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BUMC Basics.pdf - Anesthesia Home

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102<br />

3. Calculate anion gap by Na- Cl- HCO3 (nl 8-12; if albumin<br />

is low reduce normal range by 2-3 for each 1 gm reduction<br />

of albumin below normal):<br />

Causes of AGMA: KUSMALE (ketones, uremia,<br />

salicylates, methanol, paraldehyde, lactic acidosis, or<br />

ethylene glycol) or GOLDMARK-paper submitted by<br />

Mehta et al (glycols, oxyproline, L-lactate, D-lactate,<br />

Methanol, Aspirin, Renal, Ketoacidosis)<br />

If anion gap, consider the following: urine and serum<br />

ketones, renal function, lactate, Utox, plasma osmolal gap.<br />

Osmolal gap: “Delta Osmoles” =measured plasma<br />

osmolality - calculated osmolality<br />

Calculated osmolality = (2xNa)+(glucose/18)+(BUN/2.8)<br />

Osmolal gap >15 suggests methanol or ethylene glycol<br />

If anion gap is decreased, you should suspect a<br />

decreased albumin or disorders that increase<br />

“unmeasured” cations such as multiple myeloma, extreme<br />

hypercalcemia, hypermagnesemia, lithium.<br />

4. If there is a high anion gap, then calculate how much it is<br />

increased above the normal range (ie, Anion Gap Increase<br />

= observed anion gap-expected anion gap (8 - 12 if<br />

albumin is normal)<br />

Increase in Gap + measured HCO3 should = about 24<br />

(The gap should go up about the same amount the HCO3<br />

goes down)<br />

• If this is >24 consider concomitant metabolic<br />

alkalosis or severe chronic respiratory acidosis<br />

• If this is

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