Science 30 January 1999 Grade 12 Diploma Examination

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Genetic research has a significant impact on the development of medical technology.Use the following information to answer the next three questions.A Potential Gene TherapyA protein known as VP22, which is made by the cold sore virus, seems tohave good potential for gene therapy. It moves freely into and out of cells andtheir nuclei. Experiments have been performed in which the gene thatproduces VP22 has been introduced into mammalian cells. When the geneenters a cell, VP22 is produced. The protein VP22 then enters an average of200 neighbouring cells. In this way, scientists can use the VP22 as a carrierfor distributing genetic material, proteins, or drugs.9. When the gene that produces VP22 enters the nucleus of a cell and begins theproduction of VP22, the cell is expressingA. a point mutationB. a recessive geneC. recombinant DNAD. a chromosomal abnormality10. In most cases, when foreign proteins such as VP22 enter the body, they are initiallyattacked byA. antibodiesB. macrophagesC. helper T cellsD. killer (cytotoxic) T cells4
Use the following additional information to answer the next question.Steps for Using VP22 on a Rabbit1 The drug affects the functioning of the liver.2 Drug molecules are attached to VP22 molecules in the lab.3 The drug molecules attached to the VP22 enter the cells of the rabbit,including the liver cells.4 The drug molecules attached to the VP22 are injected into the bloodstreamof the rabbit.Numerical Response01. Researchers wish to use a drug to treat the diseased liver of a rabbit using VP22.The order in which the steps must occur is _____, _____, _____, and _____.(Record your four-digit answer in the numerical-response section on the answer sheet.)5
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Science 30 January 1999 Grade 12 Diploma Examination

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