Oncology Probes

ON p53 (17p13) / SE 17 (tissue)The p53 tumor suppressor gene at 17p13, has beenshown to be implicated in the control of normal cellularproliferation, differentiation, and apoptosis. Allelic loss,usually by deletion, and inactivation of p53 have beenreported in numerous tumor types and are associated withpoor prognosis in CLL.The p53 (17p13) specific DNA probe is optimized todetect copy numbers of the p53 gene region at 17p13. Thechromosome 17 satellite enumeration probe (SE 17) atD17Z1 is included to facilitate chromosome identification.ON TFE3 (Xp11) BreakAbnormalities of Xp11.2 region have often been observed inpapillary renal cell carcinomas and are sometimes the solecytogenetic abnormality present. The transcription factorbinding to IGHM enhancer 3 (TFE3) gene, which encodesa member of the helix-loop-helix family of transcriptionfactors, is located in this critical region and can be fusedto various other chromosomal regions by translocation.Known fusion partners are NONO (Xq12), PRCC (1q21),SFPQ (1p34), CLTC (17q23) and ASPSCR1 (17q25).The TFE3 (Xp11) Break probe is optimized to detecttranslocations involving the TFE3 gene region at Xp11.2 ina dual-color, split assay.Cat.# KBI-10738 p53 (17p13) / SE 17 (tissue)Cat.# KBI-10741 TFE3 (Xp11) BreakDXS6784D17Z117p13D17S960Xp11.2525 KBTFE3330 KBP53425 KB17D17S634DXS1522XP53 (17p13) / SE 17 (tissue) probe hybridized to paraffinembedded tissue (2R2G).Literature:Amiel A et al, 1997, Cancer Gener.Cytogenet,, 97; 97-100Drach J et al, 1998, Blood, 92; 802-809Ordering information Color Tests Cat#ON p53 (17p13) / SE 17 (tissue) red/green 10 KBI-10738TFE3 (Xp11) Break probe hybridized to renal cell carcinomashowing a translocation at Xp11 (1RG1R1G).Image kindly provided by Dr. Desangles, ParisLiterature:Sidhar et al, 1996, Hum Mol Genet, 5; 1333-1338.Weterman et al., 1996, Proc Natl, Acad Sci, 93; 15294-15298.Ordering information Color Tests Cat#ON TFE3 (Xp11) Break red/green 10 KBI-10741Oncology Probes - Solid Tumors65