3,840 3,665p25 = 38. wg p50 = 39. wg p75 = 40. wgPercentage of children born before completion of 37th wg: 18.95 %Birth weightin grams4,5004,2504,0003,7503,5003,2503,0002,7502,5002,2502,0001,7501,5001,2501,0007505002500

Complications as a function of ovum pick up 2009Vaginal bleedingTotal OPUs 43,192 100.00 %n. a.No complicationsComplications8242,8252850.1999.150.66OtherSurgeryrequiredHospitalizationrequiredPeritonitisBowel injuryretroperiton.bleedingOnly prospectively collected data were used.intraabd. bleedingComplication n %Vaginal bleedingIntraabdom. bleedingRetroperiton. bleedingBowel injuryPeritonitisHospitalization requiredSurgery requiredOther233112131052081.753.860.700.351.053.511.757.02Total 285 100.00OHSS as a function of the stimulation protocolIVF, ICSI, IVF/ICSI 2009Stimulation % Oocytes retrieved OHSS III/ST %Short GnRHFSH onlyhMG onlyFSH und hMGOthern. a.3,5731,5911,41543912268.52 8.019.117.586.065.578.674310000.110.190.070.000.000.00Long GnRHFSH onlyhMG onlyFSH und hMGOthern. a.Without analoguesFSH onlyhMG onlyFSH und hMGOthern. a.21,10511,6993,8473,6461,884294,1581,73288749252552250.34 10.3711.139.119.799.3711.109.92 8.7110.608.608.556.045.5071501011006500010.340.430.260.300.000.000.140.290.000.000.000.19AntagonistsFSH onlyhMG onlyFSH und hMGOthern. a.13,0887,2542,4351,4791,8903031.22 8.349.437.247.226.545.33342724100.260.370.080.270.050.00Total 41,924 100.00 9.37 115 0.27Only prospectively collected data were used.490 J Reproduktionsmed Endokrinol 2010; 7 (6)

Distribution of patients with “ideal prognosis”* as a function of size of centre2000 - 2009*) “ideal prognosis”: age of women < 35 years and first stimulation cycle transfer (IVF, ICSI, IVF/ICSI)Base: 100 largest centres with at least 1,000 stimulation cycle transfers (IVF, ICSI, IVF/ICSI) in 10 years, arranged from left (1) to right (100) size ascending (= number of stimulation cycle transfers)The linear function is a method positionig a best-fitting line ina scatter plot so that the mean square aviation of the datapoints is minimized by this function.Interpretation of results:The part of women with “ideal prognosis” does not correlate with sizeof centre (= number of stimulation cycle transfers)The straight lines indicates the linear regression function of thesingle values of the particular item.Percentage of women with “idealprognosis” per centre% 323028Prospectively and retrospectively collected data were used.26242220181614121086420Centres10095908580757065605550454035302520151051J Reproduktionsmed Endokrinol 2010; 7 (6) 491

Pregnancy rate of patients with “ideal prognosis”* and of the remaining patients as a functionof size of centre 2000 - 2009*) “ideal prognosis”: age of women < 35 years and first stimulation cycle transfer (IVF, ICSI, IVF/ICSI)Base: 100 largest centres with at least 1,000 stimulation cycle transfers (IVF, ICSI, IVF/ICSI) in 10 years, arranged from left (1) to right (100) size ascending (= number of stimulation cycle transfers)The linear function is a method positionig a best-fit line in ascatter plot so that the mean square aviation of the datapoints is minimized by this function.Interpretation of results:Women with “ideal prognosis”For women with “ideal prognosis” and for the remainingwomen the larger centres offer by trend higherpregnancy rates as the smaller centres.Remaining womenThe straight lines indicates the linear regression function of thesingle values of the particular item.Clin. PR/ET% 5452504846Prospectively and retrospectively collected data were used.444240383634323028262422201816141210Centres810095908580757065605550454035302520151051492 J Reproduktionsmed Endokrinol 2010; 7 (6)

Centres reporting to the German IVF Registryin 2009PraxisklinikDr. med. Hans-Jürgen HeldPrager Str. 8a01069 DresdenTel. 0351/501 400 0, Fax -501 400 28info@ivf-dresden.dewww.ivf-dresden.deUniversitätsklinikum Carl Gustav CarusDresden - Klinik und Poliklinik fürFrauenheilkunde und GeburtshilfeProf. Dr. med. W. Distler,Dr. rer. nat. G. Keck, Dr. med. E. GrumaFetscherstr. 7401307 DresdenTel. 0351/458-4587, Fax -458-5351gyn-LaborIVF@uniklinikum-dresden.dehttp://frauen.uniklinikum-dresden.deUniversitätsfrauenklinik, Zentrum fürReproduktionsmedizin, GynäkologischeEndokrinologie und SexualmedizinProf. Dr. med. H. Alexander,Doz. Dr. med. D. Baier, Dipl.-Biol. W. WeberLiebigstr. 20 A04103 leipzigTel. 0049-341/97 23 410, Fax -97 23 509Henry.alexander@medizin.uni-leipzig.dewww.reproduktionsmedizin-leipzig.deKinderwunschzentrum Leipzig – ChemnitzDres. F. A. Hmeidan, P. Jogschies,D. Geistert, L. Shugair, A. LahlGoldschmidtstr. 3004103 LeipzigTel. 0341/14120-0, Fax -14120-81info@IVF-Leipzig.dewww.ivf-leipzig.deKinderwunschzentrum Praxisklinik CityLeipzig, Standort Leipzig, überörtlicheBerufsausübungsgemeinschaftDr. med. Astrid Gabert,Dr. med. Katharina Bauer,Dr. med. Georg Saager,Dr. rer. nat. Stefanie Breuer (Biologin)Petersstr. 104109 LeipzigTel. 0341/215855-0, Fax -215855-17info@ivf-city-leipzig.dewww.praxisklinik-city-leipzig.deZentrum für Reproduktionsmedizin undAndrologie (ZRA)Universitätsklinikum Halle (Saale)Univ.-Prof. Dr. med. Hermann M. Behre,Dr. med. Petra Kaltwaßer,Dr. rer. nat. Ewald SeligerErnst-Grube-Str. 4006120 Halle (Saale)Tel. 0345/55747-82 Fax -55747-88ZRA@medizin.uni-halle.deReproduktionsmedizinisches Zentrum JenaPriv.-Doz. Dr. med. habil. Heidi Fritzsche,Dipl.-med. Jens-Peter Reiher,Dr. med. Angela HoffmannMarkt 407743 JenaTel. 03641/8296-80, Fax -8296-81Dr.H.Fritzsche@t-online.dewww.kinderwunschnet.deUniversitätsfrauenklinik JenaProf. Dr. med. Jürgen Weiss,Dr. rer. nat. Ines HoppeBachstr. 1807743 JenaTel. 03641/933 529, Fax -933 191ines.hoppe@med.uni-jena.dewww.uniklinikum-jena.deKinderwunschzentrum Leipzig - ChemnitzDres. F. A. Hmeidan, P. Jogschies,D. Geistert, L. Shugair, A. LahlJakobikirchplatz 409111 ChemnitzTel. 0371/503 4980, Fax -503 49881info@ivf-chemnitz.dewww.ivf-chemnitz.deKinderwunschzentrum Praxisklinik CityLeipzig, Standort Chemnitz, überörtlicheBerufsausübungsgemeinschaftDr. med. Astrid Gabert,Dr. med. Katharina Bauer,Dr. med. Georg SaagerFlemmingstr. 2a09116 ChemnitzTel. 0371/433 130 0, Fax -433 130 17info@kinderwunschzentrum-chemnitz.dewww.praxisklinik-city-leipzig.deDr. med. B. Pfüller, Dr. med. J. Bartley,Dr. med. I. Scheiber,Dr. rer. nat. H. SchmiadyUniversitätsmedizin BerlinCharité - KinderwunschzentrumCharitéplatz 110098 BerlinPraxisklinik für FertilitätDr. med. Peter Sydow/Dr. med. David J. PeetDr. med. Carmen Sydow,Dr. med. Ulrike Bergmann-HenselKronenstr. 55 – 5810117 BerlinKinderwunschzentrum BerlinAkadem. Lehrpraxis der CharitéUniversitätsmedizinFrauenärztliche GemeinschaftspraxisDr. med. Reinhard Hannen,Dr. med. Christian F. StollLandgrafenstr. 1410787 BerlinTel. 030/263 983 0, Fax -263 983 99info@kinderwunschzentrum.dewww.kinderwunschzentrum.deArbeitsgruppe Endokrinologie &Reproduktionsmedizin im Lützow CenterDr. med. Detlef H. G. Temme & KollegenWichmannstr. 510787 BerlinTel. 030/230998-0, Fax -230998-30dr.temme@ivf-berlin.dewww.ivf-berlin.deKinderwunschzentrum an derGedächtniskircheDr. Matthias Bloechle, Dr. Silke Marrin Praxisgemeinschaft m. d.Gemeinschaftspraxis Dr. Hanadi Awwadeh,Dr. Anja Mutzin Praxisgemeinschaft mit derGemeinschaftspraxis Dr. Birgit Roth,Carola KadgienRankestr. 3410789 BerlinTel. 030/219092-0, Fax -219092-99ivf@Kinderwunsch-berlin.dewww.kinderwunsch-berlin.deKinderwunschzentrum FERAim Wenckebach-KlinikumDr. Andreas Jantke, Dr. Sofia Spindeldreher,Dr. Anna Stegelmann, Dr. Manzoor NowshariWenckebachstr. 2312099 BerlinTel. 030/7600 70 130, Fax -7600 70 160Kinderwunsch@fera-berlin.dewww.kinderwunsch-ivf-berlin.deKinderwunschzentrum am Innsbrucker PlatzBerlinBabette Remberg,Dr. med. Susanne Tewordt-Thyselius,Gyn. Endokrinologie u. ReproduktionsmedizinHauptstr. 6512159 BerlinTel. 030/857 57 930, Fax -857 57 935praxis@kinderwunsch-berlin.dewww.kinderwunschpraxis-berlin.deFrauenarztpraxis KinderwunschzentrumHelle Mitte BerlinStendaler Str. 2412627 BerlinTel. 030/9927790, Fax -99277922info@berliner-kinderwunsch.deFertility Center BerlinProf. Dr. med. H. Kentenich,Dr. med. A. Siemann, Dr. med. G. Stief,Dr. med. A. Tandler-SchneiderSpandauer Damm 13014050 BerlinTel. 030/303 54 937, Fax -303 54 939info@fertilitycenterberlin.dewww.fertilitycenterberlin.deKinderwunschzentrum NeubrandenburgProf. Dr. med. Roland Sudik,Dr. med. Konstanze Kissing-PahlS.-Allende-Str. 3017036 NeubrandenburgTel. 0395/775 27 94, Fax -775 27 93gyn@dbknb.dePraxiszentrum FrauenheilkundePD Dr. med. H. Müller, A. Busecke, A. BossowSüdring 8118059 RostockTel. 0381/440120-30, Fax -440120-31info@ivf-rostock.dewww.ivf-rostock.deMVZ Fertility Center Hamburg GmbHDr. R. FischerSpeersort 420095 HamburgTel. 040/308 045 30Rfischer@fertility-center-hh.dewww.fertility-center-hh.deKinderwunschzentrum Altonaer StraßeGMP Dres. med. Bispink, Horn, Michel u.PartnerDr. Bispink, Dr. Horn, Dr. Michel,Dr. Gohmann, Dr. Aytekin, Dr. Acar-NositAltonaer Str. 5920357 HamburgTel. 040/306836-0, Fax -306836-69info@ivf-hamburg.dewww.ivf-hamburg.deKinderwunschzentrum Fleetinsel HamburgDr. med. Semsettin Kocak,Dr. med. Peter List, Dr. med. Uwe Weidner,Admiralitätstr. 420459 HamburgTel. 040/386 055 50, Fax -386 055 51info@Kinderwunschzentrum-hamburg.dewww.kinderwunschzentrum-hamburg.deJ Reproduktionsmed Endokrinol 2010; 7 (6) 493

Endokrinologikum HamburgZentrum für Hormon- und Stoffwechselerkrankungen,Reproduktionsmedizin undPränatale MedizinLornsenstraße 4 - 622767 HamburgTel. 040/306 28-200, Fax -306 28-349michael.ludwig@endokrinologikum.comwww.endokrinologikum.comUKL-Universitäres KinderwunschzentrumLübeck, Zentrum für Reproduktionsmedizinund Gynäkologische Endokrinologieam Universitätsklinikum Schleswig-Holstein, MVZAmbulanzzentrum des UK-SH GmbHProf. Dr. med. G. Griesinger,Priv. -Doz. Dr. med. A. Schultze-Mosgau,Prof. Dr. med. K. DiedrichRatzeburger Allee 16023538 LübeckTel. 0451/500-4418, Fax -500-5764kinderwunsch@uk-sh.dewww.kinderwunsch-luebeck.defertilitycenterkielPriv.-Doz. Dr. Sören von Otte,Dr. Volker Schulz, Dr. Martin Völckers,Dr. Heike EckelPrüner Gang 1524103 KielTel. 0431/97413 33, Fax -97413 22info@fertilitycenter.dewww.fertilitycenter.deKinderwunschzentrum am UK-SH,Campus KielDr. Andreas Schmutzler,Prof. Dr. Ali SalmassiArnold-Heller-Str. 3, Haus 2424105 KielTel. 0431/597 20 83, Fax -597 53 52www.kinderwunschunikiel.deKinderwunsch KielDr. med. K. Brandenburg,Dr. sc. agr. A. Bonhoff,Dr. med. A. CarstensenIm Brauereiviertel 524118 KielTel. 0431/553 433, Fax 0431/519 27 45info@Kinderwunschkiel.dewww.kinderwunschkiel.deTeam Kinderwunsch OldenburgDr. med. Saif Jibril,Dr. med. Gerhard PohligFachärzte für Frauenheilkunde undGeburtshilfeWilhelmstr. 526121 OldenburgTel 0441/248 9091, Fax - 248 9088tko@telemed.dewww.teamkinderwunsch.infoTagesklinik OldenburgZentrum für KinderwunschbehandlungDr. med. Jörg Hennefründ,Dr. med. Heike Boppert (vormals Ochs-Ring),Dr. med. Michael HeederAchternstr. 2126122 OldenburgTel. 0441/922 700, Fax -922 7028info@tagesklinik-oldenburg.deZentrum für Fortpflanzungsmedizin LeerDr. med. Wolfgang von der BurgHafenstr. 6d26789 LeerTel. 0491/4542 50, Fax -4542 510zff-Leer@t-online.dewww.fortpflanzungsmedizinfriesland.deKinderwunsch BremenDr. Achim v. Stutterheim, Tanja Finger,Dr. Susanne Meyer-StröhEmmastr. 22028213 BremenTel. 0421/2249 10, Fax -2249 122info@Kinderwunschbremen.dewww.kinderwunschbremen.deBremer Zentrum f. Fortpflanzungsmedizin(BZF)Dr. Olaf Drost,Prof. Dr. Ernst Heinrich Schmidt,Gröpelinger Heerstr. 406 - 40828239 BremenTel. 0421/6102-1212, Fax -6102-1213Info@icsi.dewww.icsi.deTeam Kinderwunsch HannoverDr. Saymé und KollegenWerner HoppenstedtBrühlstr. 1930169 HannoverTel. 0511/3130 95, Fax -3130 96info@team-kinderwunsch-hannover.dewww.team-kinderwunsch-hannover.deIVF – Labor Med. Hochschule HannoverFr. Dr. Schippert, Fr. Dr. BaßlerCarl-Neuberg-Str. 130625 HannoverTel. 0511/532 60 99, Fax -532 60 94schippert.cordula@mh-hannover.dewww.mh-hannover.deKinderwunschzentrum Langenhagen -WolfsburgDr. Martina Müseler-Albers,Horst Peter Arendt, Dr. Klaus Bühler,Dr. Thilo SchillOstpassage 930853 LangenhagenSauerbruchstr. 7b (Klinikum Wolfsburg)38440 WolfsburgTel. 0511/97230-0, Fax -97230-18praxis@kinderwunsch-langenhagen.dewww.kinderwunsch-langenhagen.deZentrum für Reproduktionsmedizin u.Humangenetik HildesheimDres. med. Algermissen, Justus, Wilke, GrafZingel 29 – 3031141 HildesheimTel. 05121/20 67 90, Fax -20 67 911praxis@Kinderwunsch-hildesheim.dewww.kinderwunsch-hildesheim.deBispink, Chandra, Breitbach, Hinrichsen,PeperDeutsche Klinik Bad MünderZetrum für ReproduktionsmedizinMVZ wagnerstibbe GmbHHannoversche Str. 2431848 Bad MünderTel. 05042/940 360, Fax -940 308info@kinderwunsch.comwww.kinderwunsch.comZentrum für Kinderwunschbehandlung u.Pränataldiagnostik MindenDr. med. Dipl.-Biochem. Onno Buurman,Dr. med. Michael Dumschat,Dr. med. Ralf Menkhaus,Dr. med. Barbara Heidecker -privat-Artilleriestr. 9a32427 MindenTel. 0571/972 60 0, Fax -972 60 99Info@Kinderwunsch-minden.netwww.kinderwunsch.netBielefelder Institut für Fortpflanzungsmedizin– BIFDr. Beate Harms, Dr. Nabaz BabanTeutoburgerstr. 5033604 BielefeldTel. 0521/581 32 77, Fax -581 92 95beate.harms@Klinikumbielefeld.dewww.klinikumbielefeld.deBielefeld Fertility CenterPaul A. Ebert, Dr. Karl Völklein,Beata SzypajloZentrum für Reproduktionsmedizin undGynäkologische EndokrinologieWerther Str. 26633619 BielefeldTel. 0521/10 10 05, Fax –10 10 79praxis@kinderwunsch-bielefeld.dewww.kinderwunsch-bielefeld.deMVZ für Reproduktionsmedizin amKlinikum KasselDr. med. Marc Janos Willi,Dr. med. Oswald Schmidt, Prof. Dr. med.Miguel HinrichsenMönchebergstr. 41 – 43 (Haus 6 B)34125 KasselTel. 0561/980 29 80, Fax -980 29 81info@kinderwunsch-kassel.dewww.ivf-kassel.deUniversitätsklinikum Gießen - MarburgGmbH, Standort MarburgKlinik für Gynäkologie, gyn. Endokrinologieu. OnkologieSchwerpunkt gyn. EndokrinologieReproduktionsmedizin und OsteologieProf. Dr. med. Peyman Hadji,Prof. Dr. med. Uwe Wagner,Dr. med. Volker ZillerBaldingerstraße35043 MarburgTel. 06421/5864-400, Fax -5864-403www.repko-ukgm.deKinderwunschzentrum MittelhessenDr. med. A. Hajimohammad, B. OelsSportparkstr. 935578 WetzlarTel. 06441/200 20 20, Fax -200 202 99info@Kinderwunschzentrum-mh.dewww.kinderwunschzentrum-mh.deKinderwunschpraxis GöttingenReproduktionsmedizin/GynäkologischeEndokrinologieDr. med. Monica Tobler, Jana RostekWaldweg 537073 GöttingenTel. 0551/41 337, Fax -41 722info@kinderwunsch-praxis-goettingen.dewww.kinderwunsch-praxis-goettingen.deGeorg-August-Universität GöttingenProf. Dr. med. Dr. Bernd Hinney,Prof. Dr. Hans-Wilhelm MichelmannRobert-Koch-Str. 4037075 GöttingenTel. 0551/39 81 31, Fax -39 65 28bhinney@med.uni-goettingen.deKinderwunschzentrum GöttingenDr. Rüdiger Moltrecht, Dr. Sabine Hübner,Dr. Thomas Welcker, Dr. Filiz Sakin-Kaindl,Dr. Stephanie Mittmann, Dr. Peter SchulzeckKasseler Landstr. 25 A37081 GöttingenTel. 0551/99888-0, Fax -99888-99info@Kiwu-goettingen.dewww.kiwu-goettingen.de494 J Reproduktionsmed Endokrinol 2010; 7 (6)

Kinderwunschzentrum MagdeburgDr. med. Ingrid Nickel,Dr. med. Evelyn RichterUlrichplatz 139104 MagdeburgTel. 0391/81140 90, Fax -85204 29info@kiwumed.dewww.kinderwunschzentrum-magdeburg.deUniversitätsklinik für Reproduktionsmedizinu. Gyn. EndokrinologieProf. Dr. med. J. Kleinstein,Dr. med. A. B. BrössnerGerhart-Hauptmann-Str. 3539108 MagdeburgTel. 0391/671 73 90, Fax -671 73 89juergen.kleinstein@med.ovgu.dewww.med.uni-magdeburg.de/fme/krgeZentrum für interdisziplinäreKinderwunschbehandlung DüsseldorfDr. M. Scholtes, Ph. D., Dipl.-med. K. Marx,Priv.-Doz. Dr. med. S. Kißler,Dr. med. Martina Behler, Dr. med. S. Pfeiffer,Dr. med. Petra Hubert, Tanja Emde,Dr. med. Selma Yildirim-AssafVölklinger Str. 4 / RWI 4-Haus40219 DüsseldorfTel. 0211/90 197-0, Fax -90 197-50info@ivf-duesseldorf.deUniKiD, Universitäres interdisziplinäresKinderwunschzentrum DüsseldorfFrauenklinik der Heinrich-Heine-UniversitätProf. Dr. med. Jan-Steffen Krüssel,Dr. med. Alexandra Hess,Dr. med. Barbara Mikat-Drozdzynski,Dr. med. Andrea Schanz,Dr. rer. nat. Jens HirchenhainMoorenstraße 540225 DüsseldorfTel. 0211/810 40 60, Fax -811 67 87info@unikid.dewww.unikid.deKinderwunschzentrum MönchengladbachDr. med. Georg Döhmen,Dr. med. Thomas SchalkVon-Groote-Str. 17541066 MönchengladbachTel. 02161/49686-0, Fax -49686-19info@kindwunsch.dewww.kindwunsch.degreen-ivf: Grevenbroicher Endokrinologikum& IVF-ZentrumDr. J. Tigges, Dr. K. Friol, PD Dr. C. GnothRheydter Str. 14341515 GrevenbroichTel. 02181/4915 13, Fax -4915 34praxis@green-ivf.dewww.green-ivf.deInstitut für Gynäkologische Endokrinologieund Reproduktionsmedizin RemscheidDr. med. J. Luckhausmail@kinderwunsch-remscheid.dewww.kinderwunsch-remscheid.deKinderwunschzentren Dortmund u. SiegenGemeinschaftspraxisProf. Dr. med. Stefan Dieterle,Dr. med. Andreas Neuer,Prof. Dr. med. Robert GrebOlpe 1944135 DortmundHermelsbacher Weg 4157072 SiegenTel. 0231/557 54 50, Fax -557 54 599Tel. 0271/7701-810, Fax -7701-8120info@ivf-dortmund.dewww.ivf-dortmund.deVITRO-MEDKinderwunschzentrum BochumYvonne GiesnerHellweg 244787 BochumTel. 0234/155 24, Fax -685 479info@vitro-med.dewww.vitro-med.deNOVUM – Zentrum für ReproduktionsmedizinEssen - DuisburgProf. Dr. T. Katzorke, Dr. Dirk Propping, Dr.Susanne Wohlers, Prof. Dr. P. BielfeldAkazienallee 8-1245127 EssenTel. 0201/294 290, Fax -294 2914info@ivfzentrum.dewww.ivfzentrum.deReprovita, KinderwunschzentrumRecklinghausenKemnastr. 3a45657 RecklinghausenTel. 02361/904 18 80, Fax -904 18 813info@reprovita.dewww.reprovita.deKinderwunschpraxis GelsenkirchenDr. med. Ute Czeromin,Dr. med. Ina Walter-GöbelDr. med. Kathrin FißelerMunscheidstrasse 1445886 GelsenkirchenTel. 0209/167 1470, Fax -167 1471info@kinderwunsch-gelsenkirchen.dewww.kinderwunsch-gelsenkirchen.deFertility Center MünsterlandDr. med. Ulrich HillandCrispinusstr. 1246399 BocholtTel. 02871/23 943 43, Fax -23 943 44praxis@fcm-net.deKinderwunschzentrum MünsterDr. Dr. med. L. Belkien,Dr. med. C. NiehoffFachärzte für Frauenheilkunde u. Geburtshilfe,akademische Lehrpraxis,Hötteweg 5 - 748143 MünsterTel. 0251/482 67 0, Fax -482 67 77info@Kinderwunschtherapie.dewww.kinderwunschtherapie.deKinderwunschsprechstunde UniklinikMünster - IVF-BereichOA Dr. med. Schüring, Prof. Kiesel,Martina Kreimer, Prof. KlieschDomagkstr. 1148149 MünsterTel. 0251/83-52410, Fax -83-56497andreas.schuering@ukmuenster.dewww.klinikum.uni-muenster.deZentrum für KinderwunschbehandlungOsnabrückIrene Coordes,Dr. med. Manfred SchneiderRheiner Landstr. 93 – 9549078 OsnabrückTel. 0541/40 45 00, Fax -40 45 040info@Kinderwunsch123.dewww.kinderwunsch123.deGemeinschaftspraxisDr. med. Dieter Struller,Dr. med. Christof EtienGraf-Salm-Strasse 1050181 BedburgTel. 02272/77 78, Fax -77 73info@Kinderwunsch-erft.dewww.kinderwunsch-erft.dePAN Institut für Endokrinologie u.ReproduktionsmedizinDr. Stefan Palm, Dr. Irene Pütz,Dr. Mirko Dannhof,Prof. Dr. Christoph Keck,Priv.-Doz. Dolores FothZeppelinstr. 150667 KölnTel. 0221/277 62 00, Fax -277 62 24repro@pan-Klinik.dewww.fertilitycenter-koeln.deUniklinik KölnKlinik und Poliklinik für Frauenheilkundeund GeburtshilfeDr. G. Rahimi, Dr. C. Moers, I. OrthKerpener Str. 3450931 KölnTel. 0221/478 4990, Fax -478 86201gohar.rahimi@uk-koeln.dewww.frauenklinik.uk-koeln.deKinderwunschzentrum-KölnPraxis und Klinik SchoenhauserstraßeDr. med. Markus MerzenichSchoenhauser Str. 350968 KölnTel. 0221/340 3070mmerzenich@kinderwunschzentrum-koeln.deKinderwunschzentrum KölnEva SchwahnSchoenhauser Str. 350968 Köln-BeyenthalTel. 0221/340 2280info@wunschkind-koeln.deUniversitäts-Frauenklinik für GynäkologischeEndokrinologie u. ReproduktionsmedizinMed. Fakultät der RWTH AachenProf. Dr. med. Joseph Neulen,Dr. med. Benjamin Rösing,Dr. rer. nat. Ute WeißenbornPauwelsstraße 3052074 AachenTel. 0241/808 8971, Fax -808 2518gyn-endokrinologie@ukaachen.dewww.gyn-endokrinologie@vkaachen.deFrauenarztpraxis mit SchwerpunktGynäkologische Endokrinologie undReproduktionsmedizinDr. med. Klaus-Michael GrunwaldEisenhütte 2352076 AachenTel. 02408/958 499, Fax -958 477KMAL54@t-online.deAbteilung für Gynäkologische Endokrinologieund ReproduktionsmedizinUniversitätsklinikum BonnProf. Dr. med. Hans Van der Ven,Prof. Dr. med. Katrin Van der Ven,Dr. med. Ulrike Bohlen,Prof. Dr. rer. nat. Markus MontagSigmund-Freud-Str. 2553105 BonnTel. 0228/2871-9186, Fax -2871-5795bettina.sander@ukb.uni-bonn.dewww.kinderwunsch-uni-bonn.dePraxisklinik für gynäkologische Endokrinologieund ReproduktionsmedizinPriv.-Doz. Dr. Dr. med. Gernot PrietlTheaterplatz 1853177 Bonn-Bad GodesbergTel. 0228/3503910, Fax -36 48 92ivf@careme.deJ Reproduktionsmed Endokrinol 2010; 7 (6) 495

Praxisklinik TrierZentrum für Gynäkologische Endokrinologie& ReproduktionsmedizinDr. med. M. Satari,Prof. Dr. med. J. P. HankerWissenschaftspark (WIP)Max-Planck-Str. 1554296 TrierTel. 0651/97906-0, Fax -97906-20info@kinderwunsch-trier.dewww.kinderwunsch-trier.deKinderwunschzentrum derUniversitätsmedizin MainzUniv.-Prof. Dr. Rudolf Seufert M.Sc.,Fr. Dr. V. Passuello,Univ. Prof. Dr. Dr. H. KölblLangenbeckstr. 155101 MainzTel. 06131/17 3929, Fax -17 6215seufert@mail.uni-mainz.dewww.wunschkind-mainz.deKinderwunsch Zentrum MainzDr. med. Robert Emig,Dr. med. Silke MettlinRheinstr. 4Fort Malakoff Park55116 MainzTel. 06131/60 30 20, Fax -60 30 210arzt@Kinderwunschzentrum-mainz.dewww.kinderwunschzentrum-mainz.deKinderwunschzentrum MittelrheinKoblenz u. NeuwiedDr. Josef Beran, Dr. Birgit MüllerMarktstr. 8356564 NeuwiedNeustadt 856068 KoblenzTel. 02631/3968-0, Fax -3968-29info@Kinderwunsch-mittelrhein.dewww.kinderwunsch-mittelrhein.deZentrum für ReproduktionsmedizinProf. Dr. Ernst Siebzehnrübl,Dr. Anja WeidnerHanauer Landstr. 328 - 33060314 FrankfurtTel. 069/426077-0, Fax -426077-10anmeldung@ivf-ffm.dewww.ivf-ffm.deKinderwunschzentrum Frankfurt a. M.Am Krankenhaus NordwestProf. Dr. med. E. MerzSteinbacher Hohl 2 - 26, Haus II, I. OG60488 Frankfurt a. M.Tel. 069/7601 3611, Fax -7601 3321info@kinderwunschzentrum-frankfurt.dewww.kinderwunschzentrumfrankfurt.deFertilitätszentrum u. Gyn. Endokrinologie,Universitätsfrauenklinik Frankfurt am MainPD Dr. med. Inka WiegratzTheodor-Stern-Kai 760590 Frankfurt am MainTel. 069/630 15 518, Fax -630 14 505info.ivf@kgu.dewww.kgu.de/zfgKinderwunschzentrum am Büsing ParkDr. med. K. ManolopoulosHerrnstr. 5163065 OffenbachTel. 069/809 075 71, Fax -809 075 73info@offenbach-kinderwunsch.dewww.offenbach-kinderwunsch.deKinderwunschzentrum DarmstadtProf. Dr. med. G. Leyendecker,Dr. med. A. Bilgicyildirim,Dr. med. M. InackerBratustraße 964293 DarmstadtTel. 06151/500 98 0, Fax -500 98 500info@KWZ-da.dewww.kinderwunschzentrum-da.deMVZ Kinderwunschzentrum WiesbadenDres. med. M. Schorsch, Th. Hahn,G. Adasz, K. SchilberzMainzer Str. 98 – 10265189 WiesbadenTel. 0611/97632-0, Fax -97632-10info@kinderwunschzentrum-wiesbaden.dewww.kinderwunschzentrum-wiesbaden.deÜberregionale GemeinschaftspraxisIVF-Saar Saarbrücken-KaiserslauternDres. med. M. Thaele, L. Happel,A. Giebel, N. Nassar, M. OtteEuropaallee 1566113 SaarbrückenMaxstr. 1367659 KaiserslauternTel. 0681/936 320 Fax -936 3210Zentrum@ivf-saar.dewww.ivf-saar.deKinderwunschzentrum LudwigshafenDr. med. Tobias Schmidt,Dr. med. Claudia Schmidt,Dr. rer. nat. Nicole MotzkusLudwigstr. 54B67059 LudwigshafenTel. 0621/592 98 688, Fax -592 98 690dr.schmidt@kinderwunsch-lu.dewww.kinderwunschzentrum-ludwigshafen.deKinderwunschzentrum MannheimKlinikdirektorProf. Dr. med. M. Sütterlin,Dr. med. R. Schaffelder,PD Dr. med. St. BussenDr. med. J. Schüttler, Dr. GentiliTheodor-Kutzer-Ufer 1-368167 MannheimTel. 0621/3833-638, Fax -3833-814Julia-Schuettler@gyn.ma.uni-heidelberg.dewww.umm.de/64.0.htmlViernheimer Institut für FertilitätPD. Dr. med. Stefanie Volz-Köster,Dr. med. Christina Nell,Dr. sc. hum. Brigitte HauffKarl-Marx-Str. 4368519 ViernheimTel. 06204/70 36 00, Fax -70 36 05info@vif-kinderwunsch.dewww.vif-kinderwunsch.deKinderwunschzentrum HeidelbergDr. Waltraud Parta-Kehry, Dr. Suat Parta,Friederike Tesarz,Dr. Daniela Seehaus, Dr. Christina ThöneRömerstr. 369115 HeidelbergTel. 06221/89300-0, Fax -89300-20info@kwz-hd.dewww.kwz-hd.deUniversitäts-Frauenklinik HeidelbergGynäkologische Endokrinologie undFertilitätsstörungenProf. Dr. Thomas Strowitzki,PD Dr. Bettina TothVoßstr. 969115 HeidelbergTel. 06621/56 79 10, Fax –56 40 99thomas.strowitzki@med.uni-heidelberg.dewww.uniklinkum-heidelberg.de/gyn-endo-reproKinderwunsch-Zentrum-StuttgartPraxis Villa HaagDr. D. B. Mayer-EichbergerHerdweg 6970174 StuttgartTel. 0711/22 10 84, Fax -22 10 85info@Kinderwunschpraxis.dewww.kinderwunschpraxis.deGynäkologie und ReproduktionsmedizinDr. med. Fred Maleika,Dipl. Biol. Dr. rer. nat. Silvia HarrerLessingstr. 970174 StuttgartTel. 0711/226 13 44, Fax -226 30 48drmaleika@aol.comFrauenarztpraxis mit TagesklinikReproduktionsmedizinProf. Dr. med. Ute FuchsKornbergstr. 2370176 StuttgartTel. 0711/22 62 728, Fax -22 62 738Prof.UteFuchs@t-online.dewww.kinder-wunsch-bw.deKinderwunschPraxis Dres. GöhringDr. med. Ulrich Göhring,Dr. med. Inés GöhringHagellocher Weg 6372070 TübingenTel. 07071/94663-0, Fax -94663-99info@Kinderwunschpraxis.comwww.kinderwunschpraxis.comUFK – TübingenIVF – ZentrumDr. Barbara Lawrenz,Dr. Eva NeunhoefferCalwerstr. 772076 TübingenTel. 07071/298 31 17, Fax -292 250Barbara.Lawrenz@med.uni-tuebingen.deAalener IVF-ZentrumDr. Rainer Rau, Dr. Birgit Schröppel,Dr. Roland Eid (Biologe)Weidenfelder Str. 173430 AalenTel. 07361/620 21, Fax -620 26rau@kinderwunsch-aalen.dewww.kinderwunsch-aalen.deIVF-Zentrum EsslingenDr. med. J. E. CosteaMarktplatz 5/173728 EsslingenTel. 0711/31059-160, Fax -31059-161ivfcostea@t-online.dewww.ivf-praxis.comCentrum für Kinderwunsch PforzheimVerena PeutenZerrennerstr. 22 – 2475172 PforzheimTel. 07231/280 82 80, Fax -280 82 888info@kinderwunsch-pforzheim.dewww.kinderwunsch-pforzheim.deKarlsruher IVF-Programm,AG für FortpflanzungsmedizinFrauenarztpraxis H. J. GräberH. J. Gräber, Dr. V. Wetzel, Dr. F. TetensLaborärzte Dr. M. Linnemann und KollegenHumangenetik Dr. G. SchlüterKaiserstr. 142 - 14476133 KarlsruheTel. 0721/82 46 700, Fax -29 527info@ivf-programm.dewww.ivf-programm.de496 J Reproduktionsmed Endokrinol 2010; 7 (6)

Centrum für Gynäkologische Endokrinologie& Reproduktionsmedizin Freiburg (CERF)GemeinschaftspraxisDr. Weitzell, Dr. Thiemann, PD Dr. Wetzka,Prof. F. GeisthövelBismarkallee 7 F79098 FreiburgTel. 0761/ 207 430, Fax -321 11info@kinderwunsch-hormone.dewww.kinderwunsch-hormone.deKlinik für Endokrinologie u. ReproduktionsmedizinUniversitäts-Frauenklinik FreiburgDr. S. Friebel,Dr. A. Hanjalic-Beck,Prof. H. P. ZahradnikHugstetter Str. 5579106 FreiburgTel. 0761/2703 187, Fax -2703 037arzt.ivf.ufk@uniklinik-freiburg.dewww.uniklinik-freiburg.deZentrum für Reproduktionsmedizin MünchenDr. med. Walter Bollmann,Dr. Thomas Brückner,Dr. med. Ulrich NossTal 1180331 MünchenTel. 089/242295-0, Fax -242295-60info@ivf-bbn.dewww.ivf-bbn.deGynäkologische Endokrinologie undReproduktionsmedizinder Uni München – InnenstadtLudwig-Maximilians-Universität (LMU)Frauenklinik InnenstadtPD Dr. med. M. S. Kupka,Dr. rer. nat. P. PapadopoulosMaistr. 1180337 MünchenTel. 089/5160-4214, Fax -5160-4918nachricht@ivf-maistrasse.dewww.ivf-maistrasse.deHormon Zentrum MünchenDr. med. H. Lacher, Dr. med. J. Puchta,Dr. med. S. Michna,PD Dr. med. H.-U. PauerWestendstr. 193 – 19580686 MünchenTel. 089/547 041–0, Fax -547 041-34info@hormonzentrum.dewww.hormonzentrum.deKinderwunsch Centrum München-PasingDr. med. Klaus Fiedler,Dr. med. Irene von Hertwig,Dr. med. Gottfried Krüsmann,Prof. Dr. Dr. med. habil Wolfgang Würfel,Ina Laubert,Dr. med. Claudia Santjohanser,Sabine Völker, Osama Meri,Dr. med. Jan KrüsmannLortzingstr. 2681241 MünchenTel. 089/244 144-0, Fax -244 144-42info@ivf-muenchen.dewww.ivf-muenchen.deHormon- und Kinderwunsch-Zentrum derLMU München-GroßhadernLeiter: Prof. Dr. Christian J. ThalerLeitende Embryologin:Dr. rer. nat. Viktoria von SchönfeldtKlinik und Poliklinik der Frauenheilkundeund GeburtshilfeDirektor: Prof. Dr. med. Klaus FrieseMarchioninistr. 1581377 MünchenTel. 089/7095-6825, Fax -7095-3844www.kinderwunsch-uni-muenchen.deA.R.T. BogenhausenProf. Dr. med. Dieter Berg,Dr. med. Bernd LesoinePrinzregentenstr. 6981675 MünchenTel. 089/414 240-0, Fax -414 240-11info@ivf-muenchen.comwww.ivf-muenchen.comKinderwunsch Centrum ChiemseeDr. med. Susann Boehm,Dr. med. Matthias LehnertHochriesstr. 2183209 Prien am ChiemseeTel. 08051/5050, Fax -63499info@Kinderwunsch-chiemsee.dewww.kinderwunsch-chiemsee.deIVF-Zentrum AugsburgDr. med. K.-F. Hiller, Dr. med. T. H. Bauer,Dr. H. KrausPrinzregentenstr. 2586150 AugsburgTel. 0821/502 780, Fax -502 78 78info@ivf-augsburg.dewww.ivf-augsburg.deKWK - KinderWunschKemptenZentrum für ReproduktionsmedizinKlinik für Frauenheilkunde und Geburtshilfe- Klinikum – Kempten gGmbHProf. Dr. med. Ricardo Felberbaum,OA Gerhard Allgayer,Dr. med. Daniela Hiltensberger,Dipl. Biol. Mohammad KousehlarRobert-Weixler Str. 5087439 KemptenTel. 0831/530-3393, Fax -530-3457Ricardo.Felberbaum@Klinikum-Kempten.dewww.kinderwunsch-kempten.dePraxisklinik Frauenstraße UlmKinderwunschzentrum UlmProf. Dr. med. K. Sterzik,Dr. med. E. StrehlerFrauenstr. 5189073 UlmTel. 0731/96 651-0, Fax -96 651-30info@kinderwunsch-ulm.dewww.kinderwunsch-ulm.deSektion für Gynäkologische Endokrinologieund ReproduktionsmedizinUniversität UlmDr. K. Hancke, Dr. B. Seemann,Dr. E. Isachenko, Dr. B. RosenbuschPrittwitzstr. 4389075 UlmTel 0731-500-58676, Fax 0731-500-58664Repromed.UFK@uniklinik-ulm.dewww.uniklinik-ulm.de/ivfKinderwunschpraxis UlmPraxis Dr. GagsteigerEinsteinstr. 5989077 UlmTel. 0731/15159473info@kidz-ulm.dewww.kidz-ulm.deKinderwunsch- und Frauen-Hormon-Centrum NürnbergDr. Barbara Munzer-Neuwinger,Dr. Joachim Neuwinger,Prof. Dr. Peter LichtAgnesgasse 2-490403 NürnbergTel. 0911/235 55 00, Fax -235 55 16aerzte@kinderwunschcentrum-nuernberg.dewww.kinderwunschcentrum-nuernberg.deKinderwunschzentrum ErlangenDr. med. J. Van UemMichael-Vogel-Str. 1e91052 ErlangenTel. 09131/8095-0, Fax -8095-30vanuem@web.dewww.vanuem.comGemeinschaftspraxis der FrauenärzteZentrum für ReproduktonsmedizinDr. Miklos Hamori,Dr. Rolf Behrens,Dr. Andreas HammelNürnberger Str. 3591052 ErlangenTel. 09131/89 530, Fax -205 410info@ivf-erlangen.dewww.ivf-erlangen.deUniversitäts-FortpflanzungszentrumFranken (UFF)Prof. Dr. med. M. W. Beckmann,PD Dr. med. Andreas Müller,Prof. Dr. rer. nat. Ralf Dittrich (Biologe)Universitätsstr. 21-2391054 ErlangenTel. 09131/85-33553fk-uff@uk-erlangen.dewww.reproduktionsmedizin.uk-erlangen.deKinderwunschzentrum RegensburgProf. Dr. med. Bernd Seifert,Prof. Dr. med. Monika Bals-PratschHemauer Str. 193047 RegensburgTel. 0941/59 20 60, Fax -59 20 623info@kinderwunsch-regensburg.dewww.kinderwunsch-regensburg.deKinderwunschzentrum NiederbayernDr. med. Hans J. Kroiss,Dr. med. E. Bernhardt.Dr. med. Anja Bräuker,Dipl. Biologin Heike Vornehm,Edith WilhelmStadtfeldstr. 5094469 DeggendorfTel. 0991/297 99 332, Fax -297 99 331heike-vornehm@t-online.dewww.ivf-bayern.deKlinik am HofgartenKinderwunschzentrum BayreuthDr. Dr. Stefan TodorowRichard-Wagner-Straße 34-3695444 BayreuthTel. 0921/745 444 0, Fax -745 444 10info@ivf-bayreuth.dewww.ivf-bayreuth.deZentrum für Kinderwunsch, Pränataldiagnostik,Medizinische GenetikDr. med. R. Mai,Dr. med. W. Schmitt,Frau Dr. med. L. MulfingerJuliuspromenade 797070 WürzburgTel. 0931/32 12 30, Fax -32 12 377kontakt@drs-mai-schmitt-mulfinger.dewww.drs-mai-schmitt-mulfinger.deUniversitäts-Frauenklinik WürzburgKinderwunschzentrumDr. med. Torsten Frambach,Dr. med. Thomas BernarJosef-Schneider-Str. 497080 WürzburgTel. 0931/201 25 619, Fax -201 25 625kinderwunsch@klinik.uni-wuerzburg.dewww.kinderwunsch-wuerzburg.deJ Reproduktionsmed Endokrinol 2010; 7 (6) 497