Oncology Probes

Satellite Enumeration probesThe primary constriction, called the centromer, is a common feature of chromosomes necessary for cell division.Presence of repetitive sequences in the centromeric regions have been proven to be essential. In humans, andmany other species, specific repetitive sequences, called ‘Satellites’ are characteristic for the centromer ingeneral. Most chromosomes have even repetitive sequences which are specific for individual chromosomes andcan be used for precise identification and enumeration of human chromosomes in metaphase and interphasecells. The Poseidon Satellite Enumeration probes – SE – allow rapid and specific chromosome analysis, markerchromosome identification and the detection of aneuploidy. Essentially, these probes can be used in all aspectsof routine work in genetics and oncology/pathology. Due to the sharp and bright signals produced, the Satelliteprobes can easily be used on various sample types, such as cultured cells, touch preparations buccal smears,cytospins, frozen and paraffin-embedded tissue sections, sputum samples, sperm samples, and bladder washes.Cat# KBI-20012-R Cat# KBI-20018-B Cat# KBI-20031 Cat# KBI-20030Satellite Enumeration ProbesAll Human Centromere (AHC) probeThis probe specifically hybridizes to the centromericregion of all human chromosomes, and is labeled withhigh fluorescence intensity in red or green color. PoseidonAHC probe is ideal for studying numerical chromosomeaberrations, studying aneuploidy, polyploidy, dicentrics,tricentrics, and other complex aberrations. It can also beused for general numerical chromosome analysis. PoseidonAHC probe is for RUO and is not meant to be used formedical purposes or as a diagnostic tool.Cat.# KBI-20000 All Human Centromere (AHC) probeTechnical information:All SE probes are supplied in a 10 test format together withhybridization buffer, labeled in green (PlatinumBright495),red (PlatinumBright550), or blue (PlatinumBright415).The SE combinations are already supplied in a dual-colorformat Ready-to-Use. Poseidon SE probes are provided inconcentrated format to allow, mixing of up to 5 SE probesin a single hybridization assay. Please refer to the Instructionfor Use Manual for further details.Note:Satellite sequences share some degree of homology between the sequences fromchromosome to chromosome. Therefore the recommended stringency conditions inhybridization and posthybridization washes must be followed to provide optimal results.Chromosomes 1/5/19, 13/21, and 14/22 share the same repetitive sequences andcannot be differentiated by chromosome specific repeats.84Cat.# KBI-20000