Oncology Probes

Sub-Telomere probesTelomeres are specialized DNA-protein structures containing long stretches of (TTAGGG)n repeats at the end of allchromosomes. They protect chromosomes from degradation and end-to-end fusion with other chromosomes.The region adjacent to sequences containing telomeric repeats is called the sub-telomer which has been foundto be relative gene-rich. Cytogenetic analysis of sub-telomeric regions is difficult due to low resolution usingconventional banding techniques. Cryptic deletions and rearrangements have been associated with unexplainedmental retardation and congenital abnormalities.FISH probes specific for the sub-telomeric regions of the terminal chromosome regions are essential to detectsuch subtle rearrangements.ST - Sub-Telomeric probesDual-Color(TTAGGG)nrepeatsDistalsub-telomericsequenceDegenerate (TTAGGG)nSub-Telomere probes 6pter and 2pter showing trisomyof tel 6p and monosomy of tel 2p.Image kindly provided by Institute Pasteur, Paris.Triple-ColorProximalsub-telomericsequenceSub-Telomere Probes82ChromosomeuniquesequenceTechnical information:The ST probes are supplied in a 5 test format together withhybridization buffer, labeled in green (PlatinumBright495), red(PlatinumBright550), or blue (PlatinumBright415).Combination of Sub-Telomere probes 6qter (red),8qter (green) and 9pter (blue)Poseidon ST probes are provided in concentrated format toallow, mixing of up to 5 ST probes in a single hybridizationassay. Please refer to the Instruction for Use Manual for furtherdetails.Note:All probes in the ST range have not shown any cross-hybridization to other chromosomalregions. However, it cannot be excluded that certain sequence polymorphism could stillexist. If any unusual hybridization patterns are observed please contact us