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<strong>BUMC</strong> BASICS
2<br />
TABLE OF CONTENTS<br />
Welcome and General Information 5<br />
Authors: Jenny Duewall, MD and Sara Lindsey, MD<br />
• <strong>BUMC</strong> <strong>Basics</strong><br />
• Intern Cross Cover Cheat Sheet<br />
• Contact List<br />
• Obtaining a Consult at Baylor<br />
• Dictation Guide for Discharge/Death Summaries<br />
• Sample Orders/Order Sets<br />
• Prn’s/Prophylaxis Meds<br />
• Social Work vs. Care Coordinators<br />
• DISPO<br />
CLINICAL SECTIONS<br />
Cardiology 29<br />
Authors: Adam Falcone, MD and Alexi Mantas, MD<br />
• CCU in General<br />
• Acute Coronary Syndrome<br />
• Atrial fibrillation<br />
• Calcium Channel Blockers<br />
• Chest Pain<br />
• EKG<br />
• Heart Failure<br />
• Hypertensive Crisis<br />
• Pulmonary Edema<br />
• Syncope<br />
• Tachycardia<br />
Gastroenterology/Hepatology 47<br />
Authors: Tom Van Dinter, MD and Alexi Mantas, MD<br />
• GI Consults and Groups<br />
• General GI/Liver Topics<br />
• General Gastroenterology<br />
• General Hepatology<br />
• GI Studies<br />
Infectious Diseases 58<br />
Author: Jenny Duewall, MD<br />
• Bugs and Drugs<br />
• Fever in the ICU<br />
• Fever of Unknown Origin<br />
• Pneumonia<br />
• Sepsis<br />
• Tests to Consider Ordering<br />
Neurology 66<br />
Author: Jenny Duewall, MD<br />
• Altered Mental Status<br />
• Brain death exam<br />
• Neuromuscular Emergencies<br />
• Seizures
• Status Epilepticus<br />
• Stroke management<br />
Oncology 73<br />
Author: Troy Neal, MD<br />
• The Acute Leukemic<br />
Palliative Care and Clinical Ethics 77<br />
Author: Troy Neal, MD<br />
Pressor Chart 82<br />
Author: Natalie Norman, MD<br />
Pulmonary 83<br />
Authors: Jenny Duewall, MD and Alexi Mantas, MD<br />
• ARDS<br />
• Asthma/COPD<br />
• Mechanical Ventilation<br />
• Pleural effusion<br />
• Pulmonary embolus<br />
Radiology 97<br />
Author: Sara Lindsey, MD<br />
• Radiology Hints<br />
Renal 101<br />
Author: Jenny Duewall, MD<br />
• Acid/Base Disturbances<br />
• Acute Kidney Injury<br />
• Basic Electrolyte Repletion<br />
• Chronic Kidney Disease<br />
• Hyponatremia<br />
• Oliguia<br />
• Renal Replacement Therapy<br />
OUTPATIENT CLINIC GUIDE 112<br />
Authors: Sophie Esmail, MD and Ryan Jones, MD<br />
• $4 Walmart Rx list<br />
OTHER INFORMATION 120<br />
• Top Ten Intern Tips<br />
• Duewall’s Mnemonics (Author: Jenny Duewall, MD)<br />
• Sustenance/Comfort Food (Author: Sara Lindsey, MD)<br />
• Map<br />
3
Special thanks to the following Attendings who dedicated their<br />
time to edit each section in his or her respective specialties:<br />
4<br />
Manish Assar, MD (cardiology/EP)<br />
Robert Black, MD (pulmonary)<br />
Erin Bowman, MD (radiology)<br />
Micheal Emmett, MD (renal)<br />
Robert Fine, MD (palliative care)<br />
Dion Graybeal, MD (neurology)<br />
Chris Haden, MD (pulmonology)<br />
Houston Holmes, III, MD (oncology)<br />
Louis Sloan, MD (ID)<br />
William Sutker, MD (ID)<br />
Ravi Vallabahn, MD (cardiology)<br />
Special thanks to Kim Miller, editorial assistant, UpToDate, Inc.<br />
EDITOR: Jenny Duewall, MD<br />
CONTRIBUTING AUTHORS:<br />
Jenny Duewall, MD, Internal Medicine Resident, <strong>BUMC</strong> Dallas<br />
Sophie Esmail, MD, Internal Medicine Resident, <strong>BUMC</strong> Dallas<br />
Adam Falcone, MD, Internal Medicine Resident, <strong>BUMC</strong> Dallas<br />
Ryan Jones, MD, Internal Medicine Resident, <strong>BUMC</strong> Dallas<br />
Sara Lindsey, MD, Radiology Resident, <strong>BUMC</strong> Dallas<br />
Alexi Mantas, MD, Internal Medicine Resident, <strong>BUMC</strong> Dallas<br />
Troy Neal, MD, Internal Medicine Resident, <strong>BUMC</strong> Dallas<br />
Natalie Norman, MD, Internal Medicine Resident, <strong>BUMC</strong> Dallas<br />
Tom Van Dinter, MD, Gastroenterology Fellow, <strong>BUMC</strong> Dallas
5<br />
Welcome to Baylor University Medical<br />
Center (<strong>BUMC</strong>)<br />
Welcome to <strong>BUMC</strong>! This book has been assembled by Baylor<br />
residents to make the transition from being a medical student<br />
to an intern as smooth as possible. Although this book has<br />
several helpful hints and is a good reference, please remember<br />
to use your clinical judgment and practice evidence based<br />
medicine using the multiple references and resources you<br />
have available to you.<br />
We look forward to working with you and we know it will be a<br />
great year!<br />
Sincerely,<br />
The <strong>BUMC</strong> Internal Medicine Residents, 2008-2009
6<br />
GENERAL INFORMATION<br />
<strong>BUMC</strong> BASICS<br />
Scheduled rounds:<br />
• Attending rounds: Usually 5 times per week, schedule<br />
determined usually at the beginning of the month<br />
• Morning Report: For R2’s and R3’s, every M,W,F from<br />
7-8 a.m.<br />
Conferences:<br />
• Noon conference daily: Roberts Medical Education<br />
Classroom<br />
• Grand Rounds: Tuesday at 8 a.m. in Beasley Auditorium<br />
• Chief’s Conference: Every Friday at noon in the Truett<br />
Conference Room 8ABC (get lunch from the Truett<br />
Cafeteria or Doctor’s lounge and charge it to the room);<br />
during interview season, chief’s conference is on<br />
Thursdays (interview day) on 17 Roberts and buffet is<br />
served<br />
• Potpourri: During Chief’s conference once monthly:<br />
Cases presented by interns and residents<br />
• Intern/Resident Evaluations/Med Student: Last Friday of<br />
each ward month. Residents and Attendings meet at 7:00<br />
and interns meet at 7:30. It is in a conference room<br />
outside of the Truett cafeteria. Get breakfast and charge it<br />
to the room.<br />
Call schedule:<br />
• On general medicine wards: Call every fifth night.<br />
• On CCU, call every fourth night.<br />
• On electives, no call and no weekends except for select<br />
electives when you may work on Saturday (ie ID).<br />
• On ER, no clinic and no call. You work 12-hour shifts,<br />
7 a.m. to 7 p.m. or 7 p.m. to 7 a.m. in the following format:<br />
3 day shifts, 3 night shifts, 3 days off.<br />
• Float month: No call and no weekends. The Float<br />
resident also usually does not work on holidays, so be<br />
considerate and try not to ask them to cover you on those<br />
days.
7<br />
Rounding on your patients:<br />
• See ICU patients first, then floor patients.<br />
• Update your attending as they request; if not specified<br />
otherwise, update them daily.<br />
• See patients you plan on discharging as early as<br />
possible and notify attending of possible discharge so they<br />
can plan on seeing the patient and evaluate readiness for<br />
discharge.<br />
The following need to be done to complete a<br />
discharge:<br />
• Medical Reconciliation Form updated and signed<br />
• Prescriptions filled out and signed<br />
• You can obtain a 2 week supply (no refills) of<br />
medications for your indigent patients if needed. Fill out<br />
the Rx form for a 2 week supply and write social work<br />
across the top and place with discharge information.<br />
• Discharge instructions with follow-up appointments<br />
(separate form)<br />
• Transfer orders are needed if going to a SNF or long<br />
term care facility<br />
• BIR/BSH have special packets that need to be done<br />
• Write discharge order (to home, SNF, BSH, BIR, etc)<br />
• Dictate patient and keep track of job # (write in the chart<br />
if dictated at time of discharge; keep track separately if<br />
dictated later)<br />
Cross cover and check-out:<br />
• Cross Cover starts after 5 p.m. on weekdays and at<br />
noon on weekends<br />
• Check out on-line: please write down user name and<br />
password at orientation<br />
• Call the cross cover intern and check out any seriously<br />
ill patients<br />
• Try to anticipate what may happen to your patient and<br />
instruct cross cover on how you would like that managed.<br />
Codes:<br />
• While on wards you are on the code team two days prior<br />
to your call day. Wear scrubs when you are on codes, oncall,<br />
and post-call
8<br />
• M-F, Code team runs codes starting at 7 a.m. until your<br />
resident lets you know you are off codes, at which time the<br />
on-call team takes over codes. On Saturday, the on-call<br />
team takes codes from 8 a.m. until 8 a.m. Sunday.<br />
Sunday, the on-call team takes codes from 8 am Sunday<br />
to 7 a.m. Monday.<br />
• The supervising resident runs the code. Medical<br />
students often do chest compressions. Interns will<br />
intubate if needed, run lines, and review the chart and<br />
other responsibilities as needed.<br />
• Simultaneous codes or codes within 30 minutes of one<br />
another: Response to the first code is by the code team.<br />
The on-call ward team should go to the second code. If<br />
there is a third code, one intern from each code team and<br />
on-call team should go to that code. If the code team is<br />
gone and the on-call team is called to a code, a second<br />
code within 30 minutes will be run by the CCU<br />
intern/resident on call.<br />
Procedures:<br />
• The ABIM requires that graduates be proficient in the<br />
procedures listed below. There is no specified number, but<br />
a minimum of 3-5 directly supervised procedures is<br />
considered appropriate.<br />
1. Paracentesis<br />
2. Arterial puncture<br />
3. Arthrocentesis<br />
4. Central line placement<br />
5. Lumbar puncture<br />
6. NG tube<br />
7. Pap smear and endocervical culture<br />
8. Thoracentesis<br />
• All other procedures are not required, but residents often<br />
have the opportunity to do intubation, punch biopsies,<br />
bone marrow biopsies.<br />
• Each time you perform a procedure, take a sticker so<br />
you can record it in new innovations (www.newinnov.com)<br />
in your procedure log.<br />
• You will be supervised by a resident until the resident<br />
feels you are proficient, and then you can perform<br />
procedures unsupervised. As a general rule, you are<br />
supervised for the first 6 months of internship.<br />
• Hints for procedures:<br />
1. Use aseptic technique (cap, mask, gown, gloves,<br />
large sterile drape) for central lines and arterial<br />
lines. Other procedures can be done with sterile
9<br />
2. gloves only. During codes, if emergent central<br />
access is needed, lines are typically placed with<br />
gloves only. These emergent lines should be<br />
replaced using aseptic technique as soon as<br />
possible.<br />
3. DO A TIME OUT AND FILL OUT TIME OUT<br />
FORMS<br />
4. Write a procedure note when you are done.<br />
5. Bone Marrow Biopsy: Call hematology lab and<br />
ask for bone marrow technician about 15 minutes<br />
prior to your planned starting time.<br />
6. IJ and Subclavian TLC: Order a stat pCXR and<br />
review it when it returns to ensure placement and<br />
rule out a pneumothorax<br />
7. Arterial line: Check a-line wave form after a-line<br />
placement<br />
New Innovations (www.new-innov.com):<br />
• On-line system for logging hours, procedures,<br />
evaluations, and reviewing curriculum.<br />
• Hours need to be logged and approved by the last day<br />
of the month.<br />
• If you log more than 80 hours a week or violate any work<br />
rules, this will appear in red and you need to change it to<br />
meet rules.<br />
• Curriculum needs to be reviewed prior to each rotation.<br />
The curriculum assigned to you for you to review will<br />
appear on your front log-in page.<br />
• When you log in at the end of the month, the front log-on<br />
page will have who you will be giving patients to or picking<br />
patients up from if you are coming on and going off<br />
general medicine wards.<br />
• Evaluations of your intern/resident/attending will be<br />
assigned to you at the end of the month and you will<br />
receive an e-mail reminder to sign-on and evaluate the<br />
other members of your team.<br />
Electives: The following electives are required. You need 3<br />
out of 4 or 4 out of 5 weeks of these (ie, no 2 weeks of<br />
vacation in a 4 week block):<br />
• Cardiology: If you are interested in a primarily<br />
outpatient experience, consider Drs. Thomas Andrews,<br />
Stephen Johnston, Charles Gottlich, or Karen Klatte. If you<br />
are interested in inpatient experience, consider Drs.<br />
Jeffrey Schussler, Rafic Berbarie, Ravi Vallabhan, Robert<br />
Stoller, James Choi, Jerold Grodin, or Carlos Velasco.
10<br />
• Dermatology: The office of Drs. Alan Menter and Dan<br />
McCoy, or the office of Dr. Farhad Niroomand.<br />
• Endocrinology: The office of Drs. Zaven Chakmakjian,<br />
Howard Heller, Brian Welch, Raphaelle Vallera, and Neil<br />
Breslau, or for diabetes intensive rotation, Dr. Priscilla<br />
Hollander.<br />
• Gastroenterology: For primarily outpatient experience,<br />
Drs. Angela Carollo, Catherine Yaussy, Christopher Vesy,<br />
Lawrence Schiller, or Charles Richardon. For more<br />
inpatient experience, Drs. Robert Anderson, Daniel<br />
DeMarco, Esmail Elwazir.<br />
• Geriatrics: (only need a minimum of 2 weeks)<br />
• Hematology: Drs. Barry Cooper, Houston Holmes, and<br />
Christopher Maisel<br />
• ID: Drs. Mezegbe Behre, Louis Sloan and Cedrik Spak.<br />
For outpatient/HIV experience, consider Dr. Mark Tribble.<br />
On ID, you work on Saturdays.<br />
• Nephrology: Drs. Fenves, Wiederkehr, Hayes, Tran, or<br />
Hebert.<br />
• Neurology: Coordinated by Dr. Dion Graybeal.<br />
• Oncology: Drs. Claude Denham, Thomas Hutson<br />
(primarily GU), David McCullum (primarily GI), Robert<br />
Mennel, Eric Nadler, John Pippin (primarily breast<br />
malignancy)<br />
• Pulmonary/Critical Care: For outpatient experience,<br />
Drs. Millard or Luterman. For inpatient, Drs. Black,<br />
Haden/Woolley, or Ausloos. You can also do one week<br />
with Black, one with Haden/Woolley, one with Millard, etc.<br />
and customize your experience.<br />
• Rheumatology: Coordinated through Alex Limanni.<br />
• Outpatient: Drs. Dean Dimmitt, William Chritensen,<br />
Aggarwal, Armstrong, Neubach, Sibley.<br />
**The remainder of your electives (2) are your choice.<br />
CCU:<br />
• Call every fourth night.<br />
• Each team member is on call by themselves.<br />
• All patients admitted by the intern are then picked up by<br />
the supervising resident in the morning and they will see<br />
the patients behind you.<br />
• All patients admitted by the resident are distributed to<br />
the interns the next day (the resident does not carry their<br />
own patients, but covers the entire service behind the<br />
interns).
11<br />
• There is one resident and 3 interns until the Spring,<br />
when the team becomes 4 interns.<br />
• Teaching rounds are with a separate CCU attending and<br />
are often daily M-F based on the attending’s preference.<br />
Clinic:<br />
• ½ Day per week on your assigned day<br />
• No clinic during ER month<br />
• No clinic when you are post-call<br />
• If clinic patients are admitted to the hospital, they will be<br />
admitted by teaching, and stay on that team unless the<br />
primary clinic intern/resident is on wards, and then they<br />
will transfer to that service in the am.<br />
• See Clinic guide section.<br />
Vacation:<br />
• 3 weeks total per year. Can be taken as 2 weeks and 1<br />
week or 1 week at a time.<br />
• Cannot be taken during ward, CCU, or float months<br />
(thus you can use it during electives or ER)<br />
• Turn in a form ahead of time (6 weeks if possible). Pick<br />
up a request from Suzanne. She will fax it to the clinic so<br />
they block out your clinic schedule for that time. See<br />
vacation policy/request.<br />
• Maternity leave is 6 weeks. You can combine it with your<br />
vacation for that year for a total of 9 weeks. The caveat is<br />
that you cannot exceed 12 weeks total off during your<br />
residency per the ABIM.<br />
• Paternity leave is 2 weeks.<br />
• Vacation does not roll over from year to year. What you<br />
don’t take is lost.
12<br />
INTERN CROSS-COVER CHEAT SHEET<br />
The following are general suggestions. Indicated medications<br />
are recommended but this sheet does not replace the need to<br />
refer to your own prescribing reference (Epocrates, etc). Not all<br />
medications or suggestions are useful for all patients. Please<br />
use your own clinical judgment.<br />
Patients that you should definitely go see are indicated with<br />
a *. Again, please use your clinical judgment when evaluating<br />
whether or not to see a patient. When in doubt, just go lay eyes<br />
on them.<br />
Altered Mental Status<br />
MOVE STUPID<br />
• Metabolic (hypothyroid, hepatic encephalopathy)<br />
• Oxygen (Hypoxia from PNA, pulm edema, etc)<br />
• Vascular (TIA, CVA, Subdural hematoma)<br />
• Electrolytes (Specifically Na, Ca)<br />
• Seizure<br />
• Trauma<br />
• Uremia<br />
• Porphyria<br />
• Infection (sepsis/meningitis)<br />
• Drugs<br />
Things to do<br />
• Chart to see hospital course<br />
• History to narrow differential<br />
• Physical, esp. neuro exam and vital signs<br />
• If fever, do BCx, UCx, CXR<br />
• Pulse ox with ABG for hypoxia. If CXR shows edema,<br />
give IV Lasix.<br />
• IVF if hypotensive<br />
• CT head to r/o bleed or CVA<br />
• Electrolytes & CBC<br />
• LP if you suspect meningitis<br />
• Lactulose therapy if hepatic encephalopathy: Lactulose<br />
30 g packet PO Q8 hours; titrate to 3-4 BM’s per day<br />
• Start ABX if patient appears ill<br />
• Stabilize seizure with drug therapy (Valium, dilantin,<br />
etc.)
Chest pain<br />
13<br />
DDx to consider<br />
• MI<br />
• Angina<br />
• PE<br />
• Pericarditis<br />
• Musculoskeletal<br />
• Pneumonia<br />
• PTX<br />
• Anxiety (very common)<br />
• Aortic Dissection<br />
• Pleurisy<br />
• Boerhave’s syndrome (ruptured esophagus)<br />
Things to do<br />
• Obtain history to try to elucidate etiology of CP<br />
• Focused Physical<br />
• Evaluate chart to see past history (CAD, etc.)<br />
• EKG after you take history. This will help limit the DDx<br />
above.<br />
• Cardiac enzymes if cardiac cause is considered.<br />
• CXR to look for pneumonia and aortic aneurysm<br />
• ABG for PE and pneumonia<br />
• Pain meds if musculoskeletal<br />
• Mild anxiolytic if anxiety<br />
• 100% O2 by facemask if small PTX, Chest tube if large<br />
PTX (>15%)<br />
If it’s angina, do following:<br />
• EKG first! Make sure it’s not a STEMI. Trend out<br />
CKMB/Troponins.<br />
• Check BP and then give NTG q 5 min until CP relieved.<br />
Make sure nurse checks BP in between each Nitro to<br />
avoid hypotension<br />
• If pt requires more than 3 nitro, give IV morphine 2 mg-4<br />
mg for pain relief. If you are unsuccessful after 20-30 min,<br />
pt will need IV NTG in ICU. Think MONA BASH for<br />
UA/NSTEMI/STEMI: Morphine/Oxygen/Nitro/Aspirin/B-<br />
Blocker/ACE Inhibitor/Statin/Heparin
Fever<br />
14<br />
DDx to consider<br />
• Infection (pneumonia, UTI, etc.)<br />
• PE<br />
• Drug fever<br />
• DVT<br />
• Fungal infection<br />
Things to do<br />
• Take history to try to find source (cough, dysuria, etc.)<br />
• Look through chart to see what has been done (previous<br />
blood cultures, etc.)<br />
• Perform focused physical exam, esp. vital signs<br />
• Do CXR, Blood cultures, Urine culture, sputum culture (if<br />
indicated)<br />
• Start abx only if patient looks ill with broad spectrum<br />
• Refer to cross cover sheet or progress notes for<br />
preference of what to advance antibiotics to if already on<br />
abx (esp neutropenic fever)<br />
Hypotension<br />
DDx<br />
• Sepsis<br />
• Cardiogenic shock<br />
• Adrenal insufficiency<br />
• Hemorrhagic shock<br />
• Volume depletion (overdiuresed)<br />
• Medication<br />
Things to do:<br />
• Try fluid bolus of 1 L NS (less if CHF/3 rd spacing)<br />
• Assess cause<br />
• If septic: volume resuscitate; check cultures; broad abx;<br />
start pressors (levophed) if needed to keep MAP>65<br />
• If Cardiogenic shock: Assess why. Start dopamine or<br />
dobutamine if needed<br />
• If concern for adrenal insufficiency, start stress dose<br />
steroids: Solumedrol 50 mg IV Q6 is a good start<br />
• If hemorrhagic shock: Volume resuscitate with NS and<br />
Blood. Check Hemostasis profile and give platelets/FFP<br />
as needed. If in DIC, give cryo. Determine source of<br />
bleeding and then stat consult for<br />
GI/Surgery/Neurosurgery/etc.<br />
• Hold BP meds, diuretics or reduce if needed
SOB<br />
DDx<br />
• Pneumonia<br />
• PE<br />
• Anxiety<br />
• Pulm edema<br />
• MI<br />
• PTX<br />
15<br />
Check CXR/ABG; O2 protocol; A/A nebs if bronchospasm, IV<br />
Lasix if volume overloaded<br />
Work-up and treat as indicated.<br />
Quick reference guide to targeted therapies<br />
to answer calls:<br />
1. Agitation: Ativan 2 mg IV x one, Haldol 2-4 mg IV/IM<br />
Q6hours prn, or seroquel 12.5-25 mg PO/NG q8hours prn<br />
agitation<br />
2. Anxiety: Ativan 2 mg IV x one<br />
3. Atrial fibrillation with RVR: Assess patient. If necessary,<br />
start on diltiazem gtt for rate control. Primary team can<br />
determine need for anticoagulation in the a.m.<br />
4. Bradycardia: Evaluate the patient and why they are<br />
bradycardic. If no symptoms, rarely need to treat. If<br />
symptoms, try atropine 0.4 mg IVP as needed x 3 doses.<br />
5. Constipation: Colace 100 mg PO Q12, sennakot one tab<br />
PO BID, Miralax 17g in 4-8 oz water QDay to BID until<br />
BM, MOM 30 ml PO Qday or Dulcolax 10 mg PR<br />
suppository Qday; If severe can try Fleet enema if<br />
needed-usually avoid enemas in neutropenic patients<br />
6. Cough: Tessalon perles 100 mg 3 times/day or every 4<br />
hours up to 600 mg/day, Guaifenesin 200-400 mg PO Q4<br />
hours to maximum of 2.3 g/day<br />
7. Diarrhea: First assess cause; If infectious causes are a<br />
concern, do not treat with anti-motility drugs. Do stool<br />
studies and treat underlying condition. Otherwise, can give<br />
Immodium 4 mg, followed by 2 mg after each loose stool,<br />
up to 16 mg/day; if ICU patient, and non-infectious, can try<br />
adding Banana Flakes to Tube Feeds as a bulking agent<br />
8. Electrolyte disturbances (low): See Electrolyte repletion<br />
9. Fever: Tylenol 325-650 mg PO Q4 hours; Abx if needed<br />
10. Gas: Mylicon
16<br />
11. Heart Burn: AOC. Maalox 320 mg PO Q6 hoursor TUMS<br />
1000 mg PO Q6 hours and/or Pepcid 20 mg PO BID or<br />
Protonix 40 mg PO Qday<br />
12. Hyperkalemia: Check EKG; if peaked T waves or<br />
prolonged QRS, give 1-2 amps Ca gluconate IV; then<br />
consider one or more of the following: 10 Units IV insulin<br />
with 1-2 amps D50, 1-2 amps HCO3; 10-20 mg inhaled<br />
albuterol, 40 mg IV Lasix, or hemodialysis if decreased<br />
GFR. If K is trending up and acute tx is not needed, give<br />
kayexalate 30-90 g PO<br />
13. Hypertension: Clonidine 0.1-0.2 mg PO or SL followed by<br />
0.1 mg Q1hour up to a max dose of 0.6 mg; can also try<br />
increasing the oral medication they are on or giving an<br />
extra dose. If IV needed, try labetalol 5 mg IVP every 5<br />
minutes if HR ok with max dose of 20 mg or Hydralazine 5<br />
mg IVP every 15 minutes, max dose 20 mg<br />
14. Insomnia: Ambien 5-10 mg PO Qhs<br />
15. Nausea/Vomiting: Phenergan 12.5-25 mg IV Q4 hours or<br />
Zofran 4-8 mg IV Q8 hours<br />
16. Nasal congestion: Ocean spray nasal one spray in each<br />
nostril Q8 hours, Oxymetazoline 0.05% 2 sprays in each<br />
nostril Q12 hours<br />
17. Pain: Norco 5/325 one to two tabs PO Q6 hours PRN pain<br />
or Morphine 1-2 mg IV Q4 hours; Careful when Rx<br />
Dilaudid. 1.5 mg Dilaudid is equal to 10 mg of IV<br />
Morphine. We tend to under dose morphine and overdose<br />
dilaudid. If adding narcotics, add a bowel regimen. If pain<br />
persists, can also try 25-50 micrograms Fentanyl every 5-<br />
10 minutes prn not to exceed 100 mcg.<br />
18. Positive Blood Culture: If not on antibiotics, start the<br />
following:<br />
Gram positive: Vanc 1 gram IV, then Rx to dose<br />
Gram negative: Zosyn or Merrem<br />
19. Pruritis: Benadryl 25 mg PO Q4 hours<br />
Drips that can be used on the floor<br />
(telemetry) as of 4/2009:<br />
• Diltiazem<br />
• Amiodarone<br />
• Dobutamine<br />
• Dopamine<br />
• Flolan (Epoprostenol)<br />
• Aggrastat (Tirofiban)<br />
• Integrillin (Eptifibatide)<br />
• Reopro (Abciximab)
17<br />
• Heparin<br />
• Lidocaine<br />
• Nitroglycerin for chest pain<br />
• Milrinone<br />
• Procainamide<br />
• Nicardipine
TPC<br />
972-545-4872<br />
Abrar Ahmad 972-451-<br />
3454<br />
Ali Bagheri 972-356-<br />
2754<br />
Thi Cao 972-356-<br />
2765<br />
Roberto Delacruz 972-356-<br />
2756<br />
Mamta Gupta 972-356-<br />
2702<br />
Stephanie Houck 972-356-<br />
2777<br />
Shalita Jones 972-451-<br />
0648<br />
Susan Kohl 972-356-<br />
2766<br />
Aysha Kunju 972-451-<br />
0647<br />
Shamim Lalani 972-356-<br />
2705<br />
Allison Lander 972-356-<br />
0291<br />
Brad Lembcke 972-356-<br />
2768<br />
Steven Lilly 972-451-<br />
4996<br />
Ankit Mehta 972-451-<br />
0346<br />
Manas Mewar 972-356-<br />
2778<br />
Pushpa Pathak 972-451-<br />
0291<br />
Paul Piper 972-356-<br />
2728<br />
Irving Prengler 972-356-<br />
2775<br />
Carolyn Quan 972-356-<br />
2757<br />
Suman Reddy 972-451-<br />
6192<br />
18<br />
CONTACT LIST<br />
Pager Cell Phone<br />
214-557-<br />
5568<br />
972-380-<br />
4994<br />
469-878-<br />
2941<br />
214-707-<br />
3137<br />
214-478-<br />
9416<br />
214-908-<br />
7590<br />
713-530-<br />
9417<br />
972-821-<br />
6599<br />
214-554-<br />
0707<br />
469-831-<br />
8924<br />
214-924-<br />
6244<br />
214-507-<br />
0816<br />
214-957-<br />
3523<br />
817-966-<br />
6255<br />
281-804-<br />
7420<br />
214-536-<br />
6931<br />
469-855-<br />
1272<br />
214-769-<br />
2357<br />
214-914-<br />
8955<br />
214-564-<br />
8516<br />
Med<br />
Provider<br />
214-820-<br />
3000<br />
After hours<br />
214-346-<br />
1494<br />
Cell<br />
Phone<br />
Robert Beard 214-912-<br />
6178<br />
Steven Bray 214-263-<br />
2016<br />
Laura De 469-939-<br />
Moya 5330<br />
Sharmila 214-282-<br />
Dias 6601<br />
Grady 214-564-<br />
Goodwin 2510<br />
Tara 214-418-<br />
Goodwin 4384<br />
Amy Haller 817-879-<br />
8131<br />
Emily Hebert 972-322-<br />
1997<br />
Nichole 469-688-<br />
Johnson 3797<br />
Anita Khetan 214-244-<br />
1435<br />
Rainer 214-244-<br />
Khetan 1413<br />
Roger 214-213-<br />
Khetan 3544<br />
Lisa Luke 214-912-<br />
7852<br />
Andrew 469-878-<br />
Masica 2715<br />
Catherine 972-352-<br />
Raver 1722
19<br />
TPC<br />
(cont’d)<br />
Pager Cell Phone Cardiologists (cont’d)<br />
Samir Sahai<br />
Brett Stauffer<br />
Bach Tran<br />
972-356-<br />
7218<br />
972-356-<br />
2706<br />
972-356-<br />
2703<br />
214-448-<br />
7264<br />
214-282-<br />
6220<br />
214-735-<br />
0039<br />
Heart Place<br />
(cont’d)<br />
Assar (EP)<br />
Berbarie<br />
Pager<br />
214-595-<br />
0131<br />
214-595-<br />
0118<br />
Sue Williams 972-356- 214-906- Donsky, M 214-595-<br />
0292 2578<br />
0105<br />
Radha Yalamachili 972-356- 214-929- Gottlich 214-595-<br />
2704 0653<br />
1607<br />
Cardiologists<br />
Hall 214-595-<br />
2002<br />
CCT<br />
214-824-8721<br />
Pager<br />
Johnson, K 214-595-<br />
0127<br />
Carry 214-657-<br />
Khan 214-595-<br />
3619<br />
0104<br />
Choi 214-657-<br />
Kowal 214-595-<br />
5508<br />
0373<br />
Donsky, A. 214-657-<br />
Kuiper 214-595-<br />
5534<br />
0130<br />
Franklin (EP) 214-657-<br />
Parmar 214-595-<br />
0525<br />
0115<br />
Grayburn 214-657-<br />
Rosenthal 214-595-<br />
6363<br />
1255<br />
Grodin 214-657-<br />
Schussler 214-595-<br />
5859<br />
0126<br />
High 214-657-<br />
Vallabahn 214-595-<br />
6853<br />
0116<br />
Hyland 214-657-<br />
Wells 214-595-<br />
9759<br />
0128<br />
Johnston 214-408-<br />
Wheelan 214-595-<br />
8096<br />
0129<br />
Klatte 214-657-<br />
Wischmeyer 214-595-<br />
7185<br />
0182<br />
Schumacher 214-657-<br />
North TX<br />
0945<br />
Card<br />
214-826-<br />
6044<br />
Pager<br />
Sills 214-410-<br />
Aggarwal 972-326-<br />
2734<br />
1641<br />
Stoler 214-657-<br />
Andrews 972-602-<br />
1998<br />
6312<br />
Yoon 214-657-<br />
Jiminez 972-602-<br />
3319<br />
6061<br />
Heart Place<br />
214-842-2000<br />
Pager<br />
Shelton 972-602-<br />
6311<br />
Anwar 214-595-<br />
Velasco 972-602-<br />
0125<br />
6313
20<br />
Cardiothoracic<br />
Surgeons<br />
Office Pager Gastroenterologists<br />
Cheung 214-821-<br />
3603<br />
214-897-<br />
0014<br />
DHAT<br />
(cont’d)<br />
Office<br />
Hammon 214-841- 214-595- John 214-821-<br />
2000 0108 Hamilton* 5266<br />
Hebeler 214-821- 214-897- D. Mallat** 214-821-<br />
3603 9342<br />
5266<br />
Henry 214-821- 214-897- Yaussy 214-821-<br />
3603 9343<br />
5266<br />
Hoang 214-942- 214-595- Wash Ave Grp<br />
8300 0109<br />
Kourlis 214-821- 214-822- Angela 214-545-<br />
3603 7867 Carollo 3390<br />
Matter 214-841- 214-595- Dan<br />
214-545-<br />
2000 0107 Demarco 3390<br />
Wood 214-827- 214-920- Katherine 214-545-<br />
3890 3030 Little 3390<br />
Colorectal<br />
Surgeons<br />
Office<br />
Daniel Polter 214-545-<br />
3390<br />
Franko, Edward 214-824-<br />
Schiller 214-545-<br />
1730<br />
3390<br />
Jacobson 214-824-<br />
Anderson** 214-821-<br />
1730<br />
5266<br />
Lichliter 214-824-<br />
1730<br />
Liver Consultants of TX<br />
Rodriguez-Ruesga 214-824-<br />
Linsheng 214-820-<br />
1730<br />
Guo<br />
8500<br />
Tulanon 214-824-<br />
Lepe- 214-820-<br />
1730<br />
Suastegui 8500<br />
Dermatologists Office<br />
Jacqueline<br />
O’Leary<br />
214-820-<br />
8500<br />
McCoy 972-386-<br />
Texas Digestive Disease<br />
7546<br />
Consultants<br />
Mentor 972-386-<br />
Esmail 214-818-<br />
7546<br />
Elwazir* 0948<br />
Endocrinologists Office<br />
Greg<br />
Hodges*<br />
214-818-<br />
0948<br />
Welch 214-823-<br />
Bhavani 214-818-<br />
6435<br />
Moparty** 0948<br />
Hollander 214-820-<br />
Charles 214-818-<br />
3466<br />
Richardon 0948<br />
Gastroenterologists<br />
C. Vesy 214-818-<br />
*does ERCP<br />
**ERCP and EUS<br />
0948<br />
DHAT Office<br />
Texas Digestive Health<br />
Consultants<br />
Landry Center Group James<br />
Burdick<br />
214-820-<br />
8899<br />
Blair Connor* 214-821-<br />
5266
21<br />
Gen Surgery Neurologists<br />
Urgent Surgical<br />
Associates<br />
Office<br />
Texas Neurology<br />
214-827-3610<br />
ASV 214-346-1317<br />
El-Feky<br />
Matthew Lovitt 214-821-<br />
1599<br />
Laura Petry 214-821-<br />
1599<br />
Greenfield<br />
Surgical Institute Office Heitzman<br />
Howard Derrick 214-826-<br />
6276<br />
Herzog<br />
Zelig Lieberman 214-826-<br />
6276<br />
Jenevein<br />
John Preskitt 214-826-<br />
6276<br />
Martin<br />
Jill Stephenson 214-826-<br />
6276<br />
Phillips<br />
Chad Tate 214-826-<br />
6276<br />
Shamim<br />
Health TX<br />
Provider Network<br />
Office<br />
Tunnell<br />
G. McKenna 214-820-<br />
Addt’l Office<br />
2050<br />
Neurologists<br />
Henry Randall 214-820-<br />
Romero 214-827-<br />
2050<br />
5525<br />
ID Office<br />
Graybeal 214-820-<br />
4561<br />
Behre 214-823-<br />
2533<br />
Psychiatrists Office<br />
Columbus 214-823-<br />
John 214-824-<br />
2533<br />
Brennan 2273<br />
Sloan 214-823-<br />
Robert 214-522-<br />
2533<br />
Moore 1960<br />
Spak 214-823-<br />
Antonio 214-363-<br />
2533<br />
Roman 2953<br />
Sutker 214-823-<br />
Vladislav 214-824-<br />
2533<br />
Yeganov 9100<br />
Neurosurgeons Office<br />
Pulmonologists (Critical Care<br />
designated with *)<br />
Bidiwala 214-823-<br />
2052<br />
TX Lung Center (214-824-8521)<br />
Doughty 214-820-<br />
8585<br />
Office Pager<br />
Finn 214-823- *Ausloos 214-246- 214-824-<br />
2161<br />
7767 8521<br />
Gray 214-820- *Black 214-246- 214-824-<br />
8585<br />
7765 8521<br />
Michael 214-823- *Brancaccio 214-246- 214-824-<br />
2052<br />
7774 8521<br />
Naftalis 214-820- *Jordan 214-246- 214-824-<br />
8585<br />
7763 8521
22<br />
Pulmonologists Rheum (214-823-6503)<br />
TX Lung Center (cont’d) Chubick<br />
Luterman 214-246- 214-824- Limani<br />
7770 8521<br />
Millard 214-246- 214-820- Himanshu<br />
7775 3500 Patel<br />
TX Pulm Assoc Pager Cell Phone Petrone<br />
*Haden 972-356- 214-370- Sackler<br />
2725 5555<br />
*Woolley 972-356- 214-673- Tehlirian<br />
2776 6298<br />
Addt’l Pulm John Willis<br />
Baird 214-820- 214-798-<br />
1000 8154<br />
Shotwell 214-824- 214-886- Texas Oncology<br />
4412 1119<br />
214-370-1000<br />
Renal Mobile<br />
Hebert 214-587-<br />
7290<br />
Dallas Nephrology Associates<br />
214-820-2350<br />
Urologists Office<br />
Barri Josh Fine 214-826-<br />
6235<br />
Carino Myron Fine 214-826-<br />
6235<br />
Chandrakantan Steven Frost 214-826-<br />
6021<br />
Fazal Goldstein 214-826-<br />
6021<br />
Fenves Schnitzer 214-824-<br />
0171<br />
Fischbach Schoenvogel 214-827-<br />
1602<br />
Gieser Shuford 214-826-<br />
6021<br />
Hays 214-497-<br />
Eric Smith 214-826-<br />
3755<br />
6235<br />
McDonald<br />
Larry Melton<br />
Webster 214-826-<br />
6021<br />
Arthi Rajagopal<br />
Palliative Care (214-<br />
820-7227)<br />
Kim Rice Minn 214-497-<br />
2612<br />
Joris Schuller Pain mgt 214-512-<br />
John Schwartz<br />
nurse 1106<br />
Long Tran Addt’l IM staff<br />
Wiederkehr Ricardo 214-557-<br />
Murillo 5410
23<br />
OBTAINING A CONSULT AT BAYLOR<br />
Obtaining a consult at <strong>BUMC</strong> is different than at a county<br />
system. Rather than consulting a service, you consult a<br />
specific physician within a service, or whoever is taking call for<br />
that physician if it is after hours. Call consults as early in the<br />
day as possible. If you call a consult after 5pm, this implies that<br />
it is emergent.<br />
If you need a consult, first ensure the attending physician<br />
agrees and ask if they have anyone specifically they would like<br />
you to call. Also, review old records and if a physician has<br />
seen the patient previously from a service, re-consult the same<br />
physician or group if that person is not available. Then, refer to<br />
the above list for whom you would like to consult (May not be<br />
all inclusive, but is a start for who to call). When you call, be<br />
sure to have the patient’s name, room number, date of birth,<br />
and pertinent history, exam, and labs.<br />
There are a few ways to consult. The best is to call the<br />
physician’s office or answering service and ask who is taking<br />
new consults for that day/night. Then ask them to be paged<br />
with the information. You can also call the ER, who has a list<br />
for who is on call. If you do not hear back, and you feel it is<br />
appropriate, then page the physician directly. Some physicians<br />
prefer text messages with name and room number, and they<br />
will let you know that when you work with them.<br />
Here are a few specifics regarding particular<br />
consults:<br />
• GI: The hepatologists rotate call every 3 rd night listed<br />
above. Also, if you need an ERCP or EUS, physicians that<br />
do one or both are noted with an asterisk under the GI<br />
contacts. GI Bleeders often require an emergent GI<br />
consult. For more information, see GI section for obtaining<br />
a consult.<br />
• Neurology: There is someone on call M-F now for<br />
neurology. Call page operator to find out who is on call.<br />
• Psychiatry: To obtain a psych consult, you may either<br />
write an order for psych consult, or call the ER and ask<br />
who is on call for Psych and call the office or answering<br />
service to have them paged.<br />
• Pulmonary Critical Care: This consult is required if<br />
your patient is on the ventilator more than 48 hours.
24<br />
• Rheumatology: The patient typically will need to have<br />
insurance to be seen. You can always call for advice over<br />
the telephone.<br />
• Palliative Care: You can write an order for a palliative<br />
care consult or call 2-7227 to speak with someone directly<br />
(always the best option).<br />
• Pain management: If you need assistance with pain<br />
management, palliative care is available.<br />
• Hospice consult: You can write an order for hospice<br />
consult. The hospice nurse will then evaluate the patient<br />
and if appropriate, write orders to convert the patient to<br />
inpatient hospice care and/or begin to work on referrals<br />
with social work to hospice facilities or home hospice. She<br />
will write orders and call you to review them with you for<br />
any orders you may have missed for comfort care.<br />
• Other: Nutrition/Social Work/Care Coordination/<strong>Home</strong><br />
Health/PT/OT/ST/Pastoral care/Recreational Therapy<br />
consults can all be written for in the order section of the<br />
chart. For vanc/gent, there is an automatic pharmacy<br />
consult. If you need pharmacy to renally dose, you can<br />
write for the medication and then write pharmacy to dose.<br />
DICTATION GUIDE<br />
Dial 26008 in-house; 972-980-8955 outside the hospital<br />
Problems/?: 6171<br />
Keypad Commands (same for <strong>BUMC</strong>/BHVH):<br />
1-play 7-fast forward<br />
2-record 8-rewind to beginning<br />
3-short rewind 9- disconnect/job confirmation<br />
4-pause (write down the confirmation<br />
5-next report number)<br />
6-go to end of job<br />
For <strong>BUMC</strong> dictations:<br />
Site ID: 43310<br />
Work type: 20 H&P, 25 D/C summary, 30 consult, 98<br />
outpatient clinic note<br />
• Enter 11 digit MRN<br />
• Press 2, begin dictating after the tone<br />
For BHVH dictations:<br />
Site ID: 43310<br />
Work type: 52 H&P, 53 D/C summary, 55 consult, 56<br />
Radiology
25<br />
• Enter 2 initial zeros and then 9 digit BHVH account<br />
number (begins with V)<br />
• Press 2, begin dictating after the tone<br />
DISCHARE SUMMARY OUTLINE<br />
Attending:<br />
Date of Admission:<br />
Date of Discharge: Tell what facility they were<br />
transferred to if applicable.<br />
Admission Diagnoses:<br />
Discharge Diagnoses:<br />
Procedures/Tests:<br />
Consultants:<br />
Discharge Medications:<br />
Follow-up:<br />
Brief History & Physical:<br />
Summarize the HPI and admission physical exam; it’s helpful<br />
to the next provider if you also briefly review the MHx,<br />
SurgHx, FamHx, Social Hx<br />
Hospital Course: Most people organize this as a numbered<br />
problem list. Mention the suspected etiology (CHF from<br />
medication noncompliance, hypokalemia secondary to<br />
diuretics, etc.) and explain what work-up, testing and<br />
treatment was performed for each issue. Mention any studies<br />
that are pending at the time of discharge. For simple admits<br />
or for death notes, you can summarize the hospital course in<br />
paragraph format.<br />
MEDICAL RECORDS<br />
Located in the basement of Jonsson. Access WebESA to<br />
edit/review your dictations & electronically sign your charts<br />
either in Medical Records or via the EMR (link on the left).<br />
You have to keep up-to-date with your dictations/charts or you<br />
lose your $50 monthly meal money and get yourself (and<br />
possibly your attending) put on the “B list.” It’s painful …<br />
made better by the giant cookies and snacks waiting for you<br />
in Medical Records.<br />
ADMISSION ORDERS<br />
1. Admit to floor/ICU/telemetry<br />
2. Attending: Dr.<br />
3. R1—Dr. xxx—call 1st<br />
R2/3—Dr. xxx<br />
4. Service: Medicine teaching/CCU teaching
26<br />
5. Diagnosis:<br />
6. Condition: Stable/fair/critical<br />
7. Vitals: per floor/ICU protocol<br />
8. Allergy:<br />
9. Diet: regular/ADA/Heart Healthy/clear liquids/full<br />
liquids/NPO<br />
10. Ins/Outs:<br />
11. Meds:<br />
12. IVF:<br />
13. Labs for AM:<br />
14. Labs for now:<br />
15. Activity:<br />
16. Code Status: Full, DNR/DNI<br />
17. Call HO (house officer) for T>100.4, SBP >170 or 120 or
27<br />
• Albuterol/Atrovent nebulizer Q6 hours prn<br />
• Benadryl 25 mg PO Q4 hours prn pruritus<br />
• Potassium Protocol (cannot use protocol if Cr>1.5,<br />
wt80)<br />
• Oxygen Protocol<br />
PROPHYLAXIS MEDS<br />
• Pepcid 20 mg po BID OR Protonix 40 mg po qday<br />
• Lovenox 40 mg SC qday (if renal function okay) OR<br />
Heparin 5000 units SC TID<br />
SOCIAL WORK VS CARE COORDINATORS<br />
Social Work:<br />
• SNF, LTAC, extended care outside of Baylor, hospice<br />
(in or outpatient)<br />
• Ambulance transport<br />
• Protective Services<br />
• Family Locating<br />
• Transportation<br />
• Crisis Intervention<br />
• Physical Needs (places to stay, vouchers, parking, etc)<br />
• PCP referrals<br />
Care Coordinators:<br />
• <strong>Home</strong> Health Care Referrals<br />
• Dallas Medical Examiner<br />
• BIR Referrals<br />
• VA/Parkland Referrals<br />
• Liason to payer/utilization management<br />
DISPO<br />
(ie, where the pt goes when they get off your service)<br />
• <strong>Home</strong><br />
Can arrange home health care, home PT/OT if<br />
needed<br />
• SNF (skilled nursing facility, pronounced “sniff”)<br />
Must require the skills of a qualified technician or<br />
professional (RN, PT, OT, ST, etc)<br />
• LTAC (long term acute care, pronounced “L-tach”)<br />
Must have 2+ complex needs to qualify<br />
• Acute Rehab<br />
Must be medically stable & able to participate in 3<br />
hours of therapy/day; must require 24 hr nursing<br />
supervision and physician care which demonstrates
28<br />
“necessity” for inpatient care; must have viable<br />
disposition to return to community upon discharge<br />
• BIR (Baylor Institute for Rehab)<br />
<strong>BUMC</strong> long term acute care; write “transfer to BIR<br />
when bed available” (no separate orders)<br />
• BSH (Baylor Specialty Hospital)<br />
<strong>BUMC</strong> physical rehabilitation hospital; just complete<br />
the BSH order set prior to transfer<br />
• NH (nursing home)<br />
• Hospice (end of life care)<br />
Must be terminally ill with life expectancy < 6months;<br />
hospice can be at home, NH, hospital or freestanding<br />
hospice facility; note: inpatient hospice is for an<br />
actively dying patient<br />
The patient’s funding (Medicaire/Medicaid/private) affects their<br />
options; the social workers and care coordinators can help you<br />
figure out each patient’s options. “Charity beds” are available<br />
at BIR and BSH on a case-by-case basis. You can write an<br />
order for a “BIR [or BSH] consult” and the liaison will review the<br />
pt’s case.
29<br />
CARDIOLOGY<br />
CCU IN GENERAL<br />
You are typically called for the following patients:<br />
• Patient in the cath lab having a stent placed 2/2 STEMI:<br />
You can go to the cath lab and watch the cath, or you may not<br />
meet them until recovery or when they get to the CCU. These<br />
patients typically come out with post-cath orders filled out by<br />
the cardiologist or fellow, but you sometimes also fill these out<br />
if you are there early in the process. You are then responsible<br />
for getting the HPI and adding additional orders/meds.<br />
• Patient transferring from OSH 2/2 MI s/p lytics: These<br />
patients will need orders as below for ACS, but no GpIIb/IIIa<br />
inhibitors. You will likely do H&P and initial orders and then talk<br />
with the cardiologist then or in the A.M. (if the patient comes in<br />
the night) whether they need to go to cath.<br />
• Patients in the ER with UA/NSTEMI: See management<br />
below<br />
• Decompensated CHF patients with pulmonary edema in<br />
the ER: Follow CHF order set and treat pulmonary edema as<br />
below in pulmonary edema section.<br />
ACUTE CORONARY SYNDROME<br />
Stable Angina: Chest pain resulting from imbalance of<br />
oxygen supply and demand to cardiac<br />
tissue. Usually happens at the same<br />
frequency, intensity, and duration. Most<br />
common cause is CAD; other causes include<br />
aortic valvular disease, HCM, and coronary<br />
artery spasm. This is due to a stable plaque.<br />
UA/NSTEMI: New onset of severe angina, angina at rest<br />
or with minimal activity, or recent increase in<br />
frequency and or intensity of stable angina. If<br />
patient has positive cardiac markers<br />
(necrosis) without ST elevation, then this is<br />
defined as NSTEMI. This is due to a partially<br />
occluding thrombus.
30<br />
STEMI: Complete occlusion of coronary artery by<br />
thrombus resulting in ST elevation on EKG.<br />
Progression — Stable plaque-unstable plaque-plaque<br />
rupture-UA/NSTEMI (partial occlusion)-microemboli-STEMI<br />
(complete occlusion)<br />
Orders — For ACS: Think MONA BASH (Morphine, Oxygen,<br />
Nitroglycerin, Aspirin, B-blocker, Statin, Heparin)<br />
Meds:<br />
1. Morphine 2 to 4 mg IV Q4 hours prn chest pain<br />
2. Oxygen per protocol to keep SpO2>92%<br />
3. Nitroglycerin 0.4 mg SL Q3-5 minutes x 3 doses prn<br />
chest pain<br />
4. ASA 325 mg PO Qday<br />
5. BBlocker: Can use coreg 3.125 mg to 6.25 mg PO<br />
BID and increase as needed: write parameters on BP<br />
meds (hold for SBP
31<br />
Unstable Angina/NSTEMI<br />
• Can use history, physical exam, and TIMI risk score to<br />
stratify.<br />
• TIMI risk score will help dictate conservative versus invasive<br />
strategy.<br />
**Get Cardiology on case soon if not admitted by a<br />
cardiologist!<br />
Tests — Chest X ray, EKG, Echo (non emergent) and cardiac<br />
enzymes (Troponin and CKMB)<br />
EKG: Will show ST depression, T wave inversion, or<br />
nonspecific changes.<br />
Treatment — Revolves around three keys: (1) anti-ischemic<br />
therapy, (2) antiplatelet therapy, and (3) anticoagulation.<br />
• Anti-Ischemic Therapy: Nitrates, Beta blockers (don’t<br />
use if hypotensive, wheezing, bradycardia), Calcium<br />
channel blockers (nondihydropyridines, if can’t use beta<br />
blockers), morphine, and oxygen.<br />
• Antiplatelet Therapy: ASA, Plavix (load with 300 or<br />
600mg, don’t use if suspect going to CABG), GP IIB/IIIa<br />
inhibitors (pts with >3 TIMI risk score and positive cardiac<br />
enzymes)<br />
• Anticoagulation: UFH (bolus and wt. based titrate for<br />
aPTT of 50-70). Use bivalirudin if patient has heparin<br />
induced thrombocytopenia.<br />
Low Risk: Negative cardiac enzymes, no ST depression,<br />
TIMI score 3. Use GPIIb/IIIa and will need angiography<br />
with in 24-48 hours.<br />
STEMI<br />
• Immediately call cardiologist on call and activate cath lab.<br />
• Will have ST elevation in >2 leads with reciprocal changes or<br />
new onset of LBBB.
32<br />
EKG Artery Areas of Complications<br />
Leads<br />
Damage<br />
V1-V2 LAD septal Septum, Nodal block and<br />
branch bundles of his BBB<br />
V3-V4 LAD diag. Ant. Wall LV LV dysfunc,<br />
branch<br />
CHF, BBB, AVB<br />
V5-V6, + I & Circumflex High lateral LV dysfunc, AVB<br />
AVL<br />
wall LV<br />
II, III, AVF RCA Post. Inf. Wall, post. Hypotension<br />
Descending Wall LV sensitivity to<br />
branch<br />
NTG and<br />
Morphine<br />
V4R (II, III, RCA proximal RV, inferior Hypotension, A<br />
AVF)<br />
branch and posterior<br />
wall<br />
fib/flutter,<br />
V1-V4 Circumflex or Posterior wall LV dysfunction<br />
Depression RCA<br />
• Need emergent fibrinolysis versus PCI. At Baylor, PCI is<br />
done, so you need to activate cath lab. **TIME IS TISSUE.<br />
• We have STEMI protocol at <strong>BUMC</strong>. Door to balloon time 60), free wall rupture (surgery), VSD<br />
(surgery), papillary muscle rupture (new onset of holosystolic<br />
murmur, get stat Echo and use diurectics, vasodilators, IABP,<br />
& surgery), A fib, VT/VF (in first 48 hours, often due to<br />
myocardial healing and can consider no treatment even in<br />
sustained; need to treat if symptomatic; more likely to treat if<br />
monomorphic, fast rate->200-, or low EF; if occurs after more<br />
than 48 hours from the MI, needs an ICD as mortality is >20%<br />
in next year from an arrhythmia), LV thrombus (anticoagulate),<br />
ventricular aneurysm (persistent ST elev.), ventricular<br />
pseudoaneurysm (surgery), pericarditis (1-4 days post MI, tx.<br />
NSAIDS), and Dressler’s syndrome (2-10 wks post MI, tx.<br />
NSAIDS)
33<br />
Post PCI Complications — In your note following PCI, be<br />
sure to comment on the following:<br />
1. Vascular access site (check for hematoma)<br />
2. Distal pulses<br />
3. Any signs of cholesterol emboli syndrome (any livedo<br />
pattern or toe necrosis)<br />
4. H&H, Tele monitoring, Creatinine<br />
5. Watch for the following complications:<br />
• Hematoma/Bleeding: Manual compression,<br />
reverse/stop anticoagulation<br />
• Retroperitoneal bleed (hypotension,<br />
abdominal/flank pain, dropping H&H): Stat CT<br />
abd/pelvis if concern for retroperitoneal bleed and<br />
stable enough to go. Blood, fluid, and pressors,<br />
and call cardiologist immediately. May need<br />
vascular consult.<br />
• Pseudoanerysm: triad of pain, expansile mass,<br />
systolic bruit; Dx with U/S; treat with compression<br />
or surgical repair<br />
• Contrast induced Acute Kidney Injury:<br />
Manifests within 24 hours; peaks at 3-5 days;<br />
Pre-hydrate patients to prevent kidney injury with<br />
IV fluids. Continue IVF’s after cath to protect<br />
kidneys<br />
• Cholesterol emboli syndrome: Renal failure,<br />
eos in urine, mesenteric ischemia, toe necrosis,<br />
Hollenhorst plaques in retinal arteries<br />
• Stent thrombosis: Urgent return to cath lab<br />
• In-stent restenosis (months after PCI)<br />
Prognosis<br />
Killip Class (on admission):<br />
Class Signs Mortality<br />
I No CHF 5%<br />
II S3, and/or crackles of lung<br />
exam<br />
17%<br />
III Pulmonary edema 30-40%<br />
IV Cardiogenic shock 60-80%
34<br />
Post MI and Discharge Medications:<br />
1. Post MI ECHO<br />
2. Meds: ASA, Plavix, Beta Blockers, statins,<br />
ACEI/ARB’s, NTG (PRN), aldosterone (if LVF
35<br />
function, elevated troponin T is still a predictor of cardiac<br />
events across all creatinine clearance levels)<br />
ATRIAL FIBRILLATION<br />
Classification — Paroxysmal (self terminating < 7 days,<br />
usually 7 days), and permanent (typically<br />
greater than a year or cardioversion failed/not attempted)<br />
Causes:<br />
• “I SMART CHAP”<br />
• Infection/Sepsis<br />
• Surgery (post CABG, post valve surgery)<br />
• Medication (theophylline, caffeine, etc)<br />
• Atherosclerotic Heart Disease<br />
• Rheumatic Heart Disease (MS, MR)<br />
• Thyrotoxicosis<br />
• Congenital Heart Disease (ASD)<br />
• Hypertension<br />
• Alcohol (dilated cardiomyopathy, holiday heart<br />
syndrome)<br />
• Pulmonary (PE, PNA, Hypoxia, COPD)<br />
Evaluation — H&P, EKG, CBC, CMP, TSH, Drug screen (if<br />
indicated), chest X-ray, TTE, cardiac enzymes.<br />
Treatment — Treatment revolves around rate control,<br />
rhythm control, and deciding on needed anticoagulation.<br />
**IF PT IS UNSTABLE, THEY NEED EMERGENT<br />
CARDIOVERSION**<br />
Rate Control: Goal HR 60-80’s<br />
• B blockers (metoprolol, coreg)<br />
• Digoxin (good for people with borderline BP's as<br />
does not lower BP; watch dig levels)<br />
• CaCh Blockers (diltiazem drip vs PO verapamil). If<br />
maintained on a diltiazem drip, can add up total mg in<br />
24 hour period, and then give them this amount in<br />
Diltiazem ER P.O. Give first oral dose then overlap<br />
with drip for 3 hours.<br />
Anticoagulation: CHADS2 Score: C (CHF), H (HTN), A<br />
(age ≥75), D (DM), S (stroke, TIA, and most add systemic<br />
embolic event).
36<br />
Get 1 point for each and 2 points for stroke or TIA.<br />
0 Points: ASA 325mg q day alone<br />
1 point: ASA 325mg q day or Coumadin (INR 2-3)<br />
2 or greater points: Coumadin (INR 2-3)<br />
Rhythm Control: Electrical or Pharmacologic cardioversion<br />
• Electrical:<br />
- 48 hours, and has been with INR 2.0 to 3.0 for<br />
3 weeks, no need for TEE. If INR not therapeutic,<br />
need IV heparin or SQ lovenox before TEE &<br />
then DC CV<br />
- If LA thrombus, anticoagulate >8 weeks, then<br />
cardiovert<br />
- If pt. is cardioverted and they were in AFIB<br />
greater than 48 hours they will need to be anticoagulated<br />
with Coumadin for at least 4 weeks.<br />
(High likelihood of reoccurrence).<br />
• Pharmacologic choices: Procainamide, ibutilide,<br />
flecainide, propafenone, amiodarone (watch PFT’s,<br />
TFT’s, LFT’s), sotalol (watch QTc), Dofetilide (watch<br />
QTc, no Bblocker effect so good for patients who<br />
can’t tolerate amiodarone or sotalol, but need special<br />
prescribing privileges.)<br />
CALCIUM CHANNEL BLOCKERS<br />
Class/Drug AV<br />
Blockade<br />
Vasodilation BP<br />
Control<br />
Dihydropyridine None +++ +++<br />
Verapamil +++ + +<br />
Diltiazem ++ ++ +<br />
CHEST PAIN<br />
Can be typical, atypical, or non-cardiogenic chest pain.<br />
Assess chest pain — If has chest pain (1 point), if occurs<br />
with exertion (1 point), and relieved with rest or NTG (1 point)
37<br />
**0-1 point non-cardiogenic, 2 points atypical chest pain, 3<br />
points typical chest pain.<br />
Cardiogenic causes: Angina, MI, pericarditis,<br />
myocarditis, aortic dissection<br />
Pulmonary Causes: PNA, pleuritis, pneumothorax,<br />
PE, Pulmonary HTN<br />
GI Causes: Reflux, esophageal spasm,<br />
Mallory-Weiss Tear, Boerhaves,<br />
PUD, pancreatitis, biliary<br />
Muscle/other causes: Costochondritis, osteoarthritis,<br />
shingles, and anxiety<br />
Initial work up: History and PE going to dictate your workup,<br />
but good places to start are EKG, chest x-ray, and<br />
troponin/CKMB<br />
Ongoing chest pain 2/2 ACS: Can start on Nitroglycerin gtt at<br />
10 mcg/min and then titrate up (side effect=HA)<br />
EKG<br />
Ventricular Rate<br />
• Count large boxes between R waves:<br />
300,150,100,75,60,50. Can also count # of beats on 6 sec<br />
strip and multiply x 10<br />
• Conduction rates of specialized tissue:<br />
20-40 Ventricular rhythm<br />
40-60 Junctional rhythm<br />
60-100 Normal sinus rhythm<br />
100-150 Sinus tachycardia<br />
150-250 Supraventricular/Ventricular<br />
tachycardias<br />
Rhythm<br />
• Sinus (upright P in I and aVF and negative in aVR<br />
suggesting that the direction of atrial depolarization is from<br />
SA to AV node, there is a P wave before each QRS, the P<br />
wave marches out w/ calipers, the P wave has the same<br />
morphology)<br />
• Junctional (no P wave but still narrow QRS; rate 40-60)<br />
• Idioventricular (no P wave and QRS is wide; rate 20-40)
38<br />
Axis<br />
• Normal (-30 to +90): upright QRS in I and aVF<br />
• RAD (+90 to +180): negative in I and positive in aVF<br />
• LAD (-30 to -120): positive in I and negative in aVF<br />
• Extreme RAD (-120 to +180): if negative in I and II, then<br />
you have either extreme LAD or RAD<br />
Intervals<br />
• PR interval: Normal 120 to 200 msec<br />
- Shortened: Think WPW or Lown-Ganong-Levine<br />
syndrome<br />
- Prolonged (>200 msec), think:<br />
• 1° AV Block: Prolonged PR interval >200 msec;<br />
QRS follows all p waves<br />
• 2° AV Mobitz Type I (Wenckebach): prolonged<br />
PR interval that gets progressively longer<br />
followed by a dropped QRS; Mobitz Type II: PR<br />
interval that are constant with intermittently<br />
dropped QRS complexes<br />
• 3° AV Block: Atria and ventricles acting<br />
independently; atrial rate>ventricular rate<br />
• QRS interval: normal is 120msec Deep S RSR’<br />
(L Heart if < then<br />
Dz) “incomplete”<br />
RBBB >120msec RSR’ Large S Slurring<br />
(R Heart if < then<br />
of S<br />
Dz) “incomplete”<br />
L Anterior Fascicular Block (LAFB) aka Hemiblock<br />
LAD + QRS
39<br />
• Erythromycin<br />
• Phenothiazines<br />
- Short QTc is caused by hyperkalemia,<br />
hypermagnesemia, and hypercalcemia.<br />
Hypertrophy and Enlargement<br />
• P (atrial depolarization)<br />
II (nl: 3mm<br />
more Negative (>1mm)<br />
RAE Tall >2.5mm More Positive Peak<br />
>1.5mm<br />
• Ventricular hypertrophy<br />
- LVH: kissing waves, S in V1 + R in V5/6 >35mm, R<br />
in aVL >11mm, or R in V4-V6 >25mm<br />
- RVH: tall R wave in V1 with an amplitude > 7 mm or<br />
R wave in lead V1 + the amplitude of the S wave in<br />
lead V6 > 10 mm.<br />
Signs of ischemia/infarction<br />
• ST Depression: Indicates ischemia; significant if the ST<br />
segment is depressed by 1 mm or more<br />
• T-Wave Inversion (TWI): Can also indicate ischemia but<br />
can be due to LVH with strain, abdominal pain,<br />
medications (digitalis), and CNS hemorrhage.<br />
• ST elevation (STE): indicates transmural infarction<br />
(injury); significant elevation is 1 mm in the limb leads and<br />
2 mm in the precordial leads.<br />
• Q wave: indicates muscle death from a lack of blood<br />
supply. A Q wave is considered pathologic if it is 1 small<br />
box wide and deeper than 25% of the R wave. “Q’s in III<br />
are free”.<br />
Other<br />
• Early repolarization: Concave “Happy” STE (early repol<br />
which is seen in young pts and those w/ LVH, pericarditis,<br />
myocarditis, head contusion, PTX)<br />
• Low Voltage (
40<br />
sleeping, EKG: ST elevation and TWI in V1-3 in setting of<br />
RBBB)<br />
• Hypothermia (Osborn Wave = small wave at J point)<br />
• Pulmonary Embolism (R heart strain signified by<br />
RBBB/RAD/RVH/RAE, sinus tachycardia, S1Q3T3:broad<br />
S in I, Q wave in III, inverted T in III)<br />
• Pericarditis (PR depression in II, diffuse STE)<br />
• COPD (R heart strain like above + Low Voltage of<br />
Precordial Leads only, Prominent P Waves)<br />
• Digitalis (therapeutic: sloping downward ST, T<br />
depressed or inverted, short QT) vs (Excess: SA Block,<br />
PAT w/ Block, AV Block, AV Dissociation) vs (Toxicity:<br />
Afib, JT, VT, multiple PVC, VFib)<br />
HEART FAILURE<br />
The heart cannot produce output to match the metabolic<br />
demands of the body.<br />
Systolic Dysfunction: Decreased EF, pump failure<br />
Diastolic Dysfunction: Preserved EF, but impaired<br />
relaxation of the ventricle.<br />
Causes:<br />
• CAD/MI<br />
• HTN<br />
• Valvular Disease: AS, AR, and MR<br />
• Arrhythmias: Long standing tachycardias<br />
• Metabolic/Toxic/Drugs: Beriberi, Pagets disease,<br />
chemo drugs, alcohol, thyroid<br />
• Infectious: Sepsis, coxsackie virus, chagas disease, etc<br />
• Pericardial Disease<br />
• Infiltrative Disease of Myocardium: Amyloid, sarcoid,<br />
and hemochromatosis<br />
Initial work up — H&P, CBC, CMP, EKG, chest X-ray,<br />
cardiac enzymes, TSH, TTE, if new onset +/- inpatient<br />
coronary angiography<br />
Functional classification:<br />
NYHA Class I: Symptomatic only with greater than<br />
ordinary activity.<br />
NYHA Class II: Symptomatic with ordinary activity.<br />
NYHA Class III: Symptomatic with minimal activity.<br />
NYHA Class IV: Symptomatic at rest.
41<br />
Therapy — Therapy is guided by stage of heart failure. For<br />
acute HF relief refer to pulmonary edema section.<br />
Stage Characteristics Therapy<br />
A No symptoms, no<br />
structural<br />
disease, just risk<br />
factors. (CAD,<br />
DM, HTN,<br />
cardiotoxic<br />
exposures)<br />
B Abnl. LVF,<br />
structural heart<br />
disease, previous<br />
MI, but<br />
asymptomatic.<br />
C Structural heart<br />
disease and<br />
symptomatic HF.<br />
Life style<br />
modifications, treat<br />
HTN, treat HLD, and<br />
control DM.<br />
ACEI: if HTN, DM, &<br />
PVD are present.<br />
All of stage A therapy,<br />
plus ACEI and beta<br />
blocker<br />
All stage’s A&B, plus<br />
diuretics, Na+ restrict,<br />
aldactone, AICD, BiV<br />
pacing,<br />
nitrates/hydralazine,<br />
and digoxin<br />
D Refractory HF All stages A,B, & C,<br />
plus LVAD, heart<br />
transplant, IV<br />
ionotropes, and<br />
hospice<br />
In the chart if you state that a person has heart failure you<br />
need to record EF, state if it’s diastolic or systolic dysfunction,<br />
and if it is acute or chronic.<br />
HYPERTENSIVE CRISIS<br />
Hypertensive Urgency: SBP >180 or DBP> 120 with<br />
minimal or no target end organ<br />
damage.<br />
Hypertensive Emergency: Acute rise in BP with end organ<br />
damage noted. Neurologic<br />
(hemorrhages, encephalopathy,<br />
papilledema), cardiac (ACS, HF,<br />
aortic dissection), or renal<br />
(proteinuria, hematuria, renal<br />
failure).
42<br />
Causes:<br />
• Progression of HTN<br />
• Medical noncompliance on BP meds<br />
• Progression of renal disease<br />
• Glomerulonephritis<br />
• Preeclampsia<br />
• Scleroderma<br />
• Pheochromocytoma<br />
• Cocaine/Amphetamines<br />
• MAO inhibitors + tyramine rich foods<br />
Treatment:<br />
• Hypertensive Urgency: Decrease MAP by 25% over<br />
hours using oral agents. Beta blockers, calcium channel<br />
blockers, hydralazine and ACEI. Then start BP regimen to<br />
get WNL.<br />
• Hypertensive Emergency: Decrease MAP by
43<br />
Nitroglycerine (Onset in 2-5 min) 5-100 mcg/hr<br />
(Tridyl): IV and titrate to keep desired MAP<br />
**Specific Conditions and Agents to Use:<br />
• In HTN Encephalopathy, use Nitroprusside and if that<br />
fails then Beta-Blocker or Nicardipine<br />
• In Subarachnoid Hemorrhage, use Nimodipine and if<br />
that fails then Beta-Blocker or Nicardipine<br />
• In CVA or aortic dissection, use Beta-Blocker and if that<br />
fails then Nitroprusside<br />
• In ARF, use Nicardipine and if that fails then Fenoldopan<br />
• In Cardiac Ischemia use Nitroglycerine + Beta-Blocker<br />
and if that fails then Nitroprusside<br />
• In post surgical patient, use Fenoldopam.<br />
PULMONARY EDEMA<br />
Causes — Revolves around three major organ systems<br />
Cardiogenic: Valvular abnormalities (acute MR, acute<br />
AR), MI/CAD, new onset arrhythmias,<br />
severe HTN, diastolic/systolic<br />
dysfunction w/ volume overloaded state,<br />
and pericardial dz. Usually must have<br />
some underlying cardiac disease<br />
(systolic/diastolic dysfunction) and<br />
another one of the other causes<br />
compounded to put pt. into cardiogenic<br />
pulmonary edema. Will have elevated<br />
PCWP >18mmHg.<br />
Pulmonary: Disruption of alveolocapillary barrier<br />
dysfunction (ARDS, trauma, aspiration,<br />
PE, and goodpastures); PCWP<br />
44<br />
Start out with aggressive diuretic therapy over first 24 hours,<br />
and reevaluate diuretic therapy every 24 hours. Oxygenation:<br />
start with nasal canula; then may need to advance to BIPAP,<br />
or even intubation if can’t keep adequate oxygenation (PaO2<br />
>60mmHg).<br />
SYNCOPE<br />
Sudden and brief loss of consciousness due to cerebral<br />
hypoperfusion<br />
Causes:<br />
• Neurocardiogenic: “Vasovagal syncope” 2/2 increased<br />
vagal tone<br />
• Orthostatic Hypotension: Hypovolemia, diuretic therapy,<br />
vasodilators, autonomic neuropathy.<br />
• Cardiovascular: Usually has a sudden onset and<br />
recovery<br />
1) Arrhythmias: Bradycardia (AVB, SSS),<br />
Tachycardia (VT, SVT)<br />
2) Mechanical: Endocardial, Myocardial,<br />
Pericardial, or Vascular<br />
• Neurological:Seizure, TIA/CVA (rare), vertebrobasilar<br />
insufficiency, and migraines.<br />
• Misc: Hypoxia, anemia, hypoglycemia.<br />
Work up:<br />
• In this Case H&P are the most important part of work up.<br />
• What was pt. doing prior to episode, how did they feel<br />
(palpitations, flushed, light headed, etc.), was it witnessed,<br />
did they lose consciousness, how long did they lose<br />
consciousness, was there seizure activity, previous<br />
episodes, PMHx important, Meds pt. taking, etc.<br />
• H&P will guide causes, work up and therapy.<br />
• Labs/Studies: EKG, CBC, CMP, check orthostatic vitals,<br />
u/s Doppler lower ext (usually not indicated), u/s carotids,<br />
TTE, CT scan head (usually not indicated but usually done<br />
in ER when pt. first comes in), EEG (if seizure is highly<br />
suspected).<br />
• Admit pt to telemetry bed, hold meds that could cause<br />
syncope.<br />
• A lot of times specific cause will not be found; try to<br />
optimize meds to avoid recurrence.
45<br />
Treatment:<br />
• Vasovagal: Recognize prodrome and take supine<br />
position when prodrome comes on. Increase salt/ fluid<br />
intake. Medications include beta-blocker, prozac,<br />
midodrine, fluorinef.<br />
• Bradycardia: Hold AVB agents, may need pacemaker. If<br />
SSS with tachy-brady, may need additional of AVN<br />
ablation.<br />
• Tachycardia: If VT/VF, may need AICD.<br />
• Valvular Disease: Surgery to correct.<br />
• Hypovolemia: Correct volume status, d/c diuretics, d/c<br />
vasodilator drugs.<br />
1) SinusTachy.<br />
(P – in AVR<br />
and + I&AVF)<br />
2) Atrial Flutter<br />
w/ 2:1 Block<br />
3) Atrial Tach.<br />
4) AVRT<br />
5)AVNRT<br />
TACHYCARDIA<br />
QRS<<br />
0.12ms<br />
Narrow Complex<br />
Regular Irregular<br />
1) Atrial<br />
Fib.<br />
2) Aflutter<br />
with<br />
variable<br />
block<br />
3) Multi<br />
focal atrial<br />
tach.<br />
Tachycardia<br />
QRS<br />
>0.12<br />
Regular<br />
1) V-Tach<br />
2) SVT<br />
with<br />
aberrant<br />
pathway<br />
(WPW).<br />
Wide Complex<br />
Irregular<br />
1) A-fib with<br />
aberrant<br />
pathway.<br />
2) A-fib with<br />
WPW<br />
3) Torsades<br />
Regular Narrow tachycardia — Can use adenosine to<br />
help differentiate. Ventricular response with Aflutter & Atrial<br />
tachycardia will transiently slow down with adenosine. AVRT &<br />
AVNRT will typically convert to SR with adenosine.
46<br />
Multi Focal atrial tachycardia — RR interval variable<br />
making rhythm irregular looking. There will be at least 3<br />
morphologically different p waves with rate greater than 100.<br />
Favors V-tachycardia on EKG — 1) AV dissociation. 2) if<br />
QRS >0.16. 3) Fusion/capture beats 4) Concordance (all R<br />
waves positive or negative). 5) Hx of structural heart dz. 6)<br />
RBBB in V1 7) look for negative in V6 8) NW axis-extreme right<br />
axis deviation (neg in I and aVF)
47<br />
GI/HEPATOLOGY<br />
GI CONSULTS AND GROUPS<br />
Digestive Health Associates of Texas (DHAT)<br />
(Ten gastroenterologists in two different call group<br />
arrangements)<br />
Washington Avenue Group (214) 545-3990<br />
Daniel Polter, MD<br />
Daniel DeMarco, MD<br />
Cathy Little, MD<br />
Angela Carollo, MD<br />
Lawrence Schiller, MD<br />
Landry center group (214) 821-5266<br />
J. Kent Hamilton, MD*<br />
Blair Conner, MD*<br />
Robert Anderson, MD**<br />
Damian Mallat, MD**<br />
Catherine Yaussy, MD<br />
Texas Digestive Disease Consultants (TDDC)<br />
(214) 820-4490<br />
Charles Richardson, MD<br />
Esmail Elwazir, MD*<br />
Greg Hodges, MD*<br />
Bhavani Moparty, MD**<br />
Chris Vesy, MD<br />
Texas Digestive Health Consultants (Health<br />
Texas/Baylor affiliate) (214) 820-8899<br />
Steve Burdick, MD**<br />
**Star designations: * ERCP **ERCP and EUS<br />
GI lab phone: (214) 820-3463<br />
(214) 820-4627<br />
Liver Consultants of Texas<br />
Inpatient Hepatologists (214) 820-8500<br />
Jacqueline O’Leary, MD<br />
Rita Lepe, MD<br />
Linsheng Guo, MD
James Trotter, MD<br />
Liverresources.com<br />
48<br />
GENERAL GI/LIVER TOPICS<br />
How do I get a GI consult?<br />
In general, you can call whomever you want. There are a<br />
few things to keep in mind- there is no consult schedule or<br />
GI service. Some gastroenterologists predominantly focus<br />
on outpatient Gastroenterology, and some have special<br />
areas of interest. Of course if a patient has a established<br />
relationship with a Gastroenterologist, then you should call<br />
that particular Gastroenterologist. You can usually find this<br />
information on EMR but it can be tricky.<br />
What do I tell the Gastroenterologist?<br />
Basic patient information; GI issue; Does the patient need<br />
to be seen today? Active bleeding? What/where do you<br />
think they are bleeding from? NSAIDs? Prior endoscopy<br />
(when, where whom) Is the patient NPO, Is a procedure<br />
needed?<br />
When do I call for an urgent GI consult?<br />
Active upper GI bleeding, specifically variceal bleeding.<br />
Most lower GI bleeding (diverticular) stops and is only<br />
occasionally brisk and persistent.<br />
How do I get a Hepatology/Liver consult?<br />
There is an inpatient “liver service.” All consults go to the<br />
general number. The inpatient hepatologist is on service<br />
for a week at a time (usually Monday to Monday). All<br />
established hepatology patients (ie, those previously seen<br />
in the Hepatology clinic or who are on the transplant list)<br />
are admitted by the TPC hospitalist group, so in general<br />
hepatology is already seeing these patients.<br />
What do I tell the Hepatologist?<br />
Basic patient information. Newly diagnosed cirrhosis? If<br />
calling for hepatitis — results of viral serologies,<br />
autoimmune studies, suspected medications.<br />
When do I call for an urgent Hepatology consult?<br />
Acute liver failure — in general, defined as new onset of<br />
encephalopathy, jaundice and coagulopathy. Remember,<br />
if they have risk factors for cirrhosis (EtOH, Chronic viral
49<br />
hepatitis, obesity), then they probably don’t have acute<br />
liver failure; they have decompensated cirrhosis.<br />
GENERAL GASTROENTEROLOGY<br />
C. difficile<br />
• Only one test is indicated: C diff toxin in stool<br />
• The test may sometimes take > 24 hours to return, so<br />
consider empiric treatment with oral Flagyl or Vancomycin<br />
• If a patient is really sick, it is best to start directly with<br />
Oral Vancomycin (pill or suspension): 125 mg po QID;<br />
Otherwise, can use oral flagyl. DO NOT use IV<br />
Vancomycin for C. difficile.<br />
• Always consider C. difficile if unexplained leukocytosis<br />
and diarrhea. Diarrhea is not always present, in fact in<br />
severe C. difficile they may get a dilated colon with ileus,<br />
so consider checking a KUB. If colon is dilated then make<br />
sure GI is following and consider surgical consultation<br />
(Colorectal or general)<br />
Cholangitis<br />
If you suspect a patient has cholangitis, then it is best to call a<br />
gastroenterologist who does ERCP. Cholangitis is an indication<br />
for urgent ERCP. Cholangitis should be suspected if a patient<br />
has symptoms of Charcot’s triad:<br />
1. Fever<br />
2. RUQ pain<br />
3. Jaundice<br />
The patient may also have hypotension and altered mental<br />
status which gives them all five of Reynold’s pentad. Patients<br />
can sometimes just present with vague upper abdominal pain<br />
and elevated transaminases. Always check a right upper<br />
quadrant ultrasound.<br />
Colonoscopy Prep<br />
Nulytely 4 liters- 8 oz PO Q 10-15 minutes until gone. We<br />
usually start this at about 5 p.m. on the day before a planned<br />
colonoscopy. NPO except meds after midnight. Write generous<br />
PRN orders for anti-emetics such as Zofran, Phenergan,
50<br />
Reglan. DO NOT prep a patient unless GI says that they were<br />
able to get the patient on the schedule for the next day.<br />
GI Prophylaxis<br />
Generally not indicated unless patient is at high risk of GI<br />
bleeding: high dose steroids, previous peptic ulcer disease,<br />
heavy NSAID use, neurotrauma, etc. GI prophylaxis may put<br />
patients at increased risk for C. difficile infection.<br />
Nutrition<br />
• TPN- there is a standard order sheet/order set. You<br />
should become familiar with this order set and in general<br />
write your own TPN. The dieticians are very good at<br />
writing and are a very valuable resource.<br />
• Tube feeds- enteral nutrition is always preferable to<br />
TPN. There are a variety of formulas available at Baylor<br />
(the Baylor EMR website has a list). Remember, Dobhoff<br />
tubes are more comfortable for patients due to their small<br />
size, but crushed meds don’t go down them very well, so<br />
order your meds as suspensions.<br />
Pancreatic Masses<br />
If a patient has a pancreatic mass, and an FNA is indicated,<br />
than it is best to call a gastroenterologist that does EUS/FNA<br />
Pancreatitis<br />
• Always assess severity — mild, moderate, severe — via<br />
Ranson’s criteria or other criteria, and watch closely for<br />
complications.<br />
• If severe, then ICU treatment is needed.<br />
• Treatment- IVF. If necrosis on CT, consider antibiotics<br />
(controversial). Pancreatic necrosis can only be<br />
determined on a CT with IV contrast (which may be<br />
problematic as many patients with pancreatitis develop<br />
AKI)<br />
• Early tube feeds (gastric or duodenal) are controversial<br />
• Always check a sonogram for stones. Consult surgery if<br />
you suspect biliary pancreatitis because they usually need<br />
a cholecystectomy before they leave the hospital. The
51<br />
timing and necessity of ERCP for biliary pancreatitis is<br />
variable.<br />
PEG tubes<br />
Preferences<br />
> 6 months life expectancy<br />
• Indications: Dysphagia- aspiration or penetration<br />
documented by speech therapy or dysphagiagram<br />
• Prefer for patients to be off anticoagulation and no<br />
coagulopathy. ASA is okay. If they have cirrhosis and<br />
ascites, then no PEG tube.<br />
When they “fall out” or are pulled out (this only happens at<br />
night)- replace with a 15-20 French foley catheter and inflate<br />
the balloon ASAP, but do not use the tube until position is<br />
verified or GI has seen patient.<br />
Upper Gastrointestinal Bleeding (UGIB)<br />
Treatment — Use Baylor GI bleeding order set.<br />
• First priority: Volume resuscitation. Ensure two large<br />
bore peripheral IV’s or central line. Give IVF and blood<br />
products as appropriate to keep HR 100.<br />
• Check hemostasis profile and give FFP and platelets as<br />
needed to correct any coagulopathy. General goal: INR<br />
50<br />
• Discontinue anti-platelet agents and anticoagulants.<br />
• Peptic ulcer disease is a common etiology, so give a<br />
Protonix 80 mg IVP, the 8 mg/hr<br />
• If cirrhosis and variceal bleeding suspected, give<br />
Octreotide 50 mcg IVP, then 50 mcg/hr (Octreotide drip<br />
per protocol). Also start cirrhotics with suspected variceal<br />
bleeding on prophylactic antibiotic coverage (usually start<br />
with 3 rd /4 th generation Cephalosporin (such as Ceftriaxone<br />
or Cefepime) or levaquin 500 mg IV qday, then change to<br />
PO
52<br />
• Vasopressin — pressor of choice if not able to maintain<br />
adequate blood pressure with blood product and fluid<br />
resuscitation.<br />
• NGT aspirate: If red blood then may indicate active GI<br />
bleeding. If coffee ground, than probably UGIB within 1 to<br />
2 days.<br />
**A negative NGT lavage does not rule out an UGIB.<br />
Large post-pyloric bleeds such as duodenal ulcers<br />
commonly have negative aspirates. It is usually okay<br />
to remove the NGT after the aspirate (unless you are<br />
going to use it for medications or something else).<br />
• Consult GI: Important things to tell them are<br />
1. Patient name and location<br />
2. Presentation<br />
3. Co morbidities and medications (including any<br />
NSAIDS)<br />
4. Actively bleeding or not (results of lavage)<br />
5. Significant labs: H&H, PT/INR<br />
6. Resuscitation efforts (how much blood/FFP has<br />
been given)<br />
7. Hemodynamics<br />
8. If a procedure is needed<br />
9. Remember the definition of urgent endoscopy is<br />
an endoscopy within 24 hours.<br />
• Follow serial H&H Q6 hours for 1-2 days, then change to<br />
Q 8-12 hrs<br />
• Make sure to repeat INR 1-2 hours after FFP<br />
• Vitamin K: Most cirrhotics who have significant jaundice<br />
are also Vitamin K deficient so give Vitamin K 10 mg SC<br />
daily x 3 days.<br />
• Keep NPO<br />
GENERAL HEPATOLOGY<br />
Acute liver failure<br />
▪ Basic definition: Jaundice, coagulopathy, and AMS<br />
▪ Very complex, sick ICU patients. Acute liver failure can<br />
progress very rapidly. Best managed on 4 west ICU (aka
53<br />
the liver transplant ICU) where the nurses are very<br />
comfortable taking care of liver patients.<br />
▪ Transplant candidacy vs evaluation.<br />
▪ If intubated in the ICU, propofol is usually your sedative<br />
of choice.<br />
▪ Levophed is in general your pressor of choice.<br />
▪ If Tylenol is on your differential, always give at least one<br />
dose of Acetadote- (acetylcysteine) which can be given<br />
orally or IV until the Tylenol level comes back.<br />
Alcoholic hepatitis<br />
▪ Always calculate the discriminant function and consider<br />
steroids or Trental if >32<br />
▪ No steroids if any sign of infection<br />
▪ Give folate 2 mg daily and thiamine 100 mg daily<br />
▪ Nutrition is very important. Always consider tube feeds<br />
(at least for a couple of days) if the patient does not have<br />
good PO intake.<br />
▪ Withdrawal precautions: Oxazepam preferred over other<br />
benzodiazepines for withdrawal. Librium is very longacting<br />
and can be problematic. Consider non-selective<br />
beta-blockers as well, if the patient is hyperadrenergic<br />
(hypertensive, tachycardic)<br />
▪ Vitamin repletion: Always give thiamine before any<br />
dextrose containing IV fluids. Because of malnourishment,<br />
alcoholics often have thiamine, folate, and magnesium<br />
deficiencies. Suggested orders: Add to first bag of IV<br />
fluids daily (aka the “banana bag”) Thiamine 100 mg,<br />
Folate 2 mg, one vial of multivitamins. Okay to follow Mg<br />
levels or give 1-2 grams of Magnesium sulfate IV daily for<br />
the first day or two. Watch Phosphate levels for refeeding<br />
syndrome.<br />
▪ High mortality<br />
Decompensated Cirrhosis<br />
When managing cirrhotics, mention patients Child’s Class or<br />
MELD score (MELD score if preferable if pt is a transplant<br />
candidate or is on the transplant list). Also mention underlying<br />
cause if known (Laennec's cirrhosis, etc)<br />
Hepatic encephalopathy<br />
Stages of encephalopathy: The simplest assessment system<br />
(most commonly used) grades HE as stages 1 to 4. The<br />
grading is based upon changes in consciousness.
54<br />
Stage 1: Mild confusion, decreased attention,<br />
irritability, reversed sleep pattern<br />
Stage 2: Drowsiness, personality changes,<br />
intermittent disorientation, asterixis<br />
Stage 3: Gross disorientation, marked confusion,<br />
slurred speech<br />
Stage 4: Frank coma<br />
The grading/staging of HE can be difficult. The presence of<br />
asterixis is a fairly reliable indicator of at least stage II HE.<br />
** Always look for what precipitated the HE. Common<br />
etiologies: Infection, bleeding, electrolyte abnormality,<br />
dehydration.<br />
• Kristalose (same as Lactulose but tastes better and<br />
comes as packets of crystals): a good starting does is 20-<br />
30 g po TID, then titrate to 3-4 BM/day<br />
• Rifaxamin: 400 mg PO TID- this is very expensive, and<br />
so it can be difficult to continue as an outpatient<br />
• For your patients with Stage III/IV HE or refractory HE:<br />
Kristalose 30-60 grams every hour until BM. Lactulose<br />
enema: 200 g of lactulose in 800-1000 mL water<br />
Ascites-volume overload<br />
Large volume paracentesis is greater than >2L<br />
If the patient’s serum albumin is less than 3 g/dL, then give 8 to<br />
10 g of albumin per liter of ascites removed. All albumin at<br />
Baylor is “sodium poor” so no need to specify “sodium poor<br />
albumin- SPA”. Albumin comes in 25 g vials, so it is best to<br />
round to the next highest 25 g interval. Usually best to hang<br />
the albumin as you are about to do the tap.<br />
• Diagnostic paracentesis - SBP, etc.<br />
- Send for: cell count/diff, albumin, total protein<br />
- Inoculate culture bottles at bedside with 10 mL of<br />
ascitic fluid in each bottle (increases yield)<br />
- SBP if >250 PMNs<br />
• Coagulopathy is not a contraindication to paracentesis.<br />
In general, we do not give FFP or platelets prior to a<br />
paracentesis unless the patient has a severe<br />
coagulopathy
55<br />
GI bleeding<br />
(**See above under GI Bleeding; in addition, think about the<br />
following)<br />
• All cirrhotics with GI bleeding should get prophylactic<br />
antibiotics to prevent SBP. Good options include a 3rd or<br />
4th generation cephalosporin or quinolone. Antibiotics<br />
should be continued for 5 days.<br />
• Fluid resuscitate- central line preferred. If not, then<br />
ensure a 18-20G IV in each arm<br />
If INR>2, then give at least 4Units FFP<br />
• Give platelets if
Liver transplant<br />
56<br />
Liver transplant evaluation (LTE)<br />
▪ Can only be initiated by a hepatologist.<br />
▪ Standardized 3 page order set which includes an<br />
extensive battery of imaging studies, labs, and consults.<br />
The evaluation usually takes 2-3 days minimum to<br />
complete. The liver transplant coordinator calls the<br />
consults (Psychiatry, etc.) as the transplant service often<br />
has consultants that they prefer to use.<br />
▪ Be careful what you tell families and patients about their<br />
candidacy for transplant. Remember that the decision to<br />
transplant a patient is a committee decision. In general<br />
always defer this to the hepatologist. Patients and families<br />
are sometimes under the impression that they are being<br />
sent to Baylor for a liver transplant. It is important to tell<br />
the patient and family that a liver transplant evaluation is<br />
required first.<br />
▪ Once a patient is transplanted, it is usually okay to sign<br />
off as the transplant surgery team will completely manage<br />
the patient.<br />
General liver patient guidelines<br />
• Avoid benzodiazepines and narcotics as they can<br />
precipitate encephalopathy<br />
• Tramadol is a good choice for pain management: 50 mg<br />
PO q12 hours prn pain<br />
• Insomnia is very prevalent. It is best to use Trazodone<br />
for insomnia. Do not use Ambien, Lunesta, etc. if possible.<br />
• If agitation is a significant problem, then low dose IM<br />
Zyprexa or Haldol is a possible treatment that can be<br />
used.<br />
• Always notify the liver transplant service if a patient that<br />
is on the liver transplant list is hospitalized.<br />
GI STUDIES<br />
Study Orders<br />
• Abdominal US (NPO 6hrs prior)<br />
• Barium Swallow (NPO 1hr prior)<br />
• Upper GI (NPO after MN)<br />
• SBFT (NPO after MN and one glass of water qhr from<br />
noon to 1900)
57<br />
• Barium Enema (clear liquids 1d prior, NPO after MN,<br />
one glass of water qhr from noon to 1900, MgCitrate at<br />
8pm, Dulcolax at 11pm, Dulcolax at 7am)<br />
• HIDA (NPO after MN)<br />
• Other notes:<br />
- CT abdomen/pelvis- always use oral contract<br />
(Gastrografin). Use IV contrast if possible.<br />
- Plain X-rays: KUBs and acute obstructive series are<br />
always best done in radiology rather than as<br />
portables.<br />
Endoscopy Orders<br />
• Colonoscopy, etc: Clear Liquid Diet day before then<br />
NPO except meds (except antiplatelets and iron) after MN<br />
and Nulytely 250cc PO Q10min until all 4L consumed<br />
starting at 1800<br />
• EGD, etc: just NPO except meds for 6hrs prioir or after<br />
MN<br />
• Permits on chart for colonoscopy, endoscopy, and<br />
anesthesia<br />
• To GI lab on call<br />
• If pt is still passing stool in am the give fleet enema x1<br />
• Have functioning IV (not heplock). The best way to do<br />
this is just to order IV fluids to start 4-6 hours before the<br />
procedure.<br />
• Patient to resume diet when alert ~1hr (for capsule can<br />
resume liquid/diet 2/4hrs after swallow<br />
• Benefits: 1/20 r/o cancer vs Risks: 1/500 r/o significant<br />
bleed, 1/2000 r/o perforation
58<br />
INFECTIOUS DISEASES<br />
BUGS AND DRUGS<br />
(This is not a comprehensive list, but think of these drugs when<br />
you are dealing with the listed bugs; refer to Sanford Guide<br />
and your prescribing references for treatment doses and<br />
specific clinical scenarios)<br />
Atypical PNA (Chlamydia, Mycoplasma, Legionella)<br />
• Azithromycin (Zithromax)<br />
• Levofloxacin (Levaquin)<br />
Candidemia<br />
• Micafungin (Mycamine)<br />
• Fluconazole (Diflucan)<br />
• Voriconazole (Vfend)<br />
• Amphotericin B<br />
• Liposomal Amphotericin B (AmBisome)<br />
Candiduria<br />
• C. albicans (No chronic foley, has symptoms, +pyuria):<br />
Fluconazole<br />
• C. glabrata (With symptoms): Fluconazole, Amphotericin<br />
B<br />
Chronic foley: Change out foley and monitor (unless<br />
neutropenic)<br />
Good anaerobic coverage:<br />
• Zosyn (and anti-pseudomonal penicillins)<br />
• Merrem (and other carbepenems)<br />
• Clindamycin (anaerobes above the diaphragm) (Cleocin)<br />
• Metronidazole (anaerobes below the diaphragm)<br />
(Flagyl)<br />
MRSA<br />
• Vancomycin<br />
• Linezolid (Zyvox)<br />
• Trimethoprim/Sulfamethoxazole (Bactrim)<br />
• Daptomycin (Cubicin)-not indicated for tx of PNA<br />
• Tigecycline (Tygacil)<br />
• Minocycline (for CA-MRSA)<br />
• Doxycycline (for CA-MRSA)
59<br />
Pseudomonas:<br />
• Piperacillin/Tazobactam (Zosyn)<br />
• Meropenem (Merrem)<br />
• Imipenem/Cilastatin (Primaxin)<br />
• Doripenem(Doribax)<br />
• Ceftazidime (Fortaz)<br />
• Cefepime (Maxipime)<br />
• Gentamicin (Garamycin)<br />
• Tobramycin (Nebcin)<br />
• Amikacin (Amikin)<br />
• Ciprofloxacin (Cipro)<br />
• Levafloxacin (Levaquin)<br />
• Colistin (for multiresistant strains)<br />
VRE<br />
• Linezolid (Zyvox)<br />
• Daptomycin (Cubicin)<br />
• Tigecycline (Tygacil)<br />
• Quinupristin and dalfopristin (Synercid)<br />
Etiologies<br />
FEVER IN THE ICU<br />
• VAP (PNA developing after 48 hours intubation)<br />
- Risk highest in the first week<br />
- Higher risk in patients with comorbidities, ARDS,<br />
paralyzed, H2B, NGT; mortality 20 to 60 percent.<br />
- Infection control/prevention: NIV; if possible,<br />
carafate over other anti-ulcer, tight cuff seal (>20cm);<br />
semi-recumbent position.<br />
• Central line infection<br />
- Infection rate: Fem>PICC>IJ>SCL<br />
- No evidence to support prophylactic scheduled<br />
changes, but should be changed if new infection<br />
arises. Consider changing anyway if in >3 weeks.<br />
• Other catheter related infections (foley catheter,<br />
arterial line, peripheral IV)<br />
• CMV infection after blood transfusion<br />
• Surgical site infections
60<br />
• Resistant pathogens: MRSA, VRE, Pseudomonas<br />
• Other infections: Cellulitis, cholangitis, cholecystitis,<br />
diverticulitis, endocarditis, intra-abdominal abscess,<br />
meningitis, sinusitis, thrombophlebitis<br />
• Non-infectious causes: Transfusion reactions, drug<br />
fever, intra-abdominal source (pancreatitis, acute<br />
mesenteric ischemia), thyroid disease, or thromboembolic<br />
disease (DVT/PE)<br />
Work-up and treatment — Consider the following:<br />
• CBC with diff, CMP<br />
• Repeat blood cultures x2<br />
• CMV PCR<br />
• UA/urine culture<br />
• Sputum gram stain/culture<br />
• Change out central lines if >48 hours (venous lines first)<br />
and culture tips<br />
• pCXR<br />
• Stool studies if indicated<br />
• Abdominal ultrasound if indicated<br />
• CT chest, abdomen, or pelvis if indicated<br />
• Bilateral lower extremity Doppler if indicated<br />
• CT sinuses if chronic NG tube<br />
• Empiric antibiotics<br />
Definition<br />
FEVER OF UNKNOWN ORIGIN<br />
• Fever >101°F (38.5°C) on one or more occasion<br />
• Duration >3 weeks<br />
• No diagnosis despite 1 week of intensive evaluation<br />
Etiologies<br />
• Infection:<br />
Tuberculosis, endocarditis, intra-abdominal abscess,<br />
osteomyelitis, fungal infection, meningitis, hepatitis, CMV,<br />
EBV, Lyme disease, HIV, etc.<br />
• Connective tissue disease:<br />
Temporal arteritis, Polyarteritis nodosa, RA, SLE, etc.
61<br />
• Neoplasm:<br />
Lymphoma, leukemia, carcinoma, etc.<br />
• Others: Drugs, DVT, PE, adrenal insufficiency, etc.<br />
Work-up — Consider if appropriate:<br />
• Reassess medications<br />
• Thorough history and physical exam<br />
• Lab — CBC with diff, CMP, Blood cultures x2, UA, urine<br />
culture, sputum gram stain and culture, Quantiferon Gold,<br />
ESR/CRP, ANA, RF, LDH, CMV PCR, EBV PCR, HSV<br />
PCR, Lyme titers, Hepatitis panel, HBV or HCV PCR, HIV<br />
antibody or PCR, fungal complement panel, D-dimer<br />
• Imaging — TTE followed by TEE if indicated, CXR, CT<br />
of targeted area, LE Doppler, CT chest with PE protocol,<br />
bone/gallium scan<br />
• Procedures — Lumbar puncture, bone marrow biopsy,<br />
temporal artery biopsy<br />
PNEUMONIA<br />
Use pneumonia admission protocol<br />
SEPSIS<br />
Define the condition of your patient in your notes<br />
using the following:<br />
• SIRS — 2 out of the 4 following criteria:<br />
- T>38 or 90<br />
- RR>20 or PaCO212,000 or >10 percent Bands<br />
• Sepsis — SIRS in response to a documented or<br />
suspected infection (does not have to have proven<br />
infection to call it sepsis)<br />
• Severe sepsis — Sepsis PLUS signs of organ<br />
hypoperfusion or damage, such as:<br />
- Capillary refill >3 sec<br />
- Mottled skin<br />
- Uop 4 mmol/liter
62<br />
- Altered mental status<br />
- Platelets 15<br />
mcg/kg/min or NE/Epi >0.25 mcg/kg/min for MAP>60<br />
Goals in sepsis:<br />
• MAP 65 to 90 (MAP = [SBP+(DBPx2)]/3)<br />
• CVP 10 to 12 (>12 if intubated)<br />
• SvO2>70 (can draw random ScvO2: early goal directed<br />
therapy suggests to transfuse to Hct>30 percent, then<br />
redraw; if 65 or SBP>90 OR<br />
• CVP≥8 or ≥12mmHg if intubated OR<br />
• Total fluid bolus of 45 ml/kg have been given including<br />
all fluid boluses in ER and on floor within 6 hours of<br />
arriving in the ICU.<br />
• If still hypotensive, then initiate pressors.<br />
• Establish central access<br />
Pressors:<br />
• Start with Levophed gtt: titrate to keep MAP>65<br />
• Can then escalate based on specific patient<br />
• Vasopressin can be added at 0.01-0.04 Units/min,<br />
neosynephrine starting at 100-180 mcg/min, or dopamine<br />
starting at 5 mcg/kg/min. Addition of vasopressin to high<br />
doses of levophed have shown to cause increases in
63<br />
mortality. It lowers mortality if added to moderate doses of<br />
levophed.<br />
Antibiotics — First dose stat in ER<br />
Blood cultures — x2 drawn in ER prior to first dose<br />
antibiotics<br />
• Order labs and antibiotics based on suspected etiology<br />
• Consider pharmacy evaluation for Xigris if >2 organ<br />
system failure 2/2 sepsis or APACHE II score ≥25<br />
Other factors in shock — If still refractory hypotenstion,<br />
check Ca, TSH, possible hemorrhage into any organ, GIB,<br />
TTE, acidosis. HCO3 drip if ph
Histoplasmosis<br />
HIV<br />
64<br />
Urine histo antigen, LDH.<br />
HIV (Multidrug-resistant) HIV genotype<br />
Acute retroviral syndrome: Order<br />
HIV PCR for viral load and CD4<br />
count.<br />
Chronic illness or AIDS: HIV<br />
antibody/CD4 count.<br />
Meningitis Blood cultures x2, CT head without<br />
contrast to r/o mass effect before<br />
LP (if indicated), LP: opening<br />
pressure, CSF gram stain and<br />
culture, Cell count with diff,<br />
Glucose, Protein.<br />
Osteomyelitis<br />
Pneumonia (Communityacquired)<br />
Pneumonia<br />
(immunocompromised)<br />
Also consider if indicated: CSF for<br />
acid fast stain/culture, fungal<br />
stain/culture, cryptococcal antigen,<br />
HSV/VZV/Enteroviral/CMV/West<br />
Nile PCR, Lyme IgG/IgM<br />
antibodies, VDRL, cytology, Serum<br />
Toxo IgG/IgM HIV test, RPR, ANA,<br />
RF<br />
Blood cultures x2, surgical<br />
sampling/needle biopsy (not swab<br />
of sinus tract or fistula), MRI (most<br />
Se and Sp)<br />
CXR, blood cultures x2, Sputum<br />
gram stain and culture, Urine<br />
Legionella antigen, Urine Strep<br />
Pneumo antigen, Rapid influenza<br />
nasal swab; consider HIV test<br />
All under CAP plus Blood fungal<br />
culture, Induced sputum for silver<br />
stain (PCP), sputum fungal<br />
stain/culture, sputum for acid fast<br />
bacilli stain/culture (TB),
Pneumonia<br />
(immunocompromised)<br />
(continued)<br />
Prion disease: Creutzfeldt-<br />
Jakob disease<br />
65<br />
Quantiferon Gold (TB), CMV PCR,<br />
HSV PCR, fungal compliment<br />
panel, aspergillus galactogamman<br />
(aspergillus), urine histo antigen;<br />
also consider bronchoscopy with<br />
fungal, bacterial, mycobacterial,<br />
viral cultures, with appropriate viral<br />
PCR’s, silver stain (PCP),<br />
Legionella DFA, Legionella culture,<br />
MTB Direct probe, and nocardia<br />
culture<br />
Send CSF for 14-3-3 Protein; If<br />
concern for prion disease, notify<br />
epidemiology as special<br />
precautions need to be taken.<br />
SBP Send ascitic fluid for: albumin, total<br />
protein, gram stain and culture<br />
(bedside inoculation of culture<br />
bottles increases Se), cell count<br />
with diff; can also send amylase,<br />
triglycerides, AFB stain/culture,<br />
adenosine deaminase (if TB<br />
suspected), or cytology<br />
Tuberculosis AFB sputum stain and culture x3<br />
(order induced sputum if needed);<br />
PPD or Quantiferon Gold
66<br />
NEUROLOGY<br />
ALTERED MENTAL STATUS<br />
Patient states:<br />
• Confused: disoriented but calm<br />
• Delerium:disoriented but agitated<br />
• Lethargic: Drifts off to sleep<br />
• Coma:Unarousable and unresponsive<br />
Etiology: MOVE STUPID<br />
• Metabolic (hypothyroid, hyperthyroid, hepatic<br />
encephalopathy)<br />
• Oxygen (Hypoxia from PNA, pulm edema, etc)<br />
• Vascular (TIA, CVA, Subdural hematoma, TTP)<br />
• Electrolytes (Specifically Na, Ca)<br />
• Seizure<br />
• Trauma<br />
• Uremia<br />
• Porphyria<br />
• Infection (sepsis/meningitis)<br />
• Drugs/Toxins<br />
Immediate ER cocktail (if history unobtainable): Thiamine<br />
IV (always give before glucose), D50, Narcan. Flumazenil only<br />
if BZD OD certain.<br />
Immediate assessment — Intubate if indicated. Vitals,<br />
Exam, ABG, DFS, O2 sat, EKG, utox<br />
Initial labs — CBC, CMP, serum osmolar gap,<br />
Acetaminophen level, Salicylate level, appropriate med levels if<br />
suspected, serum ETOH, TSH, Blood cultures x 2, UA and<br />
urine cx<br />
Consider additional diagnostic studies — CT Head<br />
(non-contrast), CXR, LP, EEG, additional infectious work-up if<br />
indicated
67<br />
BRAIN DEATH EXAM<br />
• Can order brain death exam order set and it guides you<br />
through the following:<br />
• Brain death is a clinical diagnosis<br />
• Need to exclude the presence of<br />
exogenous/endogenous toxins<br />
• Patient can’t be hypothermic: Need to warm them up to<br />
declare them brain dead<br />
• Exam has 3 components (need to have all of the<br />
following): 1) Coma 2) Absent brain stem reflexes 3)<br />
Apnea test<br />
1. Coma: Needs to be at least 6 hours if patient has a<br />
structural lesion and 24 hours if patient has anoxic<br />
brain injury<br />
2. Brain stem reflexes:<br />
- Absent motor response<br />
- Pupils are midposition or dilated (4-9 mm), absent<br />
light reflex, doll’s eye maneuver<br />
- Absent corneal reflex<br />
- Absent oculovestibular reflexes (30-60 cc ice water<br />
in ear canal results in no movement; in normal<br />
person, fast beat is described by COWS: cold<br />
opposite, warm same, in coma, a response would be<br />
seen if eye slowly moves toward ear irrigated with<br />
cold water)<br />
- Absent jaw jerk<br />
- Absent gag reflex<br />
- Absent cough with tracheal suctioning<br />
- Absent sucking or rooting reflex<br />
If all brain stem reflexes are absent, proceed to<br />
3. Apnea test: Pre-oxygenate at 100% FiO2 x 5-10<br />
minutes. Would like pCO2 to be around 40 to begin<br />
with if possible. Then, disconnect from ventilator<br />
support for 8-10 minutes (deliver O2 at 8-10L/min, a<br />
small canula is placed down the ET tube) and watch<br />
for respirations. A positive test is absence of any<br />
respiratory response and a post test ABG with PaCO2<br />
>60 or 20 mmHg greater than baseline.<br />
4. Confirmatory testing (Not mandatory):<br />
- Brain flow study: nuclear scan to evaluate for<br />
cerebral blood flow (no flow when ICP exceeds SBP)bedside<br />
(pitfall – does not evaluate posterior<br />
circulation)
68<br />
- EEG silence x2 12 hours apart (pitfall – can be<br />
confounded with medications on board, also at high<br />
sensitivities, much artifact comes through)<br />
- Cerebral angiography-Gold standard (no flow-no<br />
brain. pitfall – costly, invasive, requires transporting<br />
patient out of ICU setting to radiology, not readily<br />
available)<br />
5. Southwest Organ Transplant can come and talk to the<br />
family about organ donation, but keep that separate<br />
from the talking you do with the family.<br />
NEUROMUSCULAR EMERGENCIES<br />
Some patients will present with generalized weakness with<br />
certain neurological conditions. This may result in bulbar<br />
(facial) or respiratory weakness, and require close monitoring.<br />
Patients with severe bulbar weakness are more likely to<br />
require mechanical ventilation.<br />
• The following conditions in particular should prompt<br />
special attention: Guillain-Barre, Myasthenia Gravis<br />
Exacerbation, Polymyositis<br />
• Watch FVC and Negative Inspiratory Force (NIF)<br />
frequently (approximately Q6 hours). NIF=Maximum<br />
Inspiratory Pressure (MIP). You can write an order in the<br />
chart to monitor NIF as above and this will be performed<br />
by respiratory therapy.<br />
• If FVC drops below 15 cc/kg, the patient will require<br />
intubation and ventilation.<br />
• NIF should be at least -25 cm H20. If NIF begins to<br />
become more positive, this may indicate worsening<br />
diaphragmatic weakness and require intubation.<br />
• Also severe facial/bulbar weakness may make<br />
performance of bedside spirometry difficult if not<br />
impossible. Patients should be able to take a deep breath<br />
and count out loud to at least 1 to 20 in a single breath. If<br />
the time period is shorter, the patient may need to be<br />
intubated.<br />
• Follow ABG and if PaCO2 if creeping up, then have a<br />
low threshold for intubation.
69<br />
SEIZURES<br />
Can use BZD ativan IV or valium rectally if no access (0.1<br />
mg/kg max IV if needed) to stop seizure, most seizures will be<br />
self limiting and brief not requiring treatment. If patient having<br />
frequent convulsive seizures and not returning to baseline<br />
between events or if two or more events last longer than 30<br />
minutes and patient not awakening between, see status<br />
epilepticus below.<br />
Etiology: ABCDE<br />
• Alcohol withdrawal, illicit drugs<br />
• Brain tumor or trauma<br />
• CVA<br />
• Degenerative disorders of the CNS (Alzheimers)<br />
• Electrolytes (Na) and other metabolic (uremia, liver<br />
failure, hypoglycemic), Epilepsy<br />
Diagnostic studies — CBC, CMP, Utox, med levels,<br />
ETOH level, EEG, MRI or CT head, LP<br />
Treatment:<br />
1. Treat underlying condition<br />
2. Anti-epileptic drugs (AED) for patients with underlying<br />
structural disorder or idiopathic seizure plus: a) status<br />
on presentation, b) focal neuro exam, c) Todd’s<br />
paralysis, or d) abnormal EEG<br />
3. Introduce slowly and monitor closely<br />
4. Check levels on medication until therapeutic<br />
5. May consider withdrawing tx if seizure free for a<br />
defined interval (ex: 1 year) and normal EEG in select<br />
patients<br />
6. In TX: Need to be seizure free x 6 months to drive<br />
STATUS EPILEPTICUS<br />
Definition — One continuous seizure lasting >5-10min or<br />
two or more discrete seizures between which there is<br />
incomplete recovery back to baseline<br />
Stat labs — DFS, Na, Ca, serum and urine tox screen, AED<br />
levels
70<br />
Additional studies — MRI brain with and without contrast<br />
with seizure protocol, need LP<br />
Treatment:<br />
1. Intubate if indicated<br />
2. Ativan 0.1mg/kg IV at 2mg/min; if no response, then<br />
3. Dilantin 20mg/kg IV at 50 mg/min (or Cerebyx 20mg<br />
p.e./kgIV at 150mg p.e./min); if no response, then<br />
4. Additional IV dilantin or cerebyx (5-10mg/kg) bolus; if<br />
still no response, and continued sz>one hr, or<br />
hyperthermic, then definitely needs intubation if not<br />
already done, EEG monitoring, and ICU admission;<br />
then,<br />
5. Phenobarbital 20mg/kg IV at 50-75 mg/min initially,<br />
then additional 5-10 mg/kg bolus if still seizing; if no<br />
response then<br />
6. Sedate (versed 0.1mg/kg, then run at 10mcg/kg/min<br />
or propofol 2mg/kg, then run at 5mg/kg/hr)<br />
7. Additional phenobarb prn<br />
8. Pentobarb coma as last line of treatment with<br />
continuous EEG monitoring in place. Titrate<br />
pentobarb to burst suppression with 1 to 3 bursts per<br />
minute.<br />
Neuro consult, EEG monitoring (if sedated/unclear status)<br />
CVA: Hemorrhagic<br />
STROKE MANAGEMENT<br />
• Intracranial or SAH<br />
• Usually intubated either 2/2 AMS, elective<br />
hyperventilation, or post-craniotomy/repair/ventric<br />
placement.<br />
Diagnostic studies — Labs including CBC, CMP, PT/INR<br />
and urine drug screen, non-contrast CT head, LP to check for<br />
xanthochromia if no evidence of SAH on CT, but suspicion still<br />
high<br />
Treatment:<br />
1. Stat neurosurgery consult to review films/patient<br />
2. Admit using Hemorrhagic stroke protocol
71<br />
3. Stop anticoagulants and reverse coagulopathies,<br />
vitamin K, FFP<br />
4. Insulin for hyperglycemia<br />
5. Usually hypertensive: treat to MAP 100-120; maintain<br />
CPP (MAP-ICP) >60-70.<br />
6. HTN is usually labile use gtt: nicardipine, nipride or<br />
labetalol based on other comorbidities.<br />
7. Load with Dilantin or cerebyx to levels of<br />
approximately 20. Most indicated in lobar ICH, SAH,<br />
or subcortical ICH with diameter >4cm and shift.<br />
8. Treat ICP (goal < 20): elevate HOB to 30 degrees,<br />
sedate using propofol, mannitol IV at 1 g/kg bolus<br />
followed by 0.5 to 0.25g/kg q6hours(follow Na, Posmkeep<br />
300 to 320), hyperventilate (goal pC02 25-30)<br />
9. Bilateral SCD’s for DVT prophylaxis<br />
CVA: Ischemic<br />
• Admit using ischemic stroke protocol<br />
• If indicated, admit to stroke unit (3 Truett)<br />
Labs — CBC, CMP, Fasting Lipid level, DFS, HgbA1C, PT,<br />
PTT, utox, hypercoagulable work-up and blood cultures on<br />
young patients<br />
Imaging — Stat CT head without contrast to evaluate for<br />
hemorrhage, MRI/MRA head and neck or CTA head and neck,<br />
Carotid Doppler if you do not obtain other imaging of the<br />
neck(carotids), EKG, TEE in patients who are suspected to<br />
have embolic stroke without known source (Afib), TTE with<br />
Bubble study is acceptable as screen in others if low suspicion<br />
of central embolic process (cross out TEE on protocol as you<br />
want to order TTE with bubble study instead)<br />
Treatment:<br />
1. If
72<br />
4. Tx of HTN not of proven benefit unless >220/120 or<br />
comorbidities present: aortic dissection, MI, CHF, IC<br />
mass, etc.<br />
5. If giving lytics, treat if sbp>185, dbp>110.<br />
6. Statin: Consider Zocor 40 mg HS.<br />
7. DVT prophylaxis: Lovenox 40 mg SC daily vs heparin<br />
sc BID/TID, with renal insufficiency/failure, lovenox 30<br />
mg sc daily<br />
8. If cerebral edema (peaks 3-4 days post-stroke) with<br />
shift/impending herniation, then treat as elevated ICP<br />
(below).<br />
9. Carotid endarterectomy if indicated (see NASCET<br />
and ACST trials)
73<br />
ONCOLOGY<br />
THE ACUTE LEUKEMIC<br />
“The greatest ‘crumpability’ of any hospital patient you will care<br />
for.”<br />
-Troy Neal M.D.<br />
The acute leukemic patient, AKA the acute leuk, is a common<br />
admission during a typical ward month at <strong>BUMC</strong>. As house<br />
staff, we are involved generally in the care of patients with a<br />
NEW diagnosis.<br />
Nuts and bolts — Acute leukemia results from the clonal<br />
expansion of a hematopoietic precursor that has lost the ability<br />
to differentiate while maintaining the ability to proliferate. AML<br />
represents >80 percent of adult cases with a median age of 65<br />
years. ALL represents
74<br />
7. Serum and urine lysozyme (may be useful in cases with<br />
monocytic features)<br />
8. HLA Class I & II DNA-SBT— if patient candidate for<br />
allogeneic HSCT<br />
9. HSV IgM/IgG serologies<br />
10. Coagulation studies to rule out DIC including PT, PTT,<br />
fibrinogen, and D-dimer<br />
11. Lumbar puncture to assess cytology and administer<br />
chemotherapy for all ALL patients (sanctuary sites) and for<br />
AML patients with symptoms of CNS dysfunction<br />
Make sure your patient has the following:<br />
1. Central access via TLC (subclavian preferable for<br />
patient comfort but a non-compressible site) or PICC line<br />
by IV services (may refuse if platelets below their<br />
threshold-usually 50K, but can transfuse platelets in<br />
preparation of PICC)<br />
2. Preserved left ventricular systolic function as confirmed<br />
by TTE or MUGA scan before use of anthracyclines.<br />
3. Aggressive bicarbonate-containing IVFs to alkalinize the<br />
urine and prevent uric acid nephropathy from tumor lysis<br />
(Generally D5W in 1/2NS with 2 amps HCO3 @ 150<br />
cc/hour)<br />
4. Allopurinol 300 mg PO BID +/- rasburicase also for TLS<br />
prophylaxis<br />
5. Prophylactic antimicrobials, typically in the form of<br />
Levaquin 500 mg PO daily, Posaconazole 200 mg PO<br />
TID, and Famvir 250 mg PO BID (If HSV IgG/IgM+) once<br />
ANC approximately 500-1000<br />
6. Orders for daily weights and strict I/O’s (many chemo<br />
regimens have a large volume and need to watch for signs<br />
of volume overload)<br />
7. Orders for daily CMP and CBC<br />
8. Orders for daily TLS labs initially including potassium,<br />
uric acid, LDH, phosphorous, and calcium
Timeline*:<br />
75<br />
Day 0 (admit) — Bone marrow biopsy and other<br />
evaluations<br />
Day 1 — Induction chemotherapy with “7+3” (cytarabine &<br />
idarubicin/daunorubicin) written by Heme-Onc attending<br />
Day 10 to 14 — Bone marrow biopsy #2 to evaluate for<br />
aplasia; G-CSF if no blasts to recover neutrophils<br />
Day 30 (as outpatient) — CBC and Bone marrow biopsy<br />
#3 to assess for complete remission (CR); CR = clean<br />
bone marrow in the setting of no peripheral cytopenias;<br />
CR does NOT equal cure, therefore, induction<br />
chemotherapy if successful, must always be followed by<br />
consolidation therapy (occurs at later admission)<br />
*The above timeline roughly represents a routine<br />
admission for an acute leukemic patient. Obviously, there<br />
will be variation and numerous exceptions depending<br />
upon whether or not remission was achieved, tolerance of<br />
chemotherapy, infectious issues, etc. Intended for<br />
simplified overview only. Day to day supportive care<br />
issues omitted.<br />
Fever in the acute leukemic:<br />
In general, you want to be sure to do the following:<br />
• Examine the patient<br />
• Blood cultures x2<br />
• Fungal culture<br />
• UA and Urine culture<br />
• Sputum culture if cough<br />
• CXR<br />
• Advance antibiotics: typically with first fever, we advance<br />
from levaquin to vancomycin and merrem. The second<br />
time the patient fevers, we advance from posaconazole to<br />
voriconazole. If they continue to fever, you can consider<br />
adding micafungin but will likely need ID involvement.<br />
Most attendings have a preference that they will specify<br />
for antibiotic advancement. Also, if there is a defined<br />
etiology, obviously treat appropriately with antibiotics.
76<br />
Shortness of breath in the acute leukemic:<br />
Worry about typical causes of shortness of breath in addition to<br />
severe anemia and opportunistic infections. Also, consider<br />
leukostasis leading to hypoxemia if blast counts are greater<br />
than 50,000 to 100,000. If the patient just started<br />
chemotherapy, they could be having an acute inflammatory<br />
reaction secondary to treatment or they could have pulmonary<br />
edema secondary to volume overload. In these instances,<br />
consider the following possible treatments based on suspected<br />
etiology and diagnostic work-up: advance airway/oxygen<br />
support as needed, transfer to the ICU if needed, appropriate<br />
antibiotics, leukapheresis, and/or IV Lasix.
77<br />
PALLIATIVE CARE AND CLINICAL<br />
ETHICS<br />
The Palliative Care Consultation Service (PCCS) and the<br />
Clinical Ethics Committee are a vital element of patient care at<br />
<strong>BUMC</strong>. The services are closely linked, but not identical.<br />
The Clinical Ethics Committee is a multidisciplinary committee<br />
of the medical staff responsible for developing and maintaining<br />
clinical ethics policies/guidelines, ethics education, and clinical<br />
ethics consultation. Baylor house staff typically interact with the<br />
ethics committee when an ethics consult is requested. Ethics<br />
consultation may be requested for moral guidance in<br />
circumstances of ethical uncertainty. A consult may be as brief<br />
as a several minute conversation with one of the ethics<br />
committee consultants or may involve the consultant seeing<br />
the patient, reviewing the chart, and actively engaging the<br />
treatment team, patient, and or family to bring resolution to<br />
ethical dilemmas. Ethics consultants are advisers only and do<br />
not write orders nor tell any party what they must do (unless it<br />
is a matter of hospital policy). Any member of a treatment team<br />
may request a consult, though it is customary to seek<br />
involvement from the attending physician prior to this as a<br />
courtesy. An ethics consult may be obtained by contacting the<br />
Medical Staff Office (2-2139) or by calling the office of Dr. Fine<br />
and Dr. Casanova (214-828-5090).<br />
The Palliative Care Consultation Service is a multidisciplinary<br />
team composed of staff physicians, nurses, pharmacists,<br />
speech therapists, nutritionists, social workers, physical and<br />
occupational therapists, and chaplains, all with extra skills and<br />
competencies to help manage patients with advanced lifelimiting<br />
illnesses. It is important to realize that palliative care,<br />
although often serving as a bridge to hospice, is not the same<br />
as hospice. Patients seen by the PCCS may continue to<br />
receive all treatments while receiving expert symptom<br />
management and the additional psycho-social-spiritual support<br />
often needed by patients and families facing the most serious<br />
illness. Unlike clinical ethics consults, members of the palliative<br />
care team help actively manage patients and write orders. The<br />
physicians, nurses, and pharmacist team members all have<br />
special expertise in pain and other symptom management.<br />
Circumstances in which to consider asking for a palliative care
78<br />
consult include assistance with controlling a patient’s symptom<br />
burden, guidance with the often difficult planning and<br />
conversations associated with decisions near the end of life,<br />
spiritual support for patients and their families, and<br />
complimentary therapies. Consults for the Palliative Care<br />
Consult Service (PCCS) are easily obtained by calling 214-<br />
820-PCCS (7227). Routine consults are handled 7 days a<br />
week primarily between 8:30 and 4:30. True palliative care<br />
emergencies may be called in after hours but must be called in<br />
directly by the physician requesting emergency assistance.<br />
Physician team members<br />
• Dr. Robert Fine<br />
• Dr. Mark Casanova<br />
• Dr. Shawnta Pittman-Hobbs<br />
• Dr. Roberto De La Cruz<br />
• Dr. Susan Kohl<br />
Palliative Care nurses<br />
• Min Patel — weekdays (available at 214-497-2612)<br />
• Grace Youseff — weekends (available at 214-724-<br />
5623)<br />
Palliative Care Pharmacist<br />
Jennifer Craft — weekdays<br />
Pain control tidbits<br />
• There is ample evidence that pain is under treated in<br />
American hospitals. Among the barriers to effective pain<br />
management are failure to adequately assess the pain<br />
and failures to prescribe opioids and other pain<br />
medications appropriately.<br />
• Basic pain assessment should always include a pain<br />
severity score. Remember that pain is subjective and a<br />
patient’s pain is what they say it is. Baylor uses a 0 – 10<br />
scale where 0 is no pain at all and 10 is the worst pain<br />
ever or the worst imaginable to the patient. Some patients<br />
may not be able to put a number on their pain. If not, they<br />
should be encouraged to rate the pain as mild, moderate,<br />
or severe.<br />
• Acute and/or intermittent pain requires rapid onset short<br />
acting opioids. The onset of action for these drugs is 5-10<br />
minutes when given IV and 30- 60 minutes when given<br />
orally. Typical duration of action is 3 to 4 hours. Some<br />
commonly used short acting oral opioids include<br />
hydrocodone, immediate release morphine, immediate
79<br />
release oxycodone, and hydromorphone. Commonly used<br />
parenteral opioids are morphine and hydromorphone.<br />
• Chronic or persistent pain requires long acting<br />
(inevitably slower onset) opioids such as sustained<br />
release morphine or sustained release oxycodone – both<br />
typically dosed at 8 to 12 hour intervals, or Transdermal<br />
fentanyl.<br />
• CALCULATION OF ORAL OR PARENTERAL<br />
MORPHINE EQUIVALENTS — This is the standard way<br />
to assess a patient’s opioid analgesic requirements,<br />
generally over a 24 hr period; this allows for summation<br />
and/or rotation to a simpler and more effective regimen of<br />
pain control; the John Hopkin’s opioid calculator is a good<br />
tool for this task.<br />
• When a patient is thought to be refractory to a particular<br />
opioid, consider opioid rotation. When rotating patients<br />
from one opioid to another, begin with 50-75% of the<br />
equianalgesic dose as the maintenance dose and provide<br />
the rest as breakthrough. Then adjust the maintenance<br />
dose as needed to achieve adequate pain relief based on<br />
the breakthrough usage documented. Allow for 10-15% of<br />
the total daily dose as a PRN given every 2-4 hours.<br />
• The preferred route of administration for opioids is oral.<br />
• “The hand that writes the opioids should also write the<br />
bowel regimen.”<br />
• Some useful opiod conversions (see front of chart for full<br />
equianalgesic dosing chart):<br />
- PO Morphine : IV Morphine = 3 : 1<br />
- IV Morphine : IV Hydromorphone = 10 : 2<br />
- PO Morphine : PO Hydromorphone = 30 : 7.5<br />
- PO Morphine : PO Hydrocodone = 1 : 1<br />
• When a patient is in a pain crisis, you may redose if pain<br />
uncontrolled at the opiod’s peak.<br />
• Do not exceed 12 tabs of Norco (325 mg Tylenol) or 8<br />
tabs of Lortab (500 mg Tylenol) in a 24 hr period due to<br />
the risk of acetaminophen toxicity. For this reason, avoid<br />
Percocet and Tylox (oxycodone plus Tylenol) for<br />
chronic/severe pain.<br />
• Dose Fentanyl transdermal patch (Duragesic) based on<br />
50% of the total oral morphine equivalent dose over 24 hr<br />
period. Rapid metabolizers of Fentanyl may require<br />
changing the patch every 48 hrs vs. every 72 hrs. Also,<br />
febrile patients will liberate the medication faster. Patch<br />
may be less effective in thin/cachectic patients due to<br />
unpredictable absorption. Patch reaches peak effect in
80<br />
17-20 hrs and takes the same to be eliminated once<br />
removed. Titrate doses every 48 hrs but no sooner.<br />
• Methadone is often an effective opioid when other<br />
opioids are not working. However, it is easily mis-dosed<br />
and carries some increased risks. Involve a physician,<br />
nurse, or pharmacist member of the palliative care team<br />
when starting and titrating methadone.<br />
• There is no “ceiling” for the amount of opioids that a<br />
patient can have, but side effects may eventually become<br />
limiting and alternatives (like Ketamine, for opiod-sparing<br />
effect) may have to be explored. Undesirable effects to<br />
monitor for are 1.) respiratory depression 2.) over-sedation<br />
3.) delirium 4.) hyperalgesia 5.) myoclonus<br />
• Stimulants such as Ritalin (10 mg upon arising then 10<br />
mg 4-6 hrs later), Dexedrene, and Provigil can offer<br />
periods of improved alertness by combating the sedation<br />
of opioids during the day or more specifically for planned<br />
family time or visits. Avoid doses late in the day to avoid<br />
insomnia.<br />
• For dyspnea/air hunger, consider morphine 1-2 mg IV<br />
every 1-2 hours PRN in an opioid naieve patient. Patients<br />
tolerant of opioids may need higher doses for air hunger<br />
managment.<br />
• Saturate the opioid receptors to achieve sedation before<br />
adding benzodiazepines because you want patients to be<br />
comfortable, not just look comfortable. Benzodiazepines<br />
can mask pain despite a patient’s appearance.<br />
• Always be open to adjuvant therapies such as TENs<br />
unit, heat, trigger point maneuvers (injections, ball in<br />
sock), myorelaxants, neuropathic agents (TCAs,<br />
Neurontin, Lyrica), relaxation/complimentary therapy,<br />
nerve blockade, NSAIDs, palliative radiation,<br />
bisphosphonates, glucocorticoids, anti-emetics, and<br />
scopolamine for control of secretions<br />
• Don’t forget other potentiators of pain such as<br />
emotional, spiritual, or relational distress.<br />
Useful resources<br />
• Hopkins opioid calculator for PDA or on the web at<br />
http://www.hopweb.org/hop/login.cfm; you then create a<br />
user name and password for free to gain access.<br />
• Palliative Care “Fast Facts” available at<br />
http://www.eperc.mcw.edu/ff_index.htm<br />
• CPR Outcomes and Counseling Guidelines tri-fold<br />
brochure
81<br />
• Institutional Ethics and Palliative Care link on the Baylor<br />
home page<br />
Hospice/comfort care measures<br />
Helpful medications/orders if you are transitioning to in-patient<br />
hospice and comfort care:<br />
• The hospice nurse will write orders as she evaluates the<br />
needs of the patient and call you to make<br />
recommendations and get your verbal approval if the<br />
patient is going on in-patient hospice.<br />
• Excess Secretions: Scopolamine patch behind ear<br />
once every 72 hours; if still struggling, can add atropine<br />
1% ophthalmic solution, 2 gtts under tongue Q3 hours prn<br />
• Fever: Tylenol 650 mg PO or per rectum Q4-6 hours prn<br />
pain/fever<br />
• Nausea/Vomiting: Phenergan 12.5 to 25 mg PO or per<br />
rectum Q6 hours prn nausea or vomiting<br />
• Pain regimens: Consult above; can try morphine gtt,<br />
titrate to comfort if patient is nearing end of life and pain<br />
not able to be controlled with orals or patch.<br />
• Air hunger: Morphine 1-2 mg per hour prn; add Oxygen<br />
by NC at 4-6 L, but write for nurse to not check O2 sats as<br />
this is for comfort only.<br />
• Constipation: Milk of magnesia, Miralax, Senna, or<br />
Dulcolax on a daily basis. Constipation is better prevented<br />
than treated. Do not use fiber supplements to treat<br />
constipation due to opioids or at the end of life.<br />
• Wheezing: A/A nebs q4 hours prn.<br />
• If patient aspirates and is under aspiration precautions,<br />
including ordered to be NPO status, consider changing<br />
this to comfort feedings.<br />
• Other symptomatic treatment as needed. Pastoral<br />
services are always available.
NeoSynephrine(phenylephrine)<br />
10-300<br />
mcg/min<br />
Dobutamine<br />
2-20<br />
mcg/kg/<br />
min<br />
Levophed<br />
(norepine<br />
-phrine)<br />
1-40<br />
mcg/min<br />
Dopamine <br />
Epinephrine<br />
2-20<br />
mcg/min<br />
Primacor<br />
(milrinone) <br />
Vasopressin(antidiuretic<br />
hormone)<br />
0.04<br />
units/hr<br />
82<br />
PRESSOR CHART<br />
Alpha Beta Dopa<br />
(renal<br />
recept<br />
or)<br />
Heart<br />
Rate<br />
SVR<br />
Cardiac<br />
output<br />
++ 0 0 0 ↑↑↑ 0<br />
0 +++ 0 ↑↑ ↓ ↑↑<br />
+++ + 0 ↑↑ ↑↑↑ ↑<br />
>10<br />
mcg/<br />
kg/min<br />
2-10<br />
mcg/<br />
kg/min<br />
0.5-2<br />
mcg/<br />
kg/min<br />
↑↑ ↑↑ ↑<br />
+ +++ 0 ↑↑ ↑ ↑<br />
0 ++ 0 ↑↑ ↓ ↑↑<br />
Primarily used in conjunction with levophed or<br />
neosynephrine in septic patients to aid with<br />
peripheral vasoconstriction (direct stimulation of<br />
smooth muscle V1 receptors).
83<br />
PULMONARY<br />
ARDS<br />
Definition: Need all 4 criteria<br />
1. Acute onset<br />
2. PCWP
84<br />
Higher PEEP/lower FiO2<br />
FiO 2 0.3 0.3 0.3 0.3 0.3 0.4 0.4 0.5<br />
PEEP 5 8 10 12 14 14 16 16<br />
FiO<br />
2<br />
0.5 0.5-<br />
0.8<br />
0.8 0.9 1.0 1.0<br />
PEEP 18 20 22 22 22 24<br />
ASTHMA/COPD<br />
Treatment of Asthma exacerbation:<br />
1. Albuterol nebs at least 3 times in first hour, then<br />
scheduled Q2-4 hours, plus prn nebs<br />
2. Steroids: Either IV or PO based on severity (IV not<br />
superior to PO). 60 mg prednisone PO qday or 1<br />
mg/kg prednisone equivalent Q6-12 hours (at Baylor<br />
for severe asthma exac, typically 60 mg IV solumedrol<br />
Q6 hours) until PEFR reaches 70% predicted; then<br />
begin taper.<br />
3. Continue home dose of inhaled steroid if on one<br />
4. O2 per protocol to keep SaO2 above 90%; use NPPV<br />
if patient’s paCO2 begins to normalize or rise; also in<br />
status asthmaticus<br />
5. Determine severity of exacerbation and ward level<br />
versus ICU level of care<br />
6. Check CXR and signs of infection<br />
Treatment of COPD exacerbation:<br />
1. Ipratropium/Albuterol nebs Q1-2 hours to begin<br />
2. O2 per protocol to keep SaO2 >90%<br />
3. Steroids: IV solumedrol at 60 -125 mg IV Q6<br />
hours (usually 60), or oral at 60 mg prednisone PO<br />
Qday<br />
4. Antibiotics: amoxicillin, Bactrim, doxy,<br />
clarithromycin, levoquin (no single abx proven<br />
superior but we typically use levaquin)<br />
5. NPPV: Initiate early if mod/severe dyspnea,<br />
decreased pH/high pCO2, RR>25<br />
6. CXR<br />
7. Smoking cessation counseling
85<br />
MECHANICAL VENITALTION<br />
Oxygen support<br />
Nasal Cannula (NC)<br />
• Each L adds about 3% FiO2 therefore 1L is 24% FiO2<br />
w/ max of 6L and thus Max FiO2 of about 40%<br />
Venturi Mask (VM): Can set an FiO2<br />
• Max FiO2 of 50%<br />
Partial ReBreather (PRB) Mask w/ Reservoir Bag (exhaled<br />
gas mixes with bag oxygen)<br />
• Max FiO2 of 75%<br />
Non-ReBreather (NRB) Mask w/ Reservoir Bag (exhaled gas<br />
does not mix with bag oxygen)<br />
• Max FiO2 of 100%<br />
Types of ventilatory support<br />
Noninvasive Positive Pressure Ventilation (NPPV)<br />
Face/Nasal Mask Continuous Positive Airway Pressure<br />
(CPAP): One continuous pressure during inspiration and<br />
expiration<br />
Uses: Patients whose primary problem is hypoxemia;<br />
typically used with CHF patients as well as OSA<br />
Face/Nasal Mask Bilevel Positive Airway Pressure (BiPAP):<br />
Set different inspiratory/expiratory pressures<br />
Uses: Patients whose primary problem is hypoventilation<br />
or hypoxemia such as COPD, immunocompromised, postextubation<br />
especially if patient is high risk, DNI patients,<br />
PNA, etc.<br />
Inspiratory Pressure (IP): Start at 8 to 10 cm of H2O and<br />
increase as tolerated to improve Tidal Volume (TV) and<br />
decrease work of breathing, which will result in decreased<br />
pCO2.<br />
Expiratory Pressure (EP) ~ PEEP start at 4 to 5 cm of H2O and<br />
increase as tolerated to increase PO2.
86<br />
Invasive Mechanical Ventilation (MV) Modes<br />
Pressure Support Ventilation (PSV): *NOTE: This mode is<br />
only for patients with an intact respiratory drive*<br />
• Patient initiates a breath, which is supported by vent at a<br />
preset pressure<br />
• Flow cycled NOT volume cycled like in SIMV/AC<br />
• “Pressure Support” = inspiratory pressure selected to<br />
achieve adequate TV and ventilatory support<br />
• Can be combined w/ SIMV to partially assist<br />
spontaneous breaths<br />
• Could be considered to make patient more “comfortable”<br />
on vent; also used for SBT at the appropriate level.<br />
Synchronized Intermittent Mechanical Ventilation (SIMV):<br />
• Patient receives vent support at a given tidal volume and<br />
respiratory rate. If patient initiates additional breaths, the<br />
vent provides no support to these breaths unless pressure<br />
support is added.<br />
• This mode has been proposed to prevent respiratory<br />
alkalosis; however, it requires more respiratory muscle<br />
work than AC.<br />
• Used primarily in SICU<br />
Assist-Controlled Mechanical Ventilation (AC): Can set volume<br />
targeted or pressure targeted.<br />
• When using volume targeted: Patient receives vent<br />
support at a given tidal volume and respiratory rate. If<br />
patient initiates additional breaths, the vent delivers the<br />
pre-set tidal volume with each additional breath.<br />
• If the patient is tachypnic, then hyperventilation can<br />
occur<br />
Other modes to minimize lung injury:<br />
• High Frequency Jet Ventilation/Oscillation: Alveoli are<br />
kept fully open as if the patient is kept at full inspiration<br />
while gases are exchanged by oscillating the air at high<br />
frequency<br />
Indications for intubation<br />
• Refractory hypoxemia<br />
• Hypercapnea with respiratory acidosis (note that<br />
patients w/ COPD often live w/ pCO2 b/t 50-70)
87<br />
• Ineffective respiratory effort, ie, Agonal Breathing or<br />
Respiratory Muscle Weakness (Max Inspiratory Force 1d)<br />
I:E Ratio = 1:2 to 1:4 which is determined by your Inspiratory<br />
Flow Rate. TV and respiratory rate in Volume Controlled<br />
Ventilation<br />
Positive End Expiratory Pressure (PEEP) = 0-10 cm of H20<br />
(may have to increase more if clinically indicated)<br />
• Higher levels of PEEP in asthmatics and COPD patients<br />
may worsen auto-peeping<br />
• In ARDS, may have to use higher level of PEEP for any<br />
given FiO2 (see ARDS)
88<br />
Any time a patient is on MV, the minute volume, plateau,<br />
and peak pressures should be monitored and reported it<br />
in your daily note.<br />
VT (VTE) x RR (fTOT) = minute volume (VETOT) L/min<br />
Specific disease states and mechanical ventilation<br />
suggestions:<br />
• Acute Brain Injury: Volume cycled, Avoid PEEP, Limit<br />
suctioning, Hyperventilate with pCO2 of 34-37<br />
• Neuromuscular disease: Volume cycled, Larger VT<br />
(12-15 ml/kg), Higher flow rate<br />
• COPD: Volume cycled, VT (5-7 ml/kg), higher peak flow<br />
rate, lower mandatory rate, low level PEEP(3), Limit<br />
plateau airway pressures, Reduce autopeep/hyperinflation<br />
• ARDS: Volume cycled, VT (4-6 ml/kg), plateau airway<br />
pressures 5 days as the drug<br />
accumulates in adipose tissue.
89<br />
- Daily sedation vacations at 0700 (“Sedation<br />
Vacation”) if the following is NOT present<br />
• FiO2 >60%<br />
• PEEP >10cm<br />
• Neurosurgical Pt<br />
• Increased ICP<br />
• Hemodynamically Unstable<br />
• Neuromuscular Blockade<br />
Consider a pulmonary critical care consult for every<br />
patient on a ventilator. After 48 hours of MV, it is hospital<br />
policy that you must get a pulmonary critical care consult.<br />
Simplistic approach to adjusting the vent<br />
• Low pO2: increase FiO2 or increase PEEP (to recruit<br />
more alveoli)<br />
• High pCO2: increase TV or increase rate (to increase<br />
minute volume)<br />
• Use ratios: pCO2 current x RR current=pCO2 desired x<br />
RR desired<br />
• For every 10 change in pCO2, the pH changes<br />
approximately 0.8 (acutely)<br />
Troubleshooting the vent<br />
Decreased Peak Inspiratory Pressure (PIP)<br />
• Disconnect problem: Consider disconnected tubing, lost<br />
airway<br />
Increased Peak Inspiratory Pressure (PIP)<br />
• First, check plateau pressure<br />
• Do this by pressing Inspiratory Pause Button<br />
• Check PPlat<br />
- Normal (Plateau Pressure10): This means there is increased airway<br />
resistance. Examples of what could be causing this<br />
include: Patient biting tube (increase sedation or add<br />
bite block), Airway Obstruction from bronchospasm<br />
(BD), secretions/aspiration (suction), plugging<br />
(mucolytics), etc. When the alarm goes off, increase<br />
parameter for peak pressure alarm while<br />
troubleshooting the vent: otherwise ventilator stops<br />
giving a breath with each breath when peak pressures<br />
are high and patient is not ventilated.
90<br />
- Increased (Plateau Pressure>30 and gradient of<br />
Peak to plateau
91<br />
• After 1 wk of intubation determine likelihood of<br />
extubation at 2wks. If unlikely proceed with<br />
bedside/surgical tracheostomy with a GS<br />
• Tracheostomy may be beneficial because it is more<br />
comfortable, more ease in clearing secretions, decreased<br />
airway resistance, decreased laryngeal injury, can eat<br />
orally, can partially vocalize, etc.<br />
- Complications: Infection (mediastinitis), bleeding,<br />
accidental removal with closure of stoma and then<br />
blind reinsertion potentially creating a false tract,<br />
injury to surrounding structures<br />
- Consider a Passy-Muir valve when a patient has a<br />
trach after weaning off ventilator to help with talking.<br />
The Passy-Muir valve acts as a one-way valve<br />
allowing air to go in through the trach and be exhaled<br />
through the native airway.<br />
- You can put a red cap over trach and see if pt can<br />
breath/talk fine, and, if so, you can decanulate the<br />
patient (the hole closes on its own in 2-3d)<br />
Oxygen Toxicity — Remember oxygen toxicity (FiO2 >60%<br />
for >48hrs) from the production of oxidizing radicals which<br />
damage membranes, denature proteins, and break DNA<br />
Cardiac Output Changes — Can reduce cardiac output<br />
because of decreased venous return and increase right<br />
ventricle afterload<br />
Respiratory Muscle Atrophy<br />
Trauma to Airway, Dentition, etc<br />
ETT Migration (normally the tip of the ETT should be 2cm<br />
above carina)<br />
Critical Illness Polyneuropathy/Myopaythy<br />
• Consider when patients continually need MV despite<br />
resolution of primary problem<br />
After Extubation<br />
• Sore throat, Hoarseness, Cough, etc: Can be normal<br />
and should resolve.<br />
• Laryngeal Edema<br />
- Usually occurs when patient is extubated from 2-<br />
7days post-extubation. After extubation, an average<br />
of 40% of patients have laryngeal edema but only 5%<br />
having severe obstruction
92<br />
-If you extubate and hear stridor with poor respiration<br />
then consider edema and acutely give racemic Epi<br />
nebs prn stridor, keep HOB elevated to 90°, and give<br />
solumedrol 60 mg IV Q6 hours x 48 hours<br />
• Vocal Cord Dysfunction (VCD)<br />
- This is a long term complication: Need ENT<br />
evaluation<br />
Weaning MV<br />
When pts are clinically improved, assess the following criteria<br />
for extubation:<br />
• Original condition requiring intubation has been reversed<br />
or improved<br />
• During sedation vacation, patients are awake and alert<br />
• Hemodynamically Stable (HR60mm, no<br />
evidence of myocardial ischemia) while on minimum to no<br />
vasopressor support and no sedation<br />
• Stable Oxygenation (PaO2>60mm and O2Sat>92%)<br />
while on minimum non-toxic oxygenation settings<br />
(PEEP
93<br />
- Sustained changes in the heart rate of 20 percent in<br />
either direction<br />
- A systolic blood pressure greater than 180 mm Hg<br />
or less than 90 mm Hg<br />
- Increased anxiety<br />
- Diaphoresis<br />
If pts pass SBT then write orders:<br />
• Check Cuff Leak Test prior to extubation (Patients<br />
without a cuff leak are at increased risk for post-extubation<br />
stridor)<br />
• Respiratory to Extubate (How is it done? HOB elevated<br />
to 90°, pull ETT, suction, listen for stridor, suction, then<br />
Face Mask/NC)<br />
• Place pt on 6L NC and then proceed w/ O2 Protocol<br />
• Incentive Spirometry (IS) Q2hrs while awake<br />
• Med Nebs: IPPB A/A nebs Q4 hours x 48 hours<br />
(Intermittent Positive Pressure Breathing (IPPB)) which is<br />
mainly used to treat atelectasis after surgery or postextubation<br />
to improve inspiratory capacity<br />
• Consider BiPAP if patient is high risk for re-intubation as<br />
post-extubation BiPAP has been shown to decrease reintubation<br />
• Swallow Study and Advance Diet as tolerated if passes<br />
• PT/OT<br />
If pts fail SBT then assess cause (see below) and retry SBT<br />
Qday if you feel patient is still clinically prepared.<br />
F Fluid overload: Diurese as able<br />
A Airway resistance: Check if ET tube is too small or<br />
obstructed<br />
I Infection: Treat as indicated<br />
L Lying down, bad V/Q mismatch: Elevate head of bed<br />
T Thyroid, toxicity of drugs: check TFT’s, check med list<br />
O Oxygen: Increase FiO2 as patient is taken off<br />
ventilator<br />
W Wheezing: treat with nebs/steroids as needed<br />
E Electrolyte disturbances: Correct K, Mg, Phos,<br />
Calcium<br />
A Anti-inflammatory needed?: Consider steroids in<br />
asthma/COPD<br />
N Neuromuscular disease, neuro status compromised
94<br />
PLEURAL EFFUSION<br />
Thoracentesis needed if effusion >1 cm in decubitus view; also<br />
patient with fever, chest pain, unilateral effusion, or new<br />
effusion. Parapneumonic effusions should be tapped ASAP.<br />
Transudate versus Exudate:<br />
1. Light’s criteria:TP eff/TP serum=>0.5, LDH eff/LDH<br />
serum >0.6, or LDH eff > 2/3 upper limit of normal of<br />
LDH serum (Best sensitivity but will misidentify 25%<br />
of transudates as exudates). Light’s criteria is most<br />
used and clinically applicable.<br />
2. Exudative criteria with better specificity: two test rule<br />
(pleural fluid cholesterol >45 and pleural fluid LDH<br />
>0.45 times upper limit of normal serum LDH), or<br />
three test rule (pleural fluid protein >2.9, pleural fluid<br />
cholesterol >45, and pleural fluid LDH >0.45 times<br />
upper limit of normal serum LDH)<br />
Complicated versus Uncomplicated Parapneumonic<br />
effusion:<br />
1. Complicated=positive gram stain or culture or pH
95<br />
PULMONARY EMBOLUS (PE)<br />
Evaluating using Dichotomized Wells clinical PE<br />
Probability for Algorithm using CT angiography<br />
(CTA)<br />
Variable Point Score<br />
Symptoms and signs of DVT 3<br />
PE more likely than alternative<br />
diagnosis<br />
3<br />
HR >100 beats/ minute 1.5<br />
Recent immobilization or surgery<br />
(
96<br />
• All other combinations with V/Q scan requires further<br />
testing (ie, serial venous ultrasonography and pulmonary<br />
angiography)<br />
Treatment<br />
• Reserve TPA for patients with hemodynamic<br />
compromise (cardiogenic shock, persistent arterial<br />
hypotension, or both). If hemodynamically unstable, start<br />
on heparin drip immediately and prepare for thrombolytics.<br />
• Start patients with intermediate-risk or high risk PE on<br />
unfractionated heparin drip per protocol or enoxaparin at 1<br />
mg/kg SC BID (can use fondaparinux in HIT patients).<br />
Patient needs to be on enoxaparin or fondaparinux<br />
eventually for outpatient bridge to long term<br />
anticoagulation therapy. These agents are generally<br />
preferred because they are easier to administer and are<br />
associated with lower rates of heparin-induced<br />
thrombocytopenia<br />
• If patient has HIT, can use argatroban or lepirudin drip<br />
instead of heparin drip (there are protocols for both).<br />
• Start patient on warfarin when heparin assay therapeutic<br />
or after 1 st does of LMWH; goal INR 2-3. Need to overlap<br />
treatment-usually 2-3 days after INR is therapeutic, and<br />
then can discontinue heparin.<br />
• Send patient to IR for IVC filter placement if<br />
contraindication to anticoagulation, treatment failure, or<br />
bleeding.<br />
References:<br />
1. Fauci, AS, Martin, JB Braunwald, E. et al (Eds). Harrison’s<br />
Principles of Internal Medicine. 14 th Edition. McGraw Hill, New York,<br />
1998.<br />
2. Konstantinides, S. Acute Pulmonary Embolism. N Engl J Med 2008;<br />
359:2804-2813.<br />
3. Esteban, A, Frutos, F, Tobin, MJ, et al. A Comparison of Four<br />
Methods of Weaning Patients from Mechanical Ventilation. N Engl J<br />
Med 1995; 332:345-350.<br />
4. Manthous, C, Schmidt, G, Hall, J. Liberation from Mechanical<br />
Ventilation: A Decade of Progress. Chest 1998; 114:886-901.<br />
5. Schmidt, SL, Hyzy, RC. Overview of Mechanical Ventilation. In:<br />
UpToDate, Basow, D (Ed), UpToDate, Waltham, MA, 2009.<br />
6. Tobin, MJ. Advances in Mechanical Ventilation. N Engl J Med 2001;<br />
344:1986-96.<br />
7. Ventilation with lower tidal volumes as compared with traditional<br />
tidal volumes for acute lung injury and acute respiratory distress<br />
syndrome. The Acute Respiratory Distress Syndrome Network. N Engl<br />
J Med 2000; 342:1301-8.
97<br />
RADIOLOGY<br />
RADIOLOGY HINTS<br />
IF YOU’RE THINKING THIS: ORDER THIS<br />
FIRST<br />
Shortness of breath CXR*<br />
Chest pain CXR*<br />
Volume overload CXR*<br />
Obstruction Supine/upright<br />
KUB<br />
Acute abdomen, bowel<br />
perforation<br />
Abdomen<br />
obstructive series<br />
After subclavian line placement pCXR to r/o PTX<br />
DVT (pain, swelling) Lower extremity<br />
Doppler<br />
ultrasound<br />
PE (Consider<br />
checking ddimer<br />
+/- doing LE<br />
Doppler first) --<br />
CTA chest (CT<br />
chest PE protocol)<br />
AMS CT head<br />
Carotid stenosis Carotid Doppler<br />
ultrasound<br />
Stroke CT head<br />
WITHOUT<br />
contrast, then MRI<br />
brain
98<br />
F/U pulmonary nodules CT without IV<br />
contrast<br />
Abdominal pain CT abdomen with<br />
oral and IV<br />
contrast<br />
Cirrhosis, elevated LFT’s,<br />
jaundice<br />
RUQ ultrasound<br />
Hepatomegaly,<br />
Abdominal<br />
splenomegaly<br />
ultrasound<br />
Hepatocellular carcinoma MRI liver<br />
Confirm hemangiomas MRI<br />
GB- Chronic<br />
cholecystitis/gallstones/b<br />
iliary colic<br />
Ultrasound<br />
GB- Acute cholecystitis Ultrasound;<br />
consider HIDA if<br />
U/S equivocal<br />
Kidney stones Renal stone<br />
protocol CT<br />
Renal disease, elevated<br />
Renal Ultrasound<br />
creatinine<br />
Pancreas (complications<br />
of pancreatitis,<br />
pancreatic cancer)<br />
CT Abdomen with<br />
contrast<br />
Adrenal mass Adrenal mass<br />
protocol CT or<br />
MRI<br />
Acute GI bleed < .5-1.0<br />
Tagged RBC<br />
ml/min<br />
Acute GI bleed < 2 ml/min Endoscopy<br />
Acute GI bleed 2 ml/min Mesenteric<br />
Angiography<br />
Mesenteric Ischemia CT Angiogram<br />
Abdomen/Pelvis<br />
Appendicitis Ultrasound (if<br />
thin), CT<br />
Abdomen/Pelvis<br />
with oral and IV<br />
contrast
Superficial Abscess/Mass<br />
Abscess/Mass/<br />
Infection<br />
99<br />
Ultrasound<br />
CT chest,<br />
abdomen or pelvis<br />
with oral and IV<br />
contrast<br />
Trauma CT<br />
Tumor Staging CT with IV<br />
contrast<br />
Testicular Mass/Torsion Testicular<br />
Ultrasound<br />
Myositis MRI<br />
Osteomyelitis MRI/ Indium /<br />
Gallium<br />
Breast Mass Mammogram<br />
Dysphagia, non-cardiac<br />
chest pain, GERD<br />
GI ulcer, hiatal hernia,<br />
abdominal pain<br />
IBD, small bowel<br />
obstruction, small bowel<br />
mass, malabsorption<br />
Large bowel obstruction,<br />
LLQ pain, constipation,<br />
diarrhea<br />
Biopsy (peripheral lung<br />
mass, liver, renal, lymph<br />
node, etc)<br />
Gastrostomy tube, IVC<br />
Filter<br />
Esophagogram<br />
UGI<br />
Small bowel follow<br />
through<br />
Barium enema<br />
Consult biopsy<br />
service<br />
Consult IR<br />
Ovarian Torsion Ultrasound<br />
Endocarditis TEE<br />
Pulm HTN/CHF TTE
100<br />
*With CXR: PA/lateral if pt able to stand; portable if unable to<br />
go to radiology or if STAT<br />
If you have any questions about what test to order, feel free to<br />
call and ask. Also, when you write the order for an exam, write<br />
an indication including what you are worried about and why. It<br />
will help make sure your test gets done correctly and that your<br />
specific concern is addressed in the report. This will save you<br />
from having to track someone down later if the report doesn’t<br />
address your main concern.<br />
To hear dictations of radiology reports: call “2 X-RAY” (29729).<br />
You will be prompted to enter your “logon ID” (your 4-digit<br />
dictation number), followed by #. Then you will be prompted for<br />
your password (1 st time is your 4-digit dictation number, but it<br />
will prompt you to change it), followed by #. Then you put in the<br />
pt’s date of birth, followed by #. The most recent dictation plays<br />
first.
101<br />
RENAL<br />
ACID/BASE DISTURBANCES<br />
Quick guide to acid/base disturbances:<br />
1. Look at the Ph:<br />
7.40 = normal<br />
7.45 = alkalemia<br />
Decide primary disorder (this is if compensated):<br />
Primary disorder pH HCO3 paCO2<br />
Metabolic<br />
acidosis<br />
↓ ↓ ↓<br />
Metabolic<br />
alkalosis<br />
↑ ↑ ↑<br />
Resp acidosis ↓ ↑ ↑<br />
Resp alkalosis ↑ ↓ ↓<br />
2. Determine if degree of compensation is appropriate:<br />
Metabolic acidosis: PCO2 = HCO3 + 15 (or the Winter’s<br />
Equation — pCO2 = 1.5(HCO3) + 8 +/- 2)<br />
Also, with metabolic acidosis the last decimal digits of<br />
the pH should equal pCO2 +/-2.<br />
Metabolic alkalosis: Increase in PaCO2 = 0.75 x change<br />
in HCO3 (HCO3 + 15 works fairly well)<br />
Respiratory acidosis:<br />
Acute: for every increase in 10 in pCO2, there is an<br />
increase in HCO3 by 1<br />
Chronic: for every increase in 10 in pCO2, there is an<br />
increase in HCO3 by 4<br />
Respiratory alkalosis:<br />
Acute: for every decrease in 10 in pCO2, there is a<br />
decrease in HCO3 by 2<br />
Chronic: for every decrease in 10 pCO2, there is a<br />
decrease in HCO3 by 5<br />
If not what expected, consider a mixed disorder.
102<br />
3. Calculate anion gap by Na- Cl- HCO3 (nl 8-12; if albumin<br />
is low reduce normal range by 2-3 for each 1 gm reduction<br />
of albumin below normal):<br />
Causes of AGMA: KUSMALE (ketones, uremia,<br />
salicylates, methanol, paraldehyde, lactic acidosis, or<br />
ethylene glycol) or GOLDMARK-paper submitted by<br />
Mehta et al (glycols, oxyproline, L-lactate, D-lactate,<br />
Methanol, Aspirin, Renal, Ketoacidosis)<br />
If anion gap, consider the following: urine and serum<br />
ketones, renal function, lactate, Utox, plasma osmolal gap.<br />
Osmolal gap: “Delta Osmoles” =measured plasma<br />
osmolality - calculated osmolality<br />
Calculated osmolality = (2xNa)+(glucose/18)+(BUN/2.8)<br />
Osmolal gap >15 suggests methanol or ethylene glycol<br />
If anion gap is decreased, you should suspect a<br />
decreased albumin or disorders that increase<br />
“unmeasured” cations such as multiple myeloma, extreme<br />
hypercalcemia, hypermagnesemia, lithium.<br />
4. If there is a high anion gap, then calculate how much it is<br />
increased above the normal range (ie, Anion Gap Increase<br />
= observed anion gap-expected anion gap (8 - 12 if<br />
albumin is normal)<br />
Increase in Gap + measured HCO3 should = about 24<br />
(The gap should go up about the same amount the HCO3<br />
goes down)<br />
• If this is >24 consider concomitant metabolic<br />
alkalosis or severe chronic respiratory acidosis<br />
• If this is
103<br />
ACUTE KIDNEY INJURY<br />
Acute Kidney Injury Network (AKIN) definition of<br />
AKI: (Have offered a modification/update of RIFLE)<br />
The proposed diagnostic criteria are an abrupt (within 48<br />
hours):<br />
• Absolute increase in the serum creatinine concentration<br />
of ≥0.3 mg/dL from baseline, or<br />
• A percentage increase in the serum creatinine<br />
concentration of ≥50 percent,<br />
• Or oliguria of less than 0.5 mL/kg per hour for more than<br />
six hours.<br />
The diagnostic criteria should be applied only after volume<br />
status has been optimized and urinary tract obstruction has<br />
been ruled out if oliguria was used as the sole diagnostic<br />
criterion.<br />
The Acute Kidney Injury Network also includes a staging<br />
system that correlates to the RIFLE criteria. Stage 1 (risk),<br />
stage 2 (injury), and stage 3 (failure) are included and loss and<br />
ESRD are considered outcomes.<br />
RIFLE criteria proposed by the Acute Dialysis<br />
Quality Initiative (ADQI):<br />
• Risk — 1.5-fold increase in the serum creatinine or GFR<br />
decrease by 25 percent or urine output
104<br />
Consider obtaining the following history or ordering<br />
the following labs/studies:<br />
• History: Any history of contrast, NSAIDS, nephrotoxins,<br />
intravascular volume depletion (vomiting, diarrhea,<br />
hemorrhage, diuretics, third spacing, burns), sepsis,<br />
recent procedure or surgery (angiography, if CABG-check<br />
aorta cross clamp time, check anesthesia log for any<br />
episodes of hypotension), medication history, history of<br />
renal disease, history of vasculitis<br />
• UA with microscopy (simple test to perform and can<br />
give you very valuable information)<br />
• Consider bladder outlet obstruction. If Foley is in place,<br />
is it blocked?<br />
• Renal ultrasound to evaluate for hydronephrosis<br />
• Urine spot Na, Cr at same time as BMP to calculate<br />
FENa if oliguric<br />
• Urine eosinophils if thinking about interstitial<br />
nephritis/cholesterol emboli/ATN<br />
Treatment:<br />
• Treat underlying cause<br />
• IV Fluids if needed<br />
• Avoid nephrotoxins/contrast<br />
• Renally dose medications<br />
• See indications for renal replacement therapy below<br />
BASIC ELECTROLYE REPLACEMENT<br />
Can replete as below and then look for underlying cause of<br />
deficiency.<br />
Calcium: Check ionized calcium, then give one to two<br />
amps of Calcium gluconate IVPB if low<br />
Magnesium: Each 1 gram given increases the serum level<br />
by about 0.1<br />
MgSO4 comes as a 50% solution in 2cc amps<br />
(2cc = 1 gm MgSO4 = 98 mg Mg = 4 mM Mg = 8 mEq<br />
Mg)<br />
Send blood and urine for Mg and Cr before replacing to<br />
check FEx Mg
105<br />
Mg
106<br />
Remember to adjust this is they have an elevated creatinine,<br />
low weight, etc.<br />
If patient taking a diet:<br />
K 3.6 to 3.8 50 meq K PO x1<br />
K 3.3 to 3.5 50 meq K PO q 2 hours x 2 doses<br />
K 2.8 to 3.2 50 meq K PO q 2 hours x 3 doses<br />
K
107<br />
CHRONIC KIDNEY DISEASE<br />
Stage GFR<br />
I >90<br />
II 60-89<br />
III 30-59<br />
IV 15-29<br />
V
108<br />
disease (GFR of 30 to 59 mL/min per 1.73 m2), 70 to 110<br />
pg/mL for those with stage 4 disease (GFR of 15 to 29<br />
mL/min per 1.73 m2), 150 to 300 pg/mL for stage 5<br />
disease (dialysis or GFR of less than 15 mL/min per 1.73<br />
m2)<br />
• Hypertension: Goal blood pressure is at least
Hypovolemic<br />
Hyponatremia<br />
EABV low<br />
Renal losses<br />
Diuretics/Salt<br />
Wasting<br />
GI losses<br />
Diarrhea/<br />
Vomiting<br />
Bleeding<br />
Other<br />
Pancreatitis<br />
3 rd Spacing<br />
(Burns,etc.)<br />
Treatment:<br />
Volume replete<br />
with<br />
• NS<br />
• Blood<br />
• Colloid<br />
Uosm100<br />
• SIADH (also see Una high,<br />
Plasma BUN and uric acid low<br />
• Hypothyroidism<br />
• Glucocorticoid deficiency<br />
Treatments:<br />
• Fluid restriction<br />
• Hypertonic saline<br />
• Demeclocycline
Anuria: UOP
111<br />
fluid pulled off and into the peritoneum. Access is through a<br />
temporary or permanent catheter.<br />
Choice of therapy:<br />
• Continuous Renal Replacement Therapy (CRRT):<br />
-Continuous venovenous hemodialysis (CVVHD)<br />
-Continuous arteriovenous hemodialysis (CAVHD)<br />
-Continuous venovenous hemodialysis with filtration<br />
(CVVHDF)<br />
-Continuous arteriovenous hemodialysis with filtration<br />
(CAVHDF)<br />
-Continuous venovenous hemofiltration (CVVHF)<br />
-Continuous arteriovenous hemofiltration (CAVHF)<br />
• Intermittent Hemodialysis (IDH)<br />
• Peritoneal Dialysis (PD)<br />
Timing of therapy: Optimal timing of RRT in patients with<br />
AKI remains to be clearly elucidated. Some retrospective and<br />
uncontrolled studies suggest that prophylactic dialysis prior to<br />
the development of overt uremia among patients with<br />
progressive AKI may be associated with reduced mortality.<br />
Some show no difference in mortality. Only one prospective<br />
randomized trial has been done to evaluate the timing of<br />
CRRT and it showed no survival benefit in early versus late<br />
CVVHF. Timing is therefore very much practitioner based.<br />
Choice of modality:<br />
• Hemofiltration versus hemodialysis: HF can more quickly<br />
clear larger molecular weight molecules. However, no trials<br />
have shown improved clinical outcomes with either modality<br />
over the other.<br />
• CRRT versus IHD: Current data suggests that survival and<br />
renal recovery are equal in patients who undergo CRRT versus<br />
IHD. Data do not support the superiority of any particular<br />
mode of RRT in patients with AKI.
112<br />
OUTPATIENT CLINIC GUIDE<br />
THE PATIENT ENCOUNTER<br />
• Check-in and vitals are completed by the medical<br />
assistant (MA).<br />
• All charts are viewed via Baylor EMR. Go to “Clinic Visit<br />
History.”<br />
• Once you have completed your clinic visit, complete the<br />
following checklist:<br />
- Clinic Visit form, only middle and right column is<br />
required.<br />
- Universal Medication List at each visit with resident<br />
signature.<br />
- Lab Request form for same day, one week prior to<br />
next visit, or both.<br />
- Fill out any consult or imaging forms as needed.<br />
- Retrieve, record on log, and place med samples in<br />
bag with “Instructions” form placed inside and patient<br />
label placed on outside of bag.<br />
- Write all prescriptions with DPS and DEA # on each<br />
Rx<br />
- Return appointment/referral form.<br />
- Dictate Clinic Visit. Dictation “type” = ‘98’.<br />
- Find a nurse to “check-out” by reviewing each<br />
above item with RN. The nurse will then dispense<br />
meds, prescriptions, and papers to the patient.<br />
RESOURCES<br />
• The clinic chiefs (two residents) accept clinic patients bimonthly.<br />
<strong>BUMC</strong> then assigns them to category 1 through<br />
8, category 1 being least funded. There are various<br />
resources that can be offered to the patients based on<br />
these categories.<br />
• The patient’s category and insurance information are<br />
located on the face sheet.<br />
Referrals<br />
Specialties offered via Resident Clinic and open to all clinic<br />
patients:<br />
• Renal, Cards, Oncology, GI, OB-Gyn, General Surgery,
113<br />
Colorectal Surgery, and Plastic Surgery � Fill out consult<br />
form.<br />
• Dermatology: Dr. Menter sees un-funded patients in the<br />
resident clinic weekly, and gets booked in advance. � Fill<br />
out consult form.<br />
• PM&R, Physical Therapy � Fill out consult form.<br />
Specialties not offered via Resident Clinic:<br />
• Psychiatry:<br />
- Funded patients � <strong>BUMC</strong> Psychiatry. Make<br />
referral.<br />
- Un-funded � Northstar. Consult Social Work to<br />
arrange.<br />
• Others (eg Ophtho, Urology):<br />
- Funded � <strong>BUMC</strong> referral.<br />
- Un-funded and in-county � Parkland. Consult<br />
Social Work.<br />
• <strong>BUMC</strong> also offers Podiatry and COPD clinic, but<br />
requires insurance.<br />
Dentistry<br />
• The Dental School Clinic provides dental services at a<br />
reduced cost.<br />
• The patient will initially need to call the dental clinic at<br />
(214) 823-1376, Wednesdays from 9-10:30 am. There is a<br />
non-refundable screening fee of $54.00. To refer, let the<br />
RN know during check-out.<br />
Coumadin Clinic<br />
• Run by our Clinical Pharmacist Jennifer.<br />
Medications<br />
• Formulary medications (list posted on wall) for Category<br />
I, II, and III patients.<br />
• Samples available for all clinic patients.<br />
• Insulin (70/30 and Levemir). Write Rx and consult clinic<br />
pharmacist.<br />
• $4 Walmart List (see next section in book for full listing)<br />
Insulin-dependent diabetes mellitus<br />
When starting insulin, the clinic offers these resources:<br />
• Insulin at no cost for un-funded patients. Write Rx and<br />
pharmacy consult. Pharmacist dispenses and provides<br />
patient education.<br />
• Glucometers and strips for un-funded patients. Write Rx<br />
and social work consult.
114<br />
• Diabetes Clinic<br />
- Requires referral by resident. Form is available on<br />
wall.<br />
- Can titrate insulin without resident's signature or<br />
resident can opt to titrate insulin him/herself.<br />
Social Work - Vendetta (mostly for un-funded patients)<br />
• Off-campus specialist referrals (eg, Parkland Clinics)<br />
• Meds not offered on formulary or Walmart $4 List<br />
• Medical supplies (eg glucometers/strips)<br />
• Patient Transportation<br />
• Counseling<br />
• <strong>Home</strong> care needs<br />
• Short-term psycho-social intervention for patients, (eg<br />
emergency shelter, severe financial need, etc.)<br />
Interpreter Service:<br />
A phone service is available. The phone is in the nurse’s<br />
station. Take the phone to your exam room, press redial, give<br />
the code “<strong>BUMC</strong>” and state the language requested.<br />
Emergency psychiatric evaluation and observation (eg<br />
acutely suicidal patient)<br />
• Inform the charge nurse who will contact the ED Psych<br />
services.<br />
• If the patient is on the phone with you, inform them that<br />
you or they need to call 911, and stay on the phone until<br />
an EMT arrives.<br />
HOW TO ORDER<br />
• IVFs or PO/IV meds in clinic = order using physician<br />
order sheet. Give to RN.<br />
• Screening tests: All order sheets are on wall in<br />
resident’s area.<br />
- Mammogram = mammo order sheet<br />
- Bone density scan = on Radiology form, write in<br />
"Bone density scan" for type of study.<br />
- Colonoscopy = GI referral on Consult form.<br />
- Eye exam = if patient is un-funded and in-county,<br />
write social work order to refer to Parkland<br />
Opthalmology Resident clinic (long wait to get<br />
appointment, patients will be called.)<br />
• MRI/CT scans = Fill out Radiology form.<br />
• Flu/Pneumovax = write on Encounter form (under<br />
medication administration).
115<br />
• Social work: Circle Social Work on "Return Visit" sheet,<br />
and write a summary of what you need.<br />
HOW TO ADMIT A PATIENT DIRECTLY<br />
FROM CLINIC<br />
1. Discuss with attending before admitting.<br />
2. Call admitting resident and present the patient. If you are<br />
on wards, you will assume care of the patient the following<br />
morning.<br />
3. Inform charge RN and request bed type.<br />
4. Send patient to admitting desk.<br />
5. Fill out H&P and write brief admit orders for team.<br />
6. Dictate clinic note.<br />
URGENT CARE VISIT<br />
• If you need to see your patient on a non-clinic day for an<br />
urgent problem, contact the clinic to obtain an<br />
appointment.<br />
• For any patient emergency, advise them to go to the ER<br />
or call EMS immediately.<br />
WELL-WOMAN EXAM<br />
Once patient is gowned, have RN/MA bring tray for Pap smear<br />
and stay for breast exam.<br />
SIGNING DOCUMENTS<br />
• Labs/Imaging/Pathology results = Initial/Date each page<br />
and place folder in “Medical Records” pile at RN’s station.<br />
• No-shows = select action to be taken (eg re-schedule,<br />
call patient, discharge from clinic with attending’s consent)<br />
and place chart on counter across from Carolyn’s<br />
(scheduler) desk.<br />
• Phone messages and social work documents = After<br />
returning call and documenting your encounter, place<br />
chart in black tray behind resident’s area.
116<br />
$4 Rx LIST<br />
(Most have 90 day supply for $10)<br />
Please refer to your own prescribing reference when writing your<br />
Rx’s<br />
Allergies & Cold and Flu<br />
Benzonatate 100mg cap<br />
Ceron DM syrup<br />
C-Phen drops* (ml bottle)<br />
Dex PC syrup<br />
Loratadine 10mg tab<br />
Promethazine DM syrup<br />
Antibiotic Treatments<br />
Amoxicillin 125mg/5ml susp<br />
(80ml bottle)(100ml bottle)<br />
(150ml bottle)<br />
Amoxicillin 200mg/5ml susp<br />
(50ml bottle) (75ml bottle)*<br />
(100ml bottle)*<br />
Amoxicillin 250mg/5ml susp<br />
(80ml bottle)(100ml bottle)<br />
(150ml bottle)<br />
Amoxicillin 400mg/5ml susp<br />
(50ml bottle)(75ml bottle)*<br />
(100ml bottle)*<br />
Amoxicillin 250mg cap/500mg<br />
cap<br />
Amoxil 50mg/ml drops* (ml<br />
bottle)<br />
Cephalexin 250mg cap/500mg<br />
cap<br />
Ciprofloxacin 250mg tab/500mg<br />
tab<br />
Doxycycline Hyclate 50mg<br />
cap/100mg cap/100mg tab<br />
Erythromycin EC 250mg cap<br />
Metronidazole 250mg tab/500mg<br />
tab<br />
Penicillin VK 250mg tab<br />
Penicillin VK 125mg/5ml susp<br />
(100ml bottle)(200ml bottle)<br />
Penicillin VK 250mg/5ml susp<br />
(100ml bottle)<br />
SMZ-TMP 200mg-40mg/5ml<br />
susp<br />
SMZ-TMP 400mg-80mg tab<br />
SMZ-TMP DS 800mg-160mg tab<br />
Tetracycline 250mg cap/500mg<br />
cap<br />
Arthritis & Pain<br />
Allopurinol 100mg tab<br />
Baclofen 10mg tab<br />
Colchicine 06mg tab<br />
Cyclobenzaprine 5mg tab/10mg<br />
tab<br />
Dexamethasone 0.5mg<br />
tab/0.75mg tab/4mg tab<br />
Diclofenac DR 75mg tab<br />
Ibuprofen 100mg/5ml susp<br />
Ibuprofen 400mg tab/600mg<br />
tab/800mg tab<br />
Indomethacin 25mg cap<br />
Meloxicam 7.5mg tab/15mg tab<br />
Naproxen 375mg tab/500mg tab<br />
Piroxicam 20mg cap<br />
Salsalate 500mg tab<br />
Asthma<br />
Albuterol 2mg tab/4mg tab<br />
Albuterol 2mg/5ml syrup<br />
Albuterol 0.5% nebulizer soln<br />
(20ml bottle)<br />
Albuterol 0.083% nebulizer soln*<br />
(25x3ml vials)<br />
Ipratropium 0.02% nebulizer<br />
soln* (25x25ml vials)<br />
Cholesterol<br />
Lovastatin 10mg tab/20mg tab<br />
Pravastatin 10mg tab/20mg<br />
tab/40mg tab<br />
Diabetes<br />
Chlorpropamide 100mg tab<br />
Glimepiride 1mg tab/2mg<br />
tab/4mg tab<br />
Glipizide 5mg tab/10mg tab<br />
Glyburide 2.5mg tab<br />
Glyburide 5mg tab (blue)/(green)<br />
Glyburide, micronized 3mg<br />
tab/6mg tab<br />
Metformin 500mg tab/1000mg<br />
tab<br />
Metformin 500mg ER tab
Ear Health<br />
Antipyrine/Benzocaine otic (10ml<br />
bottle)<br />
Fungal Infections<br />
Fluconazole 150mg tab<br />
Nystatin/Triamcin cream (15gm<br />
tube)<br />
Nystatin/Triamcin ointment<br />
(15gm tube)<br />
Nystatin cream (15gm tube)<br />
Nystatin ointment (15gm tube)<br />
Terbinafine 250mg tab<br />
Gastrointestinal Health<br />
Belladonna Alkaloid/PB tab<br />
Cimetidine 800mg tab<br />
Cytra2 solution<br />
Dicyclomine 10mg cap/20mg tab<br />
Famotidine 20mg tab<br />
Lactulose syrup<br />
Metoclopramide 10mg tab<br />
Metoclopramide syrup<br />
Promethazine 25mg tab<br />
Promethazine plain syrup<br />
Ranitidine 150mg tab/300mg tab<br />
Glaucoma & Eye Care<br />
Atropine Sulfate 1% op soln (5ml<br />
bottle)<br />
Bacitracin op ointment (35gm<br />
tube)<br />
Erythromycin op ointment (35gm<br />
tube)<br />
Gentamicin 0.3% op soln (5ml<br />
bottle)<br />
Levobunolol 0.5% op soln (5ml<br />
bottle)<br />
Neomycin/Polymyxin/Dexameth<br />
asone 0.1% op ointment (35gm<br />
tube)<br />
Neomycin/Polymyxin/Dexameth<br />
asone 01% op susp (5ml bottle)<br />
Pilocarpine 1% op soln (15ml<br />
bottle)<br />
Pilocarpine 2% op soln (15ml<br />
bottle)<br />
Polymyxin Sulfate/TMP op soln*<br />
(10ml bottle)<br />
Sulfacet Sodium 10% op soln<br />
(15ml bottle)<br />
Timolol Maleate 0.25% op soln<br />
(5ml bottle)<br />
117<br />
Timolol Maleate 0.5% op soln<br />
(5ml bottle)<br />
Tobramycin 0.3% op soln (5ml<br />
bottle)<br />
Heart Health & Blood Pressure<br />
Amiloride-HCTZ 5mg-50mg tab<br />
Atenolol-Chlorthalidone 50mg-<br />
25mg tab/100mg-25mg tab<br />
Atenolol 25mg tab/50mg<br />
tab/100mg tab<br />
Benazepril 5mg tab/10mg<br />
tab/20mg tab/40mg tab<br />
Bisoprolol-HCTZ 25mg-625mg<br />
tab/5mg-625mg tab/10mg-<br />
625mg tab<br />
Bumetanide 0.5mg tab/1mg tab<br />
Captopril 125mg tab/25mg<br />
tab/50mg tab/100mg tab<br />
Carvedilol 3.125mg tab/6.25mg<br />
tab/12.5mg tab/25mg tab*<br />
Chlorthalidone 25mg tab/50mg<br />
tab<br />
Clonidine 0.1mg tab/0.2mg tab<br />
Digoxin 0.125mg tab/0.25mg tab<br />
Diltiazem 30mg tab/60mg<br />
tab/90mg tab*/120mg tab<br />
Doxazosin 1mg tab/2mg<br />
tab/4mg tab/8mg tab<br />
Enalapril-HCTZ 5mg-12.5mg tab<br />
Enalapril 25mg tab/5mg<br />
tab/10mg tab/20mg tab<br />
Furosemide 20mg tab/40mg<br />
tab/80mg tab<br />
Guanfacine 1mg tab<br />
Hydralazine 10mg tab/25mg tab<br />
Hydrochlorothiazide (HCTZ)<br />
12.5mg cap*/25mg tab/50mg tab<br />
Indapamide 1.25mg tab/2.5mg<br />
tab<br />
Isosorbide Mononitrate 30mg ER<br />
tab/60mg ER tab<br />
Lisinopril-HCTZ 10mg-12.5mg<br />
tab/20mg-12.5mg tab*/20mg-<br />
25mg tab*<br />
Lisinopril 2.5mg tab/5mg<br />
tab/10mg tab/20mg tab<br />
Methyldopa 250mg tab*/500mg<br />
tab*<br />
Metoprolol Tartrate 25mg<br />
tab/50mg tab/100mg tab*<br />
Nadolol 20mg tab/40mg tab
Nitroquick 0.3mg sub tab* (100<br />
count bottle)†<br />
Nitroquick 0.4mg sub tab* (25<br />
count)†<br />
Nitroquick 0.4mg sub tab* (100<br />
count bottle)<br />
Pindolol 5mg tab/10mg tab<br />
Prazosin HCL 1mg cap/2mg<br />
cap/5mg cap<br />
Propranolol 10mg tab/20mg<br />
tab/40mg tab/80mg tab<br />
Sotalol HCL 80mg tab<br />
Spironolactone 25mg tab<br />
Terazosin 1mg cap/2mg<br />
cap/5mg cap/10mg cap<br />
Triamterene-HCTZ 37.5mg-<br />
25mg cap/37.5mg-25mg<br />
tab/75mg-50mg tab<br />
Verapamil 80mg tab/120mg tab<br />
Warfarin 1mg tab/2mg tab/2.5mg<br />
tab/3mg tab/4mg tab/5mg<br />
tab*/6mg tab/7.5mg tab/10mg<br />
tab<br />
Mental Health<br />
Amitriptyline 10mg tab/25 mg<br />
tab/50mg tab/75mg tab/100mg<br />
tab<br />
Benztropine 2mg tab<br />
Buspirone 5mg tab/10mg tab*<br />
Carbamazepine 200mg tab<br />
Citalopram 20mg tab/40mg tab<br />
Doxepin HCL 10mg cap/25mg<br />
cap/50mg cap/75mg cap/100mg<br />
cap<br />
Fluoxetine 10mg tab*/10mg<br />
cap/20mg cap/40mg cap<br />
Fluphenazine 1mg tab<br />
Haloperidol 0.5mg tab/1mg<br />
tab/2mg tab/5mg tab<br />
Lithium Carbonate 300mg cap<br />
Nortriptyline 10mg cap/25mg<br />
cap<br />
Paroxetine 10mg tab*/20mg tab*<br />
Prochlorperazine 10mg tab<br />
Thioridazine 25mg tab/50mg tab<br />
Thiothixene 2mg cap<br />
Trazodone 50mg tab/100mg<br />
tab/150mg tab<br />
Trihexyphenidyl 2mg tab<br />
118<br />
Skin Conditions<br />
Benzoyl Peroxide 4% creamy<br />
wash (1701ml bottle)<br />
Betamethasone Dipropionate<br />
0.05% cream (45gm tube)<br />
Betamethasone Valerate 0.1%<br />
cream (15gm tube)<br />
Betamethasone Val 0.1% cream<br />
(45gm tube)<br />
Fluocinolone Acet 0.01% soln<br />
(60ml bottle)†<br />
Fluocinonide 0.05% cream<br />
(15gm tube)†<br />
Fluocinonide 0.05% cream (gm<br />
tube)†<br />
Gentamicin 0.1% cream (15gm<br />
tube)<br />
Gentamicin 0.1% ointment<br />
(15gm tube)†<br />
Hydrocortisone 1% cream<br />
(2835-g tube)†<br />
Hydrocortisone 25% cream (gm<br />
tube)†<br />
Selenium Sulfide 25% lotion*<br />
(120ml bottle)†<br />
Silver Sulfadiazine 1% cream*<br />
(50gm tube)<br />
Triamcinolone 0.025% cream<br />
(15gm tube)†(80gm tube)†<br />
Triamcinolone 0.1% cream<br />
(15gm tube)† (80gm tube)†<br />
Triamcinolone 0.1% ointment<br />
(15gm tube)† (80gm tube)†<br />
Triamcinolone 0.5% cream<br />
(15gm tube)†<br />
Thyroid Conditions<br />
Levothyroxine 25mcg tab/50mcg<br />
tab/75mcg tab/88mcg<br />
tab/100mcg tab/112mcg<br />
tab/125mcg tab/137mcg<br />
tab/150mcg tab/175mcg<br />
tab*/200mcg tab*<br />
Viruses<br />
Acyclovir 200mg cap<br />
Vitamins & Nutritional Health<br />
Folic Acid 1mg tab<br />
Klorcon 8 8mEq ER tab<br />
Klorcon 10 10mEq ER tab<br />
Klorcon M10 10mEq tab<br />
Mag 64 64mg tab
Magnesium Oxide 400mg tab<br />
Prenatal Plus qty 30<br />
Potassium Chloride 10% liquid<br />
Sodium Fluoride .5mg chewable<br />
(120ct bottle)<br />
Women’s Health<br />
Estradiol 0.5mg tab/1mg<br />
tab/2mg tab<br />
Estropipate 0.75mg tab/1.5mg<br />
tab*<br />
Medroxyprogesterone Acetate<br />
25mg tab/5mg tab/10mg tab<br />
Alendronate SOD 35mg<br />
tab/70mg tab<br />
Clomiphene 50mg tab<br />
EST Estrogen/Methyl Testost<br />
HS tab/ DS tab<br />
Sprintec 28-day tab*<br />
Tri-Sprintec 28-day tab*<br />
Tamoxifen 10mg tab/20mg tab<br />
Other Medical Conditions<br />
Chlorhexidine Gluconate 0.12%<br />
soln<br />
Hydrocortisone AC 25mg<br />
suppositories<br />
Isoniazid 300mg tab<br />
Lidocaine 2% viscous solution<br />
(100ml bottle)†<br />
Megestrol 20mg tab*<br />
Methylpred 4mg tab<br />
Methylpred 4mg dose pak (21<br />
tablets)†<br />
Oxybutynin 5mg tab<br />
Phenazopyridine 100mg<br />
tab/200mg tab<br />
Prednisone 2.5mg tab/5mg<br />
tab/10mg tab/20mg tab<br />
Prednisone 5mg dose pak (21<br />
tablets)† (48 tablets)*†<br />
Prednisone 10mg dose pak (21<br />
tablets)† (48 tablets)*†<br />
119
120<br />
OTHER INFORMATION<br />
TOP TEN INTERN TIPS<br />
1. Be sure when you admit a patient, you ask the admitting<br />
attending how often they want to be contacted, and update<br />
them as they request.<br />
2. If you plan on discharging a patient, call the attending first<br />
thing in the am (esp TPC) so they can plan on seeing the<br />
patient early prior to discharge. If you can’t reach anyone from<br />
TPC and the patient has been set for discharge based on prior<br />
days’ attending, make sure to leave a message on the main<br />
line letting them know you plan on discharging the patient at X<br />
time unless you hear otherwise. ALWAYS CALL BEFORE<br />
YOU DISCHARGE.<br />
3. Dictate in a timely manner and review dictations/electronic<br />
signatures often so your attending does not end up on the B<br />
list and lose their admitting privileges. Go to medical records<br />
and have cookies and juice and review your dictations if you<br />
need to find a happy place!<br />
4. When you order an echo, write who needs to read it: Heart<br />
Place, CCT, or NTC. Look back at old echos and have the<br />
same group read it as did before.<br />
5. If you are waiting for a read on a radiologic study, look on<br />
centricity and see if it is dictated. If so, dial 2-XRAY and enter<br />
your user name/password to hear the dictation.<br />
6. Review the nurses notes from the previous night as well as<br />
PT/OT/Respiratory notes (located under a separate tab).<br />
Nutrition leaves notes at the back of the physician progress<br />
note section.<br />
7. Help out your other interns: Write prns on your admission<br />
orders and then sign cross-cover verbal orders when you<br />
round in the am so they don’t have to have them appear on<br />
their ESA’s and sign them electronically.<br />
8. If you need to call a patient from your cell phone or home<br />
phone, dial *67 and then the number.<br />
9. If you need to obtain medical records from an outside<br />
facility, write an order and the clerk will fax the request with the<br />
help of the nurse. Follow-up if the records do not come in a<br />
few days.<br />
10. Live, laugh, and learn … take the best care of your<br />
patients that you can and you will make it with flying colors!
121<br />
DUEWALL’S FAVORITE MNEMONICS<br />
• Pancreatitis:<br />
GET SMASHED<br />
Gallstones<br />
Ethanol<br />
Trauma<br />
Steroids<br />
Mumps<br />
Autoimmune<br />
Scorpion bites<br />
Hypercalcemia/triglyc<br />
eridemia<br />
ERCP (post-ERCP)<br />
Drugs (azathioprine,<br />
thiazides)<br />
• ACS treatment<br />
MONA BASH<br />
Morphine, Oxygen,<br />
Nitroglycerin, Aspirin,<br />
B-blocker, ACE-<br />
Inhibitor, Statin,<br />
Heparin<br />
• Alt. Mental Status<br />
MOVE STUPID<br />
Metabolic<br />
(Hypothyroid, Hepatic<br />
encephalopathy)<br />
Oxygen (hypoxia)<br />
Vascular (stroke)<br />
Electrolytes<br />
(Hypercalcemia,<br />
Hyponatremia)<br />
Seizure<br />
Trauma (subdural<br />
hematoma, epidural<br />
hematoma)<br />
Uremia<br />
Porphyria<br />
Infection (Meningitis,<br />
Encephalitis, Sepsis,<br />
specifically urosepsis<br />
in elderly)<br />
Drugs<br />
• Ranson’s Criteria:<br />
At admiss.: GALAW<br />
Glucose >200<br />
Age >55<br />
LDH >350<br />
AST>250<br />
WBC >16,000<br />
• At 48 hours-C<br />
HOBBS<br />
Calcium 10%<br />
Oxygen: PaO2 5<br />
mg/dL<br />
Base deficit >4 mEq/L<br />
Sequestration of fluid<br />
>6L<br />
• TTP (FAT RN)<br />
Fever<br />
Anemia<br />
(Microangiopathic<br />
hemolytic anemia)<br />
Thrombocytopenia<br />
Renal Failure<br />
Neuro changes (AMS)<br />
+if suspect TTP, it is<br />
an emergency to get<br />
patient to plasma<br />
exchange<br />
• Acute Dialysis<br />
Indications-AEIOU<br />
Acidemia, Electrolyte<br />
disturbances,<br />
Intoxication, Overload<br />
(volume), Uremia<br />
• Fractional<br />
excretion of Sodium<br />
(FENa)<br />
“UNaP over UCraP”<br />
(Urine Na x Plasma<br />
Cr)/(Urine Cr x<br />
Plasma Na)<br />
• Kinds Of Tumors<br />
Leaping Primarily To<br />
Bone<br />
Kidney<br />
Ovarian<br />
Thyroid<br />
Lung<br />
Prostate<br />
Testicular<br />
Breast<br />
• Drug Induced<br />
Lupus Agents-<br />
SHIPS drugs<br />
Sulfasalazine,<br />
Hydralazine,<br />
Isoniazid,<br />
Procainamide, Statins<br />
• Causes of Atrial<br />
Fibrillation<br />
I SMART CHAP<br />
Infectious<br />
(endocarditis,<br />
myocarditis, sepsis)<br />
Surgery (Post-CABG)<br />
Medications (caffeine,<br />
theophylline)<br />
Artheroclerotic CAD<br />
Rheumatic Heart<br />
Disease (MS or MR)<br />
Thyrotoxicosis<br />
Congential<br />
malformation (ASD)<br />
Hypertensive heart<br />
disease<br />
Alcohol (Alcoholic<br />
CM, Holiday Heart<br />
Syn)<br />
PE<br />
• Anion Gap<br />
Metabolic Acidosis<br />
GOLD MARK or<br />
KUSMALE<br />
Glycols<br />
Oxyproline<br />
L-lactate<br />
D-lactate<br />
Methanol<br />
Aspirin<br />
Aspirin<br />
Renal<br />
Ketoacidosis<br />
Ketones<br />
Uremia<br />
Salicylates<br />
Methanol<br />
Acetaldehyde<br />
Lactic Acidosis<br />
Ehtylene Glycol
122<br />
SUSTENANCE AND COMFORT FOOD<br />
Will deliver…<br />
www.diningin.com<br />
Bangkok City (Thai) 214-824-6200<br />
www.bangkokcityrestaurant.com<br />
You can send your students…<br />
Angry Dog (salads/sandwiches) 214-741-4406<br />
2726 Commerce, www.angrydog.com<br />
Jimmy’s Italian Deli/Food Store 214-823-6180<br />
4901 Bryan, www.jimmysfoodstore.com<br />
Lenny’s Sub Shop 214-826-1500<br />
4201 Gaston, www.lennys.com<br />
Matt’s Rancho Martinez 214-823-5517<br />
6332 La Vista, www.thetexmexchef.com<br />
Pei Wei (Asian diner) 214-219-0000<br />
3001 Knox St, www.peiwei.com<br />
Fadi’s (Mediterranean) 214-528-1800<br />
3001 Know St, www.fadiscuisine.com<br />
Chuy’s (Mexican) 214-559-2489<br />
4544 McKinney Ave, www.chuys.com<br />
Pot Belly (sandwiches)<br />
www.potbelly.com<br />
5715 Lemmon 214-353-0581<br />
4447 N Central Expressway 214-520-3251<br />
Or you can eat at <strong>BUMC</strong>…<br />
Cafeteria (Truett basement)<br />
Daily 6:30 AM-7:30 PM<br />
Bake Shop/Starbucks (next to cafeteria)<br />
M-F 6:30 AM – 2 PM<br />
Atrium (Roberts lobby)<br />
M-F 6:30 AM–1:30 AM, S/S 7:30 PM-1:30 AM<br />
Frulatti (Barnett lobby)<br />
M-F 6 AM-8 PM, Sat 8 AM-4 PM
123