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BUMC Basics.pdf - Anesthesia Home

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60<br />

• Resistant pathogens: MRSA, VRE, Pseudomonas<br />

• Other infections: Cellulitis, cholangitis, cholecystitis,<br />

diverticulitis, endocarditis, intra-abdominal abscess,<br />

meningitis, sinusitis, thrombophlebitis<br />

• Non-infectious causes: Transfusion reactions, drug<br />

fever, intra-abdominal source (pancreatitis, acute<br />

mesenteric ischemia), thyroid disease, or thromboembolic<br />

disease (DVT/PE)<br />

Work-up and treatment — Consider the following:<br />

• CBC with diff, CMP<br />

• Repeat blood cultures x2<br />

• CMV PCR<br />

• UA/urine culture<br />

• Sputum gram stain/culture<br />

• Change out central lines if >48 hours (venous lines first)<br />

and culture tips<br />

• pCXR<br />

• Stool studies if indicated<br />

• Abdominal ultrasound if indicated<br />

• CT chest, abdomen, or pelvis if indicated<br />

• Bilateral lower extremity Doppler if indicated<br />

• CT sinuses if chronic NG tube<br />

• Empiric antibiotics<br />

Definition<br />

FEVER OF UNKNOWN ORIGIN<br />

• Fever >101°F (38.5°C) on one or more occasion<br />

• Duration >3 weeks<br />

• No diagnosis despite 1 week of intensive evaluation<br />

Etiologies<br />

• Infection:<br />

Tuberculosis, endocarditis, intra-abdominal abscess,<br />

osteomyelitis, fungal infection, meningitis, hepatitis, CMV,<br />

EBV, Lyme disease, HIV, etc.<br />

• Connective tissue disease:<br />

Temporal arteritis, Polyarteritis nodosa, RA, SLE, etc.

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